Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
The Category 2 Peptide Unwind: How a Rogan Appearance, 14 Withdrawn Nominations & a July PCAC Docket Will Reprice the...
Kennedy’s appearance on The Joe Rogan Experience announced that roughly fourteen peptides could be re‑classified from FDA Category 2 back to Category 1, but no Federal Register rule has been issued yet. The announcement highlights a procedural path where nominators withdraw nominations, the FDA refers the substances to the Pharmacy Compounding Advisory Committee (PCAC), and a final bulk‑list update follows. A July 2026 PCAC meeting is slated to review a larger batch of peptides, making it the next market catalyst. The compounding pharmacy market totals about $6.6 billion, with the GLP‑1 segment alone projected at $6‑8 billion, while a gray‑market for peptides is estimated at $328 million.
In Search of Novel Means to Provoke Mild Mitochondrial Stress to Slow Aging
Researchers screened 770 FDA‑approved drugs to find compounds that safely trigger a mild mitochondrial stress response, a process known as mitohormesis that can improve cellular resilience. The screen highlighted terbinafine and miglustat, which extended lifespan and healthspan in C. elegans...
Biohackers Offer a Step‑by‑Step Guide to Crack Your Body’s Feel‑Good Code
Dr Simone Koch and Maximilian Gotzler released a practical biohacking guide that details everyday routines—lemon water, sunlight, breathing exercises, high‑protein breakfast and journaling—to help individuals decode and optimize their personal “feel‑good code.” The guide blends conventional medicine with simple behavioral...
Scientists Identify Picalm Protein Activated by Exercise and Fasting
Researchers from Germany's Institute of Human Nutrition and the German Center for Diabetes Research reported that the protein Picalm surges in skeletal muscle after exercise and intermittent fasting, driving the formation of new muscle fibers. The finding opens a potential...
Bryan Johnson Unveils Simple Balance Test to Gauge Biological Age
At a San Francisco event on Tuesday, Bryan Johnson revealed a one‑leg balance test that translates standing time into an estimated biological age. The protocol, which can be performed anywhere with a timer, is quickly gaining traction among biohackers seeking...
Targeting an Appetite Hormone Receptor for Stronger Muscles
Researchers published in Aging Cell that suppressing the ghrelin receptor (GHSR‑1a) improves muscle performance and mitigates sarcopenia in aged mice. Genetic knockout of GHSR‑1a extended running endurance by up to 45% and reduced muscle fatigue, while preserving mitochondrial function through...
The Mild Nutrient Deficiency Linked To Memory Loss
A three‑year randomized trial of 3,500 adults found that a daily 500 mg flavanol supplement, including 80 mg epicatechin, reversed age‑related memory loss. Participants with mild flavanol deficiencies improved memory by 10.5% versus placebo and 16% compared with their baseline scores. The...
First Large Rapamycin Trial Aims to Boost Human Healthspan
Finally—this is the kind of study the field has been waiting for. A 720-person randomized clinical trial testing low-dose rapamycin in adults 65+ is about to get underway at @UAZPharmacy , with the goal of answering a simple but critical question:...
Your 40s‑50s: Crucial Years for Lifelong Health
As a longevity researcher, I can’t stress this enough: Your 40s and 50s are one of the most influential periods for shaping long-term health and age-related disease risk. The key is simply finding your version of the basics you can sustain -...
MitoCatch Boosts Mitochondrial Transplants, Offering New Hope for LHON Therapy
Ayupov and colleagues announced MitoCatch, a protein‑binder system that efficiently delivers therapeutic mitochondria to Leber’s hereditary optic neuropathy (LHON) neurons, markedly improving cellular health and survival. The breakthrough could reshape biohacking strategies aimed at cellular rejuvenation.
MLKL Damages Mitochondria, Accelerates Stem Cell Aging
New evidence shows that MLKL, a protein linked to cell death, drives hematopoietic stem cell aging by damaging mitochondria rather than killing cells, highlighting a novel target for preserving blood and immune health. stemcells
Build Muscle to Beat Insulin Resistance
The principle mechanism to overcome insulin resistance in this setting is to increase your onboard glucose management system — AKA skeletal muscle mass 👏🔥👊💪
SMU Launches $7.4M Longevity Institute to Steer Singapore’s Aging Transition
Singapore Management University (SMU) unveiled the Longevity Societies and Economies Institute (LSEI) on April 14, backed by a multi‑year S$10 million (≈US$7.4 million) budget. The institute will consolidate SMU’s ageing research and launch an interdisciplinary agenda that blends economics, law, computing and...
Infrared Light Essential for Health, Modern Life Deprives It
Infrared light is critical to health and longevity It penetrates through clothes deep into the tissue to: - support energy production - stimulate neurons - improve vascular function - help with skin rejuvenation - stimulate stem cells - support wound healing - lowers inflammation Unfortunately, modern living conditions are...
Three-Day Fast Triggers Free Longevity Boost via Autophagy
The best longevity drug in history is totally free. It's called autophagy. Several things happen when you do a 3 day fast: - your body cannibalizes bad cells / pre-cancer cells / heart plaque - gene expression changes at the 72 hour mark and...
Dietary Interventions for Healthy Aging: An Epigenetic Perspective
A new review from Nanjing University of Chinese Medicine argues that diet functions as epigenetic software, supplying metabolites such as SAM, NAD+, α‑ketoglutarate and acetyl‑CoA that directly shape DNA methylation and histone modifications. It dissects three evidence‑backed interventions—Caloric Restriction, the...
Researchers Discover How Stress Signals Weaken the Aging Immune System
Aging hematopoietic stem cells (HSCs) lose regenerative capacity as stress signals activate the RIPK3‑MLKL pathway, causing mitochondrial damage without triggering cell death. Researchers from the University of Tokyo and St. Jude Children’s Research Hospital demonstrated that transient MLKL activation in mitochondria...
Scientists Remove “Zombie” Cells and Reverse Liver Damage in Mice
UCLA scientists discovered that senescent liver macrophages, marked by the p21‑TREM2 signature, accumulate with age and high cholesterol. In mice, the senolytic drug ABT‑263 selectively removed these cells, dramatically reducing liver size and body weight despite a continued unhealthy diet....
Lilly's Obesity Pill Heads for Diabetes Filing After Heart Risk Trial
Eli Lilly’s newly approved obesity medication, marketed as Foun…, demonstrated a 16% lower incidence of major cardiovascular events compared with a standard insulin regimen in a recent trial. The data, presented by Lilly, suggest the drug not only aids weight loss...
Study Finds Vigorous Exercise Cuts Risk of Eight Major Diseases
CNN reports that a European Heart Journal study links a modest amount of vigorous activity—about 4% of total exercise—to dramatically lower incidence of eight chronic diseases. The findings could reshape public‑health guidelines and fitness industry offerings.
How Aging Reshapes the Mammalian Body: Atlas of 7 Million Cells Reveals All
Researchers at The Rockefeller University have created the most comprehensive single‑cell atlas of aging, profiling nearly 7 million cells from 21 mouse organs at 1, 5 and 21 months. The study identified over 1,800 cell subtypes, revealing that about a quarter...
FDA to Review Easing Restrictions on Peptide Injections Backed by RFK Jr.
The Food and Drug Administration announced a July meeting to consider easing limits on more than half a dozen peptide injections championed by Health Secretary Robert F. Kennedy Jr. The move pits the secretary’s “Make America Healthy Again” agenda against...
IGF-1 Signaling Suppression Fails to Slow Aging in Mitochondrial Mutator Mice
Researchers examined whether suppressing insulin-like growth factor‑1 (IGF‑1) signaling could extend the lifespan of mitochondrial mutator mice, which carry a high rate of mitochondrial DNA mutations. Contrary to expectations, reduced IGF‑1 signaling did not increase longevity; most downstream pro‑longevity pathways...
Heights Study Finds Multivitamin Corrects Key Nutrient Deficiencies in 12 Weeks
Heights’ Director of Science, Dr. Harry Jarrett, presented unpublished data showing that a large share of ostensibly healthy UK adults suffer hidden micronutrient gaps, with 40% lacking folate, 34% lacking active B12 and 83% showing sub‑optimal riboflavin. In a 12‑week,...
Applying Mendelian Randomization to the Correlation Between Fitness and Health
Researchers applied a phenome‑wide Mendelian randomization approach to test whether genetically predicted aerobic fitness causally influences health. Screening 712 European‑ancestry phenotypes, they identified 108 discovery associations, with 34 confirming in independent validation. Higher genetically determined fitness correlated with lower risks...
You Can Work Out Daily & Still Be Undermining This Aspect of Longevity
Even a disciplined gym routine can't fully counteract the hidden damage caused by eight hours of daily sitting. Prolonged sedentary time dulls proprioception—the body’s internal GPS—leading to poorer balance, coordination, and higher fall risk. Research shows that micro‑movement breaks and...
Worried About Alzheimer's? This Type Of Exercise May Be Protective
A 24‑week resistance‑training program for adults aged 65‑80 reduced a brain‑volume signature linked to Alzheimer’s disease, especially among participants with early amyloid‑beta biomarkers. MRI scans showed adaptive thinning in vulnerable regions, and those changes correlated with better performance on executive‑function...
Running: Will It Wreck Your Body?
In this episode of Science Versus, hosts Akedi Foster-Keys and senior producer Meryl Horn examine the science of running, focusing on injury risk, optimal training progression, and the physiological benefits of the activity. They cite research showing that about half...
Testing Tirzepatide‑CJC1295 Combo to Balance Side Effects
Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but...
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
What Your Wearable Knows That Your Doctor Ignores: Weekly Livestream W/ Brooks Leitner
The Food is Health newsletter is hosting a live stream on April 17 at 2 p.m. ET with Dr. Brooks Leitner, a Yale‑trained physician‑scientist and co‑founder of VO Health. The discussion will focus on VO2 max, a fitness metric that research shows...
DNA Circles in Cancers Show Accelerated Epigenetic Aging
30 years ago, we discovered circular DNA molecules 1. pinch off yeast chromosomes 2. multiply 3. sequester epigenetic regulators (eg sirtuins) 5. cause aging New review today @CellCellPress about DNA circles in human cancers - which are epigenetically older than normal cells https://t.co/VlkBWCFnPi
Ageing Happens Unevenly Across Organs, Not Uniformly
Mosaic ageing: from organ-specific decline to the cause of death “A growing body of biomedical and evolutionary studies increasingly questions the notion of uniform ageing: rather than a whole-body (single) trajectory, ageing appears to occur unevenly across organs, tissues and even...
TRI-K Industries Unveils NeoColla, a Next-Generation Solution for Collagen Banking and Skin Longevity
TRI‑K Industries has launched NeoColla™, a next‑generation collagen‑boosting ingredient that merges Centella asiatica‑derived exosomes with Ganoderma (Reishi) peptides. The formula promises to increase collagen synthesis, improve dermal density and reduce wrinkle depth in as little as 28 days. Positioned as...
US Study Links Telomere Length to Genes, Traits, Geography
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States [Mar 27, 2026] @NakaoTetsushi et al. @NatureGenet https://t.co/3b75zEElAP https://t.co/jWNwYRWkQv
Accelerated Biological Aging Raises Dementia Risk in Women
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study "In this cohort study of older women, accelerated biological aging measured by AgeAccelGrim2 was associated with higher risk of incident MCI/probable...
BodySpec Partners with Longevity Telehealth Clinic on DEXA Scans
Hone Health, an AI‑enabled telehealth clinic focused on longevity, has integrated BodySpec’s clinical‑grade DEXA body composition scans into its patient app. The partnership lets users purchase scans directly, view detailed metrics such as lean muscle, visceral fat, bone density and...
AI Promises Optional Death by 2030
AI Can Make Longevity Real | Death Optional by 2030! https://t.co/E9M6hX47Aw #ArtificialIntelligence #Longevity #Immortality #Aging #MedicineOfTheFuture https://t.co/mHpaEZZKKd
Aged Polystyrene Microplastics Speed Worm Aging via Ferroptosis
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway https://t.co/gGPlKDdgW1 https://t.co/NZ31ToOTp2
3 Tips From Bryan Johnson on Lowering Your Heart Rate
Bryan Johnson, the tech entrepreneur turned longevity advocate, outlines three practical ways to lower resting heart rate, a metric he says is closely tied to lifespan. He recommends consistent aerobic exercise, daily breath‑work or meditation, and optimizing sleep and nutrition...
Clonal Haematopoiesis Reveals New Insights Into Aging Biology
Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis "...how CH enhances our understanding of the biology of ageing." https://t.co/9MKGZIakFY https://t.co/noyHAviY3E
Why Your 'Normal' Lab Results May Not Be Optimal for Longevity, According to a Doctor
Doctor Daniel Ghiyam warns that standard lab reference ranges are based on average, often unhealthy, populations, meaning a result can be "normal" yet sub‑optimal for longevity. He cites vitamin D, where 20 ng/mL meets bone‑health guidelines but 40‑80 ng/mL offers stronger immune...
Free Blood Biomarker Testing Empowers Early Health Intervention
You can now get your blood work at cost. We launched a biomarkers testing platform. I make $0 on it. Blood testing needs to be more accessible. Instead, we wait until we get sick. And in the meantime, companies...
15 Bioscientist Habits to Tame Silent Inflammation
Chronic inflammation is silent — but it’s a key driver of many age-related diseases. 🧬 Here are 15 habits I prioritise as a bioscientist to keep it in check ↓
Call for Third‑Party Testing to Certify Peptide Purity
It would be interesting if there was third-party testing and authorization for peptides the same way there is for supplements. An external stamp of purity and authenticity.
Questioning Geroscience: Shingles Vaccine Shows Unexpected Effects
i don’t believe there is an evidence basis for the value proposition of the geroscience hypothesis shingles vaccination was targeted to a specific virus yet this one intervention prevents Alzheimer’s disease and increases all cause mortality is the geroscience hypothesis...
Scientists Explore Possibility of Slowing Human Aging
Can aging be slowed? Some academic scientists think so with @NirBarzilaiMD, @mkaeberlein, and @sessi73 https://t.co/1EoZ7evdDF @AAMC https://t.co/StDgRGSRqr
First Five Get $99 Vitalist Bay 2026 Pass
Courtesy @adamgries... @VitalistBay 2026: 🗓 May 14-17 🔗https://t.co/5dh7N2M7bv "The first 5 can use the code LI-T-MINUS-30 for $99" 🎤 110+ speakers across 6 tracks 🛠 60+ hands-on workshops 🧘 20+ activations running all day, every day" https://t.co/JMMNaUHMIs
FDA Reverses Ban on 12 Peptides for Review
So... @SecKennedy just announced that 12 peptides the Biden FDA shoved into "Category 2" — effectively banning them from regulated compounding pharmacies and driving people to the black market - are being pulled back for legitimate scientific review. Here's what each one...
Sleep Under 7 Hours Cuts Life Expectancy Like Smoking
Sleep isn't a nice-to-have. It's a survival requirement. A major new study from OHSU found that getting less than seven hours a night was more strongly linked to decreased life expectancy than pretty much everything but smoking. Fix your sleep...