Supplements Boost Cellular Health, FDA Finally Acknowledges
When the FDA finally admits what biohackers have known for years... 😏💊 And check out @suppgradelabs for my go-to supplements (ie: DAKE + Organs 101 = Daily Multi-Vitamin...comment DAKE for my discount code). Supplements support cellular function, mitochondrial health, and metabolic balance in ways pharmaceuticals often overlook. Invest in high-quality supplements, and it'll support your health and longevity goals. #Biohacking #DaveAsprey #Supplements #HealthFreedom #FunctionalMedicine
SIRT6 Shields Aorta by Cutting Inflammation and Aging
SIRT6 appears protective in aortic disease, as higher levels reduce vascular inflammation and smooth muscle cell aging, thereby helping prevent both aortic aneurysm and dissection progression. https://t.co/eXuKrR7oNF
Socioeconomic, Lifestyle, and Genetic Factors Jointly Shape Intrinsic Capacity
Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity https://t.co/crOBp21bRN https://t.co/LgbFdA0GEe
Breathwork + Sauna: Free Biohack Boosts Brain and Body
The ultimate biohack is free: Your breath. 🫁 I’ve been stacking SOMA breathwork with dry sauna sessions and the physiological shifts are insane. Here is why this combo is a powerhouse for your brain and body:
Quick Turnaround: Good Longevity Trial News Arrives
I post about working around longevity clinical trials and an hour later @j_n_justice tells me good news about longevity clinical trials... 😍
Meta‑analysis Finds No Benefit to Extra DHA
I am sometimes asked why @getkion fish oil does NOT have “extra” DHA…fact is, a recent meta-analysis of 96 randomized controlled trials at https://t.co/YZMb5dar8P showed no clear advantage of decreasing the EPA:DHA ratio…learn more about the formula here: https://t.co/8REbBJKoBJ
Young‑Adult Work Activity May Shield Against Dementia
Physical activity across the life course and neural biomarkers 💡"PA done as part of one's job or schooling during young adulthood, such as standing and walking, may be protective against dementia later in life." https://t.co/tGarY3gUA2
Gut Microbiome Resilience: Key to Longevity
Gut Microbiota Resilience and Environmental Stressors: A Hidden Key to Lifespan Optimization? "...The review also outlines practical ways to bolster resilience: fiber-rich, plant-based and fermented foods; targeted probiotics, prebiotics/synbiotics, and (in special cases) fecal microbiota transplantation; regular physical activity; good sleep...
Peptides Boost Hormones, Yet Trigger Serious Metabolic Side Effects
People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295....
Seed Oils Aren't Inflammatory; Cooking Methods Are
New study shows that seed oils DON'T really cause inflammation: https://t.co/kxEXYt2ghe This is something I've mentioned on my podcast a few times... ...it's not the oils per se. It's frying them, eating them in ultraprocessed foods/with fast food, etc. Guilt by association....
5 Foods That Fuel Cellular Renewal and Longevity
You’re not just getting older, your body is constantly renewing itself. 🧬 These 5 foods deliver nutrients your body actually uses to protect your brain, reduce inflammation, and support long-term energy. Small shifts. Big impact. Which one are you already eating regularly? #Longevity...
Visceral and Muscle Fat Dramatically Boost Disease Risk
Excess visceral fat around organs is associated with 2.3 higher diabetes risk High muscle fat raises cardiovascular event risk by 54% Low muscle predicts 44% higher risk of death from any cause Eat less. Move. Work out https://t.co/ZLhRXdu1H6
AI MRI Links Body Composition to Longevity
As a medical school professor and radiologist, this is one of the most important imaging-meets-longevity studies of the year. AI-driven whole-body MRI body composition in 66,608 adults (UK Biobank + German National Cohort, mean age 57.7, mean BMI 26.2), published in...
Family Office CWO Claims Alzheimer's Can Be Predicted, Prevented
As a family office Chief Wellness Officer (CWO), I have great news: we can predict and prevent Alzheimer's Disease. Here's what you need to know. By Gregory Charlop, MD, DipABLM
More Steps Can Counteract Sedentary Disease Risk
As a medical school professor, the most actionable longevity finding of April 2026 came from 15,327 adults in the All of Us Research Program, published in Nature Communications. Researchers tracked Fitbit data over years (millions of person-days). They asked: can extra...
India's Deep-Tech Startup Crafts Next-Gen Sleep System
This is wild. Look at how seriously the Indian deep-tech scene is taking sleep now: > bed senses your sleep stage in real time > auto-cools when you hit deep sleep > auto-elevates when it detects snoring > tracks HRV, RHR, breathing without a wearable >...
Treat Roots, Not Just Symptoms: Prioritize Holistic Health
Medication saves lives. I prescribe it every day, and when it’s needed, it matters. But more and more, I see patients already on treatment for problems that were never fully explored: no one asked about their sleep, their movement, their...
Insilico Medicine Leads AI Longevity, Featured on Triple A Cover
Honored and humbled to be featured on the cover and in a major in-depth interview in the January 2026 issue of Triple A, the premium business magazine of Stuttgarter Zeitung in Germany. Many years ago I lived near Munich while working...
Decades of Inactivity, Not Aging, Shrink Our Lives
Love this topic... I refer to it as "the narrowing" of our lives. It's slow... it's insidious... and it's very real. We rationalize and normalize far too many changes and blame them solely on aging. Yes... aging brings changes-- but...
Your Future Health Starts with Today’s Choices
The heart attack in your 70s began in your 30s. The dementia in your 80s began in your 40s. The hypertension in your 60s began in your 50s. The diabetes in your 30s began in your 20s. Your future health starts with today’s choices.
Klotho Deficiency Heightens Stroke Risk in Aging
The antiaging protein Klotho is a key factor in susceptibility to cerebral ischemia Highlights: • Klotho deficiency links aging to higher vulnerability to ischemic stroke • Klotho deficiency increases inflammation and disrupts the blood–brain barrier. • Loss of Klotho intensifies ischemia-induced oxidative and ER...
Direct Protein Reading Platform Ends Proteomics Blind Spot
🐠 Everything we know about biology has been built on an incomplete picture. DNA tells us what a cell might do. Proteins tell us what it’s actually doing. Pumpkinseed announced their $20M Series A today (led by Future Ventures and NfX)...
New Framework Separates True Aging Effects From Study Bias
Mitigating the Hawthorne effect in aging “This Comment proposes a methodological framework to distinguish true biological aging modulation from the confounding effects of study participation.” https://t.co/h9Z2qiFzwv https://t.co/KdnJfSJzhe
Young Gut Microbes Fail
Gut microbiota transplantation from young adult mice fails to restore low bone and muscle mass in old mice https://t.co/BXKJo3Ovi6 https://t.co/JZ3O4BqXd6
Longevity Experts Reveal How to Live to 100
How to Live to 100, According to Longevity Experts In his new book, ‘Longevity Nation,’ Michael Clinton shares insights from experts about how to make the most of the second half of your life. @ROARforward | @goodhousemag https://t.co/hwABZaPQ49
CJC‑1295 Extends Sauna Heat‑Shock Time, Delays Threshold
Bodybuilders use the peptide CJC-1295 to grow muscle. I tried it for two weeks. Unexpectedly, it changed how my body responded to 200°F sauna protocol. First, the good. I spent more total time above the heat shock protein (HSPs) threshold. This...
Anemia Raises Alzheimer Biomarkers and Dementia Risk in Seniors
In a large study of older adults, anemia was linked to higher levels of blood biomarkers associated with Alzheimer’s disease, neurodegeneration, and brain inflammation, as well as a significantly increased risk of developing dementia over time. https://t.co/cnUbvkidIO
Aged Male Mice Stay Glucose Tolerant Despite Obesity
Aged Male Mice Remain Glucose Tolerant Despite Increased Energy Storage Efficiency Favoring Diet-Induced Obesity https://t.co/PzeRMKqvKw https://t.co/mUihjmGsSG
Brain IGF-1 Shields Male Mice From Age‑Related Decline
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice https://t.co/7U25aLdLFv
Nastent Nasal Insert Outperforms CPAP in Compliance
Your doctor will not tell you this. Most CPAP patients hate it and abandon it within months. Their oxygen crashes at night. Their mitochondria suffer. Their glymphatic system cannot clear amyloid beta. A clinical trial just completed on Nastent. It is...
My Trusted Peptide Source: Clean Labs, Certified Products
Since everyone is DM'ing me about my peptides "source", this is it: https://t.co/feX9CCNNYz (code BGL10 saves) Why? Clean labs, good certificates, catalog of injectables/nasal sprays/patches/capsules, etc.
Luck, Not Lifestyle, Drives Extreme Longevity
My AI just analyzed the data from all super centenarians (>110 yo) and found the most important common feature that drove that extreme longevity. They did not exercise, diet, or sleep. They were all very lucky. Luck is the ultimate...
Blocking IGF1 Senescence Reverses Hair Follicle Aging
Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging - Wang - 2025 - Aging Cell - Wiley Online Library https://t.co/LwbNFih66G
Hip Mobility Scores Predict Lifespan, Assess With Simple Moves
Hip mobility is essential for healthy and pain-free movement. And it might even predict how long you'll live. What does that look like? According to Dr. Kelly Starrett (@thereadystate), you should be able to squat with your hip crease below your knee,...
Exercise Decline Accelerates Aging—New Review Offers Solutions
We now exercise five times less than we did 100 years ago. Our lifestyles are accelerating aging New review @Cell_Metabolism how to counter it https://t.co/rmb527oP0Y
FDA Approvals for Aging Therapies: Updated Insights
My 20min talk on FDA approvals of aging therapies & more coming soon from the Dec 2025 Longevity Summit at the Buck Institute is now on YouTube: https://t.co/L024jUz9iT It's an updated version of the one I gave at Vitalist Bay May'25. I'll be...
Time‑Restricted Eating Counteracts Hypoxia‑Induced Glucose Dysregulation
Time-restricted eating improves intermittent hypoxia-induced dysglycemia "In IH, TRE mitigates adverse hypoxic effects on glucose homeostasis, via improvements in pancreatic insulin secretion. Some beneficial glycemic effects of TRE are accentuated in IH. TRE may represent a novel therapeutic strategy in OSA" https://t.co/SQgSGnX6Ay
Moderate Training Boosts Brain Metabolism; HIIT Adds Benefits
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats "These findings suggest that MICT is the preferred regimen for enhancing cerebral metabolic function and neurovascular adaptation, while HIIT serves as a complementary strategy to involve other brain...
Chemical Reprogramming Triggers Toxic Lipid Droplets In Vivo
https://t.co/F6dZ4lFcUZ problem is that most groups don't publish negative results here's a recent paper from @gladyshev_lab showing that chemical reprogramming (yes, different thank OSKM) causes lipid droplet formation and significant in vivo toxicity
Reading Books Adds Years to Your Life
Reading books can help you live longer. Here are 5 studies that show how: 1) Researchers followed 3,635 adults aged 50 and older over 12 years and examined how reading habits related to survival. They found that people who regularly read books...
From Telecom to Longevity: Big Science Aging Talk
TODAY @ 10AM PT: LBF Conversation with Todd White @DToddWhite (Director @ Thalion Initiative). We'll be discussing Big Science for Aging Biology, fundraising, and his founder story pivoting from a career in telecom to longevity biotech. 👉 RSVP: https://t.co/UJP8xs8nrc
Genetic Variant Determines Individual GLP‑1 Drug Response
As a medical school professor, I get asked why GLP-1 drugs work miracles for some and barely budge for others. A new Nature paper from 23andMe gives part of the answer: your genes. Researchers ran a genome-wide association study in 27,885...
ApoB, Not LDL, Predicts True Heart Attack Risk
Lie I was taught in medical school: your LDL cholesterol number is the gold standard for heart attack risk. Reality: a normal LDL with high ApoB is far more dangerous than a "high" LDL with low ApoB. ApoB counts the actual...
RAGE Gene Therapy Cuts Inflammation, Not Lifespan
It's a gene therapy that targets the RAGE pathway (Receptor for Advanced Glycation End-Products) that mediates inflammation and oxidative stress signaling. So far, the mice data doesn't show significant longevity benefits and mostly reduced inflammation and vascular stiffness and kidney damage. On...
Male‑dominant Dementia Risks Highlighted in 2024 Lancet Report
Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework Your dementia risk profile may differ by sex. Which risk factors matter most for you? 🤔👇👨⚕️ "The 2024 report identifies 14 modifiable risk factors for...
Coauthoring Landmark EU Study on Longevity Research
Very proud to be one of the authors of this important paper to support longevity research in the European Union, with many of the leading experts in our region. https://t.co/RpsdF5zmXD #healthylongevity #ageing #longevitydividend #geroscience #healthpolicy https://t.co/HRCphTuY3Q
Astaxanthin's Lifespan Boost Hinges on Dose and Timing
Astaxanthin was tested for lifespan in mice. In 2023, it increased lifespan by ~12% in male mice But a new 2026 study found no effect. The big difference: dose and timing. Full video breakdown: https://t.co/6r7rqMc8jw https://t.co/Lm8ApCG64t
New Method Dramatically Cuts Inter‑animal Variability
"Second, and relatedly, this method dramatically attenuates inter-animal variability." Good time to resurface an old figure: https://t.co/VgRlZrurPE
Mixing Exercise Types Cuts Early Death Risk 19%
This new 2026 BMJ Medicine study of over 100,000 people followed for over 30 years suggests that varying your exercise routine (doing a mix of strength, cardio, sports, etc.) is linked to a 19% lower risk of premature death compared...
Healthy Habits Boost Odds of Living Past 100
Healthy lifestyles and survival beyond age 100: Evidence from a national cohort of Chinese centenarians https://t.co/FsfcGUzlFV