Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
HIV Treatment Reduces Accelerated Biological Aging by Nearly Four Years, Landmark Study Shows
A landmark study presented at ESCMID Global 2026 shows that antiretroviral therapy (ART) reduces the accelerated biological aging seen in people with HIV (PWH) by an average of 3.7 years after roughly 1.5 years of treatment. Researchers used a plasma proteomic aging clock (PAC) built from hundreds of blood‑protein markers to compare pre‑ART and post‑ART samples from the Swiss HIV Cohort Study. Untreated HIV infection was associated with a median ten‑year age acceleration, while sustained viral suppression gradually restored proteomic age toward chronological levels. The findings highlight inflammation‑driven aging as a reversible component of HIV disease.
Combined NMN and CD38 Inhibitor Rejuvenates Aging Muscles
Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration https://t.co/bnkkn0xblj Scheme 1: A novel synergistic drug combination (N + A) consisting of an NAD+ precursor (NMN) and an NAD+ consumption (CD38) inhibitor (API) promotes musculoskeletal regeneration in aging.
AI-Optimized Molecules Drive Clinical Interest and Expansion
#AACR2026 is in full swing and our posters are very popular. And some pharma companies realized that we have clinical data now and the molecules were AI-optimized to avoid the common liabilities. Finally, some genuine interest and we will have...
Irregular Bedtimes Linked to Double Cardiac Risk in 10‑Year Study
Researchers publishing in BMC Cardiovascular Disorders report that adults with irregular bedtimes face roughly twice the risk of major cardiovascular events over ten years. The finding, based on device‑measured sleep data from middle‑aged participants, underscores sleep timing as a modifiable...
Try KillSwitch: A Simple Biohack for Better Sleep
Many people have told me to tape my mouth shut over the years, but they don't realize it's actually one of my favorite biohacks. If you're looking for more ways to improve your sleep quality, I suggest trying @switchsupplements. A...
Lifespan.com: Underrated Hub for Longevity Research
OMG. I’m getting worried 🙈 No one has told me Lifespan.com - with its podcast show, magazine and community to support longevity research - is crazy. 🤔 Anyone?!
The Best Morning Routine to Help You Live a Longer Life
Experts say a consistent morning routine can boost longevity by aligning sleep, exercise, and nutrition. Wake up at the same time each day to reinforce circadian rhythms, then prioritize resistance training to preserve muscle mass before it becomes harder to...
AI Obsession Derails Life, Sparks Tech Regret
I got C-holed. Suffered sleep consequences. I busted my screens-off rule. Turned down socializing. Fell behind on work. Kate is now upset. AI is preposterous. As close to magic as I’ve experienced (except a seed becoming a tree and a zygote becoming a baby)....
Stop Letting Your Body Quietly Narrow Your Life
Don’t let your life "narrow." I’ve been an orthopedic surgeon for 30 years. The thing I watch happen to people — more than any injury or surgery — is what I call the narrowing. Most of my patients have no idea it’s...
Why Do Falls Rise with Age? Cerebellar Neuron Firing Problems (and Potential Therapeutics)
A new McGill University study published in PNAS shows that age‑related motor decline is not due to loss of cerebellar Purkinje neurons but to a drop in their intrinsic firing frequency. The researchers demonstrated that suppressing Purkinje firing in young...
Dasatinib and Quercetin as Senolytic May Cause Brain Damage
A March 2026 PNAS study shows that the senolytic combo dasatinib and quercetin (D+Q) triggers demyelination in the corpus callosum of aged mice. The researchers used intermittent oral doses of 5 mg/kg dasatinib and 50 mg/kg quercetin, identical to regimens linked to...
USC Compound Halts Alzheimer-Linked Brain Inflammation
As a medical school professor at USC, this one is personal. My colleagues at Keck School of Medicine developed a compound that stops brain inflammation linked to Alzheimer's -- while preserving normal brain function. The target: cPLA2, an enzyme that drives inflammation...
5 Hidden Lab Numbers Reveal Why You Feel Unwell
Your labs are "normal." But you haven't felt normal in years. There are 5 numbers your doctor probably isn't checking — and they tell a very different story. Free live webinar: May 5, 5 PM PT → 30dayhealth.co/webinar
Expert Names Metamucil Top Soluble Fiber Supplement to Cut LDL by Up to 7%
Registered dietitian Janet Bond Brill, PhD, RDN, recommends Metamucil as the best soluble fiber supplement for lowering LDL cholesterol, pointing to a clinical trial where 10 g of psyllium husk cut LDL by up to 7%. The endorsement highlights a growing...
The Longevity Effects of Reduced IGF-1 Signaling Depend on the Stability of the Mitochondrial Genome (Paper April 2026)
The study shows that reducing IGF‑1 signaling via Pappa loss does not extend lifespan in Polg D257A mutator mice, which harbor unstable mitochondrial DNA. While Pappa deletion improves several health metrics—splenomegaly, anemia, inflammation, muscle and cardiac function—the longevity benefit seen in...
Longevity Doctor Julie Chen Highlights Four Simple Habits for Healthy Aging, Emphasizing Nutrition
Longevity physician Dr. Julie Chen, advisor to the Buck Institute and CMO of precision‑medicine firm Radence, detailed four simple habits for healthy aging, centering on sleep, strength training, a rotating diet and proactive health data. Her recommendations signal a growing...
Scientists Set Formal Criteria for Blue Zones, Spotlight Sardinia as Model
An international research team led by the American Federation for Aging Research announced rigorous, data‑driven standards to certify Blue Zones, naming Sardinia’s Ogliastra region as a benchmark. The move replaces anecdotal claims with measurable metrics, offering biohackers concrete lifestyle targets...
MIND Diet Slows Brain Atrophy Over Ten Years
Adherence to the MIND diet and longitudinal brain structural changes over a decade: evidence from the Framingham heart study offspring cohort “In this prospective cohort study, greater adherence to the MIND diet was associated with slower brain structural atrophy, particularly...
Epigenetic Aging Rate Outperforms 13 Biomarkers in Mortality Prediction
Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II https://t.co/q9jmoubgex
Robust Mouse Rejuvenation (RMR1) Study Update
The Robust Mouse Rejuvenation (RMR) program, led by Dr. Aubrey de Grey and the LEV Foundation, is testing multi‑intervention stacks to extend mouse lifespan far beyond the ~4‑month gains seen with single agents. RMR1 combined rapamycin, telomerase gene therapy, heterochronic bone‑marrow...
Consistent Sleep Cuts Mortality Risk More Than Duration
Sleep regularity was a stronger predictor of all-cause mortality than sleep duration 👉 Higher sleep regularity was associated with a 20%–48% lower risk of all-cause mortality. https://t.co/AO6rthJcdU https://t.co/em0u1eKZiA
Future Medicine Targets Aging, Not Just Symptoms
The future of medicine is treating causes, not symptoms. Aging is the main cause of disease
New Study Shows Vitamin D May Reduce Colon Cancer Risk By 58%
A new meta‑analysis of 50 studies covering over 1.3 million people finds that higher vitamin D levels cut colorectal cancer risk by up to 39%, with long‑term tracking showing a 20% reduction. The review highlights a 58% lower risk among women with...
DASH and Anti‑inflammatory Diets Lower SCD Risk, Boost Cognition
Dietary Patterns and Indicators of Cognitive Function “healthy diets, exemplified by the DASH diet for blood pressure control and diets with lower hyperinsulinemia and inflammation potentials, were associated with a lower SCD risk and better cognitive function” https://t.co/Km7DxqqtJa
Rejuvenation Stems From Removing Old Blood, Not Young Transfusions
Munger was right to “avoid crazy” regarding young blood transfusions. While animal data is compelling, evidence shows rejuvenation (in mice) comes mostly from removing old blood components to dilute age-elevated factors. 🩸
This One Habit Can Support Joints & Smooth Skin For Women 35+
A recent review by registered dietitian Molly Knudsen highlights that daily collagen peptide supplementation can alleviate joint discomfort and improve overall physical health for women in their 30s and 40s. Clinical data from the Journal of the International Society of...
Explore the Ubiquity of Peptides with Expert Jon Slotkin
Peptides are everywhere. Don’t miss this conversation with clinical expert @slotkinjr if you’re curious. Jon is my go to on this topic. Link here: https://t.co/luQcHXz3cQ https://t.co/FhsQNVv1Hp
Early Detection Tools Exist—Yet Prostate Cancer Screening Lags
Prostate cancer: a PSA on PSA We have the tools to catch prostate cancer early—why aren’t we using them? https://t.co/w8lN6rfNmO https://t.co/dapKLiI4aX
Is VC6TF the OSK Reversal Cocktail?
Researchers at the Sinclair Lab have identified a five‑molecule mix called VC6TF that chemically mimics the OSK (Oct4, Sox2, Klf4) gene‑therapy cocktail used to reset cellular age. The core of the “three‑chemical” version discussed by Dr. Sinclair includes CHIR‑99021, RepSox...
21st‑Century Models Show Longevity Escape Velocity
Life expectancy is rising across the world. Some people think we’re on the verge of “longevity escape velocity” — where medical progress starts extending life faster than aging takes it away. But what do the actual models for the 21st century predict?...
New Research Points To Key Driver Of Biological Aging—With An Easy Fix
New research published in Cell Metabolism identifies “ferro‑aging,” a gradual buildup of iron in tissues that impairs organ function. The study shows the enzyme ACSL4 drives iron‑induced cellular damage, and blocking it in mice improves age‑related decline. In a 40‑month...
Is The Gut The Missing Link To Women's Longevity? An Expert Explains
Nutrition expert Cynthia Thurlow argues that gut health, protein, and fiber are critical to women’s longevity during menopause. She recommends at least 100 g of protein and 25‑30 g of fiber daily, along with anti‑inflammatory foods and a diverse plant palette. Thurlow...
Refined Diets Damage Amygdala Memory in Aging Rats
The aged amygdala’s unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis 👉 “Refined diets impaired amygdalar memory in aged rats, regardless of fat or sugar…” https://t.co/GfWLeVTb9z https://t.co/xLCIniZq5B
Sinclair's 1g NMN: Myth Vs. Cellular Reality
David Sinclair is one of the smartest longevity researchers on the planet. I interviewed him here: https://t.co/dZCOAD5PLU and recently @tombilyeu released an interview with him here: https://t.co/F2pHBy9xuw... ...in which @davidsinclair says he takes 1g of NMN every morning. But some people say...
They Promise Glowing Skin, a Ripped Body and Better Sex. Peptides Are Having a Moment – but Are They Safe?
Peptide injections have surged in popularity after influencers and startups like Superpower, a $300 million health‑tech firm, began touting benefits ranging from youthful skin to enhanced workouts and sexual performance. The debate intensified when Superpower founder Max Marchione faced off with...
Swedish Study Links Anemia to Higher Dementia Risk, Flagging Iron Deficiency for Longevity Hackers
Swedish researchers from Karolinska Institutet and Stockholm University reported that anemia triples the risk of dementia in older adults, based on a cohort of 2,200 participants. The study, published in JAMA Network Open, shows low hemoglobin correlates with elevated Alzheimer’s...
Keto Diet Induces Ulcerative Colitis Remission, Challenges Conventional Care
A ketogenic diet put his ulcerative colitis into complete remission — off all medications, confirmed on colonoscopy. Dr. Nick Norwitz (PhD Oxford, MD Harvard) explains why "evidence-based" care isn't always optimal care, how keto rewires the gut and brain, and...
Japanese Longevity Secrets From 105‑Year‑Old Doctor
3 million people in Japan are older than 90 years old. 105 year old Japanese doctor on how to live a long and healthy life https://t.co/gk05haz14D
Therapeutic Plasma Exchange Shows Temporary 2.5‑Year Biological Age Reduction, Study Finds
Researchers publishing in Aging Cell say a therapeutic plasma exchange protocol trimmed biological age by roughly 2.5 years in a small human trial, but the effect largely disappeared by the study’s end. The mixed results have ignited both excitement and...
Exploring Abundant Futures with Longevity Visionary David Wood
A Roadmap to Abundant Futures: A Conversation with David Wood @dw2 is well worth your time. I have a lot of respect for him, having collaborated together, and his work with @LongevityEVF alongside @aubreydegrey, another great visionary, speaks for itself https://t.co/Jr4k0g9HnB https://t.co/qwgshYdPXT
Late‑stage Oral Cocktail Adds 33% Lifespan in Obese Mice
An oral drug combination, including a senolytic (quercetin), NR, urolithin A, and alpha-lipoic acid, extended median remaining lifespan in mice by 33%. Important to note, however, that the mice were fed a high-fat "Western Diet" and the intervention started at 18...
Rubedo’s AI‑Designed Senolytic RLS‑1496 Begins First‑In‑Human Trials
Rubedo Life Sciences has started Phase 1 human trials of RLS‑1496, the first GPX4‑targeting senolytic drug designed by its ALEMBIC AI platform. The parallel trials in Europe and the United States aim to assess safety and dosing of a therapy that...
Oliver Zolman Discusses Cutting‑Edge Aging Research Insights
New interview, by the terrific Oliver Zolman who was for a time Bryan Johnson's main doctor and who knows a great deal about aging research too: https://t.co/LCenNXC9xg
Hidden Ingredient in Processed Foods Sabotages Your Metabolism
An ingredient hiding in almost every processed food and restaurant meal you’ve ever eaten is destroying your metabolism. If you are looking for another way to support your gut health, I recommend supplements from @omnibiotics. https://t.co/cDHxaz0aiw
The Science Behind the Peptide Craze
The DIY peptide market has exploded, driven by influencers promising faster recovery, anti‑aging, and muscle growth. In 2023 the FDA barred compounding pharmacies from producing several popular peptides, pushing users to gray‑market imports. Health officials, including HHS secretary Robert F....
NAD+ Rhythms Drive Sleep, Aging; Resetting Delays Decline
NEW PAPER: Ups & downs in NAD+ over 24 h dictates our body's clock & sleep but declines with age. Disrupting the cycle promotes mouse aging & restoring it improves fitness & metabolic function, pointing to "circadian reprogramming" as a...
Upgrade Your Downstairs: Essential Renovation Tips
Want to upgrade your 'downstairs'? ;) Here are some tips on what works best. https://t.co/yYkziHeWX6
Longevity: What 2 or 3 Other Supplemental Medications Would You Use Along with Rapacan/Sirolimus?
An anonymous forum user seeks supplemental drugs to pair with rapamycin (sirolimus) for longevity, already taking resveratrol. Community responses recommend metformin, acarbose, and SGLT2 inhibitors such as dapagliflozin to counter rapamycin‑induced glucose spikes, plus statins or ezetimibe for lipid control...
104‑Year‑Old Sprinter Credits Sleep, Stress‑Free Life, Vodka
Stanisław Kowalski, a 104-year-old Polish guy set a European record in 2014 in the 100-meter sprint for the 100-year-old age group with a time of 32.79 seconds He says his secret is avoiding stress, lots of sleep, and the occasional vodka https://t.co/tyVGWukUTI
PFAS Exposure Linked to Faster Biological Aging in Men
Aging process could accelerate due to 'forever chemicals' exposure, study finds Higher concentrations of PFAS chemicals were associated with faster biological aging in men of certain age groups https://t.co/ZClEw0Gj1p https://t.co/tYBTJTmlt9