Start Strength Training in Your 30s to Preserve Muscle Quality
Muscle loss can begin as early as your 30s, with measurable declines in muscle mass and function occurring well before old age. The study also found that women may lose strength and fitness faster than muscle mass itself, highlighting the importance of early strength training and focusing on muscle quality as well as quantity. https://t.co/6zEiUqG8Cf
Nattokinase Lacks Evidence; Choose Omega‑3 or Berberine
Nattokinase isn’t high on my list for cardiovascular prevention. I don’t see convincing evidence that it should be a primary strategy for cardiovascular disease or stroke risk reduction. If the goal is cardiovascular prevention, there are options with much stronger support. Omega-3...
20 Minutes of Daily Stillness Boosts Longevity
As a longevity scientist, I’m giving you permission to do absolutely nothing for 20 minutes a day. No phone. No guided meditation. Just sit and let your mind wander. We’re more overstimulated than we realise, and it may be that...
Supplements Fail Without Solid Sleep, Diet, Exercise Foundations
Controversial opinion: the supplement industry is largely built on people’s reluctance to do the unglamorous basics. For most people, supplements have limited impact if sleep, diet, exercise, and lifestyle foundations aren’t nailed down. Sort the foundations first.
HDL Inflammatory Markers Predict Mortality in Elderly
High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANES data https://t.co/WdNtpIgGpI https://t.co/cM0LeTv7io
CNS Gene Therapies Showcase Tau-Targeted VY170
CNS Gene Therapies Featured in Multiple Presentations at ASGCT 2026, Including Late Breaker on Tau-Targeted VY1706 for Alzheimer’s Disease https://t.co/oQ5MCd5piS https://t.co/8KeWSTJ1q7
High‑dose Semaglutide Cuts Alcohol Use in RCT
Clinicians and patients saw big reductions in alcohol intake when starting GLP-1 medicine. This is the first randomized trial to look at the high dose of semaglutide. There was a study a couple years back looking at a lower dose....
Aging Science Promising Yet Still Lacks Core Understanding
Aging biology is full of promise, but the reality is that it's still a nascent field. Great to be back at the @MPIAGE speaking with students and researchers about some uncomfortable truths in geroscience: We still don't understand the drivers of aging. And...
Menopause Signals a Hidden Heart Risk—Act Early
What I wish I knew earlier… I now teach every day. Menopause is not just about symptoms. It’s a cardiovascular inflection point—and one of the most missed opportunities in prevention. We were taught to watch for heart disease later. But for women, risk begins...
Decoding Ovarian Aging to Extend Reproductive Lifespan
Ovarian aging: Mechanisms and strategies to extend reproductive lifespan Core mechanisms include genomic instability, epigenetic noise, mitochondria, inflammation, senescence & fibrosis PhD student Maria Lopez @sinclarfriends is working on it https://t.co/tuJbQb2Xcu https://t.co/K1GlXY4KsY
Glymphatic Failure Links Dog Dementia to Alzheimer’s
Canine Cognitive Dysfunction and Alzheimer’s Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration "...growing evidence suggests that impairment of the glymphatic system is a key pathogenic mechanism in both CCD and AD." https://t.co/1fft2OIrIP
Exploring Immortality: Dr. Cordeiro Discusses Curing Death
Can We "Cure" Death? An Evening with MIT alumnus and futurist Dr. José Cordeiro, PhDMay 13, 2026 9:00 PM - May 14, 2026 12:00 AM CLT Valley Research Park, Mountain View 319 N Bernardo Ave, Mountain View, CA 94043, USA https://t.co/3o72lbHrCM https://t.co/U6qgewbN1B
Blood Test Pinpoints Amyloid‑to‑tau Transition in Alzheimer’s
Tracking the turning point in Alzheimer’s disease A blood biomarker reveals the mechanistic shift from amyloid to tau pathology https://t.co/p2UfYwgBHW https://t.co/Kuu82UPrFv
Calorie Restriction Deactivates Complement C3a, Slowing Inflammaging
"complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging" Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging https://t.co/FxGHE6Obm0
Longevity Depends on Movement, Whole Foods, Purpose, Connection
The research on longevity is surprisingly consistent. The longest-lived people on earth share 4 things: They move naturally throughout the day, eat mostly whole food, have strong social ties, and experience a sense of purpose. Not supplements. Not biohacking. Not optimized sleep scores. Purpose...
Unified Redox Strategy Prevents Multiple Diseases Simultaneously
The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity https://t.co/TaDq4wbrH7 https://t.co/P8QYDgcmiH
GLP‑1 Drugs Cause Less Muscle Loss than Assumed
Do GLP-1 drugs really cause muscle loss? Turns out perhaps less than what we thought… here’s what you need to know, from: https://t.co/VwrRxnoblW https://t.co/M2RaE1f3EG
Organelles Drive Aging: Metabolic Engines and Signaling Hubs
Cellular organelles play a central role in aging by acting as both metabolic engines and signaling hubs that coordinate processes within and between cells. Their dynamic interactions influence lifespan, health, and even inheritance, making them key targets for interventions aimed...
Try Retention: Boost Blood Flow and Performance Naturally
Try retention for a few weeks, and see how different you feel. Want better blood flow and performance without drugs or surgery? The Wasabi Method rebuilds both from the ground up. https://t.co/iHBlgB6cvQ
Aging Evolves: Unveiling the Longevity Bottleneck Hypothesis
Fantastic video on the evolution of ageing and the longevity bottleneck hypothesis 🚀 Thank you @EonsShow @PBS for the brilliant work 🙏 https://t.co/GjHMlIn3hg
Neko Delivers Affordable, Instant Preventive Health Checks
We need to all work hard to live as long as possible, and in good health. I’ve met many companies trying to support this mission. One stands out, that those in the US haven’t experienced yet. I was blown away by...
Extreme Quantified Self: My Week of Full-Body Monitoring
How I've measured my body this week: + 7 blood draws + colonoscopy + esophagogastroduodenoscopy + whole body MRI + comprehensive eye exam + 24/7 + core body temp (ingestible pill) + blood glucose...
P‑tau217 Blood Test Predicts Alzheimer’s Risk Early
Good summary of p-tau217, the breakthrough blood test to predict risk of Alzheimer's in people well before onset of symptoms @ScienceMagazine https://t.co/qVJtYR4bnz https://t.co/OhjLExTroG
Age Can't Be Stopped, But Slowing Down Can Be
Getting older is not optional. But getting slower is. Power declines faster than strength with age. The fast-twitch fibers go first and athleticism follows. Most people accept it as inevitable and stop training the one thing that could slow it down....
Roughage Myth Debunked: Bulletproof Recipes Boost Longevity
You may have been told "roughage" is good for you, but that's a lie. Do you need help finding recipes that will benefit your mind, body, and longevity? My Bulletproof Cookbook is full of recipes and tips that upgrade your...
Irisin Hormone Reverses Obesity and Insulin Resistance
Irisin, a hormone released by muscle during exercise, reverses obesity and insulin resistance in mice -- without cutting food intake or causing muscle loss. As a medical school professor, I find this striking. We have spent a decade asking how to...
Key Factors That Truly Impact Aging After 40
I’m a bioscientist studying aging. 🧬 If you’re 40+, this is what actually matters ↓
Normal Bloodwork ≠ Healthy: Most Adults Have Hidden Metabolic Risk
Lie I was taught in medical school: if a patient's standard bloodwork is normal, they're healthy. Reality: only about 7% of American adults are metabolically healthy. The other 93% pass routine labs while quietly drifting toward heart attacks, strokes, dementia, and...
Diet‑Microbiota‑Polyamine Axis Drives Intestinal Aging
The Diet–Microbiota–Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications https://t.co/UJwPyVroBn https://t.co/xQTAAszA0w
Consistent Training Outweighs Intensity for Lasting Fitness
Age-related muscle loss (sarcopenia), reduced circulation, and reduced tissue repair capacity all contribute to slower recovery. Unless training… muscle mass continues to decline with age, and deconditioning following injuries or illness can happen quickly. This creates a cruel paradox: It takes...
Low RHR & High HRV Signal Longevity
There's a proverb that you only have a certain number of heartbeats in your life Low resting heart rate (RHR) and high heart rate variability (HRV) are good signs of good heart health and fitness Low RHR and high HRV are...
True Power Comes From Sleep, Not Flashy Watches
The most powerful people in the room aren't wearing the loudest watch. They're sleeping eight hours.
Exercise Proven to Reduce Biological (Epigenetic) Age
What is the most established intervention linked to lower biological (epigenetic) age? Exercise A new systematic review @LancetLongevity of 44 studies, >145,000 participants https://t.co/agmAazwDxs
Vaccines May Reduce Alzheimer Risk and Slow Aging
I'm getting two vaccines next week: Tdap and shingles. The Tdap because Kate's family has a newborn and we're visiting. Shingles for the potential longevity benefits. Data we're looking at: 1. Lower Alzheimer risk with vaccination in 1.6 million people,...
Higher Omega‑3 Levels Cut Alzheimer’s Risk by Half
Higher omega-3 status is associated with dramatically lower Alzheimer’s risk. People with a high omega-3 index (~10%) have about a 50% lower risk of Alzheimer’s disease compared with those at the low end (~4%). Other studies have reported a dose-dependent relationship -...
Organs Age at Different Rates; Reproductive Organs Confirmed
Our organs age at a different pace intra-individual, as tracked through plasma proteins. Now confirmed for female reproductive organs @NatureAging https://t.co/v20xGZglMU https://t.co/3oiQ14yesf
We Battle Each Other While Aging Kills Us
Genius few minutes - every word is gold. But now think about the probability of dying due to aging? Is it 10%? 90%? And instead of fighting aging, we are fighting each other... https://t.co/cmvlibOsVh
Ageing Forms Gene Network Linking Diseases via Two Pathways
Ageing isn't one disease, it's a network. Excited to share our latest study exploring the genetic links between ageing and age-related diseases 🧬 We show how shared pleiotropic genes connect disease clusters, revealing two distinct genetic architectures: one driven by ageing-related...
AI Will Gift Us More Time and Longevity
The Time of Your Life: How AI Will Give You More of It | Michael Nuschke | TEDxAjijic "What if you won the "Time" lottery? Guess what...you just did. Artificial Intelligence (AI) will transform our lives, taking over the mundane tasks...
FDA to Relax Peptide Rules After High‑profile Endorsement
FDA moves toward easing restrictions on certain peptides The agency’s decision to hold an advisory committee meeting on the topic comes after HHS Secretary Robert F. Kennedy Jr. told podcaster Joe Rogan he’s a “big fan” of peptides. https://t.co/wynhLuBUPE https://t.co/y9dgG0xWAq
AI Model Detects Pre‑Symptom Alzheimer’s Fingerprint
𝐀𝐈 𝐅𝐨𝐮𝐧𝐝 𝐭𝐡𝐞 𝐊𝐞𝐲 𝐭𝐨 𝐏𝐫𝐞-𝐒𝐲𝐦𝐩𝐭𝐨𝐦 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 #FINGERPRINT Introducing #FINGERS7B, the first AI foundation model designed specifically to prevent Alzheimer’s disease via @NeuroscienceNew https://t.co/J7XKdg7drF https://t.co/QQKyverDNZ
30‑Minute Daily Brain Training Reverses Decade‑Long Acetylcholine Decline
NIH-funded research showed 30 minutes a day of cognitive training reversed roughly a decade of age-related decline in a key brain chemical. As a medical school professor, I teach that acetylcholine -- the neurotransmitter for attention and memory -- drops 2.5%...
Five Longevity Secrets From 100‑Year‑Old Attenborough
David Attenborough at 100: Discover the five secrets to a long and healthy life Everyone is talking about the latest longevity health trends, but to what extent can we actually increase our lifespan? https://t.co/yP8ooC06zg https://t.co/P1VPMAar10
Aging Immune Networks Shift From Inflammation to Disease
Network Rewiring in the Aging Immune System: From Chronic Inflammation to Age-Related Pathologies https://t.co/HxKXGUq8wB https://t.co/ErZBeYwuhJ
Even Morning Coffee Can Harm Sleep Quality
If you struggle with sleep issues, cutting caffeine intake, even if consumed in the early AM, may be beneficial Caffeine intake from different dietary sources and its association with sleep quality in employed adults https://t.co/NuwkDpwmk2
Lifestyle Changes Can Prevent Nearly Half of Dementia
45% of dementia cases are entirely preventable with lifestyle changes. @fountainlife_hq found that 25% of their members had advanced brain age. After 13 months of optimized sleep, nutrition, and exercise, they improved brain age in 46% of those cases. You can become...
Palm‑sized Infrared Laser Boosts Skin and Muscle Health
This device will not only improve your skin, but the muscles beneath as well. Infrared laser treatment used to mean expensive clinic visits. LYMA put that same technology into an at-home device that fits in your palm. Your skin, healing,...
UK Healthspan Shrinks; Target Ageing, Not Symptoms
Healthspan is decreasing in the UK. Instead of treating the symptoms of ageing, we should be targeting ageing itself.
High‑Normal Ferritin May Lower Sarcopenia Risk, Homocysteine Harmful
Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia 🔎"These findings suggest that high-normal ferritin levels may be optimal for alleviating PS risk, irrespective of age, and that elevated Hcy levels could be detrimental for older adults...
Endurance Exercise Protects Joints, Boosts Fat Oxidation
Ha... no. He's wrong. Yes, there's an Afib signal. But his other conclusions... no. Run and cycle... we know why we do it... and my patients who run/ride are by far better off than those who don't. You need...