Resveratrol Alters Sperm Epigenetics, Boosts Offspring Metabolism
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications" 🤯 https://t.co/2Uzsy2H1xm
Peptual Peptides Pass Tests Despite Contamination Claims
If you read this “peptides are contaminated” article carefully, you will notice that this source that I recommend (Peptual) purchased by reporter via @thegarybrecka website tested just fine… https://t.co/Cq8I6D8QZz
Vitamin D3 Preserves Telomeres, Slowing Cellular Aging
As a medical school professor, I have watched vitamin D research for decades. This trial finally delivers causal evidence. The VITAL randomized controlled trial -- the gold standard -- followed nearly 1,000 adults aged 50+ for 4 years and found that...
Sleep Powers Brain's Waste Removal, Preventing Alzheimer Risk
Human biology fact: during sleep, your brain’s waste clearance system — the glymphatic system — becomes more active. Poor sleep is linked to greater build-up of metabolic waste, including amyloid (associated with Alzheimer’s disease), over time. Sleep isn’t optional. It’s...
Prioritize Sleep, Movement, Nutrition Over Fancy Biohacks
Speaking as a scientist in the longevity space: Too many people “major in the minors” when it comes to health. They obsess over biohacks — cold plunges, supplement stacks, red light panels — and neglect the fundamentals that drive most...
Your 70‑year Health Hinges on 30‑50 Habits
I’m a scientist studying the biology of aging. I focus my research on people in their 30s–50s because this is when lifestyle habits begin to compound and shape long-term health trajectories. Good health at 70 starts decades earlier.
Promoting OSKM Therapy with MYC Is Borderline Criminal
The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal
Early Time-Restricted Eating Beats All Fasting Strategies
As a medical school professor, I used to think all fasting windows were created equal. This massive analysis proves they are not. A network meta-analysis of 113 trials published in BMJ Medicine found that early time-restricted eating -- finishing food by...
A Single Nerve Links Brain, Heart, Gut, Immunity, Longevity
What if one small nerve quietly connects your brain to your heart, your gut, your immune system — and even how long you live? That was the question I brought to Dr. Elisabetta Burchi, a clinical psychiatrist, neuroscience researcher, and Head...
Optimal Sleep for Insulin Resistance: 7 Hours 18 Minutes
As a medical school professor, I teach that sleep matters for metabolism. But now we have the precise number. A study of 23,475 adults published in BMJ Open Diabetes Research & Care found the optimal sleep duration for preventing insulin resistance:...
Aging Gut Loses Magnesium, Boosting Inflammation Risk
As a medical school professor, I never imagined a single mineral could be this important to gut health. But the data is staggering. A new study in Aging Cell found that magnesium levels decline specifically in the gut as we age...
Aging Science Reveals How to Extend Dogs' Lifespans
Dr. Daniel Promislow has spent 30+ years studying the biology of aging and has published 180+ papers. Now he’s applying that science to something millions of people care about personally: Why do dogs age the way they do, and can we help...
AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation
New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd
Peakspan: Key Concept Shaping Economy and Everyday Life
You will see many posts from me on the concept of Peakspan and Peakspan Extension. Here is what Peakspan is and why it is important. It is important for our economy and for our life. #Peakspan https://t.co/yGL6zMr4Rh
Consistent Workouts May Preserve Fitness Better Than Constant Switching
In terms of slowing the age-related loss of fitness, I'd bet the same is true for those who standardize their workouts, when compared with those who "switch it up"
Genomic Instability and Epigenetic Reprogramming Drive Vascular Aging
DNA repair-driven epigenetic changes as a cause of disease is going mainstream. A general medical review on CVD says: Genomic instability & epigenetic reprogramming are the deep mechanisms of vascular aging. Intervention strategies are the most promising & complex interventions https://t.co/xbEytAnIUH
AI Model Maps Cell Trajectories Driving Human Aging
Impressive temporal AI model of aging by @GladstoneInst Based on ~175M single-cell transcriptomes, the model predicts drivers of cell trajectories across human aging. Also great that the first author, Javier, trained in our lab. Always rewarding to see our alumni flourish.
Balanced Hormones Boost Longevity, Backed by Research
New research confirms: optimal hormone levels don't just make you feel better, they help you live longer. Everything you need to support your hormones in one place. Biolongevity Labs, where all supplements and compounds are USA-made, third-party tested, with 99% purity....
Block Night Light, Boost Sleep, Transform Your Life
If you prioritize one thing to completely change your life, focus on your sleep. For less than $200, you can block junk light and repair your circadian rhythm. Studies show that even a small amount of streetlight pollution at night...
Centenarians Share Simple Habits for Lasting Health
What do the oldest people in the world have in common? Longevity expert explains ☝🏼 #longevity #doctor #health #wellness #diet
Preserving Human Knowledge and Biology for Future Longevity
At Lifespan, we care about you, your loved ones, and humanity. A special project is to record and safeguard human knowledge and biological information, so civilization and our biology can be restored if lost. @joinlifespan, and let's achieve longevity for...
One Daily Drink Ages Brain by Two Years
As a medical school professor, I need to be honest: there is no safe level of alcohol for your brain. A landmark study of 36,000 brain scans found that even one drink per day shrinks your brain -- and the damage...
Extra Virgin Olive Oil Shields Brain via Gut Microbiome
As a medical school professor, I used to tell patients to "eat healthy fats." But the type of olive oil matters more than we ever taught. A new study in Microbiome (Feb 2026) tracked 650 adults for 2 years and found...
Risk-Weighted ApoB Outperforms LDL in CVD Prediction
LDL is only part of the equation. What's your Lp(a), VLDL, ApoB? Risk-weighted ApoB, which incorporates all of the above, is a better measure than LDL for predicting CVD risk: https://t.co/y5Hc9ZXIWG
Women Need Their Own Longevity Blueprint, Not Male Models
Women are not “mini-men.” That line from Dr. Jennifer Pearlman MD CCFP NCMP FAARM ABAARM stuck with me from our @Optispan_Inc Podcast conversation—and it sets the stage for a much bigger issue. For decades, medicine and biomedical research have often treated...
Seeing Biological Age Data Drives Real Health Improvements
Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...
Longevity Escape Velocity Could Grant 50 Extra Healthy Years
If longevity escape velocity arrives by 2033 (Ray K’s prediction), a 50-year-old today has a shot at seeing 2100. The prize: 50 extra healthy years of compounding knowledge, relationships, and impact. Worth optimizing for? Focus on a longevity mindset.
Future Peptide Therapy Needs Automated Multi‑dose Syringe
The peptide revolution will require a small (reservoir enabled) auto syringe that doses at intervals with multiple peptides throughout the day. Basically a parallel exo-somatic signaling system.
Scientists Caution: Only Nerve Cells, Not Whole Mice, Age-Reversed
This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone...
Longevity Biotech Isn’t New—Build Sustainable Business First
Anyone who thinks that Longevity Biotechnology is new and in the next 10 years we will find a cure for aging with AI should read Paul Segall's "Living Longer, Growing Younger". 1989. Read "Merchants of Immortality" 2003 next. I think that the...
Black Elderberry Tops Anthocyanin‑rich Foods List
Highest anthocyanin-containing foods: 1. Black elderberry: 1,317 mg per 100 g 2. Black chokeberry (aronia): 878 mg per 100 g 3. Blackcurrant: 592 mg per 100 g 4. Black raspberry: 589 mg per 100 g 5. Black rice: 325 mg per 100 g 6. Bilberry: 299...
Age Is Dynamic, Not Fixed—A Century‑Defining Insight
Age is not fixed. It’s dynamic. This is one of the most remarkable discoveries of the century
Incretin Modulators Boost Health, Happiness, and Longevity
Life is a marshmallow test. Incretin modulators help you win while staying happy. I often ask big audiences - "how many of you are on GLP1?" and only a couple hands go up. Sometimes, none. That's when I understood that...
Real Anti‑aging Breakthroughs Needed to Shift Public Discourse
Kudos to Peter - and to David for highlighting it to 8x more people than I am doing here :-) But yes, without actual life-extension progress in a mammal, the Overton window seems immoveable. My TED talk was 20 years...
Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy
This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...
Microplastics in Food May Accelerate Cancer Development
As a medical school professor, I never learned this in training: the plastic in your food may be fueling cancer. A new Journal of Clinical Investigation review (Feb 2026) maps how micro/nanoplastics drive cancer through 4 mechanisms: 1. Inflammation: Macrophages engulf plastic...
Aging May Be Evolutionary Program, Not Random Decay
Is aging programmable? It implies there IS a program created by evolution, not only accident or entropy. But that's a debate. Here's a paper by business consultant Michael Ringel, on this very topic, with many good citations. https://t.co/fREM4AHnJG
Aging Isn't Destiny—It's a Modifiable Biological Process
Most people treat aging as fate.�Biology treats it as a process that can be changed
Every “Hassler” Adds ~9 Months to Your Biological Age
Negative relationships may accelerate biological aging. In a new study, each additional “hassler” - someone who often causes problems or makes life difficult - was linked to ~1.5% faster aging and ~9 extra months of biological age. The catch: this showed up...
Reasoning Data Enables Age Prediction Without Biological Samples
This may be the most important breakthrough from Insilico in aging research this year (kind of building on the concepts from the MMAI Gym). Turns out, you do not need original biological data to train foundation models to predict...
Japan Approves Conditional Stem‑cell Parkinson’s Replacement Therapy
Woah. I'm slightly embarrassed that I missed this for a few weeks. Finally there is approval, in a Large Nation, for a stem cell-based REPLACEMENT therapy for an age-related condition. The condition is, no surprise, Parkinson's, which I always highlight...
Running, Not Coordination, Boosts Brain Neurogenesis
As a medical school professor, I tell students exercise is medicine. But a new study shows the TYPE of exercise determines whether your brain grows new neurons. Researchers compared treadmill running vs. coordination exercises at matched intensity. Published in Frontiers in Neuroscience: ->...
Nanosecond Electric Pulses Rejuvenate Aging Endothelial Cells
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication https://t.co/DT8GXNLlxO
33 Simple
I’ve spent the last decade studying the biology of aging. 🧬 Here are the 33 simple principles for healthy aging that consistently show up in the research ↓
Peakspan: Targeting 90% Peak Capacity Across Lifespan
"Peakspan" should be the longevity marker everyone's talking about. It refers to how long we can maintain 90% or more of our peak capacity in one of several health domains like muscle strength, cognitive function, or fertility. And it recognizes that these...
Longevity Tests Often Mirror Horoscopes, Not Science
What if your doctor handed you a report… and it was no more meaningful than a horoscope? That’s the uncomfortable reality we’re facing right now in longevity medicine. When clinicians use unvalidated, non-actionable tests, they are replacing evidence-based medicine with something that...
Muscle Loss Spikes After Inactivity, Not Just Aging
Muscle loss doesn’t just gradually decline with age. A lot of it may happen in ‘catabolic crises’ - sharp drops after periods of disuse like injury, bed rest, hospitalization, or stopping training. The real harm is not just aging itself,...
First Human Trial Shows Fasting Mimic Boosts Autophagy
As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against aging and disease. Now the first-ever human clinical trial proves a fasting mimicking diet activates it. Cedars-Sinai and...
Fine Particulate Air Pollution Raises Alzheimer's Risk
As a medical school professor, I teach students that Alzheimer's has many risk factors. But this one is invisible -- and almost nobody talks about it. A massive study of 27.8 million Medicare beneficiaries just found that fine particle air pollution...
Record Female Life Expectancy Defies Predicted Limits
enjoying this piece on record life expectancy increasing over time - the *insane* linear regression in 1840 - 2010 period just tracking record life expectancy over time (I think trend not consistent since, partic w COVID) - how funny it is that...