New Toolkit Maps Human Ageing Hallmarks for Translation
🔬 Excited to share our new preprint on a translational toolkit for ageing research. We present a multi-modal approach to profile key hallmarks of human ageing, from immune function to mitochondrial activity and mTOR/autophagy. Our aim is to improve standardisation, reproducibility, biomarker discovery, and ultimately clinical translation. https://t.co/3cyEm11ZmQ
Annual Grail Liquid Biopsy: Early Cancer Detection for the Wealthy
Everybody with a net worth over $5 million should do a Grail Liquid Biopsy every year. My wife, me and my parents all do it annually. $1k to do it. Every 3 years for $1-5 million net worth. Can give you super early detection...
Blue Zones After 25 Years: Mixed Evidence on Longevity
What is the status of the Blue Zones 25 years after they were claimed? @ShelleyWood2 and I did an extensive look into this question, one of the forces behind the current longevity movement @statnews https://t.co/avrbAbgr90
EU Should Launch Coordination Programme for Healthy Ageing
The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity 🌟This paper calls for the establishment of an EU Coordination and Support Programme on...
ML Model Shows CPAP Cuts Heart Risk in Sleep Apnea
As a medical school professor, I've long argued sleep apnea is undertreated metabolic disease in disguise. A new Mount Sinai study in Nature Communications Medicine adds a wrinkle... https://www.youtube.com/@RobertLufkinMD https://www.mountsinai.org/about/newsroom/2026/mount-sinai-researchers-develop-machine-learning-model-to-predict-how-cpap-affects-cardiovascular-disease-risk-in-patients-with-obstructive-sleep-apnea SleepApnea #CPAP #MetabolicHealth #PrecisionMedicine #HealthLongevitySecrets
Tech-Based Programs Boost Activity in Adults 55+
Interventions for promoting physical activity and reducing sedentary time among people aged 55 years and older: an overview of systematic reviews "Consistent evidence suggests that technology-based interventions are effective in increasing physical activity, step counts and MVPA, whereas inconsistent findings support...
Klotho Buffers Age‑Related Brain Atrophy Effects in Seniors
Serum Klotho Levels, Brain Structure, and Cognitive Performance "Results suggest that circulating serum klotho levels modified the known adverse association between age-related brain atrophy and cognition in older, but not younger, adults at risk for AD, suggesting that the neuroprotective effects...
Mitochondrial Dysfunction Drives Frailty; Biomarkers Needed for Precision Therapy
The mitochondrial side of frailty "Mitochondrial dysfunction lies at the intersection of musculoskeletal, metabolic, and immune changes underpinning frailty. While integrative biomarker panels have defined metabolic signatures, early diagnosis and personalized therapies remain unmet needs. Longitudinal studies are required to establish...
From 18 Years to 1M: Health Literacy Wins
Congrats Bryan. The outcomes worth naming: •Destigmatizing prioritizing health systematically •Pushing quantified self into mainstream conversation •Raising lifestyle medicine literacy Yes biohacking debates get the headlines, but those wins deserve a lot more credit👨🏻⚕️
Train Sideways Now to Prevent Falls Later
Most gym training happens in a straight line. Squats, deadlifts, rows, presses. Forward and backward, up and down, all in the sagittal plane. But… life doesn't stress you in a straight line. You step off a curb at an angle, shuffle...
Consider Renaming Senescent Cells as “Aged” Cells
Good point, we may soon be talking of "aged" senescent cells. Maybe it's time to rename senescent cells?
Glucagon Signaling Required for Caloric Restriction Benefits
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice https://t.co/xZYiHWkw5s @GeroScienceAGE https://t.co/WcZgdHgsG2
Nature Study Turns Into Immediate
I wrote about this 6 weeks ago at Ground Truths when the 2 @Nature papers by @HugoAerts and colleagues came out. Today it's a "Health Alert"! https://t.co/CgxBU7IAk1 https://t.co/24PijmLhzR
Higher‑intensity Aerobic Exercise Cuts Loneliness in Older Adults
Effects of aerobic exercise of different intensities on the social, emotional, and financial functioning of healthy older adults: results from a 16-week exercise randomized control trial https://t.co/SePImekLGY Interaction plot depicting change across time in loneliness by condition:
Three Key Nutrients for Brain Longevity, Plus Polyphenols
As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.
Vaccines, Not Geroscience, Drove Lifespan Gains; GLP‑1s Now Hype
fun facts: class of medicines that have most greatly extended human lifespan: vaccines class of medicines longevity docs are most excited by now: GLP1s did these come from geroscience? they did not by the way, NR didn't come from geroscience either
Longevity Genes Trade Growth for Extended Lifespan
if there were no aging, you would not have matured as a man in fact, the most powerful monogenic life-extending mutations in mice impair growth and maturation
Tadpoles, Dolly, and Salamanders Prove Age Reversal Possible
That’s what I used to think, too, but tadpoles, Dolly, and salamanders changed my mind about age reversal
GLP Success Sparked Unstoppable Peptide Boom
The (hard for some to accept) reality is that the popularity of GLPs, which of course have lots of RCTs to support them, are actually what opened the doors for the immense interest in all the other peptides. People are...
Small Daily Habits Compound Into Lifelong Longevity
As a scientist studying aging, I can’t stress this enough: You don’t need to optimise everything. What really moves the needle is the compounding effect of small habits repeated over years. The 20-minute daily walks. The nutrient-dense, fibre-rich breakfast bowl...
Family Offices Add Wellness Services for Next‑Gen Principals
Folks constantly ask me, what do I do? What is a family office chief wellness officer (CWO)? I help family offices add health, wellness, longevity, and lifestyle design services into their offerings. Modern principals, particularly the next-gen, want their family offices...
Curing Disease Doesn't Change Its Classification,
cool. as soon as you show me a worm or mouse you modify so that it doesn’t degrade or end life, i’ll accept your premise your position is it’s a disease if it’s curable now i want to know if you told...
Hope for Recursive Boost and Human Longevity Progress
Let's hope there is another level of recursion where Craig will wake up to a great deal of bonus points. And we will work hard on human longevity https://t.co/NriaobLBMS
Blood Test May Forecast Alzheimer’s Years Before Symptoms
A new study by researchers at Harvard-affiliated Mass General Brigham has found that a blood test has the potential to predict progression of Alzheimer’s disease ***years before*** symptoms or brain scan changes. https://t.co/WtghaB12r2
Five Hidden Lab Numbers Reveal Your True Health
Your labs are "normal." But you haven't felt normal in years. There are 5 numbers your doctor probably isn't checking — and they tell a very different story. Free live webinar: May 5, 5 PM PT → 30dayhealth.co/webinar
Sinclair Explains GLP‑1’s Role in Longevity Protocols
David Sinclair just did a 25-minute live Q&A on aging, longevity and AI. Here are the top 9 questions the audience asked him and his answers to each one: 1) How can GLP-1 drugs be used in longevity protocols? https://t.co/q5V2fyfFnq
Glial Senescence Drives Neuroinflammation and Brain Degeneration
Disentangling causality in brain aging: The complex interplay between glial senescence, neuroinflammation, and neurodegeneration https://t.co/kiLXyxFUL0 https://t.co/XmyARd1bst
Your Lifespan Mirrors Your Same‑sex Parent’s Longevity
How long you live is influenced by how long your same-sex parent lives♀️♂️ Men whose fathers lived to 90 were 42% more likely to reach 90 as well. If their fathers lived to 100, their odds were 1.5–2× higher. Women whose mothers...
Depression Reduces Chances of Exceptional Longevity in Older Women
Prospective association of depression symptoms with exceptional longevity among older women "...Depression symptoms associated with lower odds of healthy longevity..." https://t.co/RnVcQs7XG4
One Hour Screen‑free Before Bed Restores Sanity
For real, turn screens off 60 min before bed. I know it feels like death at first. Do it for a few days, and you’ll realize that it was slowly chipping away your sanity.
Epigenetic Reprogramming Enters Human Trials for Vision
Aging biotech has made TIME's "New Frontiers" list. @lifebiosciences is using Yamanaka factors, and the FDA just cleared their first-in-human trial for optic neuropathies. Partial epigenetic reprogramming is no longer theoretical. It's in human trials. https://t.co/ZtVT5PxbHZ https://t.co/OhqLtNfqGT
Low Leukocyte mtDNA and High Inflammation Predict Elderly
Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults https://t.co/AeqAZIv3er
Daily Brain Boost: Exercise, Hydration, Sleep, Supplements
3 things I’ve started to do for my brain health daily: Trying to incorporate more walking (and working out) Drinking enough water Less alcohol Sleep Creatine Lion’s Mane Methyl B-12
Blood Factors Drive Aging or Rejuvenation; Therapies Emerging
Aging is increasingly understood as a system-wide process shaped by factors in the blood, which can actively drive either decline or rejuvenation rather than just reflect it. Emerging therapies that modify the circulatory environment show promise in reversing aspects of...
NMN Curbs Antibody Attacks, Eases Bleeding Disorder
NEW CLINICAL TRIAL RESULT: NMN suppresses harmful antibody-driven immune attacks to alleviate a common bleeding disorder. Authors suggest it may help other autoimmune diseases like lupus and rheumatoid arthritis 🙏🧵 https://t.co/eMvefTFxZo
Longevity Pill May Redefine Human‑dog Bonds
YOUR NEXT DOG A new pill could soon extend dogs’ lives. How will that change our relationship with our pets? By @andersen 🔗https://t.co/u2cuBfKGuU https://t.co/Iaw4uoZfZe
Fever‑level Sauna Spikes Heat‑shock Proteins, May Boost Longevity
3x this week I sat in 200°F (93°C) dry sauna for 55 min to get my core body temp to 102.4°F (39°C) That temp, at that duration, triggers primal panic. Took blood samples before and after each session to measure heat shock protein...
Morning Coffee Shown to Protect Brain Health
Your morning coffee is protecting your brain. JAMA just confirmed it with 131,821 people and 43 years of data...
Basics Beat Gadgets: Sleep, Food, Relationships, Movement
I hate to break it to you - but no supplement stack or wellness gadget will save you if the foundations aren’t there. Consistent sleep. Home-cooked meals. A couple of close relationships. Daily movement. These will do more for your...
Melatonin Shields Mitochondria From Radiation Damage
Melatonin as a radioprotectant against mitochondrial damage 🤔"Melatonin can protect against irradiation-induced mitochondrial damage, suggesting utility for mitigating the health effects of accidental radiation exposure." https://t.co/XHZYDE916a
It's Never Too Late to Transform Your Health
If you’re in your 50s or 60s and feel like it’s too late to start prioritising your health, take it from a bioscientist who studies aging: it’s not. Start the resistance training. Fix up your diet. Limit the harmful habits....
AI Links Healthy Thymus to Longer Lifespan
As a medical school professor, I've taught that the thymus shrinks and fades after puberty. A new Nature paper says we should start watching it again. Researchers applied deep learning to routine chest CTs across 25,031 participants in the National Lung...
SIRT1 Emerges as Exercise‑driven Exerkine Boosting Longevity
Sirtuin 1 as an emerging exerkine in the aging process: unveiling its multifaceted biological roles "Taken together, these observations support the notion that SIRT1 functions as a potential exerkine, and understanding its role in exercise-induced adaptations offers new insights into non-pharmacological...
Boosting NAD+ May Restore Sleep in Dementia
NAD+‒circadian rhythm coupling in dementia "Pharmacological and lifestyle-based strategies targeting NAD+ restoration are outlined as potential approaches to improve sleep and circadian rhythm integrity..." https://t.co/qQXLHS8nou https://t.co/te8QGUftC4
Lifestyle Signals Misaligned: 90% of Heart Disease Preventable
Cardiovascular disease is the leading cause of death globally. Yet up to 90% of cases are linked to lifestyle-related risk factors we can influence. As a longevity scientist, this points to a simple information problem: the daily signals we give our...
Train With Age, Not Against It
Midlife and Master's Athlete Training: The Biological Realities We Face For the better part of 15 years, I have been training in the gym, running, cycling, climbing, and more. But the biology of aging and the physiological changes that come with...
Resistance Training Boosts Metabolism, Independence, and Sleep After 40
As a bioscientist studying aging, I could list 50+ reasons why adults 40–60 should be resistance training. Here are 3: 1) Muscle is a major site of glucose disposal - improves blood sugar regulation 2) Key to maintaining physical function and independence...
Microplastics Threaten Longevity: One Health Perspective
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity https://t.co/CAs0yrtcQy https://t.co/rzXoOMwI40
Weekly Sauna Sessions Slash Cardiovascular Death Risk
15-year study, 1,688 people: Sauna 4–7 times per week cut cardiovascular death by 70%. • 2–3x/week: 29% lower • 4–7x/week: 70% lower • More sauna = more protection (linear effect) Inside the body: +45% heat shock proteins, +28% mitochondrial function, lower...
Longevity Boils Down to Diet, Sleep, and Daily Exercise
I've gone way deep down the rabbit hole on longevity and about 80% of the stuff you see is BS. There are some basics that are very simple. Number one, stop eating crap food. Number two, sleep seven hours and...