Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
New Launches for In-Cosmetics Global: EpiSnow and PhytoSpherix Hair
in‑cosmetics Global unveiled two new actives: EpiSnow, a biotech‑derived skin‑rejuvenating ingredient that tackles seven ageing hallmarks, and PhytoSpherix Hair, a plant‑based glycogen extracted from non‑GMO sweet corn designed to energize hair follicles. EpiSnow leverages extremophile snow algae to support epigenetic health and reduce cellular senescence, while PhytoSpherix Hair supplies targeted natural energy to promote faster growth and denser‑looking hair. Both products respond to rising consumer demand for scientifically backed, longevity‑focused beauty solutions.
PEPITEM as a Potential Therapy for Autoimmune Arthritis
Researchers at the University of Birmingham have identified a decline in the anti‑inflammatory peptide PEPITEM as a key driver of worsening inflammatory arthritis with age. Laboratory tests showed that adding synthetic PEPITEM restores white‑blood‑cell responsiveness to adiponectin in early‑stage rheumatoid...
From 920lb Deadlifts to Marathons: 5 Lessons on Extreme Performance and Resilience
Pete Rubish, once famed for a 920‑lb deadlift, has reinvented himself as a marathon runner, underscoring a profound shift from raw strength to cardiovascular health. After quitting performance‑enhancing drugs, he grappled with heightened health anxiety, a 24 mm kidney stone that...
Why Aspirin Is Becoming a Weapon Against Cancer
Aspirin, the 4,000‑year‑old painkiller, is now shown to cut colorectal cancer risk in high‑genetic‑risk patients. A 10‑year trial of 861 Lynch‑syndrome participants found a daily 600 mg dose halved cancer incidence, and a lower 75‑100 mg dose appears equally effective. The UK...
Celastrol Disrupts Hsc70‑Bim to Boost Longevity, Reduce Fibrosis
Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis https://t.co/Iv51QlhH5l
Centenarians Defy Immunosenescence, Boost Geroscience Insight
Biological age and immunosenescence in Colombian centenarians “These findings challenge the notion of immunosenescence in centenarians and highlight the value of translational research in geroscience.” https://t.co/e63NgGmmzL
Peptides / Bioregulators
The invite‑only California Peptide Club convened over 100 tech‑savvy attendees in San Francisco to discuss self‑optimization peptides, a trend now outpacing even pickleball in Google searches. Participants, ranging from clinicians to DIY biohackers, shared personal stacks and demonstrated injection techniques...
Dr. Kaeberlein's Optispan Podcast Series - Rapamycin and More
The Optispan podcast hosted by Dr. Kaeberlein outlines a translational protocol for 3‑hydroxyanthranilic acid (3HAA), a mouse‑tested longevity molecule. Using FDA BSA scaling, the human equivalent dose (HED) is calculated at roughly 1.1 g per day for a 70‑kg adult. Safety...
Resistance Training Cuts Fat and Boosts Grip Strength
Exercise, nutrition, physical agent therapy in older adults with sarcopenic obesity: a systematic review and network meta-analysis RT can reduce BF% while simultaneously improving grip strength, representing an effective management strategy for sarcopenic obesity. https://t.co/p0wR2R5M1E
Irregular Bedtimes Double Risk of Major Cardiac Events
Sleep timing irregularity in midlife: association with incident major adverse cardiac events and cardiovascular disease mortality over a 10-year follow-up 🫀Individuals with irregular bedtimes had a 2-fold higher risk of MACEs compared to those with regular bedtimes Irregular sleep midpoints? Also a...
Single-Cell Epigenomes Link Fat to Heart Disease Risk
A new study leveraging single‑cell epigenomic profiling of human adipose tissue has uncovered distinct regulatory signatures that link excess fat to heightened heart disease risk. Analyzing over 200,000 fat cells from 500 donors, researchers identified 12 epigenetic regions that correlate...
Tenofovir Alafenamide Cuts Biological Age in Adults
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics 💫 https://t.co/FFvTmJv2zv https://t.co/DHHQ18nAmy
Lifting Weights Builds a Sharper Mind and Reduces Anxiety in Older Women
A three‑month randomized trial found that older women who engaged in resistance training—whether using heavier weights for eight to twelve reps or lighter weights for ten to fifteen reps—experienced significant gains in cognitive performance and marked reductions in depression and...
Choose Triglyceride Omega‑3s for Superior Absorption
Not all omega-3 supplements are created equal. Most fish oil on the market is in ethyl ester form, which is cheaper to produce after purification. But it's not found in nature and is less bioavailable. What you want is triglyceride form omega-3s....
Promising Longevity Molecule Stalled by Misaligned Incentives
The Longevity Drug You’ve Never Heard Of This is one of those stories that captures both the promise—and the frustration—of longevity science. In this preview episode, Dr. George Sutphin (@senmorteco ), Associate Professor of Molecular and Cellular Biology at the @uarizona @UAZCancer , walks...
Protein, MIND and Mediterranean Diets Touted as Keys to Graceful Aging
Dr. Ronan Factora of the Cleveland Clinic highlighted that many seniors fall short on protein, a shortfall that can accelerate muscle loss and bone fragility. He recommends protein‑rich foods and the MIND or Mediterranean diets, both linked to better brain...
Excess Energy Resistance Drives Aging; Lifestyle Lowers It
The energy resistance principle 💡Hypothesis and framework by @MitoPsychoBio & colleagues ⚡️ 👉 “Energy resistance (éR) is the fundamental property that enables transformation, converting into useful work the unformed energy potential of food-derived electrons fluxing toward oxygen. 👉 Although éR is required to...
Lonvi’s New Capsule Boosts Mouse Lifespan by 9% and Extends Survival 64% in Trials
Lonvi announced that its experimental capsule, built around the grape‑seed compound procyanidin C1, increased overall mouse lifespan by 9.4% and extended survival by 64% from the first day of treatment. The claim, posted on the company’s website and amplified by...
Garlic-Derived DAS Outperforms Metformin, Extending Mouse Lifespan
👉 “Chronic treatment with DAS (found in garlic 🧄) freshly added to the diet weekly revealed geroprotective effects, since it extended lifespan and improved metabolic homeostasis, locomotor function, and relevant cognitive parameters in wild-type male mice fed with an STD....
Eat 30 Plant Varieties Weekly for Microbiome Health
As a scientist studying aging, I’m fully behind the “eat 30 different plant foods per week” advice. The research linking microbiome diversity to long-term health is compelling. Fruit, veg, legumes, herbs, nuts, and seeds all count — it’s more achievable than...
Considering How to Define Animal Models of Intrinsic Capacity in Aging
A decade after the WHO introduced the intrinsic capacity (IC) framework, researchers still lack a unified way to measure its five domains—cognition, locomotion, vitality, sensory function, and psychological health. Numerous human‑centric metrics exist, but they are not comparable across studies....
AOL Health Guide Urges Incremental Tweaks to Boost Fitness, Cites New Research
AOL's health guide published a piece recommending modest, incremental lifestyle changes to improve fitness, drawing on recent research from University of Sydney scientists that links modest activity to dramatically lower mortality risk.
Prioritize Performance; Longevity Follows as a Bonus
The goal isn’t longer life.�It’s longer function and performance. Longer life is the side effect
High-Dose Vitamin C May Slow Aging, Study Finds
New research in Cell Metabolism suggest high-dose vitamin C might slow aging👇 (details in comments)
Researchers Map Mediterranean Diet’s Multi‑Pathway Longevity Networks
Scientists from KGK Science Inc. and partner institutions published a review on April 19, 2026 that maps the complex network of polyphenols in the Mediterranean diet and their combined effects on longevity. Using liquid chromatography‑mass spectrometry and network‑biology analysis, the...
Study Backs Five Standing Exercises to Cut Falls for Adults Over 55
A recent health report highlights five standing, weight‑bearing exercises that improve hip strength and cut fall risk for adults over 55. Backed by a 2023 JAMA Network Open study and a 2024 randomized trial, the regimen delivers a 34% reduction...
Daily Intake of Cuminaldehyde-Rich Cumin Essential Oil Improves Cognitive Function in Healthy Elderly Japanese Adults: A Randomized, Double-Blind, Placebo-Controlled Pilot...
A 12‑week, double‑blind pilot trial in 38 healthy Japanese seniors found that daily ingestion of a cumin essential oil capsule containing 25 mg cuminaldehyde significantly enhanced psychomotor speed and reaction time compared with placebo. Cognitive gains were measured using the Cognitrax...
Dietitians Highlight Five Supplements to Support Longevity
Registered dietitians identify five key supplements that may help adults age more vibrantly. Their recommendations focus on compounds that support mitochondrial health, antioxidant capacity, and sleep quality, offering a science‑backed toolkit for longevity.
ATF5 as a Point of Tradeoff in Muscle Mass versus Muscle Quality
Researchers discovered that deleting the transcription factor ATF5 in mice prevents the typical age‑related loss of skeletal muscle mass, but this comes at the cost of reduced muscle quality and endurance. ATF5‑deficient mice showed lower activation of mitochondrial quality‑control proteins,...
Certain Drugs Like SGLT2 Inhibitors Cut Mortality Risk
A 2024 study on half a million UK individuals analyzed the mortality effects of 406 medications 92% were seen to be associated with increased mortality risk because of the underlying diseases. However, 14 were surprisingly associated with reduced mortality. An overview by...
What It Actually Means To “Live Mediterranean,” According To A Large Study
A new international study of 4,010 adults across ten countries used the MedLife Index to measure adherence to a Mediterranean‑style lifestyle, not just diet. Spain emerged as the top performer, scoring high on diet, sleep quality, physical activity, and social...
There’s New Evidence for How Loneliness Affects Memory in Old Age
A new six‑year longitudinal study of 10,217 Europeans aged 65‑94 found that loneliness is linked to lower initial scores on immediate and delayed recall tests, but it does not accelerate the rate of memory decline. Age, depression and chronic illnesses...
Salt Harms Arteries via Immune‑driven Senescence, Not Direct Toxicity
Salt has been blamed as the culprit for damaging your arteries. A new mouse study puts salt-sensitive hypertension in context. Salt doesn't do it directly, it triggers your immune system to do it. 4 weeks on a high-salt diet (8% NaCl) cut...
Century of Gains Slows; Future Life Expectancy Uncertain
Life expectancy in high-income countries increased ~50% over the past century, but gains have slowed in recent decades (≈70 in 1975 to ≈80 today in US). What will be the life expectancy in 100 years?
Blue Zones’ Dan Burden Marks 80th with Call for Outdoor Adventure to Boost Longevity
Dan Burden, Blue Zones Director of Inspiration & Innovation, celebrated his 80th birthday by telling Blue Zones how outdoor adventure fuels longevity and purpose. His interview highlights the need for community‑driven outdoor programs to keep aging adults engaged and healthy.
Vaccinated Donor Plasma Contains No Spike Proteins or mRNA
One of the top questions I get about young plasma exchange (YPE): “What if the donor was vaccinated? Does that mean I’m getting spike proteins or mRNA injected into me?” Short answer: No. Here’s the breakdown... https://t.co/JDoAi2yPmR
GLP‑1 Drugs Aren’t a One‑size‑fit Solution
Should everyone be taking a GLP-1 medication? From my discussion with @RealDoctorMike on his podcast https://t.co/d3M8cFHggz
Nestlé and NTU Singapore to Establish Research Lab Focusing on Longevity, Women’s Health
Nestlé and Singapore’s Nanyang Technological University have signed a multi‑year agreement to create a joint research lab focused on nutrition‑driven healthy longevity. The partnership will combine Nestlé’s global R&D capabilities with NTU’s Lee Kong Chian School of Medicine expertise and...
Higher Muscle Strength Cuts Mortality Risk in Elderly Women
Muscular Strength and Mortality in Women Aged 63 to 99 Years 👉 “this study of ambulatory older women, greater muscular strength was associated with lower mortality even when controlling for accelerometer-measured PA and sedentary time, walking speed, and systemic inflammation.” https://t.co/xi913FibKy
Blood and Fat Markers Forecast Heart Disease Risk
Neutrophil-to-Lymphocyte Ratio, Bone Marrow, and Visceral Fat Metabolism as Predictors of Future Cardiovascular Disease in an Asymptomatic Healthy Population https://t.co/Oq1a3fH5qa
Immune‑Inflammatory Balance Linked to Extreme Longevity
Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study https://t.co/UPfK7vrIUT #mdpibiology
Rejuvenated CD4 T Cells Promote Longevity, Infections Accelerate Senescence
Rejuvenated CD4 T cells--> longevity https://t.co/FH5XTQc3zl On the other hand, infection-->increased senescent T cells, shorter lifespan? https://t.co/wtsDnmIdnh
Modern Bodies Face a Silent Energy Crisis
Fuel for thought 👉 ”A quiet energy crisis may be unfolding within modern bodies…” and brain 👨🏻⚕️🧠 🔗 https://t.co/19h7kfdhNK 🗣️@HanCritchlow
Key Nutrients: Vitamin D, B‑vitamins, Magnesium, Melatonin, NAD
Vitamin D is the master hormone. B vitamins are the master vitamins. Magnesium is the master mineral. Melatonin is the master antioxidant. NAD is the master coenzyme.
Scientists Reverse Mouse Aging by 75%, Promising Human Breakthroughs
Dr. David Sinclair just dropped a two-hour masterclass on Tom Bilyeu's podcast. He shared 10 mind-blowing insights on how to reverse biological age in animals (and why it should work in humans too). 1) They already reversed a mice's age by 75%...
Ageing Biomarkers Compared Across Humans and Primates
Biomarkers of ageing of humans and non-human primates https://t.co/Cav2bIwrLX "A comprehensive overview of ageing biomarkers in humans and non-human primates, divided into three hierarchical levels: cellular, tissue and organism..." https://t.co/tT3JXBnj0S
Low Testosterone Linked to Vascular Aging via Mitochondrial Dysfunction
Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone https://t.co/pQna8PVe1t
Boosting Mitochondrial NAD+/NADH Extends Life, Eases Alzheimer’s
Extension of Lifespan and Amelioration of Alzheimer's Disease Phenotypes by Genetic Manipulation of Mitochondrial NAD+/NADH Ratio https://t.co/m8K1Tm9sIR https://t.co/SU85G9FsgW
Zombie Immune Cells Linked to Fatty Liver, Inflammation, Aging
UCLA scientists identify zombie immune cells as a driver of fatty liver disease, inflammation and aging https://t.co/28Ql5er4kb https://t.co/IoAD5I6AJr
Strong Glutes Extend Longevity and Midlife Independence
This Muscle Is the Unsung Hero of Longevity Building your butt muscles will help you stay injury-free and independent in midlife and beyond. https://t.co/m6NODA1e2P https://t.co/vq6a8HFntM