High-Resolution Pan-Viral Antibody Profiling and Brain Health in People with HIV
Dr. Patricia Katie Riggs presented her latest research on high‑resolution panviral antibody profiling and its relationship to brain health in people living with HIV, emphasizing well‑controlled patients and the role of chronic co‑infections. Using a molecular indexing of proteins (MIP‑A) platform, Riggs mapped antibody responses against 529 known human viruses from plasma and cerebrospinal fluid. The technique captures epitope‑specific signatures, revealing that antibodies targeting herpesviruses such as CMV and EBV are linked to neurocognitive impairment, even when traditional viral load assays are negative. Riggs argued that “antibodies should be viewed as integrated biomarkers,” noting that EBV epitope responses predict multiple sclerosis risk and that specific HIV peptide antibodies differentiate elite controllers. She also referenced ongoing CMV‑based HIV cure trials and the potential of antiviral vaccines. The findings suggest that high‑resolution serology can stratify patients for targeted antiviral or vaccine strategies, potentially mitigating accelerated aging and cognitive decline in the HIV population. The work highlights the value of multidisciplinary collaboration that blends clinical insight with advanced computational immunology.
Rare Disease Day 2026 | Gene Therapy in Practice
The Rare Disease Day 2026 session titled “Gene Therapy in Practice” highlighted Johns Hopkins’ emerging program to deliver gene‑based treatments for pediatric neuromuscular disorders. Speakers—Dr. Jessica Nance, nurse practitioner Maria Belellios, and pharmacy coordinator Danielle Pennock—outlined the institution’s clinical‑trial legacy,...
Rare Disease Day 2026 | From Odyssey to Innovation, A Rare Journey to N of 1 Trial
Rare Disease Day 2026 highlighted a deeply personal yet broadly instructive case: the journey of Heidi, a patient with adult polyglucosan body disease (APBD), from a prolonged diagnostic odyssey to the launch of an N‑of‑1 clinical trial. The session brought...
Neuroimaging of Lyme Disease | Cherie Marvel, Ph.D.
Dr. Cherie Marvel, an associate professor at Johns Hopkins, presented her latest neuroimaging work on Lyme disease, emphasizing brain‑based changes and emerging blood‑marker data. The talk linked her expertise in cognitive neuroscience, functional MRI, and brain stimulation to the understudied...
Neurophysiological Markers of Elevated Inflammation and Cognitive Impairment in People with HIV
Dr. Tony Wilson presented his laboratory’s work on neurophysiological markers linking inflammation to cognitive impairment in people living with HIV. Leveraging a multimodal imaging platform—MRI, PET, and especially magnetoencephalography (MEG)—his team investigates how viral‑driven immune activation reshapes brain dynamics across...
Childhood and Adolescent Obesity | Q&A
The video introduces the Fit and Healthy Kids Clinic at Kennedy Creger Institute, a multidisciplinary service designed for children and young adults—ages two to twenty‑six—who have a BMI above the 95th percentile or are experiencing rapid weight gain, especially those...
Informatics Grand Rounds with Dr. Cindy Cai
Johns Hopkins’ Grand Rounds featured Dr. Cindy Cai, an ophthalmologist‑researcher who uses biomedical informatics to tackle diabetic retinopathy, a leading cause of vision loss in working‑age adults. She outlined how gaps in routine eye‑care—often driven by social determinants of health...
A High-Resolution Atlas of the Developing Human Brain
The video introduces a high‑resolution atlas that charts how neurons are generated in the human cortex, leveraging single‑cell transcriptomics to capture roughly 30,000 molecular measurements from each of millions of cells. Researchers highlight that this scale of data—unprecedented in neurobiology—allows them...
Ep 10. Sleep: The Other Vital Sign | Medicine Made General
In this episode of Medicine Made General, Johns Hopkins neurologist Dr. Charlene Gamaldo frames sleep as the "other vital sign," arguing that without adequate rest the body’s systems operate like a car missing its steering wheel—functional but dangerously misdirected. She...
Belina Yi, D.O. | Pediatric Rheumatologist
The video introduces Dr. Bellina Yi, a pediatric rheumatologist at Johns Hopkins Children’s Center, who treats children with autoimmune and autoinflammatory diseases. She emphasizes that, unlike common perception, arthritis and systemic conditions can affect patients from infancy through adolescence. Dr. Yi...
Bone Health of Women with CF Across the Age Spectrum
At the 2025 North American Cystic Fibrosis Conference, pediatric endocrinologist Melinda Woo presented findings on bone health among women with cystic fibrosis, emphasizing how contraceptive choices may influence osteoporosis risk. The study, part of the CASE for CF project, surveyed...
Recurrent Brain Tumor | Elena's Story
Elena, a patient at Johns Hopkins Kimmel Cancer Center, was diagnosed with a rare brain cancer and achieved remission after initial treatment. Years later, her tumor recurred, prompting physicians to administer a novel drug. The medication stems from a 2008...
EphB2-Ephrin-B1 Signaling in Microglia and Implications for NeuroHIV
The seminar presented Dr. Marcus Call’s recent work on EphB2‑ephrin‑B1 signaling in microglia and its relevance to neuroHIV. While antiretroviral therapy has reduced systemic viral loads, roughly half of people living with HIV still develop neurocognitive impairment, ranging from asymptomatic...
Johns Hopkins Psychiatry Grand Rounds | Preteen Suicide Assessment
Johns Hopkins psychiatrists present a five‑year NIMH‑funded study developing a reliable, developmentally appropriate assessment for suicidal thoughts and behaviors in children ages eight to twelve. The initiative grew from a 2021 NIMH call to address the emerging public‑health crisis of...
Johns Hopkins Psychiatry Grand Rounds | Mild Behavioral Impairment (MBI)
The Grand Rounds presentation introduced Mild Behavioral Impairment (MBI) as a framework for understanding neuropsychiatric symptoms that emerge before overt dementia, using a 72‑year‑old patient with late‑onset depression and subsequent Alzheimer’s pathology as a case study. The speaker highlighted that...
Two Heart Transplant | Chandra's Story
The video follows Chandra’s journey through two heart transplants, detailing how the first graft failed shortly after surgery and a second donor heart ultimately saved her life. It highlights the emotional and medical challenges she faced, from prolonged hospitalization to...
Adaptive Rock Climbing in Rehabilitation
Movement Timmonium hosted its second adaptive wall‑climbing event, showcasing how climbing can be modified for individuals recovering from traumatic injuries or living with disabilities. The organizers highlighted a range of adaptations—custom harnesses, tactile route markers, and specialized coaching techniques—that transform a...
Living Donor Evaluation Process
The video outlines Johns Hopkins Hospital’s step‑by‑step living liver donor evaluation, guiding prospective donors through registration, testing, review, and pre‑operative phases. Candidates must first register online, confirming age (18+), absence of cancer, infections, substance use, and a solid support network. An...
Dr. Yannis Paulus | Medical and Surgical Retina
Dr. Yannis Paulus, the Jonas Freedom Professor of Ophthalmology and Biomedical Engineering at Johns Hopkins, heads a multidisciplinary retina program that treats macular degeneration, diabetic retinopathy, retinal vein and artery occlusions, and other sight‑threatening conditions. He emphasizes a family‑like,...
Intestinal Bowel Ultrasound (IUS) | Q&A
The video introduces intestinal bowel ultrasound (IUS) as a bedside, non‑invasive imaging modality designed to evaluate the small and large intestines in patients with inflammatory bowel disease (IBD). Using a handheld transducer, high‑frequency sound waves generate real‑time images that can identify...
Johns Hopkins Medicine Cost Estimate Tool
Johns Hopkins Medicine launched an online cost estimate tool that lets patients preview the price of medical procedures before receiving care. The platform pulls data from the health system’s billing database and adjusts figures based on a user’s insurance information....
TIMS 2026 | Johns Hopkins Medicine
The video introduces TIMS – a Technology‑Enabled Interview Management System pioneered at Johns Hopkins Medicine by ICU chaplain Elizabeth Tracy during the COVID‑19 surge. Faced with patients isolated behind ventilators, Tracy designed a brief, four‑question interview to capture each person’s...
Millions of Oligodendrocytes Mapped in the Mouse Brain over Its Lifespan
Johns Hopkins researchers combined 3D light‑sheet microscopy, specialized optics and AI‑driven image analysis to chart more than 10 million oligodendrocytes across the mouse brain throughout its lifespan. The resulting atlas pinpoints myelin density at the level of individual circuits, revealing how...
Maie St. John, M.D., Ph.D., F.A.C.S. | Head and Neck Surgeon
Dr. Maie St. John, professor and director of otolaryngology‑head and neck surgery at Johns Hopkins, recounts how a childhood encounter with a facial tumor set her on a path to become a head‑neck cancer surgeon. She describes a recent case of...
Cognitive Speed Training and Dementia | The ACTIVE Study
The ACTIVE study examined whether a brief cognitive speed‑training regimen can lower the incidence of dementia among older adults. Using Medicare claims data, participants who completed an hour‑long exercise twice a week for six weeks showed a 25 % reduction in dementia...
Informatics Grand Rounds with Dr. Ahmed Hassoon
The talk introduced a sweeping vision for AI alignment in medicine, emphasizing that today’s health‑care ecosystem is rapidly filling with autonomous agents—clinical decision‑support bots, patient‑facing assistants, insurance claim processors, and emerging regulatory AIs. Dr. Hassoon framed this proliferation as an...
Nakul S. Talathi, M.D. | Pediatric Orthopaedic Surgeon
Dr. Nakul S. Talathi, also introduced as Nick Totti, is a pediatric orthopedic surgeon at Johns Hopkins Medicine, specializing in hip, spine, and trauma care for children, adolescents, and young adults. He stresses a listening‑first philosophy, collaborates closely with families to...
Your Reproductive Health in Your 20s & 30s: What to Know, What to Watch For
The video walks viewers through comprehensive reproductive‑health care for women in their twenties and thirties, emphasizing the annual OB‑GYN visit as a cornerstone of lifelong preventive medicine. It outlines what the exam entails—pelvic and breast exams, pap smears, HPV testing after...