Know What's Happening in Longevity
Know What's Happening in Longevity
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Every morning
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University of Arizona launches $12M rapamycin trial for seniors
The R. Ken Coit College of Pharmacy is starting a double‑blind, randomized Phase 3 study to test low‑dose rapamycin’s ability to improve resilience and immune function in adults aged 65 and older. The six‑year trial, funded by a $12 million philanthropic gift from alumnus Ken Coit, will randomize participants to rapamycin or placebo for two years before long‑term follow‑up.
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after receiving experimental stem‑cell and related injections from Dr. Adil Khan’s unregulated clinics. The series links spinal and intravenous therapies to bacterial infections, highlighting the doctors’ concealment of adverse outcomes to protect their commercial interests. It also exposes broader practices such as natural‑killer‑cell infusions, exosome treatments, and fecal microbiota transplants performed outside FDA oversight. The reporting underscores the lethal risk of unproven regenerative procedures and the ethical dilemma posed by influencer‑physicians.
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after receiving experimental stem‑cell and related injections from Dr. Adil Khan’s unregulated clinics. The series links Hyman’s spinal abscess and Peterson’s pneumonia‑sepsis to a pattern of...
Stem cell therapy is gaining traction as a non‑surgical skin‑rejuvenation option, leveraging the body’s own regenerative cells to boost collagen and elastin. Clinical reports suggest visible improvements in texture and firmness within two to three weeks, with full benefits emerging...
Biotech researchers are moving from organoid cultures toward multi‑organ pseudo‑embryos that mimic early human development without brains. Companies such as R3 Bio and Kind Biotechnology are pioneering these brain‑less constructs as a bridge between tissue engineering and full‑body regeneration. The...
Recent debates on growth hormone (GH) supplementation highlight its ability to rejuvenate the thymus but raise serious concerns about lifespan effects. Experts from the 2013 Erice workshop and subsequent literature argue that while transient GH can restore immune tissue, chronic...
A long‑term COSMOS trial involving more than 21,000 adults over 60 found that daily multivitamin use modestly improves memory, global cognition and slows biological aging markers. Recent analyses showed reductions in metabolomic risk scores and a small but significant 0.11‑year...
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after receiving experimental stem‑cell and regenerative‑medicine injections from Dr. Adil Khan’s unregulated clinics. The series links spinal injections and intravenous therapies to life‑threatening infections, highlighting the...
The Longevity Technology Unlocked podcast highlights how studying extreme‑stress animals—such as hibernating ground squirrels and aging dogs—reveals mechanisms that could reverse age‑related disease in humans. Fauna Bio is mining repair pathways in hibernators and translating them to human genomic networks,...
The study published in Nature Aging shows that mice carrying the human APOE4 allele develop smaller, hyperexcitable CA3 hippocampal neurons long before any cognitive symptoms appear. Early interictal spike rates in young APOE4 knock‑in mice forecast spatial learning deficits observed...
A 2026 Cell Metabolism study gave aged cynomolgus monkeys 30 mg kg⁻¹ vitamin C daily via drinking water for 40 months, showing direct inhibition of the ACSL4‑driven ferro‑aging clock. Pharmacokinetic data reveal vitamin C’s plasma half‑life ranges from 30 minutes to two hours at high doses,...
ARPA-H announced a $100 million program to fund clinical trials for joint regeneration. Three leading academic centers were selected to test innovative therapies aimed at repairing and regrowing damaged cartilage and bone. The projects will explore senolytic drugs, engineered tissue scaffolds,...
A 2024 peer‑reviewed study in *Nutrients* used a 3‑dimensional human keratinocyte model to test a NOVOS formulation containing the NOVOS Core blend. The research showed that a 24‑hour treatment did not cause DNA damage and significantly lowered oxidative‑stress and DNA‑damage...
Longevity medicine, also known as geromedicine, lacks formal board certification or standardized guidelines in the United States, allowing any physician to market themselves as a longevity specialist. While some clinicians genuinely aim to extend healthy lifespan through personalized, preventive care,...
Recent human trials show that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise blood NAD levels similarly, contradicting a small crossover study that claimed NR was superior. Both compounds appear to be metabolized largely by gut microbes into nicotinic acid...
The debate between nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) is losing relevance after recent trials. A crossover study of six adults showed NR raised blood NAD 2.3‑fold more than NMN, but a larger 65‑participant Nature Metabolism trial found both...
Recent research highlights lactoferrin’s ability to modulate iron metabolism and reduce age‑related inflammation. A 2026 piglet study showed combined human milk oligosaccharides and lactoferrin enhanced lipid mobilization, antioxidant capacity, and neurodevelopment. A randomized trial in obese children reported three‑month lactoferrin...
We talk a lot about brain aging as if it’s inevitable. It’s not. In my latest podcast conversation with @DrRagnar—author of The Stimulated Mind—we unpack what’s actually working for brain longevity and what isn’t. A few takeaways that stood out to me: • The...
A wave of strategic collaborations is reshaping the longevity and digital health landscape. Cymbiotika has partnered with wellness futurist Gary Brecka to launch precision‑wellness offerings, while Beacon Biosignals secured more than $97 million in a Series B round. WELL Health announced two...
I thought this was an excellent, balanced article on the current state of unapproved peptides from a safety and regulatory perspective by @AnjeanetteDamon in @propublica https://t.co/DbA8cdvTY5 The fundamental problem is that we don't have quality data on safety or efficacy for...
Recent peer‑reviewed studies reveal that lactoferrin, especially when paired with human milk oligosaccharides, enhances lipid mobilization, antioxidant capacity and neurodevelopment in animal models, while a 2026 randomized trial shows it improves weight, liver enzymes and insulin resistance in obese children....
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after undergoing experimental stem‑cell and regenerative‑medicine procedures at Dr. Adil Khan’s unregulated clinics. The series links spinal injections and intravenous therapies to bacterial infections, highlighting the...
The University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to boost resilience and immune function in adults aged 65 and older. The six‑year study, funded by a $12 million...
As a medical school professor, the protein recommendation I was taught -- 0.8 g/kg body weight -- is actively harming older adults. New data proves it. A 2025 Frontiers in Nutrition trial randomized 126 elderly women with sarcopenia into two groups...
University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to improve resilience and immune function in adults 65 and older. The $12 million study is fully funded by...
What if one small nerve quietly connects your brain to your heart, your gut, your immune system — and even how long you live? That was the question I brought to Dr. Elisabetta Burchi, a clinical psychiatrist, neuroscience researcher, and Head...
As a medical school professor, I can tell you the most dangerous disease you have never heard of is sarcopenia -- and a massive new meta-analysis just proved it. A 2026 Frontiers in Nutrition review of thousands of community-dwelling older adults...
AI modeling compares 6 mg rapamycin taken with grapefruit juice versus berberine 1000 mg daily. Grapefruit juice irreversibly destroys intestinal CYP3A4 and P‑gp, boosting rapamycin AUC 3‑4× and Cmax 2.5‑3.5×, effectively tripling the dose for up to three days. Berberine provides reversible...
I think that it is easier to measure Peakspan than Healthspan. And something we should study hard. I don't want just healthspan - I want to be at my peak. Not for myself but for all of you - we...
Longevity testing starter pack: 1. VO2 max/Cooper test - cardiorespiratory fitness 2. Grip strength - muscle mass and strength 3. Blood pressure - cardiovascular disease risk 4. DEXA scan - muscle and bone density 5. Blood panel - a dozen most common blood markers 6. Waist...
Researchers at Memorial Sloan Kettering demonstrated that CAR T cells engineered to target the urokinase plasminogen activator receptor (uPAR) can eradicate solid‑tumor cells and metastases in multiple preclinical models. uPAR was found elevated in 12 of 14 examined cancer types,...
Meet Dr. Mark Woodward, undergrad and grad from Stanford, PhD from Harvard, Many years at Google as part of Google brain. One day he realizes that we need the enabling technology to pause biological time for patients that are about...
The question is no longer if we can intervene in aging. It’s how safely and how many times
A recent small crossover study suggested nicotinamide riboside (NR) raised blood NAD 2.3‑fold more than nicotinamide mononucleotide (NMN), but a larger Nature Metabolism trial with 65 participants found both precursors increased NAD similarly. Mechanistic work shows oral NR and NMN...
Recent human trials have shown that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise circulating NAD levels to a similar extent, contradicting a small Bergen study that suggested NR was superior. Both compounds appear to be metabolized largely by gut...
Recent human trials have reignited the NR‑vs‑NMN debate, with a small six‑person crossover study suggesting NR raises blood NAD 2.3‑fold more than NMN, while a larger 65‑participant Nature Metabolism trial found no meaningful difference between the two. Both studies, however,...
The article highlights a surge in avoidable mortality as Europe ages, linking air pollution to cardiovascular risk and noting a sharp decline in the United Kingdom's healthy life expectancy to 61 years. In the United States, liberal states have achieved...
Researchers led by Zhang published in Cell Press Blue identified two polyunsaturated lipids that selectively trigger ferroptosis in senescent cells. The study demonstrates that senescent cells are uniquely vulnerable to iron‑dependent lipid peroxidation, and that these lipids can clear them...
Researchers led by Liu et al. identified a conserved iron‑driven lipid peroxidation pathway that accelerates aging in primates, mediated by the enzyme ACSL4. The study demonstrates that vitamin C directly binds and inhibits ACSL4, curbing ferroptotic damage and extending healthspan...
Researchers have identified microplastics in the bile of all 14 patients studied, revealing six polymer types dominated by PET and polyethylene. Patients with gallstones carried significantly higher microplastic loads, suggesting bile stasis may promote retention. Laboratory exposure of cholangiocytes to...
I've measured my body a lot. I'm about to dwarf what we've done by building real-time continuous multi-omic monitoring and intervention. Cars drive themselves. Software writes itself. I'm building Autonomous Health. First for me, then for you. > Peptides...
UCLA researchers unveiled MethylScan, a low‑cost blood test that analyzes cell‑free DNA methylation to detect multiple cancers and liver disorders in a single sample. By using methylation‑sensitive enzymes to strip away background DNA, the assay reduces sequencing needs to about...
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Researchers at UT Health San Antonio have launched a multi‑phase academic clinical trial to evaluate rapamycin’s biological effects in older adults. The program begins with a younger‑cohort benchmark study, then seeks the optimal dose that restores immune and metabolic markers...
I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in...
As a medical school professor, I have watched vitamin D research for decades. This trial finally delivers causal evidence. The VITAL randomized controlled trial -- the gold standard -- followed nearly 1,000 adults aged 50+ for 4 years and found that...
As a medical school professor, I used to think all fasting windows were created equal. This massive analysis proves they are not. A network meta-analysis of 113 trials published in BMJ Medicine found that early time-restricted eating -- finishing food by...
What's your biological age? Experts explain the benefits and risks of at-home tests https://t.co/NSr8O4EGnU via @nbcnews
Could a plant-based diet make your bones weaker? In this meta-analysis that looked at 529,672 participants (average ages of 46–63; 57% women, 43% men), both vegetarian diets and vegan diets were associated with a HIGHER risk of hip fracture: https://t.co/3u18PxPmrk...
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications"...
The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal
