Today's Longevity Pulse
Retro Biosciences raises $1.8B, targeting ten extra healthy years
Longevity startup Retro Biosciences announced a new fundraising round that values the company at $1.8 billion. Backed by OpenAI CEO Sam Altman, the firm is developing gene and cell‑replacement therapies and is currently testing a pill designed to clear protein aggregates in Alzheimer’s patients.
Also developing:
Vitalist Bay Returns: Four Day Longevity Festival in the Bay Area, May 14 to 17
Vitalist Bay, a bootstrapped longevity festival, returns to Berkeley for a four‑day event May 14‑17, 2024. Organized by Adam Gries and Nathan Chang, the conference compresses two months of last year’s content into six thematic tracks covering AI in biotech, biopreservation, and biomarker testing. The lineup features leading figures such as Aubrey de Grey, Joe Betts‑LaCroix, Michael Snyder, and offers hands‑on workshops, DEXA scans, and other health assessments. Early‑bird discounts and a free DEXA scan are available for the first ten registrants using code RAPAMYCIN20.
Loss of Resilience as the Key Measure of Aging, And How to Track It
A new kinetic resilience protocol shifts longevity medicine from static damage snapshots to dynamic stress‑response testing. By challenging metabolic, cardiorespiratory, autonomic and immune systems, clinicians can measure how quickly biology returns to equilibrium, using metrics such as OGTT clearance velocity,...
Polypharmacy and Anticholinergic Load Accelerate Aging via Inflammation
Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing Note the observational design, with corresponding limitation in inference. The authors concluded: "Both polypharmacy and anticholinergic burden are associated with accelerated biological ageing, partly mediated by inflammation, including a potential serial...
Microplastics Found in Chewing Gum: Longevity Warning
Follow the journey to live longer than anyone that has ever lived: Today's Diet (5/8/26); Microplastics in Gum https://t.co/NlaDOfWF4m
Beacon Biosignals Launches At-Home Sleep EEG Platform for Brain Health Diagnostics
Boston‑based Beacon Biosignals introduced an at‑home sleep EEG platform that uses a lightweight headband to capture clinical‑grade brain activity while users sleep. The FDA‑cleared device is already deployed in more than 40 global clinical trials, positioning the company to reshape...
Bold Ambition Drives Growth, Inspires Longevity Ventures
Bold ambition pays off, and it tends to lift everyone around it. Elon, have you ever thought about starting a longevity company down the road? If not, what’s holding you back? If so, what would it take to make it happen?
Spermidine
Recent clinical research confirms spermidine, a natural polyamine, boosts autophagy in brain cells, reducing amyloid‑beta and tau aggregates linked to Alzheimer’s disease. Levels of spermidine fall roughly 50 % between the twenties and seventies, correlating with increased cognitive decline, but supplementation...
New Brain Scan Index Detects Hidden Alzheimer’s Patterns Before Memory Loss Begins
Researchers at the University of Texas Health Science Center have introduced the Regional Vulnerability Index, a mathematical tool that evaluates standard MRI scans for Alzheimer’s‑like structural patterns. The index quantifies how closely an individual’s brain matches a disease blueprint, revealing...
GlycanAge to Launch Inflammaging Conference in Dubrovnik, Targeting Clinical Use
GlycanAge, together with the Mayo Clinic, announced a landmark conference in Dubrovnik, Croatia, opening June 19 with a dedicated clinical day on June 20. The event aims to turn 25 years of inflammaging research into actionable diagnostics for doctors and patients.
We’ve Launched the Most AI‑discovered Longevity Drugs
This is cool. Not sure why you need so much money if you are making drugs faster and cheaper. But it is great - maybe I should be thinking about raising more to scale. At the end of the day,...
Smart Homes Integrated with Biotech Extend Lifespan
A bigger house is not going to give you significantly longer life. But a much smarter house integrated into the advanced biotechnology research and clinical ecosystem will. Very happy to see our chapter with CY Leung published in Springer Nature...
10 Cancer-Prevention Habits Oncologists Do Every Day
Oncologists are modeling cancer‑prevention habits they recommend to patients, from cutting alcohol entirely to eating a plant‑forward diet rich in fiber. They aim for about 30 grams of fiber daily, cook at home, get 7‑9 hours of sleep, and incorporate strength...
Mabwell IPO Highlights China’s Rising Biologics Powerhouse
Do you remember the company which sold their IL11 nanobody to Google Calico after it realized that after 13 years in the business they need a drug for aging? The company is called Mabwell and they just listed in Hong...
Electromagnetic Field Activation of Gene Therapy as an Approach to Reprogramming
Researchers have engineered an electromagnetic‑field (EMF)‑responsive DNA element that remotely activates partial cellular reprogramming genes in mice. By cycling EMF exposure, the system triggers the Oct4‑Sox2‑Klf4 cassette without permanent gene integration, extending median lifespan to 108 weeks—about 70 human years....
This Engineer Spent 100 Days Underwater—And It Added 10 Years to His Life, He Claims
Biomedical engineer Joseph Dituri spent 100 days in a 22‑foot‑deep underwater chamber at 1.6 ATA, claiming dramatic health improvements. He reported weight loss, lower cholesterol, a seven‑fold testosterone boost, and doubled REM sleep. While Dituri sees the results as proof that...
Being Overweight May Lead to Faster Cognitive Decline
A 24‑year longitudinal study of more than 8,200 U.S. adults over 50 found that higher body‑mass index (BMI) accelerates cognitive decline, affecting memory, executive function and emotional regulation. Each unit increase in BMI was associated with a faster deterioration of...
New Review Finds Most Brain‑Boosting Supplements Lack Strong Evidence, Creatine Leads the Pack
A September 2025 narrative review and a February 2026 systematic review conclude that the majority of brain‑boosting supplements have limited scientific support, with creatine emerging as the only compound with consistent cognitive benefits. The findings reinforce the superiority of whole‑food...
Safety Debate Heats Up Over Stem Cell Longevity Treatments
Leading researchers and clinic founders are confronting the safety of stem‑cell therapies marketed for longevity, with experts warning that not all products are genuine stem cells and that regulatory oversight remains limited. The debate underscores a booming market driven by...
Junyue Cao on How the Body Ages, Cell by Cell
Dr. Junyue Cao’s lab at Rockefeller University released the most extensive single‑cell epigenomic atlas of mammalian aging, profiling chromatin accessibility in roughly seven million cells from 21 mouse tissues at three life stages. The study identified about 1,800 distinct cell...
GLP‑1 and Testosterone Boosters Are Outright Scams
GLP-1 drops are a scam GLP-1 patches are a scam GLP-1 boosting supplements are a scam Also… Testosterone boosting supplements are a scam
Shark Heart Study Uncovers Longevity Mechanisms, Fueling Biohacker Quest for Longer Life
Scientists at Italy's Superior Normal School have detailed how Greenland sharks maintain heart function for centuries, highlighting robust DNA repair and cancer‑suppression genes. The findings, published April 23, could give biohackers fresh molecular targets for extending human lifespan.
Heart, Kidney, Metabolic Issues Raise Cancer Risk 30%
Heart, Kidney, Metabolic Disease Linked to 30% Higher Cancer Risk As a medical school professor, I teach cardiovascular and cancer medicine as separate silos. A new study of 1.4 million adults says we have to stop. Circulation: Population Health and Outcomes, April...
Longevity Field Shifts From Consensus to Convergence
‘We are not at consensus but we are at convergence’ @LongevityTech @TinkingGumbel with @prof_horvath https://t.co/rGqQhNHYxw https://t.co/tcfNH3S2bH
Cornell Study Links Vitamin B12 to Muscle Mitochondria, Aging and Longevity
Cornell University scientists published a study in the Journal of Nutrition showing that vitamin B12 deficiency impairs skeletal‑muscle mitochondrial energy production and reduces muscle mass in aged mice. The findings broaden B12’s role beyond anemia, pointing to potential interventions for...
Optimal Exercise‑Fasting Dose Boosts Metabolic Health
Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis https://t.co/JFrFVMpGDq
Rapamycin's 50-Year Odyssey: From Easter Island to Medicine
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine https://t.co/Jn67QrGVi6 https://t.co/dwGPgUVB83
Study Finds Brain Health Improves at Any Age with 5‑15 Min Daily Training
Researchers at the University of Texas at Dallas tracked nearly 4,000 participants for three years and found that just 5 to 15 minutes of daily, targeted brain‑healthy practice can measurably improve performance at any age. The findings challenge the long‑standing...
Organ‑Specific Aging Clocks Reveal Multi‑Omics Lifespan Patterns
The big advance in the science of human aging is the ability to quantify it and relate the metrics to health and disease. A new paper today @CellCellPress takes this to the next level with organ clocks and multiple biologic...
Metformin's Primary Action Is Gut, Not Liver
Metformin, one of the most commonly prescribed drugs, was thought to work via the liver. Check that. It's primarily through the gut. @NatMetabolism https://t.co/i2CpZip61B https://t.co/bhsI7p7SYx
Study Links Consistent Daily Rest Patterns to Slower Biological Aging
Johns Hopkins scientists reported that adults with stable daily rest‑activity rhythms show slower biological aging, based on epigenetic clock data from 207 participants. The finding positions consistent sleep and activity as a measurable lever for longevity‑focused biohackers.
IGF‑1 Switch Drives Biphasic SASP Aging Model
The IGF-1 senescence switch: a biphasic model for SASP-driven aging and precision senomodulation https://t.co/f0BoHbaeCK? https://t.co/NjDlT0O9hQ
The Science Behind Social Media’s Peptide Obsession
Social media and Silicon‑Valley influencers are driving a surge in gray‑market peptide sales, from weight‑loss candidates like Eli Lilly’s experimental retatrutide to DIY stacks such as BPC‑157 and TB‑500. These compounds, often sold as “research‑only” powders for $130 a vial, bypass...
Schneider Shorts 8.05.2026 – Incredible Future Is Now Becoming Reality
The biotech sector faced a series of high‑profile setbacks in early May 2026. Amgen was forced to withdraw its drug avacopan after the FDA uncovered fabricated trial data, a scandal tied to a $4 billion acquisition of ChemoCentryx. Russia announced a...
Regular Fish Intake Supports Cognitive Health in Aging
Fish consumption and cognitive function in aging: a systematic review of observational studies "In conclusion, the evidence suggests that regular fish intake (typically ≥1–2 servings per week) is linked to preserved cognitive performance, although some inconsistent findings require further investigations." https://t.co/1axIS85WGf @GeroScienceAGE
Science Advances Toward Immortality Through Longevity Hacking
Longevity Hacking: Can We "Cure" Death? "For millennia, humanity has dreamed of immortality, but we are finally living in an era where science is catching up to the dream. "(Sparks) https://t.co/wv28wrTI77 #longevityhackers #longevity #science https://t.co/CTo5hLtD4a
Study Finds Rapamycin May Undermine Exercise Gains in Older Adults
Researchers led by Dr. Brad Stanfield reported that older adults taking a low weekly dose of rapamycin gained less muscle strength and physical function from a structured exercise program than those on placebo. The findings suggest the popular anti‑aging drug...
Fuel Your Mitochondria, Unlock Peak Performance
I don’t take 150 pills a day to feel average. I take them because your biology responds to inputs, and most people never give their cells what they need to perform. Your mitochondria run the entire energy economy of your...
Eating Eggs Could Cut Alzheimer’s Risk by 27%
Researchers at Loma Linda University analyzed data from about 40,000 older adults over a 15‑year span and found that eating at least one egg per day was linked to a 27% lower risk of Alzheimer’s disease. Even modest consumption—1‑3 eggs...
Astellas Touts Data From Early Test of Stem Cell-Derived Eye Therapy
Astellas Pharma announced early-stage data from its stem cell‑derived retinal therapy, aimed at treating age‑related macular degeneration (AMD). In a small cohort receiving the highest dose, patients showed statistically significant gains in best‑corrected visual acuity and no serious safety signals....
Psychedelic Figures Don’t Live Longer than Researchers
Psilocybin and human longevity "All groups exceeded population life expectancy, reflecting the effect of socioeconomic advantage on lifespan, but psychedelic personalities did not outlive cancer and aging researchers." 🙂"We examined mortality among prominent psychedelic personalities, researchers, and advocates who claimed psychedelic use...
AI Reads Retina to Diagnose Multiple Metabolic Diseases
In 2014 I predicted we'd diagnose metabolic disease just by looking into your eyes. Nature Medicine just published the proof. Researchers built an AI called Reti-Pioneer. You look into a camera. It scans your retina. No blood draw. No needles. No lab. What it can...
Garlic Compound May Hold Clue to Slowing Muscle Aging
Japanese researchers identified S‑1‑propenyl‑L‑cysteine (S1PC), a compound in aged garlic extract, as a potent activator of the LKB1 enzyme that boosts eNAMPT secretion and NAD+ production. In aged mice, long‑term S1PC supplementation lowered frailty scores, increased muscle force, and restored...
60‑Year‑Old Milind Soman Swims 15 Km Strait of Gibraltar, Showcasing Discipline‑Driven Fitness
On May 1, 2026, Indian actor‑athlete Milind Soman, aged 60, completed a 15‑kilometre swim across the Strait of Gibraltar from Tarifa, Spain, to Morocco. The feat underscores his minimalist diet, short daily workouts and intermittent fasting routine, offering a concrete example of...
How Intestinal Aging Encourages Harmful Bacteria
Researchers in Aging Cell examined 3‑month‑old and 24‑month‑old C57BL/6 mice to chart how intestinal aging reshapes the gut microbiome and mucosal immunity. Older mice showed a sharp decline in beneficial Bifidobacterium and Faecalibacterium, replaced by pathogenic Enterobacteriaceae, alongside reduced IgA...
AI Longevity Promises Overlook Tiny Real-World Gains
If you hear another AI celebrity telling you on stage that in the next 5 years we will double lifespan or eliminate all diseases - please show them this output from their own LLMs and ask them "How?". This simple...
ART Reverses HIV‑Induced Aging, Cutting Years Off Biological Clock
Great news for HIV positive patients. A study presented at ESCMID Global 2026 found that untreated HIV can accelerate biological aging by up to a decade, but antiretroviral therapy can reverse this effect by nearly four years within about 18...
Immune System Aging Is a Major Contribution to Neurodegeneration
A new open‑access review links age‑related immune dysfunction—both chronic inflammation (inflammaging) and declining immune competence (immunosenescence)—to the onset and progression of neurodegenerative diseases. Mislocalized mitochondrial and nuclear DNA continuously trigger innate immune sensors, creating a persistent inflammatory milieu in the...
Only Proven Sleep Hacks Actually Improve Your Rest
I Tested Every Sleep Hack on the Planet — Here's What Actually Works https://t.co/13yp3N9anK via @YouTube
Clarify Healthspan: When Does Quality Living End?
Lifespan stops at death, but when does healthspan stop? "...Greater conceptual clarity is essential..." https://t.co/ybrK3kkQCS
Recent Longevity Pioneer Deaths Urge Faster Breakthroughs
Craig Venter (79), Ham Smith (94) and Clyde Hutchinson (86) died in the span of just 12 months. Time to accelerate, my friends. It would be sad if we land on Mars and don't make a significant breakthrough in longevity......