Aim for Peak Longevity, Not Just Healthspan
Check out my new https://t.co/lzzxyoQMxZ post titled "Peakspan: The True North of Longevity and Why We Must Aim Beyond Healthspan?". Link in the comments. Geroscience got a bit too woke for my taste. Can we set staying at or near the peak as the objective function? https://t.co/H9n7CVKZTO
Rapamycin Fails to Slow Epigenetic Aging, Sinclair Concedes
David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals •...
Loss of Smell Predicts Five‑year Mortality Risk
A failing sense of smell may be an early warning sign of biological decline. In a study of ~3,000 older adults, those who couldn’t identify common odors had 3–5x higher risk of dying within 5 years, independent of disease, smoking, or...
Analyzing Causal Datasets to Uncover Disease and Aging Mechanisms
Now lets do this for the datasets that contain causal information on how diseases and aging work
Key Habits Shared by the World’s Longest-Lived People
What do the oldest people in the world have in common? Longevity expert explains ☝🏼 #longevity #doctor #health #wellness #diet
Aging Biology Targets Key to Better Stroke Outcomes
Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration 🔎Addressing age-specific pathophysiology will be critical for improving outcomes in cerebrovascular diseases in the aging population... https://t.co/DuScTnSIh5 https://t.co/Irok29jqMx
Regenerative Medicine Needs Data Over Hype
I recently had the opportunity to sit down with Scott Carney for a wide-ranging conversation on regenerative medicine, stem cells, peptides, and the growing gap between scientific promise and clinical reality. In the conversation, we dig into: – Why stem cell therapies...
GLP‑1s Reveal Calorie Restriction as Longevity Key
Its interesting that for the thousands of books written on health, we've learned since GLP-1s came on the market the best way to extend lifespan is to eat fewer calories
SIRT6 Gene Therapy Remains Safe, Effective in Aged Beagles
Genflow sees sustained safety and efficacy in SIRT6 beagle trial 🐶 “Genflow Biosciences reported that three-month follow-up data from its SLAB trial in aged beagles show sustained safety and efficacy of its SIRT6 centenarian gene therapy, with no adverse events and...
Statins for Seniors: Benefits vs Diabetes, Alzheimer Risks
Should older adults use statins for heart health? Do statins increase the risk of diabetes and Alzheimer's Disease? Dr. Gregory Charlop shares the results of an important new health study. www.buckheadlongevity.com/blog/should-older-adults-use-statins-a-top-atlanta-longevity-doctor-answers
Discover Cutting‑Edge Longevity Tech at Biohacking Conference
The Biohacking Conference is three days of the most advanced longevity technology on the planet. Join me and 5,000 in Austin, TX, May 27-29. World-class speakers, live technology demos, and tools that change everything. https://t.co/R1vZblFx0z
Urolithin A Enhances Mitochondrial Health and Endurance
I'm fascinated by Urolithin A. It's a compound that stimulates mitophagy (mitochondrial autophagy), helping clear out and replace damaged or dysfunctional mitochondria. Recent studies show that urolithin A improves endurance performance and even keeps immune cells "younger" with age. The data are early...
Statins Cut Mortality for Over‑80s Without Added Risks
Should people over age 80 use statins? The answer is increasingly: YES. A recent study found that patients over 80 on statins had a one-third reduction in mortality. Perhaps more telling, people who stopped their statins appeared to have a 1/3...
Flu Shot Cuts Alzheimer’s Risk Up to 55%
💉 Want to reduce the risk of Alzheimer' by 55%? A simple flu shot at the dosage recommended by the CDC for those 65 and older should do the trick. With 165,000 people in the study, they also...
Microbiome Loss Triggers Intestinal Cells to Absorb Nutrients
Loss of gut microbiota increases a dual-function cell in the large intestine, shifting its role from mucus secretion to nutrient absorption and revealing adaptive changes in the intestinal barrier, especially with age. microbiome
Sleep Hacks: 5 Science-Backed Ways to Boost Rest
Diet and exercise get all the attention. But poor sleep can blunt the benefits of both. Here are 5 research-supported habits that transformed my sleep quality ↓
Disabling Light Sensing Extends Worm Lifespan by 40%
Great study in the bristleworm showing that light perception can regulate lifespan. Disrupting light sensing slows development, prolongs growth and extends lifespan by ~40%. More evidence that aging is not just damage accumulation, but is modulated by developmental processes.
Modifying Gut Microbiome Boosts Memory, Slows Dementia
As a medical school professor, I teach that the gut-brain axis is real. But even I was surprised by this. A review in Nutrition Research confirmed: reshaping the gut microbiome can enhance cognitive performance and slow dementia progression. Key findings across multiple...
Stop Losing Muscle: Start Resistance Training Now
We start losing muscle from our 30s — and by our 70s, 30–40% can be lost if we don’t actively maintain it. Resistance training is the most effective way to counter this — yet most adults aren’t doing it consistently. I’m on...
Walk After Meals to Slash Post‑meal Blood Sugar
An underrated habit for longevity? Walking after meals. Blood sugar control is fundamental to healthy aging. Contracting your muscles helps shuttle glucose into them and can reduce the post-meal rise by 20-30%. Just 10-15 minutes is enough. Small habit. Big metabolic return.
NRH Prevents Age‑related Hearing Loss via Sirt3‑mediated Ferroptosis Suppression
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation https://t.co/MOqQblWYNM https://t.co/uhSMXRIxDK
Aging Is Evolutionary Program, Not Survival Strategy
Why do humans age and die when some species are practically biologically immortal? Josh Mitteldorf, PhD, is an astrophysicist-turned-biologist who has spent decades thinking about that question. One of his main insights is that aging doesn’t look like a system trying...
Training at 62 to Prevent Gradual Decline
Why I Train This Way at 62 1/ I’ve been an orthopedic surgeon for nearly 30 years, and over that time, I’ve watched something happen to many of my patients that isn’t dramatic or sudden, but ends up being far more...
Exercise 60‑75 Min Daily Offsets Long Sitting Risk
Sitting a lot isn’t equally harmful for everyone. In this meta-analysis of >1 million adults, people who sat >8 h/day had no increased mortality risk if they also did about 60–75 min/day of moderate physical activity. (35.5 MET h/week). People doing...
Molecular Evolution Explains Animal Aging Diversity
Molecular evolution of animal aging 🗣️"...As a step toward this goal, this field perspective outlines general biological mechanisms that help explain the variability in aging patterns and longevity across the animal kingdom..." https://t.co/mHVAlyQbfM https://t.co/NoronuZDaL
Not Smoking Wins; Proactive Healthcare Dominates Longevity Bracket
The Longevity March Madness Final Four is Set: Here’s a wrap-up of how the four division finals played out. Lifestyle: A heavyweight classic It doesn’t get bigger than this. Top-seeded Not Smoking held off a furious push from Strength Training, surviving 53–47 in...
Targeting Liver ApoE Boosts Bone Healing in the Elderly
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing "Our work here identifies novel liver-to-bone cross-talk and a noninvasive, translatable therapeutic intervention for aged bone regeneration" https://t.co/KSzvkKOzZt https://t.co/1p0cXQlalT
Α‑Eleostearic Acid Acts as Senolytic via Ferroptosis
α-eleostearic acid as a senolytic via ferroptosis. Found in high concentrations in Tung oil (which is toxic) and in small amounts in Bitter Melon oil. https://t.co/FSCix3OZtD
Neighborhood Disadvantage Accelerates Cellular Aging via CDKN2A
Neighborhoods with limited social and economic opportunities are linked to increased cellular aging, as indicated by higher CDKN2A RNA levels, suggesting that structural conditions may influence biological aging beyond individual lifestyle factors. publichealth
Conjugated PUFAs Target Senescent Cells
Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells “ Conjugated PUFAs α-ESA and its methyl ester selectively eliminate diverse senescent cells… These lipid senolytics reduce tissue senescence and extend health span in aged mice” 👉 Lipid peroxidation underlies selective vulnerability...
Follistatin: Dual Weapon Against Cancer and Muscle Loss
Follistatin protein, which plays a key role both in inhibiting tumors and promoting muscle tissue growth. https://t.co/OebCo6FSI7
Fatty Acids Target and Eliminate Aging “Zombie” Cells
NEW STUDY finds certain fatty acids selectively kill senescent "zombie" cells. The molecules exploit a fundamental biophysical weakness in senescent cells, a totally new approach. Could we simply consume these moleculs to treat aging? ...🧵 https://t.co/EceCAfdlvz
Weight‑loss Drugs Boost Life by Aiding Sick, Not Slowing Aging
Weight loss drugs may increase human longevity but that's because they reduce the mortality of folks at the lower end of the lifespan distribution (i.e., unhealthy individuals), not because they delay the aging process. That's still valuable, but if this is...
First Human Trial Tests Cellular Age Reversal Therapy
This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs. 💡"Technologies to refresh ageing tissue...
Brain Aging Isn't Inevitable: Basics Beat Supplements
We talk a lot about brain aging as if it’s inevitable. It’s not. In my latest podcast conversation with @DrRagnar—author of The Stimulated Mind—we unpack what’s actually working for brain longevity and what isn’t. A few takeaways that stood out to me: • The...
Peptide Vials Contaminated, Underdosed, and Unsafe
Besides the lack of data for safety or efficacy on peptides, or any assurance of sterility, here's what an independent lab found of samples: —The vial of BPC-157 contained lead —The vial of TB-500 contained endotoxins —The vial of CJC-1295 contained <42% of...
Aging Intervention Possible—Now Prioritize Safety and Frequency
The question is no longer if we can intervene in aging. It’s how safely and how many times
Fund NIH Trials to Validate Unapproved Peptide Safety
I thought this was an excellent, balanced article on the current state of unapproved peptides from a safety and regulatory perspective by @AnjeanetteDamon in @propublica https://t.co/DbA8cdvTY5 The fundamental problem is that we don't have quality data on safety or efficacy for...
Longevity Hack: Rotate Veggies Using a Calendar
Seeking longevity? Forget risky and unproven biohacks. Stick with proven, common-sense solutions. Here's a tip I give my family office and concierge medicine patients: Use a calendar and rotate through various veggies. Why?
Higher Protein Intake Reverses Sarcopenia in Elderly Women
As a medical school professor, the protein recommendation I was taught -- 0.8 g/kg body weight -- is actively harming older adults. New data proves it. A 2025 Frontiers in Nutrition trial randomized 126 elderly women with sarcopenia into two groups...
The Vagus Nerve: Your Body’s Hidden Lifespan Connector
What if one small nerve quietly connects your brain to your heart, your gut, your immune system — and even how long you live? That was the question I brought to Dr. Elisabetta Burchi, a clinical psychiatrist, neuroscience researcher, and Head...
Sarcopenia Doubles Death and Disability Risk in Seniors
As a medical school professor, I can tell you the most dangerous disease you have never heard of is sarcopenia -- and a massive new meta-analysis just proved it. A 2026 Frontiers in Nutrition review of thousands of community-dwelling older adults...
Prioritize Peakspan Over Healthspan in Drug Discovery
I think that it is easier to measure Peakspan than Healthspan. And something we should study hard. I don't want just healthspan - I want to be at my peak. Not for myself but for all of you - we...
Essential Low-Cost Tests for Longevity Baseline
Longevity testing starter pack: 1. VO2 max/Cooper test - cardiorespiratory fitness 2. Grip strength - muscle mass and strength 3. Blood pressure - cardiovascular disease risk 4. DEXA scan - muscle and bone density 5. Blood panel - a dozen most common blood markers 6. Waist...
Bootstrapped Cryo‑AI: LLMs Power Life‑Saving Freeze Tech
Meet Dr. Mark Woodward, undergrad and grad from Stanford, PhD from Harvard, Many years at Google as part of Google brain. One day he realizes that we need the enabling technology to pause biological time for patients that are about...
Creating Autonomous Health via Real-Time Multi‑Omic Monitoring
I've measured my body a lot. I'm about to dwarf what we've done by building real-time continuous multi-omic monitoring and intervention. Cars drive themselves. Software writes itself. I'm building Autonomous Health. First for me, then for you. > Peptides...
Experts Weigh Pros and Cons of At‑home Biological Age Tests
What's your biological age? Experts explain the benefits and risks of at-home tests https://t.co/NSr8O4EGnU via @nbcnews
Immune Training Against Senescent Cells Reduces Tumor Growth
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Vegetarian and Vegan Diets Linked to Higher Hip Fracture Risk
Could a plant-based diet make your bones weaker? In this meta-analysis that looked at 529,672 participants (average ages of 46–63; 57% women, 43% men), both vegetarian diets and vegan diets were associated with a HIGHER risk of hip fracture: https://t.co/3u18PxPmrk...
232 Saunas Reveal 20‑Minute Sessions Miss Heat‑Shock Threshold
I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in...