Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
Beyond Calcium: Vitamin D, Protein and Exercise Essential for Bone Strength
Orthopedic specialists say calcium supplements alone are insufficient for preventing fractures. A new consensus emphasizes vitamin D, adequate protein, and regular weight‑bearing activity as the missing pillars of bone health, reshaping nutrition advice and supplement markets.
Peptides: Unregulated, Risky, and Growing in Popularity
"What's your star sign?" "I'm a Taurus." "Cool, and what's your peptide stack?" Special Lifers episode on Peptides Part 1 with Sunita Mohanty Spotify: https://t.co/nRCBnLOjqm Apple: https://t.co/iibWpZHNZ7 Youtube: https://t.co/ijtPosgt4t Timestamps: (00:00) Intro (00:04) Peptides everywhere (00:42) Meet Sunita and Ultralight (01:08) Regulatory whiplash explained (01:58) Stacks and the gray area (03:34) Black market...
R&D Hype Unchecked: No Accountability for Drug Promises
Nice article by @TClozel in @FastCompany. Link in comments. The funny thing is that every company he mentioned and many others promised many years ago and still promise cheaper, faster, higher PoS drugs and many of them do not...
Spanish Study Finds Daily Intermittent Fasting May Slow Biological Aging
Researchers in Spain have published a clinical trial showing that a daily intermittent‑fasting regimen can modestly slow epigenetic signs of aging in older adults. The findings, appearing in Nature Medicine, add scientific weight to a practice long championed by the...
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative "Genetic IL6R blockade was not associated with incident chronic-disease risk, including invasive cancer and longevity, in a large, ethnically diverse cohort of postmenopausal women. No significant...
Partnering with Epigen
Dr. @M_S_Ringel is a knowledge fountain. COO of @lifebiosciences & a world's expert in epigenetic rejuvenation. Formerly Senior Partner @BCG for 20 years, it's a thrill to be working with him on the trials
Cortisol Kill-Switch: Exercise Rewires Stress Biology
A year‑long, randomized clinical trial of 130 mid‑life adults found that meeting the American Heart Association’s recommendation of 150 minutes of moderate‑to‑vigorous aerobic exercise each week significantly lowered long‑term hair cortisol, the primary stress hormone. The same participants also exhibited...
Blood‑based ECM Protein Clock Predicts Biological Age and Disease
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease https://t.co/3VOwhGCz5S
Moderate Calorie Restriction Lowers Fat C3, Slowing Aging
Moderate calorie restriction in humans reduces levels of the immune protein C3 in fat tissue, potentially slowing aging and inflammation without the negative effects of severe dieting or weight loss. aging
Why the Rich Want to Live Forever — with Kara Swisher
In this episode, Kara Swisher explores the burgeoning obsession among tech billionaires with longevity and body optimization, tracing how figures like Jeff Bezos, Mark Zuckerberg, and Larry Ellison are funding anti‑aging research, hormone therapies, and cutting‑edge biotech. Swisher critiques the...
Superfoods May Deplete Minerals—Supplements Fill the Gap
What if the superfoods you eat every day are actually stealing minerals from your body? Spinach, kale, sweet potatoes, almonds, and raspberries are all designed by nature to limit how much you consume, and glyphosate-sprayed foods make it worse. That's exactly...
The Interventions Testing Program Shows that Another Eleven Compounds Do Not Slow Aging in Mice
The National Institute on Aging’s Interventions Testing Program evaluated eleven small‑molecule and supplement candidates—including astaxanthin, meclizine, mitoglitazone, pioglitazone, α‑ketoglutarate, mifepristone, methotrexate, and an atorvastatin‑telmisartan combo—in genetically heterogeneous UM‑HET3 mice and found none extended lifespan. Earlier studies that suggested modest benefits...
Stop Eating Three Hours Before Bed for Better Sleep
One of the simplest things I do for sleep is to stop eating about 3 hours before bed. It's something that’s supported pretty consistently in the research. When you eat (especially a large meal), you’re activating the sympathetic nervous system... not what...
New Delivery Bypasses Diet, Fuels Cells with Urolithin A
Only 30% of people can actually produce Urolithin A from food. And even if you are one of them, you would need six cups of pomegranate juice a day to hit the minimum effective dose. Scientists have found a way...
Home Cooking Linked to 27% Lower Dementia Risk in Japanese Seniors
Researchers analyzing data from 11,000 Japanese adults aged 65+ found that cooking at home at least once a week cut dementia risk by 23% for men and 27% for women. The observational study suggests regular home cooking could be a...
Prioritize Healthspan over Chasing Immortality
As a longevity scientist, I’m not interested in helping people live forever. I’m interested in helping people avoid the long period of decline and chronic disease that has become normal in the final 10–20 years of life. Extend healthspan - and a...
Ultra-Processed Foods Boost Death Risk for Cancer Survivors
As a medical school professor, this study should be front-page news. Researchers tracked cancer survivors and found those eating the most ultra-processed food had: -- 48% higher risk of death from any cause -- 57% higher risk of... https://www.youtube.com/@RobertLufkinMD https://www.aacr.org/about-the-aacr/newsroom/news-releases/high-consumption-of-ultraprocessed-foods-may-be-linked-to-cancer-survivors-risk-of-death/ CancerPrevention #UltraProcessedFood #MetabolicHealth #Nutrition #Longevity
Brain Health: Staying More Active During the Day Helps Retain Brain Volume
A new Johns Hopkins study using wrist accelerometers and MRI scans found that older adults with less fragmented daily rest‑activity rhythms retain larger volumes in the hippocampus, parahippocampus and amygdala, while highly fragmented rhythms accelerate brain atrophy and ventricular expansion....
Stable Weight Maintenance Predicts Longer Lifespan in Mice
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice "We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an...
A Few Weeks Of This Brain Training Could Protect Your Mind For Decades
A 20‑year study of 2,021 adults over 65 compared memory, reasoning and speed‑training exercises. Only the brief speed‑training protocol, which targets rapid visual processing, reduced dementia diagnoses by 25 %. The benefit persisted only when participants added occasional booster sessions. The...
CDC Data Shows 14% Rise in Supplement‑Linked Illnesses Among Adults 65+
The Centers for Disease Control and Prevention reported a 14% jump in supplement‑related illnesses among adults aged 65 and older over the past year. The rise comes as supplement use remains near‑ubiquitous in this age group, prompting public‑health officials to...
Oxygen Sensing as a Component of Differences in Regenerative Capacity Between Species
Researchers investigated how oxygen sensing influences tissue regeneration by comparing amphibian and mammalian models. They cultured frog tadpole limbs and mouse embryos under varied oxygen levels, focusing on the HIF1A protein that stabilizes under low oxygen. Reduced oxygen accelerated wound...
10 Science-Backed Ways To Improve Your Mitochondrial Health Daily
Mitochondrial health has moved from a textbook concept to a daily wellness priority, influencing energy, aging, and resilience. Experts explain that light exposure, movement, nutrition, sleep, and stress management directly shape mitochondrial function. The article outlines ten science‑backed habits—ranging from...
Antarka Unveils ANKros-CPD, a DNA Repair Active for Skin Longevity
Antarka introduced ANKros‑CPD, a biotechnology‑derived enzyme that repairs UV‑induced DNA lesions in skin, at in‑cosmetics Global in Paris. The active is a stabilised CPD‑photolyase sourced from Antarctic microorganisms, enabling topical use. By targeting cyclobutane pyrimidine dimers, it addresses DNA damage,...
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...
Prof. Sinclair’s Aging Research Redefines My Perspective
I get the best emails: Dear Professor Sinclair, I came across your work on aging [and how it might] be modulated or restored. I was perfectly happy with my old way of thinking about aging until you showed up. Thanks for that. Hannah
![[Emergency Pod] Peptides - Part 1 with Sunita Mohanty of Ultralight](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://megaphone.imgix.net/podcasts/d0db1eda-2c6f-11ef-958d-9fb4aba9c1ce/image/0bfc12f76c8a92fdb53253e1c884033d.jpg?ixlib=rails-4.3.1&max-w=3000&max-h=3000&fit=crop&auto=format,compress)
[Emergency Pod] Peptides - Part 1 with Sunita Mohanty of Ultralight
In this episode of Lifers, host Christina Farr talks with Sunita Mohanty, CEO and co‑founder of Ultralight, about the booming interest in peptide therapies for wellness and longevity. Sunita explains that while peptides are gaining popularity—driven by anecdotal success, recent...
Daily Choices Shape Healthy, Cognitive Aging
Aging is a natural process, but how we age is influenced by the choices we make each day. A nutrient-dense, anti-inflammatory diet, regular movement, and effective stress management can support both physical and cognitive health over time. #HealthyAging #AntiInflammatory...
Childhood NAD+ Deficiency Triggers Lifelong Muscle Aging
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood https://t.co/K0MAkv7hIB https://t.co/eRCOesGwL5
Plant‑Based Diet Cuts Multimorbidity Risk in Seniors, Study Finds
A multinational research team has demonstrated that increasing plant‑based food consumption markedly reduces the likelihood of older adults developing two or more chronic conditions. The findings, published this week, provide empirical backing for dietary biohacking strategies aimed at extending healthspan....
Why Female Influencers Rarely Promote Peptide Stacks
It was on this day that I learned what a Wolverine Peptide stack is! I spoke to @sunitasmohanty on the market demand for peptides, how she's experimenting with them & why we don't see as many female influencers hawking them. Full...
Blood Test Identifies Molecules Predicting Short‑term Survival
New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe
High-Precision Human Immune Aging Clock Identifies RUNX1 as Key Target for T Cell Senescence
Researchers from the Chinese Academy of Sciences unveiled a high‑precision Human Immune Aging Clock (HIAC) that leverages single‑cell multi‑omics to predict immune age with a 5.66‑year mean absolute error. The clock identifies T cells as the most sensitive cellular indicator...
Rejecting Life Extension = Costly, Intentional Aging Choice
"If you have access to life extension therapies and decline them, you’re making a deliberate choice to age and die on an old biological timeline." -- the additional medical cost associated with NOT choosing these therapies, may make it an...
Anemia May Heighten Alzheimer’s Risk Alongside P‑tau217
In evaluating p-tau217 and other biomarkers for risk of Alzheimer's disease, keep an eye on anemia, which may add to the risk, as seen in this new report https://t.co/ezbcLr4HIf https://t.co/TOKLRVBM4f
Episode 194: Tommy Wood Discusses How to Future-Proof the Adult Brain
In this episode, neuroscientist Dr. Tommy Wood expands on his new book, The Stimulated Mind, outlining science‑backed strategies to future‑proof the adult brain against dementia. He emphasizes that neuroplasticity persists throughout life and that diet, exercise, and continual mental challenge...
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy
Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp
‘Harvard Thinking’: How super-agers keep their brains young Experts break down ‘biological contradiction’ of a 65-year-old with the memory of a 25-year-old — and what that means for the rest of us https://t.co/29qpNudp1J https://t.co/X951FiSfiS
Vitamin C Cuts Iron‑Related Aging Markers in Monkeys
Researchers have demonstrated that high‑dose vitamin C supplementation lowers iron‑induced oxidative damage and senescence markers in aged cynomolgus monkeys. The findings point to a nutraceutical strategy for slowing cellular aging and have sparked interest across the biohacking community.
Taurine Leads Supplement Tierlist, BCAAs Bottom
Supplement tierlist: - Taurine: 9/10 - Glycine: 8.5/10 - CoQ10: 8/10 - Lutein & zeaxanthin: 7/10 - Ginger: 6/10 - Inositol: 5/10 - Multivitamin: 4/10 - Beta-carotene: 3/10 - Tribulus terrestris: 2/10 - BCAAs 1/10
Peptide Hype Stalls Until IQ>70 Hits Market
Peptide bros can’t shut up about BPC-157, TB-500, CJC-1295, etc etc. Just wait until you guys try IQ>70.
AI Creates Orexin Activator to Boost Focus, Reduce Sleep
Two researchers just used AI to design a selective orexin activator. If you care about focus, steady energy, or needing less sleep, this is worth paying attention to. https://t.co/3qbzB6J7X3
Sauna Benefits Require 31 Minutes to Trigger HSPs
Most people might miss the biggest benefit of sauna You need to get really really hot… Your core body temperature needs to hit 102.4°F (39°C). For reference, a fever is anything above 100.4°F (38°C) So I swallowed a temperature monitoring pill. It goes through...
Mitochondrial Transplantation Reverses Cell Degeneration
In terms of my top bets for rejuvenation-based therapies, mitochondrial transplanation has entered the chat Cell-type-targeted mitochondrial transplantation rescues cell degeneration https://t.co/izvDaRk7kz
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Reversing Aging Could Halt Chronic Disease Progression
Aging is the primary driver of most chronic diseases. But what if aspects of aging can be reversed? I join @TomBilyeu on Impact Theory to discuss the latest about what we’re learning in the lab and in human clinical trials Full conversation:...
Stress‑induced Mitochondrial Condensate Fusion Drives Aging
It works by phase separation, where mitochondrial DNA and proteins cluster into droplet-like biomolecular condensates that organize gene activity, but under stress these droplets fuse and grow abnormally, disrupting function and contributing to aging. https://t.co/dRzhFVzxQQ
Better Health Can Shrink Your Sleep Needs
Some people actually live longer while sleeping less than eight hours a night. Improve your health, and your sleep requirement often drops. https://t.co/hkfVvcsD4t
P21⁺TREM2⁺ Macrophages Drive Inflammaging and Liver Disease
Delighted to be part of this study identifying p21⁺TREM2⁺ senescent macrophages as drivers of inflammaging and metabolic liver disease. A fantastic collaboration led by @ACovarrubiasPhD 👏
Ancient Pomegranate Remedy Validated by Modern Science
Pomegranates have been used by Persian and Greek doctors for thousands of years to improve vitality, and modern science is finally catching up to why. https://t.co/6Ei5AXfk1Y