Ubiquinol Boosts Mitochondrial Efficiency in Active Men
Ubiquinol supplementation may enhance mitochondrial respiratory function 🫁 Ubiquinol is a reduced form of CoQ10 with enhanced bioavailability 🔍 This new study investigated the effects of 300 mg/day ubiquinol or placebo in healthy active males 💊 Supplements were taken for 6-weeks 🗓️ Results 📊 Compared to pre-supplementation and placebo, ubiquinol led to significantly… 🩸 Increased plasma CoQ10 🧬 Lowered inverse respiratory control ratio (indicative of improved oxidative phosphorylation)
Exercise Slows DNA Methylation Aging, Review Finds
Physical activity and biological age measured by DNA methylation clocks: a systematic review and meta-analysis https://t.co/gtAub5negp
Build Muscle and Nutrition Before Relying on Semaglutide
Semaglutide may slow biological aging, but so do the fundamentals. Before you reach for the injection, build muscle, optimize hormones, eat real protein, and fix the inputs that drive longevity. The goal isn't just losing weight—it's staying strong while you...
Obesity Speeds Biological Aging: A Geroscience Roadmap
Obesity and biological aging across the life course: A geroscience framework for metabolic health https://t.co/gRRL1Oakdw https://t.co/SK1YrVcmXM
Targeted Supplements Boost Molecular Health for Aging
Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits https://t.co/u5QUHR3HiC
Glycine & NAC Boost Brain Health, Reduce Frailty
Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults https://t.co/ptIWI0PHKz https://t.co/UA425kYfkI
Glucosamine May Accelerate Memory Loss in Alzheimer’s Brains
Before you take a supplement every day, it is worth asking one simple question: 🔎 What does it do in a vulnerable brain? 🧠 A new Nature Metabolism study raises that question about glucosamine, a supplement many people take for joint pain....
Consistent Bedtimes Boost Longevity More Than Sleep Hours
New in Sleep: how regular your bedtime is may matter more for longevity than how many hours you log. (1/5)
Gene Therapy Shows Promise for Reversing Aging
New paper on gene therapies in longevity and aging 🧬 Gene therapies have enormous potential to treat age-related diseases, target aging and extend lifespan. We discuss recent advances and remaining challenges in gene therapies for aging, highlighting promising targets, delivery strategies, and...
Psilocybin Shows Promise for Aging-Related Inflammation Disorders
Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging-From Depression to Neurodegeneration https://t.co/Aoz0iNFwJ3 https://t.co/SMm2i7Tw6Q
AI Predicts Six New Lifespan‑extending Drugs
Can we use machine learning to predict longevity drugs? 💊 In our updated preprint led by @AlekseyVBelikov we trained ML models on compounds in the DrugAge database that extend lifespan in mice. Features associated with longevity drugs included receptors for neurotransmitters,...
APOE Ε2 Variant Boosts Longevity and Cognitive Resilience
Longevity and cognitive resilience in a Colombian family carrying the APOE ε2 variant https://t.co/NiDOqChNNB https://t.co/Pj6hV9t3zA
Scientists Test Cellular Reprogramming to Reset Human Aging
For years, I've said aging is a software problem, not just a hardware problem. Now, for the first time, scientists are testing cellular reprogramming in humans to reset the body's biological instructions and potentially reverse aspects of aging. The question isn't whether...
Glucosamine: Brain Health Determines Longevity Benefit
Glucosamine -- taken by millions for creaky knees -- looked like a longevity drug for years, with a 15% lower risk of death in the UK Biobank. But a new 2026 study flipped that story: the same pill, same dose,...
Sleep Decline Reveals Integrated Metabolic, Inflammatory, Circadian Aging
Sleep deterioration as a systems-level readout of aging biology: integrating metabolic, inflammatory and circadian mechanisms https://t.co/6G13bnNuK6 https://t.co/W6JIKN9DFP
Fasting May Preserve Vascular Health as We Age
As we age, our blood vessels age too—and that may drive many age-related diseases. This review discusses how #IntermittentFasting and #TRE could help keep blood vessels healthier for longer. https://t.co/RqERn5QXud https://t.co/WkhHxlRikl
Cellular Aging Signatures in Blood Predict Disease Risk
Plasma proteomic signatures of cellular aging predict human disease “🔘 We observed that 20–25% of individuals exhibited accelerated aging in a single cell type and 1–3% in 10 or more cell types. 🔘 Cellular aging signatures were associated with disease status...
Aging ECM Drives Senescent Cell Buildup and Persistence
The aging extracellular matrix as a missing link in senescent cell accumulation and persistence https://t.co/ENVIiUn0Dl https://t.co/mhznrNkFsX
Nanomedicine Targets Senescent Cells to Combat Aging
Translational nanomedicine strategies for selective senescent cell clearance in aging and age-related diseases: a critical review https://t.co/fxuHAOkKSs
Life Bio Achieves First Clinical Milestone for OSK Therapy
Life Bio reaches first clinical milestone for OSK therapy 🏥 “The longevity field has spent much of the past decade debating whether aging can be modified at the level of cellular identity itself. Now, one of the sector’s most closely watched...
Community Connection Is Essential Medicine for Longevity
Something I’ve realised over the past few years: You can do everything “right” with diet and exercise, but if you’re lacking connection, something feels missing. Feeling part of a community not only makes everyday life feel better, but the biological...
UAE's $8 Trillion Healthy‑Ageing Market Opens Investment Opportunities
Dubai Longevity Authority: Investment opportunities in UAE’s $8 trillion healthy ageing market 💫"We firmly believe that every scientific breakthrough should deliver tangible benefits to people's lives, and that serving humanity will always remain the ultimate purpose of every investment in science,...
Omega‑3, Vitamin D, and Exercise Trim Biological Age
Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which @prof_horvath believes is one of...
NMN Boosts NAD+, Reviving Cellular Repair in Humans
NAD+ is the currency your cells spend to repair themselves. When NAD+ drops, your cells stop fixing damage. You age faster. Newer human trials prove what I've been testing for years. NMN raises NAD+ levels in real people. Not mice, not...
90‑119 Min Weekly Resistance Training Cuts Mortality Risks
New in the British Journal of Sports Medicine: 90-119 minutes a week of resistance training is associated with a 13% lower risk of dying from any cause -- and 27% lower neurological disease mortality. (1/4)
SuperAgers' Brains Generate Twice as Many New Neurons
Twenty-five years of Northwestern's SuperAger Program produced one of the most counterintuitive findings in modern neuroscience. SuperAgers, adults over 80 with the memory of people three decades younger, generate new hippocampal neurons at roughly twice the rate of typical older adults....
Eight Years of Aging Biology, 40 Simple Rules
I study the biology of aging. 🧬 This is it. Everything I’ve learned over 8 years - in 40 simple rules ↓
Shared Blood Metabolite Patterns Predict Lifespan in Dogs and Humans
Dogs and humans showed similar metabolite patterns linked to earlier or later death. The signals came from broad metabolic fingerprints in blood, but they do not show what is causing the outcome. aging
Cut Seed Oils, Boost Health with Stable Fats
If you're chronically inflamed, look at the fats you're eating. Seed oils flood your body with omega-6 linoleic acid. Your cells turn that into arachidonic acid. Arachidonic acid drives inflammation. I have seen thousands of people remove seed oils and watch...
Mitochondrial Transfer Advances Stem Cell Therapies
The progress of mitochondrial function and transfer in stem cell regulation and therapy https://t.co/rltLeBPkHU https://t.co/WreIarDoAo
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Tiny Tweaks in Sleep, Activity, Diet Extend Lifespan
Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study https://t.co/5q1WnJhN78
New Epigenetic Clocks Reveal Faster Aging in Disadvantaged Groups
Faster biological aging was consistently tied to lower socioeconomic status and discrimination across 140 studies. The pattern was strongest in newer epigenetic clocks, while older measures captured far less. aging
Longevity: Measurable, Influenceable, Reversible Aging Factors
Honored to speak at Harvard about longevity and the science of extending healthspan. For decades, we've treated aging as something that happens to us. Today, we're learning that many of the factors that drive aging are measurable, influenceable, and in...
DNMT3A Mutations Drive Hyper‑methylation, Accelerating Age‑related Diseases
Getting to the root of age-related diseases. By studying a rare accelerated aging genetic disorder, gain-of-function mutations of DNMT3A were found to be causal. DNA hyper-methylation was then linked to stem cells dysfunction and multiple age-related diseases (blood, bone, metabolic). Work...
One Gene Can Halt Cellular Aging, Hinting at Reversal
Scientists like Hayflick once viewed replicative senescence as a complex, multifactorial form of cellular wear and tear. So when a single gene manipulation (telomerase expression) was shown to prevent replicative senescence, it came as a surprise. Aging is more...
Aging Linked to Loss of Cellular Information, Not Damage
NEW PREPRINT: Scientists may have found direct evidence that aging is driven by the loss of cellular information, not just the accumulation of damage For decades we've focused on what aging cells accumulate. This paper focuses on what they lose:...
Vitamin K2 Directs Calcium to Bones, Protects Arteries
You take calcium and vitamin D for your bones thinking that’s the end of the story. Vitamin D helps your body absorb calcium from food and move it into your bloodstream. But once calcium is in circulation, your body still has to...
Cycling Cuts Epigenetic Age by Seven Months
Consistent endurance exercise may be one of the most powerful ways to slow down biological aging. Six months of cycling (about 4.5 hours/week) reduced GrimAge by 7 months relative to the expected trajectory of normal aging. GrimAge is an epigenetic clock...
From Self-Optimization to Collective Joyful Longevity Raves
From self-optimization to collective joy at scale By @TinaWoods 🏆 Note for readers: Dr. Woods is not only a global thought leader on healthspan, the exposome, & joyspan, she is also a talented DJ. Her “Longevity Rave” events come highly recommended 🪩 https://t.co/D0vRHnvjc4...
Metformin Restores NCoR1, Delays Primate Gut Aging
The aging gut, mapped at single-cell resolution in primates. NCoR1 decline = barrier failure + chronic inflammation + stem cell lineage shift away from absorptive cells. Metformin restores NCoR1 and delays intestinal aging in NHPs. Li et al., Nature Aging 2026 https://t.co/OLdXp99EiG
Epigenetic Drift and Stress Trigger Senescence, Accelerating Aging
Nice review about how epigenetic drift and cell stress can cause cellular senescence to drive aging and disease https://t.co/40OXfSTDhV
Daily Multivitamin Slows Brain and Biological Aging
A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent...
Seeking Advice on Epithalon and BPC Use Abroad
OK @AbudBakri let’s just say I have a friend flying to EU from CA for 21 day work stint & wanted to explore (confirmed clean) epithalon & bpc use, what should I tell them? Hypothetically of course. No obligation to...
Unlocking Biohacking Science for Longevity and Performance
I sat down and chopped it up good with @SecKennedy on “The Science of Biohacking, Longevity, and Human Performance” https://t.co/FTqoziiIal
Age Doesn't Have to Mean Decline: Boost Performance
If you don't feel like you did 10 years ago, it's time to stop accepting age-related decline as normal. Performance, energy, and resilience can improve with age when you learn how to work with your biology instead of against it. My conversation...
Aged Blood NAD Irrelevant; Organ Levels Matter
The naysayers saw no change in blood NAD levels with age (something we’ve known for yrs) and concluded an entire field is wrong We’re treating organs not blood, and aged NAD levels are irrelevant to whether therapies work Beware of commentators...
Renowned Cardiologist Exposes Longevity Industry’s Empty Promises
A bestselling cardiologist just took apart the longevity industry by name, and he started with the supplement in your kitchen. Eric Topol, MD has spent his career in medical research. His new book "Super Agers" carries over 1,800 citations. He...
First Human Trial of Cellular-Reprogramming Eye Therapy
World-first: therapy to make cells young again trialled in a person A participant in a landmark clinical trial has been given a cellular-reprogramming treatment that aims to rejuvenate damaged cells in the eye. By Heidi Ledford | @heidiledford @Nature https://t.co/OlrhvNuXVC https://t.co/MfHAQdX3fm
First Reverse‑aging Drug Administered to Human
The first-ever reverse-aging drug was just injected into a human Featuring @lifebiosciences @M_S_Ringel and @davidasinclair, with interviews by Daniel Oliver @rejuvenatebio, @mkaeberlein, @BKennedy_aging, and many more.👨⚕️ By @Hilarx @BusinessInsider🗞️ https://t.co/vdxr1geDzM https://t.co/sL2Ts1IjPA