Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
Phosphatidylcholine Synthesis Declines with Age to Contribute to Mitochondrial Dysfunction
Researchers identified a conserved age‑related decline in phosphatidylcholine (PC) synthesis as a key driver of mitochondrial dysfunction. Using C. elegans, human transcriptomic and metabolomic data, they showed that reduced activity of SAMS‑1 and PEMT enzymes leads to mitochondrial fragmentation and lower respiration. Supplementation with choline or PC rescued these defects in worms, cell cultures, and aged tissues. Human GTEx and UK Biobank analyses confirmed PC and PEMT levels drop with age, particularly in post‑menopausal women.
Omega-3s May Affect Brain Repair: Should You Avoid Them?
A new study indicates that eicosapentaenoic acid (EPA), a common component of fish‑oil supplements, can impair brain‑vascular repair after repeated mild traumatic brain injuries. In mouse models and human brain‑cell cultures, EPA reduced endothelial wound‑healing and promoted tau protein buildup...
Physicians, Not Consumers, Drive U.S. Supplement Purchases, Sermo Survey Finds
A real‑time Sermo survey of 374 U.S. physicians shows that 92% recommend dietary supplements and 94% have observed patient purchases directly linked to that guidance. The data overturns the long‑standing belief that supplement sales are primarily consumer‑driven, highlighting physicians as...
Mimio Health’s Fasting‑Mimetic Supplement Cuts Cholesterol and Glucose in RCT
Mimio Health’s fasting‑mimetic supplement Mimio lowered total cholesterol, LDL, oxidized LDL and fasting glucose in an eight‑week, double‑blind trial of 42 older adults. The study, published in Scientific Reports, also reported improved appetite regulation and reduced abdominal discomfort, suggesting a...
Ageing Forms Gene Network Linking Diseases via Two Pathways
Ageing isn't one disease, it's a network. Excited to share our latest study exploring the genetic links between ageing and age-related diseases 🧬 We show how shared pleiotropic genes connect disease clusters, revealing two distinct genetic architectures: one driven by ageing-related...
Daytime Napping and Mortality Association in Older Adults
A JAMA Network Open study of 1,338 older adults used wrist actigraphy to objectively measure daytime napping patterns and found that longer nap duration and higher nap frequency are linked to increased all‑cause mortality. Each additional hour of napping adds...
AI Will Gift Us More Time and Longevity
The Time of Your Life: How AI Will Give You More of It | Michael Nuschke | TEDxAjijic "What if you won the "Time" lottery? Guess what...you just did. Artificial Intelligence (AI) will transform our lives, taking over the mundane tasks...
Infinite Epigenetics Acquires Tally Health in ‘Largest Epigenetic Testing Deal to Date’
Infinite Epigenetics announced the acquisition of Tally Health, creating the largest private‑sector DNA methylation database. The deal merges Infinite's TruDiagnostic biological‑age platform with Tally's at‑home epigenetic test and supplement program, forming a vertically integrated measurement‑to‑intervention stack. Executives say the combined...
The Molecule Your Doctor Will Never Prescribe — That Does the Same Thing as Metformin (Without the Side Effects)
The article spotlights berberine, a plant‑derived alkaloid that mirrors metformin’s glucose‑lowering effects without its gastrointestinal side effects. It explains how berberine activates AMPK, improves insulin sensitivity, and reduces inflammation, making it attractive to biohackers and patients seeking natural alternatives. The...
SRN‑901 Extends Mouse Lifespan by 33% in Preclinical Trial, Raising Longevity Hopes
SinoGen, Tsinghua University and China National Pharmaceutical announced that the oral anti‑aging candidate SRN‑901 extended median remaining lifespan by 33% in naturally aging mice. The study also cut tumor incidence by 30% and slowed visible aging signs, positioning the drug...
30‑Minute Daily Brain Training Reverses Decade‑Long Acetylcholine Decline
NIH-funded research showed 30 minutes a day of cognitive training reversed roughly a decade of age-related decline in a key brain chemical. As a medical school professor, I teach that acetylcholine -- the neurotransmitter for attention and memory -- drops 2.5%...
Organs Age at Different Rates; Reproductive Organs Confirmed
Our organs age at a different pace intra-individual, as tracked through plasma proteins. Now confirmed for female reproductive organs @NatureAging https://t.co/v20xGZglMU https://t.co/3oiQ14yesf
Key Trends Emerge in Vitafoods Europe Education Programme
The Vitafoods Europe education programme showcased a series of high‑profile sessions that mapped emerging nutrition trends across gut health, longevity, GLP‑1 impacts, cognitive resilience, performance nutrition and nutricosmetics. Experts from Mintel, Euromonitor, Yakult and Nestlé highlighted how gut microbiome insights...
We Battle Each Other While Aging Kills Us
Genius few minutes - every word is gold. But now think about the probability of dying due to aging? Is it 10%? 90%? And instead of fighting aging, we are fighting each other... https://t.co/cmvlibOsVh
FDA to Relax Peptide Rules After High‑profile Endorsement
FDA moves toward easing restrictions on certain peptides The agency’s decision to hold an advisory committee meeting on the topic comes after HHS Secretary Robert F. Kennedy Jr. told podcaster Joe Rogan he’s a “big fan” of peptides. https://t.co/wynhLuBUPE https://t.co/y9dgG0xWAq
DSM‑Firmenich to Unveil Science‑Backed Longevity Suite at Vitafoods Europe 2026
DSM‑Firmenich announced it will present a suite of science‑backed longevity innovations at the upcoming Vitafoods Europe 2026 trade show in Barcelona. The portfolio targets four key hallmarks of aging—cellular senescence, chronic inflammation, gut dysbiosis, and mitochondrial dysfunction—signaling a push toward...
AI Model Detects Pre‑Symptom Alzheimer’s Fingerprint
𝐀𝐈 𝐅𝐨𝐮𝐧𝐝 𝐭𝐡𝐞 𝐊𝐞𝐲 𝐭𝐨 𝐏𝐫𝐞-𝐒𝐲𝐦𝐩𝐭𝐨𝐦 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 #FINGERPRINT Introducing #FINGERS7B, the first AI foundation model designed specifically to prevent Alzheimer’s disease via @NeuroscienceNew https://t.co/J7XKdg7drF https://t.co/QQKyverDNZ
Reduced Ghrelin Receptor Activity Improves Mitochondrial Function and Muscle Function in Aged Mice
Researchers demonstrated that reducing activity of the ghrelin receptor (GHSR‑1a) improves muscle endurance and mitochondrial function in aged mice. Both genetic knockout and the inverse‑agonist PF‑5190457 increased markers of mitochondrial biogenesis and mitophagy, enhancing fatigue resistance. The interventions did not...
Arguing for an Emphasis on Comparative Organelle Biology
Researchers argue that aging studies should shift from a gene‑by‑gene focus to holistic comparisons of organelle structures across species. While genome‑centric approaches have identified hallmarks of aging, they often fail to explain why interventions that extend lifespan in short‑lived models...
Scientists Scanned 26K Brains & Found This Metric Predicted Cognitive Decline
A new MRI study of nearly 26,000 UK Biobank participants identified six distinct fat‑distribution profiles and linked two of them—pancreatic‑predominant fat and a “skinny‑fat” pattern—to accelerated brain aging and cognitive decline. The research shows that where fat accumulates, not just...
These 2 Brain-Supporting Nutrients May Help Slow Cognitive Decline As You Age
Researchers tracking 6,610 middle‑aged adults with metabolic syndrome found that higher dietary intakes of choline and its metabolite betaine were linked to modest but statistically significant preservation of attention, language, and executive function over a two‑year period. Average choline consumption...
Five Longevity Secrets From 100‑Year‑Old Attenborough
David Attenborough at 100: Discover the five secrets to a long and healthy life Everyone is talking about the latest longevity health trends, but to what extent can we actually increase our lifespan? https://t.co/yP8ooC06zg https://t.co/P1VPMAar10
Aging Immune Networks Shift From Inflammation to Disease
Network Rewiring in the Aging Immune System: From Chronic Inflammation to Age-Related Pathologies https://t.co/HxKXGUq8wB https://t.co/ErZBeYwuhJ
What Are Peptides And Why Is Everyone Talking About Them?
Peptide therapies, short chains of amino acids that act like hormones, have surged in popularity as wellness supplements promising vitality and longevity. The most clinically vetted peptide, GLP‑1, is now used by roughly 10 million Americans for obesity and appetite control,...
Eli Lilly Inks AI Partnership with Profluent, Eyeing $2.25 B in Gene‑editing Milestones
Eli Lilly announced a collaboration with AI‑focused biotech Profluent to create advanced gene‑editing tools that could insert whole genes. The agreement may trigger $2.25 billion in milestone payments, highlighting Lilly’s rapid expansion into genetic medicines.
LV Longevity Lab Claims Up to 47% Cognitive Boost for Executives via Concierge Optimization
LV Longevity Lab in Las Vegas announced that its executive‑performance concierge service can raise cognitive processing speed by as much as 47% and decision‑making accuracy by 62% through evidence‑based optimization protocols. The clinic projects a potential annual ROI of $2.3 million...
Lifestyle Changes Can Prevent Nearly Half of Dementia
45% of dementia cases are entirely preventable with lifestyle changes. @fountainlife_hq found that 25% of their members had advanced brain age. After 13 months of optimized sleep, nutrition, and exercise, they improved brain age in 46% of those cases. You can become...
Peptides / Bioregulators
The AGI House in San Francisco hosted the inaugural California Peptide Club, drawing over 100 invite‑only attendees to discuss self‑optimization peptides. Organiser Julius Ritter highlighted the fragmented information landscape and showcased stacks ranging from growth‑hormone releasers to cognitive enhancers. Days later, HHS...
Berkeley Conference on Aging This Weekend
The University of California, Berkeley will host the BerkeleyCAL Conference on Aging and Longevity on May 2‑3, 2026, featuring a keynote by Her Royal Highness Dr. Haya Al Saud and leading researchers such as Cynthia Kenyon, Felipe Sierra, Michael D. West,...
FOXO4-DRI Is Fascinating, but Was Never Intended for Human Use, What Are the Takeaways?
FOXO4‑DRI is an experimental senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4‑p53 interaction, prompting p53‑mediated apoptosis. Pre‑clinical studies across vascular, reproductive, musculoskeletal and renal models report improved endothelial function, restored testosterone production, chondrocyte rejuvenation, and reduced frailty....
HIV Drug (Maraviroc) Reverses Muscle Aging by Purging “Zombie Cell” Signals
Researchers are exploring the HIV CCR5 antagonist maraviroc as a senomorphic agent that could blunt muscle aging by dampening chronic SASP signaling. Modeling suggests a 75 mg once‑daily dose achieves high CCR5 occupancy, but human data on sarcopenia are absent. The...
Holistic Health Strategies Prove Key to Extending Healthspan, Experts Say
Health researchers and clinicians say a holistic blend of nutrition, regular movement, quality sleep and strong social connections can dramatically extend healthspan. The insight builds on decades of studies, including the Harvard Study of Adult Development, and real‑world recovery stories...
Study Finds Daily Steps Can Delay Preclinical Alzheimer’s Onset by Up to Seven Years
Researchers at Mass General Brigham analyzed 296 adults in the Harvard Aging Brain Study and identified three distinct cognitive‑decline trajectories in preclinical Alzheimer’s. Walking 5,000‑7,500 steps daily delayed symptom onset by roughly seven years, while 3,000‑5,000 steps postponed decline by...
Importing Rapamycin to Save Money (2)
A community member placed a test order for sirolimus tablets from RL Pharma Jagdish in India via IndiaMart.com, paying a $25 wire transfer. The package left on Oct 16 2025 and arrived after 26 days on Nov 10 2025, experiencing delays in Zurich, JFK customs,...
Smoking May Spark Reaction Tied to Dementia
A University of Chicago team discovered that nicotine triggers a previously unknown lung‑brain signaling pathway. Pulmonary neuroendocrine cells (PNECs) release exosomes packed with serotransferrin, which upset iron regulation in neurons and spark oxidative damage linked to dementia. The researchers created...
A Popular Senolytic Treatment Causes Brain Damage in Mice
A recent PNAS study shows that the widely used senolytic cocktail dasatinib plus quercetin (D+Q) impairs myelination in the mouse corpus callosum. The treatment altered oligodendrocyte morphology within minutes, reduced myelin thickness, and triggered endoplasmic reticulum stress, without killing the...
Endurance Exercise Protects Joints, Boosts Fat Oxidation
Ha... no. He's wrong. Yes, there's an Afib signal. But his other conclusions... no. Run and cycle... we know why we do it... and my patients who run/ride are by far better off than those who don't. You need...
Naked Mole-Rats Exhibit Little Change in Gut Microbiome Composition with Age
Researchers examined the gut microbiome of naked mole‑rats across more than three decades and found minimal age‑related changes, in stark contrast to the pronounced shifts observed in mice. Only the archaeon Methanomassiliicoccus intestinalis increased with age, while breeding queens displayed...
Chinese Cohort Finds U‑Shaped Cholesterol‑Mortality Link, Upending Biohacker Dogma
Researchers analyzing a Chinese cohort of 163,115 adults uncovered a U‑shaped relationship between total, LDL and non‑HDL cholesterol and all‑cause mortality. Levels below 120 mg/dL (TC) or 70 mg/dL (LDL‑C) were linked to higher cancer and hemorrhagic stroke deaths, while higher levels...
This Common Deficiency May Raise Dementia Risk By 66%, Study Finds
A new longitudinal study of 2,200 adults over age 60 found that anemia, indicated by low hemoglobin, increases dementia risk by 66% over nine years. Participants with low hemoglobin also showed higher levels of blood biomarkers linked to neurodegeneration. The...
Fasting Mimetic May Improve Cardiometabolic Health Markers: RCT
A randomized, double‑blind, placebo‑controlled trial found that an eight‑week regimen of Mimio, a fasting‑mimetic supplement, significantly improved cholesterol fractions, oxidized LDL, and fasting glucose in older adults with elevated BMI and HbA1c. The formulation delivers nicotinamide, PEA, OEA and spermidine...
Daily Multivitamin Slows Biological Aging Up to Five Months, Study Finds
Researchers led by Howard Sesso published a peer‑reviewed trial showing that a daily Centrum Silver‑type multivitamin slowed two epigenetic aging clocks by 2.7–5.1 months over two years. The finding, based on 958 participants from the COSMOS study, marks the first...
7 Expert Habits for Healthy Aging From Longevity Doctor Florence Comite
Longevity specialist Dr. Florence Comite released her new book Invincible, outlining a science‑backed roadmap for healthy aging. She emphasizes building muscle early, monitoring hereditary risk factors, and maintaining strong social connections to preserve metabolic and bone health. The doctor also advises dietary...
GLP‑1 Therapy Shows Benefit for Type 1 Diabetes Patients
A 174,000-patient analysis just delivered the first hard evidence that GLP-1 drugs work in a population every clinical trial has excluded. As a medical school professor, I teach that Type 1 diabetes is autoimmune, Type 2 is metabolic. But the cardiovascular...
Even Morning Coffee Can Harm Sleep Quality
If you struggle with sleep issues, cutting caffeine intake, even if consumed in the early AM, may be beneficial Caffeine intake from different dietary sources and its association with sleep quality in employed adults https://t.co/NuwkDpwmk2
Palm‑sized Infrared Laser Boosts Skin and Muscle Health
This device will not only improve your skin, but the muscles beneath as well. Infrared laser treatment used to mean expensive clinic visits. LYMA put that same technology into an at-home device that fits in your palm. Your skin, healing,...
UK Healthspan Shrinks; Target Ageing, Not Symptoms
Healthspan is decreasing in the UK. Instead of treating the symptoms of ageing, we should be targeting ageing itself.
High‑Normal Ferritin May Lower Sarcopenia Risk, Homocysteine Harmful
Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia 🔎"These findings suggest that high-normal ferritin levels may be optimal for alleviating PS risk, irrespective of age, and that elevated Hcy levels could be detrimental for older adults...
PAI‑1 Deficiency Extends Lifespan via Longer Telomeres
“🔘 Heterozygosity was associated with significantly longer leukocyte telomere length, lower fasting insulin levels, and lower prevalence of diabetes mellitus. 🔘In the extended Amish kindred, carriers of the null SERPINE1 allele had a longer life span. 🔘Our study indicates a causal effect...
Anthocyanins Improve Cardiometabolic and Anti‑
Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects https://t.co/tHwVYQ3yvQ https://t.co/cxiRpkIj7W