Bryan Johnson

Bryan Johnson

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Entrepreneur/self-experimenter (Blueprint); shares biomarker-driven protocols and results.

Scrotal Sun Myths Debunked: UV Boosts Testosterone Generally
SocialApr 23, 2026

Scrotal Sun Myths Debunked: UV Boosts Testosterone Generally

Sorry to be the bearer of bad news but this is bullshit. The 1939 paper referenced is a study conducted on institutionalized men with documented depression, measuring a urinary testosterone byproduct, not serum levels, and without a control group. There...

By Bryan Johnson
AI Discovers Chromogranin A Shields Brains From Alzheimer’s
SocialApr 22, 2026

AI Discovers Chromogranin A Shields Brains From Alzheimer’s

20 to 30% of older adults have full blown Alzheimer's pathology in their brains (plaques, tangles etc.). But they never develop symptoms and nobody knew why. An AI just read thousands of human brains and named the reason: a protein...

By Bryan Johnson
What’s Actually in a Chick-Fil-A Sandwich?
VideoApr 22, 2026

What’s Actually in a Chick-Fil-A Sandwich?

The video scrutinizes the composition of Chick‑Fil‑A’s fried chicken sandwich, arguing that the chain’s “quality ingredients” claim masks a host of potentially harmful substances. It notes the chicken is deep‑fried in refined peanut oil, which at high temperatures generates aldehydes—known carcinogenic...

By Bryan Johnson
5‑MeO‑DMT Reveals Self‑Other Illusion in Brain
SocialApr 21, 2026

5‑MeO‑DMT Reveals Self‑Other Illusion in Brain

> Self and other is a toggle switch in the brain > 5-MeO-DMT flipped mine > 100% decoupling from self > 150% tightening with others > Others felt like me for four weeks > First-in-human data Makes you wonder if "me" and...

By Bryan Johnson
Most Food Is Toxic... So I Fixed It
VideoApr 21, 2026

Most Food Is Toxic... So I Fixed It

The video argues that the U.S. food system has become a toxic, ultra‑processed industry that hijacks human biology, and introduces Blueprint, a startup that builds a healthier alternative from the ground up. It points out that engineered combinations of fat, sugar,...

By Bryan Johnson
JRT: LSD-Derived Antidepressant Boosts Brain Spines without Hallucinations
SocialApr 20, 2026

JRT: LSD-Derived Antidepressant Boosts Brain Spines without Hallucinations

One dose: > 46% more dendritic spines in prefrontal cortex > 100x more potent than ketamine as an antidepressant What is it? LSD with a two atom swap. > no trip > no hallucinations > no schizophrenia signature It's called JRT. https://t.co/sozMqlJctc

By Bryan Johnson
Salt Harms Arteries via Immune‑driven Senescence, Not Direct Toxicity
SocialApr 20, 2026

Salt Harms Arteries via Immune‑driven Senescence, Not Direct Toxicity

Salt has been blamed as the culprit for damaging your arteries. A new mouse study puts salt-sensitive hypertension in context. Salt doesn't do it directly, it triggers your immune system to do it. 4 weeks on a high-salt diet (8% NaCl) cut...

By Bryan Johnson
Health Starts With a Simple Routine: Sleep, Exercise, Eat
SocialApr 19, 2026

Health Starts With a Simple Routine: Sleep, Exercise, Eat

Best things you can do for health. Decide: + when to sleep + when to exercise + what to eat Routine does the heavy lifting.

By Bryan Johnson
AI Obsession Derails Life, Sparks Tech Regret
SocialApr 19, 2026

AI Obsession Derails Life, Sparks Tech Regret

I got C-holed. Suffered sleep consequences. I busted my screens-off rule. Turned down socializing. Fell behind on work. Kate is now upset. AI is preposterous. As close to magic as I’ve experienced (except a seed becoming a tree and a zygote becoming a baby)....

By Bryan Johnson
Don't Let Cravings Design Their Own Rescue Plan
SocialApr 18, 2026

Don't Let Cravings Design Their Own Rescue Plan

I used to believe the person experiencing the craving should be the one deciding whether to act on it. That's kinda like letting a drowning person design the rescue plan.

By Bryan Johnson
Two Weeks Offline Boosts Mental Health, Reverses Decline
SocialApr 18, 2026

Two Weeks Offline Boosts Mental Health, Reverses Decline

Two weeks without mobile internet improved mental health more than antidepressants and reversed roughly 10 years of attentional decline. Screen time dropped 49% (314 to 161 min/day). https://t.co/9sU6ZFXDCr

By Bryan Johnson
Pregnancy's Neglect Sparks Women’s Self‑Experimentation for Empowerment
SocialApr 17, 2026

Pregnancy's Neglect Sparks Women’s Self‑Experimentation for Empowerment

Pregnancy is severely underappreciated in our society. Most women don't get the guidance they need from doctors. Self experimentation gives the power back.

By Bryan Johnson
Skipping Exercise Turns Mood and Self‑perception Sour
SocialApr 17, 2026

Skipping Exercise Turns Mood and Self‑perception Sour

I'm in a bad mood right now because I didn't get to exercise this morning. I had a bunch of stuff done to my face yesterday and had to take the day off. I become an entirely different person...

By Bryan Johnson
Sauna Benefits Require 31 Minutes to Trigger HSPs
SocialApr 16, 2026

Sauna Benefits Require 31 Minutes to Trigger HSPs

Most people might miss the biggest benefit of sauna You need to get really really hot… Your core body temperature needs to hit 102.4°F (39°C). For reference, a fever is anything above 100.4°F (38°C) So I swallowed a temperature monitoring pill. It goes through...

By Bryan Johnson
Bryan Johnson | Pulse