PAI‑1 Deficiency Extends Lifespan via Longer Telomeres
“🔘 Heterozygosity was associated with significantly longer leukocyte telomere length, lower fasting insulin levels, and lower prevalence of diabetes mellitus. 🔘In the extended Amish kindred, carriers of the null SERPINE1 allele had a longer life span. 🔘Our study indicates a causal effect of PAI-1 on human longevity…”
Anthocyanins Improve Cardiometabolic and Anti‑
Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects https://t.co/tHwVYQ3yvQ https://t.co/cxiRpkIj7W
GLP‑1 Therapy Shows Benefit for Type 1 Diabetes Patients
A 174,000-patient analysis just delivered the first hard evidence that GLP-1 drugs work in a population every clinical trial has excluded. As a medical school professor, I teach that Type 1 diabetes is autoimmune, Type 2 is metabolic. But the cardiovascular...
Why Aging Solutions Aren’t Scientific Priorities
I've met Laurent, and it's great to see him now focusing on aging. Why isn't solving aging a top scientific priority?
AI: Our Best Bet to Beat Aging
AI is likely the only hope we have to solving aging. In fact, it is the opposite of David’s paint analogy.
TB‑500 Is Not TB‑4: No Human Evidence
TB - 500 is a short chain fragment synthesized from Thymosin Beta-4. TB-4 has solid human evidence for use. TB500 has absolutely no evidence. Totally different compounds. They cannot be referred to interchangeably because they simply are NOT the same
Balanced Longevity Research Shows Real Human Impact
Longevity Science Is Overhyped. But This Research Really Could Change Humanity. We were delighted to have @susandominus with us at the last academy meeting earlier this year. She does gives a balanced take on the latest rejuvenation science. This...
Resistance Training Plus Polyphenols Boost Aging Health
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals https://t.co/mDL393xerp @GeroScienceAGE https://t.co/qr3yxiZuHB
Cellular Rejuvenation Could Shift Medicine to Youthful Resilience
Cellular rejuvenation may redefine medicine—not by treating disease, but by restoring youthful resilience at the cellular level. But science, safety, and hype are colliding. Worth the read (gift link) : 👇 https://t.co/7JGNdhFsFP via @NYTimes
Infinite ROI on Longevity, Yet We Plan Vacations Instead
Question: What's the ROI on preventing your own death? Answer: Infinite. Yet 99% of people spend more time planning vacations than planning longevity.
HIIT Boosts Brain Health in Heart Disease Patients
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients “the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more...
Low Post‑Surgery Klotho Predicts Inflammation and Cognitive Decline
Lower levels of the anti-aging protein Klotho after surgery were strongly linked to higher inflammation and worse cognitive function in patients with postoperative cognitive dysfunction (POCD). This suggests Klotho could be a useful early biomarker—and possibly a treatment target—for predicting...
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Aging Can Be Solved—Join the LBF8 Fellowship
1/ How long do you want to live? For most of human history, aging was inevitable. It's now solvable. Apply for LBF8 cohort program: longbiofellowship dot org /THREAD🧵
Shared Pathways Link Gut Aging and IBD; Target Early
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging "this article highlights both the shared and distinct pathways driving gut dysfunction in aging and IBD, and underscores the importance of early recognition and targeted...
ACC Endorses Universal CRP Screening for Heart Risk
I've been waiting for this for a long time... The American College of Cardiology now recommends universal screening for a marker I've been writing about since 2011 - and most doctors still don't order it. The American College of Cardiology now highlights inflammation...
Diet Diversity Spans From 20 to 86 Foods, Women Lead
We’re told to “eat a diverse diet”—but how diverse is it in reality? Over 2 weeks: • Lowest 10% consume ~20 unique items • Highest (novelty seekers) reach ~86 Interesting twist: women tend to sample more unique foods than men. Where do you fall? @NatMetabolism https://t.co/08GlVexklU
Food Sources for All Your Essential Supplements
Eat your supplements cheat sheet 💊🥦🥘 - Creatine: herring, red meat - Glycine: gelatin - Magnesium: pumpkin seeds - Boron: dried fruit, avocado - Potassium: potatoes - Omega-3s: salmon, sardines - Spermidine: wheat germ, cheese - Vitamin K2: natto, cheese - Taurine: seaweed, fish - Trimethylglycine: beets - Astaxanthin: salmon, shrimp -...
AI Accelerates Longevity Science at London Tech Show
AI is reshaping longevity science faster than ever. At the Health + AI Insiders Tech Show, I'll be discussing how computational biology is transforming our understanding of ageing. 📍 London | 29 April 2026 🔗 Complimentary tickets: https://t.co/4XipXYfWcc
Swedish Clinic Finds Limited Eligibility for New Alzheimer Drugs
Preparing for the implementation of anti-amyloid therapies in Europe: Assessing real-world eligibility for lecanemab and donanemab in a Swedish memory clinic https://t.co/H3TgYvgVSk
Uridine Boosts Synapse Formation in Aging Brains
Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses https://t.co/bOoaNebYmn
Engineering Immortality: AI Challenges Death as System Failure
The New York Times says wanting to live is pathological. What do you think? Two thirds of the human population believes in some form of life after death. Ancient Egyptians built pyramids for it and Gilgamesh searched deserts for it. 1.9 billion...
Ageing Is a Multilevel Network; Target Central Hubs
Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions 👉 “Because molecular, cellular, tissue and organismal levels retain partial autonomy, human ageing can be viewed as a multilevel phenomenon. 🔬Geroscience may therefore advance by mapping this network...
Epigenetic Clocks Predict Lung Cancer Risk Beyond Self‑reports
New paper: Epigenetic age clocks help predict lung cancer risk & mortality by estimating smoke exposure. Is independent of self-reported smoking history, so people probably lie about it. Clocks could help doctors predict lung cancer risk & decide on...
Raw Peptides Degrade Instantly, Never Achieve Effect
Hi @MartinShkreli - if as you say at https://t.co/qJh2vgV0Wm that "raw peptides have a half-life measured in seconds or minutes, meaning your body destroys them almost instantly after you inject them. They never get a chance to do anything."...
MIB‑626 NMN Shows Lifespan Boost and New Mechanism
1. No living forever 🙈 2. Some MIB-626 (crystaline polymorph, pure NMN) human clinical trial results are in 😀 3. About to resubmit a revised mouse MIB-626 paper with Alice Kane, showing improved health measures + lifespan & a putative new mechanism...
Shingles Vaccine Boosts Longevity for Over‑50s
Done. Herpes virus neutralized 🦠 Not taking any chances with my longevity, now that shingles is associated with faster aging (though not yet a known cause). If you’re 50+, consider it. The shot will likely be money- & pain-free I even...
Oral Health May Influence Alzheimer’s Risk—Floss Daily
Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s. Either way, to reduce overall inflammation, maintain oral heath by: 1. Flossing daily 2. Using an electric toothbrush 3. Seeing a dentist >2x a year 4. Chewing oral probiotics 🦷🧠💪
Track and Treat Silent Blood Pressure for Lifelong Health
High blood pressure is one of the quietest threats in medicine. You can feel completely fine while it silently damages the heart, brain, blood vessels and kidneys for years. The good news: it’s measurable, trackable, and highly modifiable. Check it...
AI's Role in Extending Human Healthspan
My interview on healthspan and AI with @mmlederman1 and @LCalabreseDO @paijournal transcript video https://t.co/cRGtTIN1EN https://t.co/soUWAuPU02
Ergothioneine Ties Blood Metabolome To
Ergothioneine. The blood metabolome of cognitive function and brain health in middle-aged adults – influences of genes, gut microbiome, and exposome https://t.co/H8tWyRhswR
GLP‑1s Spark Massive Consumer Biotech Revolution
GLP-1s have paved the way for massive consumer biotech Discussed in Lifespan and still rolling out as predicted
Heat Therapy Mimics Exercise Through Shear Stress and Genes
Best review yet: We have identified plausible ways heat therapy works, such as shear stress and heat-sensitive genes “We find heat therapy to be analogous to exercise in many respects” 💪 https://t.co/RAFMTK8j3S https://t.co/iTVyZZuFZc
Midlife Fitness Proven to Boost Longevity and Health Span
A new JACC study from the Cooper Institute (April 22, 2026) followed nearly 25,000 adults for 30 years. As a medical school professor, I teach that the strongest longevity drug we have is not on a prescription pad. This study makes...
BMI Alone Misses Long‑term Heart Risk, Study Shows
A new Mass General Brigham study of 136,498 adults rewrites how we should screen cardiovascular risk. As a medical school professor, I teach that one lab number rarely tells the long-term story. This study (PLOS One, April 2026) shows the same...
Nesprin‑2 Protein Blocks Heart Cancer, May Aid Other Tumors
Wondered why we don’t hear about heart cancer? Contraction-sensing Nesprin-2 protein is discovered to prevent heart cancer By causing cells to pulse (or adding in Nespirin) we might be able to treat cancer in other organs 👏 @ScienceMagazine https://t.co/A8fOuw31N2
Consumer Biotech Poised to Dominate, Telehealth Captures Value
I’ve said this before: I believe consumer biotech will become the most compelling sub-sector within biotech - without question - and one of the most attractive investment opportunities overall. At its core, this category targets products that slow or reverse aging,...
High LDL Remains Dangerous, Even for Lean Responders
There is no safe gamble with high LDL cholesterol The pitfalls of the lipid energy model and why “lean mass hyper-responders” should still take high LDL cholesterol seriously. https://t.co/lbRnOfe2py
H. Pylori and T. Gondii Infections Accelerate Frailty in Aging
Associations of common infections with frailty and mortality in two UK cohort studies "Our results indicate that infection with H. pylori and T. gondii, and the combined burden of infection may detrimentally impact ageing health. These pathogens may warrant targeting beyond...
Doctors Warn DIY Peptide Injections Cause Serious Injuries
People are injecting DIY peptides for weight loss and longevity. Doctors are alarmed at the side effects. “Doctors working on the bleeding edge of longevity care in high-end clinics around the globe — from concierge practices in wealthy enclaves of California...
Anecdotes Aren’t Data: Call for Rigorous Rapamycin Trials
Table updates worth noting 🔎 🔘 @bryan_johnson stopped it 🔘Alan Green died at 80 from hereditary cardiomyopathy 🫀 🔘Misha Blagosklonny died at 63 from cancer 👉These are cases, not data. Instead of adjusting the tally, what we actually need are rigorous human trials. Is rapamycin...
Eight Healthy Habits by 40 Add 24 Years
👉Adopting all eight healthy lifestyle habits by age 40 can increase life expectancy by an average of 24 years for men and up to 23 years for women compared to individuals who adopt none of these habits. 👨🏻⚕️ •Being physically active •Not...
Your Face Mirrors Health—Change Habits, Rejuvenate Quickly
True. The face is the most honest biomarker we have. Sleep, stress, food, exercise, and sun all show up within weeks. The good news is it runs in reverse just as fast. Better inputs, younger face.
Russian Gene Therapy Claims to Extend Life to 150
Russian scientist in bombshell ageing drug claim after Putin discussed 'living to 150' The Russian gene-therapy treatment could benefit Putin and his inner circle. https://t.co/dunqBJEPxN https://t.co/sH2GNbRqSs
Russia Claims Progress on 150‑year Human Lifespan Plan
Vladimir Putin's plan to make humans live for 150 years is in process under supervision of Russian scientists 🔎 “ Denis Sekirinsky, a Russian science and education minister, claimed his country's researchers are on course…” https://t.co/tVx2REdovu https://t.co/1WCXvDFWnf
Longevity Enthusiasts Aim to Live Longer for Space Exploration
The number of people in the longevity space who want to extend lifespan so they can explore the stars is surprisingly high.
Power Nap After Sauna Boosts Recovery and Longevity
Loved this morning. Included a nap in today's routine. May start napping more. > asleep before 9 pm > up at 5 am > 8h sleep, no wake events > work 2 hrs with fresh mind > 50 min strength > 12...
Every 1,000 Steps Cuts Mortality Risk by 15%
The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis A 1000-step increment was associated with a 15% decreased risk of all-cause mortality... with significant benefits starting event at 2500/4000 steps/day. https://t.co/8d6VGnP0Dg https://t.co/f9h0D5dWlV
Facial Age Acceleration Predicts Earlier Death, Varies by Job
Face photo-based age acceleration predicts all-cause mortality and differs among occupations "We found that face photo-based age predicts all-cause mortality for middle-aged and older individuals meaning that those age faster based on their face photo die sooner." https://t.co/QUUzK4fe9G
Metabolic, Epigenetic, Immune Links Drive Ovarian Aging
Metabolic, epigenetic, and immune crosstalk in ovarian aging "This work provides a conceptual foundation for developing personalized strategies to mitigate reproductive aging and its systemic health impacts..." https://t.co/IgYU6f36nP https://t.co/rRgC7Dh65g