IVNS1ABP Mutation Triggers Premature Aging and Neurodegeneration
A mutation in the IVNS1ABP gene causes a new disease combining premature aging and severe neurological decline by disrupting cell scaffolding, leading to DNA damage and “zombie-like” senescent cells. https://t.co/xtDrjy72h4
Reprogramming Caps at ~75% Epigenetic Age Reversal
🤣 That’s why we make sure the reprogramming technologies we develop can’t take cells back in epigenetic age more than ~75%
Deep Aging Processes Can Be Slowed with Simple Habits
Facial aging is not a surface-level process. It reflects progressive changes in bone structure, fat compartments, collagen architecture, UV exposure, and hormonal signaling over time. The important point is that many of these pathways are modifiable. Daily photoprotection, resistance training, adequate...
Doctors Will Swap Pills for Gene Therapies and Epigenetics
Longevity 2.0: Your next doctor won't prescribe pills—they'll prescribe gene therapies, epigenetic reprogramming, and personalized longevity protocols. Medicine is shifting from "treat symptoms" to "reverse aging at the cellular level."
Dehydration Shrinks Brain, Confounds MRI and TMS
Dehydration can shrink your brain by over 0.5%, and may be a reason you get a headache. Hydrate to maintain light yellow urine. Also hydrate before an MRI, as dehydration-related small decreases in brain volume can confound MRI-based assessment...
Visceral Fat Loss Preserves Brain Volume and Cognition
This study on visceral fat loss blew my mind... It found that sustained visceral fat reduction over years was linked to preserved brain volume and cognitive function in middle age. They tracked people for up to 16 years, and those who lost...
Astaxanthin: 100× Stronger Antioxidant Boosts Health
Astaxanthin is a major antioxidant that's 100x more potent than vitamin E and vitamin C - protects skin against UV damage - lowers inflammation and neuroinflammation - lowers lipids and blood pressure - protects against oxidation of fats - protects the eyes - senolytic properties - lowers...
Choosing Aging Over Longevity Highlights Pathology, Not Greed
One reason I dislike saying healthspan or lifespan & prefer aging as label for the field over longevity. Aging puts focus on its terrible consequences/pathology. It makes the field defensive like medicine not greedy as some see wanting more life...
Metabolically Healthy Obese Children Still Develop Diabetes
As a medical school professor, I've seen textbooks call it "metabolically healthy obesity." A new study proves that label is dangerously misleading. Karolinska Institute tracked 7,275 children with obesity until age 30. The results in JAMA Pediatrics are staggering: -> 9% of "metabolically...
Shift From Disease Treatment to Building Durable Health
When 'Normal Labs' Are Unhealthy We sit down with Dr Sandeep Palakodeti —an Ivy League–trained internist who left elite institutions—to unpack why so much of healthcare reacts to disease instead of building durable health, and how treating your body like your...
Metformin Undermines Exercise’s Insulin‑Sensitivity Gains
As a medical school professor, I've recommended metformin to countless patients. But a new double-blind trial just revealed something alarming. Metformin BLUNTED the insulin-sensitizing benefits of exercise in adults at risk for metabolic syndrome. The findings from a 16-week RCT: -> Exercise +...
Trim Visceral Fat to Neutralize High Lp(a) Risk
Lp(a) is the new Voldemort of cardiology—a genetically determined risk factor that can raise your risk of heart disease by >200%. And while elevated Lp(a) is largely written into your DNA, there’s good news: You may be able to neutralize its...
Paragon Launches Korsana Biosciences, Targeting Alzheimer's
Paragon launched its 7th company today -- Korsana Biosciences, merging into the $CYCN public shell. New ticker will be $KRSA. Lead drug candidate is a shuttled anti-amyloid beta antibody for Alzheimer's disease in early studies. https://t.co/RcJ8adMakm
Spermidine Linked to Heritable Red Blood Cell Longevity Trait
The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity https://t.co/rHT8XoWHFz
Longevity Thrives on Simple, Sustainable Habits, Not Extremes
After 8 years in biological research, one thing is clear: The healthiest agers aren’t doing anything extreme. They’ve simply found a version of the basics they can sustain.
Strong Social Ties Boost Health and Longevity
social disconnection is not just painful emotionally, it puts the body under biological stress. It is linked to higher inflammation, worse cardiovascular health, and a higher risk of early death, while stronger social relationships are consistently associated with better survival....
Sleep Deprivation Triggers Hormone That Fuels Heart Disease
Sleep loss can causally drive heart disease. 1/2) Here's how it works: Sleep loss causes release of a brain hormone (hypocretin) --> goes to bone marrow to simulate the production of inflammatory cells --> these go to arteries and drive atherosclerosis But...
Consistent Sleep Schedule Beats Hours for Brain Health
Sleep timing regularity may be just as (if not more) important than total hours. Irregular sleep–wake times (even 1–2 hour shifts) are linked to: → Poorer cognitive performance → Higher inflammation & blood pressure → Increased risk of cardiovascular & neurodegenerative disease Your brain’s “master...