Today's Longevity Pulse
Retro Biosciences raises $1.8B, targeting ten extra healthy years
Longevity startup Retro Biosciences announced a new fundraising round that values the company at $1.8 billion. Backed by OpenAI CEO Sam Altman, the firm is developing gene and cell‑replacement therapies and is currently testing a pill designed to clear protein aggregates in Alzheimer’s patients.
Also developing:
Broken at the Biochemical Level: The B Vitamin Series - Part 1
The opening post of the "B Vitamin Series" frames B‑vitamins as foundational metabolic regulators rather than optional nutrients. It argues that adequate B‑vitamins are essential for energy generation, nerve transmission, cardiovascular health, and cellular repair. When levels dip, the body exhibits fragmented function—unstable nerve signals, reduced energy, mood changes, and tissue breakdown. The author highlights a widening gap between the biochemical importance of B‑vitamins and their modest treatment in mainstream clinical practice.
GLP‑1 Therapy Shows Benefit for Type 1 Diabetes Patients
A 174,000-patient analysis just delivered the first hard evidence that GLP-1 drugs work in a population every clinical trial has excluded. As a medical school professor, I teach that Type 1 diabetes is autoimmune, Type 2 is metabolic. But the cardiovascular...
How to Add 7.5 Years to Your Life (Without Drugs or Surgery)
A Yale study led by Dr. Becca Levy tracked 660 adults over 23 years and found that people who hold optimistic views about aging live about 7.5 years longer than pessimists, outpacing benefits from lower blood pressure or cholesterol. The...
AHA Links Lifelong Lifestyle Factors to Brain Health in New Scientific Statement
The American Heart Association released a scientific statement in the journal Stroke that frames brain health as the cumulative result of mental, physical, environmental and lifestyle choices from early life onward. The statement highlights the aging U.S. population and calls...
Reducing Cardiovascular Risk: A Playbook for Lipid-Lowering Pharmacotherapy
The episode outlines a practical decision‑making framework for lipid‑lowering pharmacotherapy, emphasizing that the key question is not whether to treat high LDL‑C but how to choose the optimal therapy. It explains how to assess baseline labs, identify the dominant cholesterol...
Tony Robbins Opens AI-Powered Fountain Life Clinic in Houston
Tony Robbins, co‑founder of the AI‑driven longevity brand Fountain Life, opened the company's fifth clinic on the first floor of Houston’s Park House. The launch, attended by roughly 500 guests, showcases a luxury‑focused preventive health model that blends advanced diagnostics,...
Targeting Senescent Cells as a Treatment for Chronic Obstructive Pulmonary Disease
Researchers have introduced BCLXL-PROTAC, a proteolysis‑targeting chimera that degrades the anti‑apoptotic protein BCLXL in senescent lung cells. In primary small‑airway epithelial cells and fibroblasts from COPD patients, the compound induced caspase‑3‑mediated apoptosis and lowered classic senescence markers such as p21,...
Senescent Macrophages Are Important in Liver Aging and Liver Disease
Researchers identified a distinct p21‑positive, TREM2‑positive senescent macrophage population that accumulates in aging and fatty livers. These cells drive chronic inflammation through a senescence‑associated secretory phenotype linked to type I interferon signaling. In mouse models, senolytic agents that selectively eliminate these...
AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD
In this episode, Dr. Robert Lovekin talks with Dr. Daniel Ives, founder of Shift Bioscience, about moving from hypothesis‑driven aging research to data‑driven, AI‑powered approaches. Ives explains how his early focus on mitochondrial DNA mutations as the primary cause of...
TB‑500 Is Not TB‑4: No Human Evidence
TB - 500 is a short chain fragment synthesized from Thymosin Beta-4. TB-4 has solid human evidence for use. TB500 has absolutely no evidence. Totally different compounds. They cannot be referred to interchangeably because they simply are NOT the same
Balanced Longevity Research Shows Real Human Impact
Longevity Science Is Overhyped. But This Research Really Could Change Humanity. We were delighted to have @susandominus with us at the last academy meeting earlier this year. She does gives a balanced take on the latest rejuvenation science. This...
Does Exposure to Air Pollution Literally Accelerate Aging?
A new open‑access study using UK Biobank data links long‑term exposure to five common air pollutants with accelerated biological aging, reduced gray‑ and white‑matter volumes, and a higher risk of dementia. Participants in the highest exposure tertile showed hazard ratios...
Why Aging Solutions Aren’t Scientific Priorities
I've met Laurent, and it's great to see him now focusing on aging. Why isn't solving aging a top scientific priority?
AI: Our Best Bet to Beat Aging
AI is likely the only hope we have to solving aging. In fact, it is the opposite of David’s paint analogy.
The Longevity Economy Is Built for the Rich
The episode examines the $6 trillion "longevity economy"—the booming market built around anti‑aging and wellness innovations—and highlights how its benefits are disproportionately accessible to the wealthy. It outlines macro trends driving investment in longevity, critiques the uneven distribution of cutting‑edge therapies,...
Resistance Training Plus Polyphenols Boost Aging Health
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals https://t.co/mDL393xerp @GeroScienceAGE https://t.co/qr3yxiZuHB
HIIT Boosts Brain Health in Heart Disease Patients
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients “the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more...
A Robust Senescence Response Helps Wounds Heal
Scientists compared wound healing in young (2‑month) and old (24‑month) mice and found that a rapid, temporary surge of senescent cells in the young animals accelerates closure. The younger mice displayed sharp up‑regulation of senescence markers p16, p21 and SA‑β‑gal,...
Shared Pathways Link Gut Aging and IBD; Target Early
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging "this article highlights both the shared and distinct pathways driving gut dysfunction in aging and IBD, and underscores the importance of early recognition and targeted...
ACC Endorses Universal CRP Screening for Heart Risk
I've been waiting for this for a long time... The American College of Cardiology now recommends universal screening for a marker I've been writing about since 2011 - and most doctors still don't order it. The American College of Cardiology now highlights inflammation...
Cellular Rejuvenation Has the Potential to Reverse Aging
Researchers have identified a natural cellular rejuvenation process that resets embryonic cells to a youthful state within two weeks, effectively erasing parental age markers. Over the past two decades, labs have revived skin cells from 90‑year‑olds and rejuvenated diseased mice,...
Study Links Centenarians' Children Diet to Lower Chronic Disease Risk
Scientists at Tufts University report that offspring of centenarians who follow diets high in fish, fruits and vegetables and low in sugar and sodium have markedly reduced risks of stroke, dementia, type‑2 diabetes and cardiovascular disease, based on a 20‑year...
UT Southwestern Study Links Refeeding Phase to 41% Lifespan Boost in Worms
UT Southwestern scientists discovered that the metabolic response to refeeding after a 24‑hour fast extends Caenorhabditis elegans lifespan by about 41%, highlighting the refeeding phase—not the fast itself—as the key driver of longevity. The finding could reshape human dietary recommendations...
Pilot Study Finds 300 Mg NMN Cuts Post‑Exercise Inflammation in Young Men
Researchers in Taiwan reported that a six‑day regimen of 300 mg NMN lowered key inflammatory cytokines in young men after intense blood‑flow‑restriction resistance training. The crossover trial suggests NMN could become a targeted supplement for athletes and biohackers seeking faster recovery.
Dartmouth Researchers Launch Smartphone Study to Predict Alzheimer’s Risk in Williamstown Seniors
Dartmouth Medical School researchers began a pilot study with 23 Williamstown seniors, part of a nationwide 200‑person trial, to test the RealVision smartphone app that analyzes walking, speech, eye‑tracking and smiling to flag early Alzheimer’s risk. The effort showcases big‑data...
Food Sources for All Your Essential Supplements
Eat your supplements cheat sheet 💊🥦🥘 - Creatine: herring, red meat - Glycine: gelatin - Magnesium: pumpkin seeds - Boron: dried fruit, avocado - Potassium: potatoes - Omega-3s: salmon, sardines - Spermidine: wheat germ, cheese - Vitamin K2: natto, cheese - Taurine: seaweed, fish - Trimethylglycine: beets - Astaxanthin: salmon, shrimp -...
Cellular Rejuvenation Could Shift Medicine to Youthful Resilience
Cellular rejuvenation may redefine medicine—not by treating disease, but by restoring youthful resilience at the cellular level. But science, safety, and hype are colliding. Worth the read (gift link) : 👇 https://t.co/7JGNdhFsFP via @NYTimes
Zepbound’s and Ozempic’s Greatest Benefit May Be Their Anti-Inflammatory Power
GLP‑1 drugs such as Ozempic and Zepbound are gaining recognition for anti‑inflammatory effects that go beyond weight loss and glucose control. Clinical data show semaglutide reduces C‑reactive protein by about 40% independent of weight loss and improves liver inflammation in...
Infinite ROI on Longevity, Yet We Plan Vacations Instead
Question: What's the ROI on preventing your own death? Answer: Infinite. Yet 99% of people spend more time planning vacations than planning longevity.
Low Post‑Surgery Klotho Predicts Inflammation and Cognitive Decline
Lower levels of the anti-aging protein Klotho after surgery were strongly linked to higher inflammation and worse cognitive function in patients with postoperative cognitive dysfunction (POCD). This suggests Klotho could be a useful early biomarker—and possibly a treatment target—for predicting...
Study Finds Exercise Variety Cuts Mortality Risk, Extending Lifespan
Researchers analyzing data from the Nurses' Health Study and the Health Professionals Follow-Up Study report that a varied exercise regimen, not just higher volume, is linked to a markedly lower risk of death. The finding challenges the prevailing biohacker focus...
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Aging Can Be Solved—Join the LBF8 Fellowship
1/ How long do you want to live? For most of human history, aging was inevitable. It's now solvable. Apply for LBF8 cohort program: longbiofellowship dot org /THREAD🧵
Longevity Medicine’s New Vanguard: 11 Innovators Poised to Drive an $8 Trillion Market
Business Insider unveiled its 2026 Rising Stars of Longevity, naming 11 innovators whose AI‑driven diagnostics, biotech breakthroughs and gerotherapeutics aim to capture a market expected to grow to $8 trillion by 2030. The list, vetted by experts like Andrea Maier and...
Diet Diversity Spans From 20 to 86 Foods, Women Lead
We’re told to “eat a diverse diet”—but how diverse is it in reality? Over 2 weeks: • Lowest 10% consume ~20 unique items • Highest (novelty seekers) reach ~86 Interesting twist: women tend to sample more unique foods than men. Where do you fall? @NatMetabolism https://t.co/08GlVexklU
Evidence for MLKL to Be Important in Hematopoietic Stem Cell Aging
Researchers have identified the RIPK3‑MLKL signaling axis as a central driver of hematopoietic stem cell (HSC) aging. Activated MLKL accumulates in HSC mitochondria, impairing self‑renewal and lymphoid differentiation without causing necroptotic cell death. The study links multiple stress responses—such as...
AI Accelerates Longevity Science at London Tech Show
AI is reshaping longevity science faster than ever. At the Health + AI Insiders Tech Show, I'll be discussing how computational biology is transforming our understanding of ageing. 📍 London | 29 April 2026 🔗 Complimentary tickets: https://t.co/4XipXYfWcc
Abdominal Contractions May Drive Brain Fluid Flow, Aiding in Neural Waste Clearance
A new study in Nature Neuroscience shows that abdominal muscle contractions compress vessels linked to the spinal cord, nudging the brain within the skull. This subtle motion drives cerebrospinal fluid flow, helping to wash away neural waste. Researchers demonstrated the...
Ivermectin: The New Wonder Drug?
A new consortium paper from Texas institutions challenges the long‑standing hygiene hypothesis that helminths are essential for immune maturation. The authors show that common roundworms and Toxocara remain prevalent in low‑income U.S. communities and are linked to worse asthma and...
Swedish Clinic Finds Limited Eligibility for New Alzheimer Drugs
Preparing for the implementation of anti-amyloid therapies in Europe: Assessing real-world eligibility for lecanemab and donanemab in a Swedish memory clinic https://t.co/H3TgYvgVSk
The Cure for Death Means Billionaires Will Live Forever—And Be Rich Forever
U.S. billionaires enjoy a dramatically higher life expectancy, with 20% living past 80 compared to just 3.8% of the general population. Their longevity stems from access to premium healthcare, personal trainers, and cutting‑edge nutrition. Meanwhile, leaders like Putin and Xi...
Free Radicals Podcast (Longevity / Biotech Oriented)
Kexin Huang, the a16z‑backed founder of Pho, argues that biology is entering an "Agentic Biology" era where AI agents orchestrate research rather than merely analyze data. His Integrated Biology Environment (IBE), embodied in the Biomni platform, acts like an IDE...
Free Radicals Podcast (Longevity / Biotech Oriented)
Nathan Cheng argues that aging remains untreated due to a coordination failure rooted in cultural "deathism," despite roughly 100,000 daily deaths from age‑related diseases. He highlights a stark $5 B versus $100 B+ funding gap between longevity and cancer research, underscoring the...
Uridine Boosts Synapse Formation in Aging Brains
Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses https://t.co/bOoaNebYmn
Blue Zones Longevity Claims May Rest on Flawed Records, Essay Argues
A new essay in Revista de Salud Pública challenges the scientific foundation of the Blue Zones longevity concept and the long‑standing Lipid Hypothesis. The authors argue that many extreme‑age records stem from poverty‑related clerical errors, weak vital‑registration systems, and selection...
Engineering Immortality: AI Challenges Death as System Failure
The New York Times says wanting to live is pathological. What do you think? Two thirds of the human population believes in some form of life after death. Ancient Egyptians built pyramids for it and Gilgamesh searched deserts for it. 1.9 billion...
Ageing Is a Multilevel Network; Target Central Hubs
Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions 👉 “Because molecular, cellular, tissue and organismal levels retain partial autonomy, human ageing can be viewed as a multilevel phenomenon. 🔬Geroscience may therefore advance by mapping this network...
Cornell Researchers Show Stem‑Cell Vesicles Halt Cellular Aging in Lab
Researchers at Cornell University's College of Veterinary Medicine have shown that extracellular vesicles derived from embryonic stem cells can completely halt cellular senescence in cultured cells. The finding opens a new molecular pathway for anti‑aging interventions that biohackers and biotech...
Epigenetic Clocks Predict Lung Cancer Risk Beyond Self‑reports
New paper: Epigenetic age clocks help predict lung cancer risk & mortality by estimating smoke exposure. Is independent of self-reported smoking history, so people probably lie about it. Clocks could help doctors predict lung cancer risk & decide on...
Raw Peptides Degrade Instantly, Never Achieve Effect
Hi @MartinShkreli - if as you say at https://t.co/qJh2vgV0Wm that "raw peptides have a half-life measured in seconds or minutes, meaning your body destroys them almost instantly after you inject them. They never get a chance to do anything."...