NMN Curbs Antibody Attacks, Eases Bleeding Disorder
NEW CLINICAL TRIAL RESULT: NMN suppresses harmful antibody-driven immune attacks to alleviate a common bleeding disorder. Authors suggest it may help other autoimmune diseases like lupus and rheumatoid arthritis 🙏🧵 https://t.co/eMvefTFxZo
Maternal Polyphenols Boost Fetal Brain Development in Rodents
New review: The effect of the mother's consumption of polyphenols (resveratrol, curcumin, quercetin, naringin, ferulic acid, genistein) on fetal neurodevelopment in rodents & improvements in brain development 🧠🧠🧠 https://t.co/xN2GISamzy https://t.co/bVFiIjoZem
Decoding Ovarian Aging to Extend Reproductive Lifespan
Ovarian aging: Mechanisms and strategies to extend reproductive lifespan Core mechanisms include genomic instability, epigenetic noise, mitochondria, inflammation, senescence & fibrosis PhD student Maria Lopez @sinclarfriends is working on it https://t.co/tuJbQb2Xcu https://t.co/K1GlXY4KsY
Depression Linked to Faster Brain Aging and Suicide Risk
Major Depressive Disorder (MDD) is associated with increased risk of suicide. New study of people ~40-50 finds associations between suicide & accelerated brain aging, suggesting altered "neural development, signaling & neurogenesis." https://t.co/Fjgx1yH690 https://t.co/ARKfWDTbin
Legacy Media Sensationalizes Cautious Science for Profit
Legacy media turns cautious scientific findings & statements into sensational headlines, then seeks out quotes from critics calling it hype It’s not journalism. It’s business https://t.co/l1qcyhYTMQ
Scientists, Not Regulators, Block Revolutionary Medicines
Finally, a show exposing the main obstacle to new medicines. Hint, it’s not the FDA: “Throughout history, society hasn’t always appreciated revolutionary scientific findings. For hundreds of years & still today, some of the biggest attackers are fellow scientists.” 🧑🔬🔥👩🔬 https://t.co/h2BpILNV4D
Epigenetic Clocks Predict Lung Cancer Risk Beyond Self‑reports
New paper: Epigenetic age clocks help predict lung cancer risk & mortality by estimating smoke exposure. Is independent of self-reported smoking history, so people probably lie about it. Clocks could help doctors predict lung cancer risk & decide on...
Get VZV Tested, Then Vaccinate for Shingles or Chickenpox
Ask your doctor for a Chicken Pox VZV test. If you're positive, the shingles vaccine is the next step. If you've never been exposed, you can get a chickenpox vaccine, which is safe for adults, too
MIB‑626 NMN Shows Lifespan Boost and New Mechanism
1. No living forever 🙈 2. Some MIB-626 (crystaline polymorph, pure NMN) human clinical trial results are in 😀 3. About to resubmit a revised mouse MIB-626 paper with Alice Kane, showing improved health measures + lifespan & a putative new mechanism...
Shingles Vaccine Boosts Longevity for Over‑50s
Done. Herpes virus neutralized 🦠 Not taking any chances with my longevity, now that shingles is associated with faster aging (though not yet a known cause). If you’re 50+, consider it. The shot will likely be money- & pain-free I even...
Oral Health May Influence Alzheimer’s Risk—Floss Daily
Would be shocking if bacteria that cause gum disease also contribute to Alzheimer’s. Either way, to reduce overall inflammation, maintain oral heath by: 1. Flossing daily 2. Using an electric toothbrush 3. Seeing a dentist >2x a year 4. Chewing oral probiotics 🦷🧠💪
GLP‑1s Spark Massive Consumer Biotech Revolution
GLP-1s have paved the way for massive consumer biotech Discussed in Lifespan and still rolling out as predicted
Heat Therapy Mimics Exercise Through Shear Stress and Genes
Best review yet: We have identified plausible ways heat therapy works, such as shear stress and heat-sensitive genes “We find heat therapy to be analogous to exercise in many respects” 💪 https://t.co/RAFMTK8j3S https://t.co/iTVyZZuFZc
Nesprin‑2 Protein Blocks Heart Cancer, May Aid Other Tumors
Wondered why we don’t hear about heart cancer? Contraction-sensing Nesprin-2 protein is discovered to prevent heart cancer By causing cells to pulse (or adding in Nespirin) we might be able to treat cancer in other organs 👏 @ScienceMagazine https://t.co/A8fOuw31N2
Wearables Create Lifelong Health Baselines for Future Goals
Wearables aren’t just for tracking you in real time They’re building your personal baseline The numbers you see today become the targets you’ll aim to return to decades from now https://t.co/S44Yk812Gp
ER-100 Cleared for Trials; Safety Promising, Translation Uncertain
So far, the data suggest ER-100 should be safe in humans, and the FDA has cleared us to move into clinical trials. Translation from primates to humans is never guaranteed If it doesn’t work as hoped, we’ll learn & improve, just...
OSK Reprogramming Restores Adult Heart Regeneration
NEW STUDY: OSK rewinds the clock and pushes adult heart cells into a regenerative state that improves heart repair Why is this such a big deal? Because adult heart cells do not meaningfully divide, which is why the heart heals with scar...
Scientists Save Billions; CRISPR Cures Sickle Cell
You live in luxury. Without scientists, 6 billion of us would not be alive & the rest would live in hell. Remember that Great choices @brkthroughprize 🏆 Congrats to my colleague @Harvard, Stu Orkin, who won the prize for helping cure...
Top Scientist Warns US Dismantling Biomedical Infrastructure
Breakthrough Prize winner Dr. Stu Orkin: We were in a golden age of biomedical science. Universities were operating at high efficiency and speed. They’re disassembling [US] scientific infrastructure. I’m at a total loss to explain why people in leadership would...
Breakthroughs Now Cost Jeans, Not Billions
What once took $2B and an army of scientists was just done in a kitchen for the price of a pair of jeans Most people have no idea how fast science is moving
Future Medicine Targets Aging, Not Just Symptoms
The future of medicine is treating causes, not symptoms. Aging is the main cause of disease
Two Nutritious Meals a Day Suffice for Desk Workers
For people with a desk job, which is 80% of us, two nutritious meals a day usually provide all the calories we need. If you overdo it one day, the next day eat less
NAD+ Rhythms Drive Sleep, Aging; Resetting Delays Decline
NEW PAPER: Ups & downs in NAD+ over 24 h dictates our body's clock & sleep but declines with age. Disrupting the cycle promotes mouse aging & restoring it improves fitness & metabolic function, pointing to "circadian reprogramming" as a...
Stop People‑Pleasing: Upgrade Your Life, Family, Career
If you’re a people pleaser, outgrowing it will be the biggest upgrade you will make to your life, family and career Trust me on this 🚀
Partnering with Epigen
Dr. @M_S_Ringel is a knowledge fountain. COO of @lifebiosciences & a world's expert in epigenetic rejuvenation. Formerly Senior Partner @BCG for 20 years, it's a thrill to be working with him on the trials
Prof. Sinclair’s Aging Research Redefines My Perspective
I get the best emails: Dear Professor Sinclair, I came across your work on aging [and how it might] be modulated or restored. I was perfectly happy with my old way of thinking about aging until you showed up. Thanks for that. Hannah
Reversing Aging Could Halt Chronic Disease Progression
Aging is the primary driver of most chronic diseases. But what if aspects of aging can be reversed? I join @TomBilyeu on Impact Theory to discuss the latest about what we’re learning in the lab and in human clinical trials Full conversation:...
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
Hygiene Breakthroughs Face Ridicule Before Saving Lives
Soap & disinfectants have saved more lives than any therapy Mother deaths before Semmelweis: ~10–15% After Semmelweis (1847):~1–2% Doctors laughed at him. He went to asylum & died from a beating Breakthroughs are ridiculed until they become part of everyday life
DNA Circles in Cancers Show Accelerated Epigenetic Aging
30 years ago, we discovered circular DNA molecules 1. pinch off yeast chromosomes 2. multiply 3. sequester epigenetic regulators (eg sirtuins) 5. cause aging New review today @CellCellPress about DNA circles in human cancers - which are epigenetically older than normal cells https://t.co/VlkBWCFnPi
Barley Leaf–Derived Gut Microbes Boost Mouse Cognition, Slow Aging
Bizarre experiment, but OK... Middle-aged mice were given human fecal samples from young people taking barley leaf (BL), rich in dietary fiber, chlorophyll & polyphenols. Bifidobacterium in the mice rose, along with restored cognition & slower testicular aging 🧠🥜
Aging May Be a Software Issue, New Primate Study Shows
Cool new paper: Cellular aging biomarkers in primates - increasingly supportive of aging being a software problem But what kind of software? And can an update be reinstalled? 🧵 https://t.co/1CKLNtHwZ4
Heart Metrics Reveal Youthful Physiology and Peak Fitness
Left chart: my resting heart rate = 46 on Apr 12 60, top 5% A.I. says - High parasympathetic activity Efficient cardiac output Exceptionally strong pairing Your physiology seems “younger” than your chronological age
Calorie Cutting Lowers Epigenetic Age and Inflammaging Protein C3a
Caloric restriction (CR) slows aging in rodents. People who cut calories by 14% over 2 years had lower epigenetic ages of some tissues & inflammatory protein C3a, regardless of BMI. In mice, lowering C3a levels reduced inflammaging, especially in fat....
Safe Cell Reprogramming Restores Identity, Nature Reports
You're confused. Let me explain: My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed We tried innumerable combos to find the solution Story is @Nature...
NMN Reverses Ovarian Aging in Mice, Human Trials Needed
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓 https://t.co/oVeGUZSaQ0
Early Aging Jargon Now Mainstream After Decade-Long Obscurity
In the 2000s, our lab invented new terms, just so we could converse about the Information Theory of Aging: Epigenetic noise Epigenetic drift Exdifferentiation Redifferentiation The Observer… No one understood us. We couldn’t publish Crazy to see them being used widely now https://t.co/7bkYUrudfp
Epigenetic Clock Detects Aging and Cancer via Blood Test
This is the future: An epigenetic clock for the simultaneous assessment of biological aging and cancer from a simple, cheap blood test 👏 https://t.co/uzGoZWos9C
Aging Isn't Destiny—It's a Modifiable Biological Process
Most people treat aging as fate. Biology treats it as a process that can be changed
3D-Printed Scaffold + Vesicles Boost Bone Regeneration
Reprogramming of cells via a 3D printed scaffold and extracellular vesicles substantially enhances bone regeneration https://t.co/w6AyvguUjS https://t.co/R32ULM1Rzt
Fatty Acids Target and Eliminate Aging “Zombie” Cells
NEW STUDY finds certain fatty acids selectively kill senescent "zombie" cells. The molecules exploit a fundamental biophysical weakness in senescent cells, a totally new approach. Could we simply consume these moleculs to treat aging? ...🧵 https://t.co/EceCAfdlvz
Aging Intervention Possible—Now Prioritize Safety and Frequency
The question is no longer if we can intervene in aging. It’s how safely and how many times
Immune Training Against Senescent Cells Reduces Tumor Growth
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Resveratrol Alters Sperm Epigenetics, Boosts Offspring Metabolism
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications"...
Promoting OSKM Therapy with MYC Is Borderline Criminal
The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal
AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation
New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd
Genomic Instability and Epigenetic Reprogramming Drive Vascular Aging
DNA repair-driven epigenetic changes as a cause of disease is going mainstream. A general medical review on CVD says: Genomic instability & epigenetic reprogramming are the deep mechanisms of vascular aging. Intervention strategies are the most promising & complex interventions https://t.co/xbEytAnIUH
Preserving Human Knowledge and Biology for Future Longevity
At Lifespan, we care about you, your loved ones, and humanity. A special project is to record and safeguard human knowledge and biological information, so civilization and our biology can be restored if lost. @joinlifespan, and let's achieve longevity for...
Cures Emerge From Incremental Advances, Not Single Breakthroughs
The media makes it seem like cures are one breakthrough away. In reality, cures come from smaller breakthroughs and improvements made by the work of thousands of scientists, drug developers and doctors. We’re witnessing this evolution in real time with...
Seeing Biological Age Data Drives Real Health Improvements
Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...