Today's Longevity Pulse
Retro Biosciences raises $1.8B, targeting ten extra healthy years
Longevity startup Retro Biosciences announced a new fundraising round that values the company at $1.8 billion. Backed by OpenAI CEO Sam Altman, the firm is developing gene and cell‑replacement therapies and is currently testing a pill designed to clear protein aggregates in Alzheimer’s patients.
Also developing:
Impact of World Ageing Festival Singapore 2026
The World Ageing Festival Singapore 2026, organized by Singapore Management University, convened policymakers, healthcare innovators, and senior‑care providers under the theme “Embracing Longevity: Asia’s Priority, The World’s Opportunity.” The three‑day event attracted thousands of participants and hundreds of exhibitors from more than 40 countries, showcasing assistive‑living tech, smart health monitoring, and wellness tourism solutions. By spotlighting the trillion‑dollar “silver economy,” the festival positioned Singapore as a regional hub for ageing‑related innovation and policy dialogue. It also reinforced government efforts to upskill the longevity workforce and promote active ageing across the Asia‑Pacific.
Shingles Vaccine Boosts Longevity for Over‑50s
Done. Herpes virus neutralized 🦠 Not taking any chances with my longevity, now that shingles is associated with faster aging (though not yet a known cause). If you’re 50+, consider it. The shot will likely be money- & pain-free I even...
Track and Treat Silent Blood Pressure for Lifelong Health
High blood pressure is one of the quietest threats in medicine. You can feel completely fine while it silently damages the heart, brain, blood vessels and kidneys for years. The good news: it’s measurable, trackable, and highly modifiable. Check it...
10 Psychological Traits That Shape How Long You Will Live (P)
A growing body of research identifies ten psychological traits—such as optimism, purpose, and strong social ties—that consistently predict longer lifespans. These mental and personality factors influence how individuals handle setbacks, interact with others, and approach daily life, often adding years...
World-Renowned Doctor Reveals These 5 Everyday Foods that Help Your Body Fight Cancer and Cut Death Risk
World-renowned physician Dr. William Li identifies five everyday foods—soy, cooked tomatoes, apples, berries, and tea or coffee—that research links to lower cancer mortality and incidence. A Shanghai breast‑cancer cohort found daily soy consumption reduced death risk by about 30%, while...
Year-Long Exercise Trial Cuts Cortisol, Boosting Biohack Credibility
Researchers at the University of Pittsburgh and AdventHealth published a randomized trial showing that 150 minutes of weekly aerobic exercise over a year significantly reduced cortisol levels in 130 adults. The findings give biohackers a rigorously tested tool for stress...
Midlife Fitness Proven to Boost Longevity and Health Span
A new JACC study from the Cooper Institute (April 22, 2026) followed nearly 25,000 adults for 30 years. As a medical school professor, I teach that the strongest longevity drug we have is not on a prescription pad. This study makes...
FDA Approves Eli Lilly's Foundayo, First New Oral Weight‑Loss Pill in Years
The U.S. Food and Drug Administration has approved Eli Lilly’s once‑daily oral weight‑loss pill, Foundayo, marking the first new molecular entity for obesity in years. Priced between $149 and $349 a month, the drug promises a simpler regimen that could broaden...
Sea Squirts’ Plasmalogens Show Promise in Reversing Aging Markers in Mice
Researchers from Xi’an Jiaotong‑Liverpool University, Stanford, Shanghai Jiao‑tong University and the Chinese Academy of Sciences reported that daily plasmalogen supplementation—derived from sea squirts—reversed key cognitive and physical aging markers in older female mice. The two‑month trial showed faster maze navigation...
BMI Alone Misses Long‑term Heart Risk, Study Shows
A new Mass General Brigham study of 136,498 adults rewrites how we should screen cardiovascular risk. As a medical school professor, I teach that one lab number rarely tells the long-term story. This study (PLOS One, April 2026) shows the same...
Birdwatching to Stretch the Brain
Recent neurological research shows that activities requiring detailed visual identification—like birdwatching—can counteract age‑related brain shrinkage. By repeatedly distinguishing flora and fauna, participants build stronger neural pathways and increase cognitive reserve, a buffer against dementia. Brain scans of avid birdwatchers reveal...
Scientists Identify CIRBP Protein That May Extend Human Lifespan to 200 Years
Scientists have isolated the cold‑inducible RNA‑binding protein (CIRBP) from bowhead whales and shown it dramatically improves DNA repair in human cells, raising the prospect of a 200‑year human lifespan. The finding fuels both excitement and caution across the anti‑aging and...
Consumer Biotech Poised to Dominate, Telehealth Captures Value
I’ve said this before: I believe consumer biotech will become the most compelling sub-sector within biotech - without question - and one of the most attractive investment opportunities overall. At its core, this category targets products that slow or reverse aging,...
This Hormone May Be The Strongest Predictor Of How Fast You’re Aging
A new study of 22 hormones across adults aged 20 to 73 found cortisol to be the strongest predictor of biological age. When cortisol levels doubled, participants’ biological age was roughly 1.5 times higher than their chronological age. The research...
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This ‘Longevity Vitamin’ Has Puzzled Scientists for 30 Years — Now They May Have Answers
Researchers have pinpointed the SLC35F2 gene as the transporter that moves queuosine—a bacteria‑derived, vitamin‑like compound—into human cells. Queuosine, abundant in fermented foods such as kefir, kimchi and tempeh, supports protein synthesis, brain function and may suppress cancer cells, earning it...
H. Pylori and T. Gondii Infections Accelerate Frailty in Aging
Associations of common infections with frailty and mortality in two UK cohort studies "Our results indicate that infection with H. pylori and T. gondii, and the combined burden of infection may detrimentally impact ageing health. These pathogens may warrant targeting beyond...
Doctors Warn DIY Peptide Injections Cause Serious Injuries
People are injecting DIY peptides for weight loss and longevity. Doctors are alarmed at the side effects. “Doctors working on the bleeding edge of longevity care in high-end clinics around the globe — from concierge practices in wealthy enclaves of California...
Japan Revives Radio Taiso to Boost Longevity, Mobilizing Millions in Daily 10‑Minute Sessions
Japan has re‑launched its century‑old Radio Taiso exercise, drawing millions to daily 10‑minute group calisthenics in parks, workplaces and homes. The low‑impact routine is promoted as a public‑health biohack to sustain the nation’s high life expectancy.
Anecdotes Aren’t Data: Call for Rigorous Rapamycin Trials
Table updates worth noting 🔎 🔘 @bryan_johnson stopped it 🔘Alan Green died at 80 from hereditary cardiomyopathy 🫀 🔘Misha Blagosklonny died at 63 from cancer 👉These are cases, not data. Instead of adjusting the tally, what we actually need are rigorous human trials. Is rapamycin...
Eight Healthy Habits by 40 Add 24 Years
👉Adopting all eight healthy lifestyle habits by age 40 can increase life expectancy by an average of 24 years for men and up to 23 years for women compared to individuals who adopt none of these habits. 👨🏻⚕️ •Being physically active •Not...
HIV Medication Reverses Epigenetic Aging Markers in First Human Proof-of-Concept Trial
A proof‑of‑concept trial found that the HIV pre‑exposure drug FTC/TAF (Descovy) significantly reduced several epigenetic aging clocks in healthy adults, with declines of up to 3.4 years in heart, brain and metabolic markers. The molecular data showed an improved immune...
MIB‑626 NMN Shows Lifespan Boost and New Mechanism
1. No living forever 🙈 2. Some MIB-626 (crystaline polymorph, pure NMN) human clinical trial results are in 😀 3. About to resubmit a revised mouse MIB-626 paper with Alice Kane, showing improved health measures + lifespan & a putative new mechanism...
Oral Health May Influence Alzheimer’s Risk—Floss Daily
Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s. Either way, to reduce overall inflammation, maintain oral heath by: 1. Flossing daily 2. Using an electric toothbrush 3. Seeing a dentist >2x a year 4. Chewing oral probiotics 🦷🧠💪
The Rich and Powerful Want to Live Forever. What if They Could?
President Vladimir Putin has formalized a multi‑year, $26 billion National Project to develop anti‑aging therapies, aiming to extend healthy life expectancy for 175,000 Russians by 2030. The initiative, overseen by Kurchatov Institute director Mikhail Kovalchuk, targets sarcopenia, osteoporosis, cognitive decline and...
AI's Role in Extending Human Healthspan
My interview on healthspan and AI with @mmlederman1 and @LCalabreseDO @paijournal transcript video https://t.co/cRGtTIN1EN https://t.co/soUWAuPU02
Ergothioneine Ties Blood Metabolome To
Ergothioneine. The blood metabolome of cognitive function and brain health in middle-aged adults – influences of genes, gut microbiome, and exposome https://t.co/H8tWyRhswR
Tiny Mitochondrial Proteins May Explain the Health Benefits of the Mediterranean Diet
A study in Frontiers in Nutrition found that older adults who closely follow the Mediterranean diet have higher circulating levels of the mitochondrial microproteins Humanin and SHMOOSE, both linked to protection against heart disease and cognitive decline. The research compared...
GLP‑1s Spark Massive Consumer Biotech Revolution
GLP-1s have paved the way for massive consumer biotech Discussed in Lifespan and still rolling out as predicted
Heat Therapy Mimics Exercise Through Shear Stress and Genes
Best review yet: We have identified plausible ways heat therapy works, such as shear stress and heat-sensitive genes “We find heat therapy to be analogous to exercise in many respects” 💪 https://t.co/RAFMTK8j3S https://t.co/iTVyZZuFZc
Intrinsic Capacity, Activity Linked to Heart Risk in Elders
A 2026 BMC Geriatrics study by Zhang, Liu, Ye and colleagues examined how intrinsic capacity—a composite of physical and mental function—interacts with physical activity to influence cardiovascular risk in older adults. Drawing on four large longitudinal cohorts, the researchers quantified...
Nesprin‑2 Protein Blocks Heart Cancer, May Aid Other Tumors
Wondered why we don’t hear about heart cancer? Contraction-sensing Nesprin-2 protein is discovered to prevent heart cancer By causing cells to pulse (or adding in Nespirin) we might be able to treat cancer in other organs 👏 @ScienceMagazine https://t.co/A8fOuw31N2
High LDL Remains Dangerous, Even for Lean Responders
There is no safe gamble with high LDL cholesterol The pitfalls of the lipid energy model and why “lean mass hyper-responders” should still take high LDL cholesterol seriously. https://t.co/lbRnOfe2py
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Experts Say These 9 Superfoods Can Help You Live a Longer, Healthier Life
A team of registered dietitians identifies nine superfoods—kimchi, turmeric, blueberries, avocado, spinach, kale, lentils, chia seeds, and tempeh—that contain antioxidants, fiber, healthy fats, and micronutrients linked to reduced inflammation and chronic disease risk. The experts explain how each food supports...
Power Nap After Sauna Boosts Recovery and Longevity
Loved this morning. Included a nap in today's routine. May start napping more. > asleep before 9 pm > up at 5 am > 8h sleep, no wake events > work 2 hrs with fresh mind > 50 min strength > 12...
Severe Infections Independently Amplify the Risk of Dementia Later in Life
Researchers analyzing Finland’s nationwide health registry found that severe infections requiring hospitalization increase the risk of later‑life dementia. After reviewing up to 21 years of records for 62,555 dementia patients and five matched controls each, they identified cystitis and unspecified...
Ultra-Processed Foods Linked to Measurable Drops in Human Attention Span
A new cross‑sectional study of over 2,100 Australian adults links higher consumption of ultra‑processed foods (UPFs) to measurable declines in attention span, even among those following otherwise healthy diets. Researchers found that a 10 percent increase in UPF intake—roughly one extra...
This Everyday Nutrient Could Influence Alzheimer’s Before It Begins (M)
A new longitudinal study finds that higher blood concentrations of vitamin D during midlife are linked to a reduced risk of developing Alzheimer’s disease and other dementias later in life. Researchers tracked over 5,000 participants for two decades, measuring vitamin...
Personalised Treatment Plans Reverse Early Dementia Symptoms in New Study
A new study reported that personalised medical and lifestyle protocols reversed symptoms in people with early-stage dementia. The approach targets nutritional gaps, infections and environmental factors, offering a biohacking‑style route to cognitive improvement.
The Step Count That Cuts Dementia Risk The Most (M)
A recent epidemiological study identified a specific daily step count that most effectively lowers the risk of Alzheimer’s disease. Participants who logged roughly 10,000 steps per day experienced up to a 30% reduction in dementia incidence compared with sedentary peers....
Battery‑free Textile Powers Real‑time Blood Pressure Monitoring
A new battery-free textile enables continuous, real-time monitoring of systolic blood pressure by wirelessly connecting ultra-thin epidermal sensors to a smartphone, eliminating the need for bulky batteries in wearable health technology. wearabletech
Your Face Mirrors Health—Change Habits, Rejuvenate Quickly
True. The face is the most honest biomarker we have. Sleep, stress, food, exercise, and sun all show up within weeks. The good news is it runs in reverse just as fast. Better inputs, younger face.
Battery-Free Textile Turns Clothing Into a Real-Time Blood Pressure Monitor
Researchers from the National University of Singapore, the University of Arizona and Tsinghua University unveiled a battery‑free wearable system that uses a metamaterial textile to wirelessly power epidermal sensors from a smartphone. The dual‑mode fabric separates power (13.56 MHz) and data...
Russian Gene Therapy Claims to Extend Life to 150
Russian scientist in bombshell ageing drug claim after Putin discussed 'living to 150' The Russian gene-therapy treatment could benefit Putin and his inner circle. https://t.co/dunqBJEPxN https://t.co/sH2GNbRqSs
Russia Claims Progress on 150‑year Human Lifespan Plan
Vladimir Putin's plan to make humans live for 150 years is in process under supervision of Russian scientists 🔎 “ Denis Sekirinsky, a Russian science and education minister, claimed his country's researchers are on course…” https://t.co/tVx2REdovu https://t.co/1WCXvDFWnf
Hone Health Survey Shows 70% of Midlife Adults Feel More in Control of Health Than in Their 30s
Hone Health’s nationwide survey of 1,000 U.S. adults ages 35‑65 reveals that nearly three‑quarters now feel more in control of their health than they did in their 30s. The data highlights a surge in proactive health behaviors across midlife, challenging...
Longevity Enthusiasts Aim to Live Longer for Space Exploration
The number of people in the longevity space who want to extend lifespan so they can explore the stars is surprisingly high.
Every 1,000 Steps Cuts Mortality Risk by 15%
The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis A 1000-step increment was associated with a 15% decreased risk of all-cause mortality... with significant benefits starting event at 2500/4000 steps/day. https://t.co/8d6VGnP0Dg https://t.co/f9h0D5dWlV
Facial Age Acceleration Predicts Earlier Death, Varies by Job
Face photo-based age acceleration predicts all-cause mortality and differs among occupations "We found that face photo-based age predicts all-cause mortality for middle-aged and older individuals meaning that those age faster based on their face photo die sooner." https://t.co/QUUzK4fe9G
Metabolic, Epigenetic, Immune Links Drive Ovarian Aging
Metabolic, epigenetic, and immune crosstalk in ovarian aging "This work provides a conceptual foundation for developing personalized strategies to mitigate reproductive aging and its systemic health impacts..." https://t.co/IgYU6f36nP https://t.co/rRgC7Dh65g
GLP‑1 Weight Loss Drugs Lower HRV, Raise Heart Rate
Reducing body weight with GLP-1 agonists isn't a free lunch: negative impacts on HRV, RHR GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons https://t.co/4QNy141TtK