Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
Peroxisome Activity Linked to Metabolic Flexibility and Longevity in New Nature Aging Study
Scientists publishing in Nature Aging have identified peroxisome activity as a key driver of metabolic flexibility and lifespan extension. The study maps an inter‑organelle cascade that preserves lipid oxidation capacity in aging cells, positioning peroxisomes as a promising biohacking target for metabolic health.
First FDA‑approved Longevity Drug Targets Dogs First
NEW Exclusive Interview: This miracle pill could make dogs live longer, with Celine Halioua, Founder & CEO of Loyal @celinehalioua is building the first drug ever FDA-approved for lifespan extension itself — starting with dogs. We sat down on Onward to...
Ergothioneine-Rich Water Extracts of Hericium Erinaceus HE-17 Alleviate Alzheimer’s Disease in Mice by Regulating Oxidative Stress, Inflammation, and the Gut...
Researchers identified a high‑ergothioneine Hericium erinaceus strain (HE‑17) and optimized its fermentation to produce a water extract containing 2.57 mg/g ergothioneine. In APP/PS1 transgenic mice, daily oral dosing of the extract for 90 days improved spatial learning, reduced amyloid‑β plaques, tau phosphorylation,...
Johns Hopkins Study Links Consistent Daily Rhythms to Slower Biological Aging
A team from Johns Hopkins Bloomberg School of Public Health analyzed a week of activity data from 207 seniors and discovered that steady daily rhythms are associated with slower biological aging, as measured by epigenetic clocks. The finding fuels biohacking...
Centenarians Retain Youthful Immune Profile, Hinting at Longevity
Centenarians show immune function found in younger individuals. Their immune system show reduced inflammatory signaling, enhanced autophagy, and controlled cellular senescence. They have low or no autoimmune disease, robust immunity against cancer and a distinct immune cell profile. Together, these...
Scientists Just Reversed About 80% of Aging in Elderly Mice in a Single Month — and They Did It by...
Researchers at Bar‑Ilan University reported that boosting the protein SIRT6 in elderly male mice reversed about 80% of age‑related chromatin accessibility changes in liver cells within a month. The reversal was achieved using a hepatocyte‑specific AAV8 viral vector, and it...
Plasma Spermidine Mirrors Diet Slightly; Muscle Levels Regulated
"Spermidine, a polyamine abundant in plant-based and fermented foods, has been associated with reduced cardiovascular and all-cause mortality. However, whether dietary spermidine intake is reflected in circulating and skeletal muscle concentrations remains unclear, and tissue data are scarce... These findings...
Unproven “Mitochondrial Activator” Risks Echo Deadly DNP
Some functional medicine doctors are prescribing a drug with essentially zero human safety data. The drug is called SLU-PP-332. It’s being marketed in some circles as a “mitochondrial activator” or exercise mimetic. Here’s the problem: as far as I can tell, there...
Untangling Cellular Senescence at Its Roots
Researchers in Aging Cell used single‑cell RNA sequencing to compare primary senescent cells induced by radiation with secondary senescent cells triggered by SASP exposure in kidney cells. They identified multiple transcriptional clusters within each group and mapped distinct developmental trajectories,...
Longevity Biotech Matures: Precise Indication‑Focused Drug Development
The longevity biotechnology field is coming of age in the best possible way. A recent analysis captures how the sector has learned to speak pharma’s language fluently—moving from broad claims about “slowing aging” to precise, indication-focused drug development with conventional endpoints,...
Methylene Blue: From Dye to Mitochondrial Therapeutic Breakthrough
As a medical school professor, I have watched methylene blue go from a 19th-century dye to a serious mitochondrial story. A new paper adds a striking chapter. (1/4)
China Launches Standardized Physician Education in Longevity
China has launched its first national competency‑based education programme in longevity medicine, targeting physicians across internal medicine, geriatrics, cardiology and related fields. Developed by the China Non‑public Medical Institutions Association and the Asia‑Pacific Longevity Medicine Society, the curriculum blends ageing...
Ovarian Age Clocks Predict Menopause Years Early
Know Exactly When You Stop Ovulating As a medical school professor, I keep coming back to one number women have never had access to: when your ovaries will actually stop. A new generation of "ovarian age clocks" — blood-based and follicular markers...
Sam Altman's Anti-Ageing Bet: How AI And Biology Are Beginning To Converge
Sam Altman is backing a new biotech venture that merges AI‑driven protein design with advanced cellular reprogramming to reverse biological aging. The company claims its platform can reset epigenetic clocks and simultaneously address age‑related diseases such as Alzheimer’s, cardiovascular disease,...
‘Morbid’ Doesn’t Want You to Fall for Antiaging Hype
‘Morbid’ by Oxford scientist Saul Justin Newman pulls back the curtain on modern longevity research, revealing how many claimed super‑centenarians are the result of record‑keeping errors or outright fraud. The book spotlights cases like Irma Borgoglio, whose supposed age was...
Genes Only Explain Up to Half of Lifespan
5 Longevity Myths the Latest Science Has Just Debunked As a medical school professor, I just published a piece walking through 5 longevity beliefs that the latest peer-reviewed evidence has flipped. 1. "Your genes determine how long you live." A 1996 twin...
2026‑2035 Longevity Metatr
I've spent decades studying exponential tech, and this longevity report is one of the most important I've done. My 2026–2035 Longevity Metatrends Report covers the breakthroughs that will redefine healthspan, performance, and the meaning of aging. Read it here: https://t.co/mLVBlpmmCg
Topical Senolytic ABT-263 Boosts Wound Healing in Aged Mice by 43%
Researchers at Boston University demonstrated that a cream containing the senolytic ABT-263 removed aging skin cells and accelerated wound repair in elderly mice, achieving an 80% healing rate by day 24 versus 56% in controls. The finding points to a...
Higher Predicted Age by a Metabolomic Aging Clock Correlates with Dementia Risk
Researchers applied a metabolomic aging clock (MileAge) to 223,496 UK Biobank participants and found that a higher metabolomic‑age delta predicts a 61% increase in all‑cause dementia risk and earlier disease onset. The hazard ratio for dementia rose to 1.61 per...
Enhanced Mediterranean Diet Cuts Type‑2 Diabetes Risk by 31% in Spanish Trial
A large Spanish clinical trial, PREDIMED‑Plus, demonstrated that a Mediterranean‑style diet paired with modest calorie reduction, regular exercise, and professional weight‑loss coaching lowered the six‑year risk of developing type‑2 diabetes by 31%. The findings provide a data‑backed blueprint for biohackers...
Meet Kate Tolo: First Ultra‑Measured Woman for Free Health Data
We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline....
Strength Training and Longevity: New Study Says Muscle Strength May Help You Live Longer
A University of Buffalo longitudinal study tracked 5,500 women aged 63‑93 for eight years, measuring grip strength and sit‑to‑stand speed. Results showed that higher muscular strength was linked to significantly lower all‑cause mortality, even among participants who did not meet...
Study of 117‑Year‑Old Maria Branyas Morera Uncovers Youthful Epigenetics and Microbiome
Scientists at the Josep Carreras Leukaemia Research Institute published a multi‑omics analysis of 117‑year‑old Maria Branyas Morera, showing that her epigenetic age markers and gut microbiome resembled those of people decades younger. The findings could reshape how researchers approach longevity...
Five‑Minute Daily Exercise May Cut Premature Deaths by 10%, Study Finds
Researchers analyzing data from 150,000 adults across the UK, US and Scandinavia found that five minutes of moderate exercise each day could prevent roughly 10% of premature deaths. The finding offers a low‑effort longevity hack for biohackers and public‑health officials...
Essential Anti‑Aging Habits Most People Overlook
The “anti-aging stack” most people miss: - getting lean (3,500 mg of dietary potassium a day
Defying Death: The Immortality Movement Goes Mainstream
The longevity movement, once confined to ultra‑wealthy circles, is breaking into mainstream investment. Investor Boyang Wang, backing Vibe Science, highlights a new wave of bold research, including the controversial concept of brainless clones that could receive brain transplants. Venture capital...
GHK-Cu Rescues Cigarette Smoking‐induced Skeletal Dysfunction via Sirt1
The so‑called Glow Protocol mixes GHK‑Cu, TB‑500 and BPC‑157 into a sub‑cutaneous blend marketed by clinics as an anti‑aging treatment. No peer‑reviewed human trials exist for this injection regimen; the evidence base consists mainly of animal studies and topical human...
High‑Carb Omnivore Diet Cuts Biological Age Markers in Four Weeks, Study Finds
Researchers reported that older adults who switched to an omnivorous high‑carbohydrate diet saw significant reductions in biological age markers after just four weeks. The findings, published in Aging Cell, suggest rapid physiological responses to macronutrient shifts, fueling interest among longevity‑focused...
Dietary Change Can Shift the Klemera-Doubal Method Aging Clock by a Few Years
Researchers evaluated whether a short‑term dietary shift could move the Klemera‑Doubler Method (KDM) biological‑age clock. In a 4‑week trial with 104 adults aged 65‑75, participants were assigned to high‑fat or high‑carb omnivore and semi‑vegetarian diets. The high‑carb omnivore group showed...
Buck Institute Finds APOE2 Variant Boosts Neuronal DNA Repair, Slowing Brain Aging
Researchers at the Buck Institute for Research on Aging have shown that the APOE2 gene variant improves DNA repair and reduces cellular senescence in human neurons. The discovery reframes APOE2 as a genome‑protective factor, opening fresh therapeutic and biohacking strategies...
Daily Omega‑3 Intake Slows Biological Aging by a Month Per Year, Study Finds
A new analysis of the DO‑HEALTH trial reveals that participants who took a daily 1‑gram omega‑3 supplement slowed their epigenetic aging by roughly one month per year. The benefit extended to fewer falls, infections, and, when combined with vitamin D...
Walking Pace Beats Blood Pressure as Top Longevity Indicator, Study Finds
Researchers at the University of Leicester analyzed data from 407,569 UK Biobank participants and found walking pace to be the strongest single predictor of death, eclipsing traditional metrics like blood pressure and cholesterol. The findings, published in Mayo Clinic Proceedings,...
Exercise Remodels Mitochondrial Quality Control to Slow Aging
The role of exercise-mediated mitochondrial quality control remodeling in aging https://t.co/EYmKmjpRDA Mechanisms by which Different Exercise Modes Regulate MQC to Delay Aging. 👇👨⚕️ https://t.co/Dz5bQtrExK
Start Where You Are: #1 Orthopedic Surgeon’s Proven Protocol to Feel Stronger & Look Younger in Weeks
In this episode, Mel Robbins talks with Dr. Vonda Wright, a double‑board‑certified orthopedic surgeon and longevity researcher, about how women can prevent the frailty they fear in aging. Dr. Wright shares that the body can respond positively to small, consistent...
Aged Immune Cells May Drive Memory Decline by Releasing a Brain-Aging Protein
A new study in Immunity shows that aged circulating CD8⁺ T cells release granzyme K, a protease that impairs hippocampal‑dependent memory in mice. Transfer of old CD8⁺ T cells to young animals reproduces learning deficits, while blocking T‑cell signaling with pertussis...
Update on Brad Stanfield's Rapamycin Clinical Study in NZ
Brad Stanfield’s New Zealand rapamycin trial tested a 6 mg weekly dose over 13 weeks in sedentary adults aged 65‑85. The intervention blunted improvements in functional tests such as sit‑stand, walking speed, and grip strength compared with an exercise‑only control, though participants...
Blood Reveals and Controls Aging Mechanisms
Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies https://t.co/WayE8XIBWp https://t.co/dZt8wHQ2yp
Reading Boosts Cognitive Reserve, Cuts Alzheimer Risk 38%
A Lifetime of Reading and Learning Linked to 38% Lower Alzheimer's Risk As a medical school professor, I have watched cognitive reserve go from a fuzzy idea to a measurable signal. A new study just put hard numbers on it. (1/5)
Eight Daily Micro‑Habits Scientists Say Can Add Years to Your Life
A Times of India feature outlines eight science‑backed micro‑habits—movement, whole‑food eating, social connection, sleep, stress management, lifelong learning, and more—that can collectively add years to life. The piece argues that consistency, not intensity, drives longevity, positioning habit formation as a...
Quality Over Quantity: Making Future Years More Capable
Protect Your Future Self: The Real Strategy Behind Longevity – Interview with Dr. David Barzilai, founder and CEO of Barzilai Longevity Consulting and Lecturer at Harvard Medical School 👉The real win isn't more years. It's more capable years.👨⚕️ https://t.co/jkvbggX9s1 https://t.co/KJX7KqIRZO
Midlife Exercise Adds Two Healthy Years, Study Finds
A longitudinal analysis of adults in their 40s and 50s found that those in the top fitness quartile added roughly two years of disease‑free life. The research also highlights that just 30 minutes of high‑intensity exercise each week can produce...
Can We Reverse Aging?
The episode explores the rapidly advancing field of longevity science, focusing on cellular rejuvenation techniques that aim to reverse aging at the cellular level. It traces the discovery of Yamanaka factors, their initial cancer risks, and subsequent refinements by researchers...
Calorie Restriction Deactivates Complement C3a, Slowing Inflammaging
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging Complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging. https://t.co/UaBPbf84pM
Bryan Johnson Shifts to Simple Longevity Tips, Shares 41 Lifestyle Hacks
Tech entrepreneur Bryan Johnson released a Twitter thread of 41 practical longevity tips, signaling a pivot from his previous high‑budget biohacking experiments to everyday lifestyle advice. The list emphasizes sleep, nutrition, and reduced screen time, while still nodding to medical...
Mayo Clinic Develops DNA Aptamers to Tag Senescent Cells, Advancing Precision Senolytics
Mayo Clinic researchers announced a DNA‑aptamer method that reliably labels senescent cells in mouse tissue, overcoming a long‑standing detection barrier. The breakthrough could allow precision senolytic drugs to eliminate harmful cells without damaging healthy tissue, a key step toward clinical...
Fudan University Unveils IgG Glycan Test to Pinpoint Biological Age
Researchers at Fudan University have introduced a blood‑based assay that quantifies IgG glycans to predict biological age with unprecedented accuracy. By moving from relative to absolute measurement, the test promises a stable biomarker for monitoring aging and the effectiveness of...
Dogs Extend Life Through Walks, Purpose, and Oxytocin
Honored and delighted to be interviewed by Steven Petrow for this article in the Washington Post. It's titled, "Can having a dog boost your longevity? Here's what science says." I talked about how dogs encourage you to walk, at least twice a...
Half‑Million‑Person Study Finds 6‑8 H Sleep Optimizes Biological Aging
Researchers analyzing UK Biobank data of more than 500,000 adults identified a 6.4‑7.8 hour sleep range as the sweet spot for minimizing biological age gaps across 23 organ‑specific aging clocks. The findings, published in Nature, reinforce sleep as a core...
Lymphatic Dysregulation Fuels Aging and Disease
From repair to disease: lymphatic contributions to regeneration, cancer and ageing "...Lymphatic vessel dysregulation drives aging and age-associated diseases, highlighting an urgent frontier for intervention...." https://t.co/w0hztPYH3t https://t.co/2FEk9LaqUT