DNA Circles in Cancers Show Accelerated Epigenetic Aging
30 years ago, we discovered circular DNA molecules 1. pinch off yeast chromosomes 2. multiply 3. sequester epigenetic regulators (eg sirtuins) 5. cause aging New review today @CellCellPress about DNA circles in human cancers - which are epigenetically older than normal cells https://t.co/VlkBWCFnPi
Barley Leaf–Derived Gut Microbes Boost Mouse Cognition, Slow Aging
Bizarre experiment, but OK... Middle-aged mice were given human fecal samples from young people taking barley leaf (BL), rich in dietary fiber, chlorophyll & polyphenols. Bifidobacterium in the mice rose, along with restored cognition & slower testicular aging 🧠🥜
Aging May Be a Software Issue, New Primate Study Shows
Cool new paper: Cellular aging biomarkers in primates - increasingly supportive of aging being a software problem But what kind of software? And can an update be reinstalled? 🧵 https://t.co/1CKLNtHwZ4
Heart Metrics Reveal Youthful Physiology and Peak Fitness
Left chart: my resting heart rate = 46 on Apr 12 60, top 5% A.I. says - High parasympathetic activity Efficient cardiac output Exceptionally strong pairing Your physiology seems “younger” than your chronological age
Calorie Cutting Lowers Epigenetic Age and Inflammaging Protein C3a
Caloric restriction (CR) slows aging in rodents. People who cut calories by 14% over 2 years had lower epigenetic ages of some tissues & inflammatory protein C3a, regardless of BMI. In mice, lowering C3a levels reduced inflammaging, especially in fat....
Safe Cell Reprogramming Restores Identity, Nature Reports
You're confused. Let me explain: My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed We tried innumerable combos to find the solution Story is @Nature...
NMN Reverses Ovarian Aging in Mice, Human Trials Needed
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓 https://t.co/oVeGUZSaQ0
Early Aging Jargon Now Mainstream After Decade-Long Obscurity
In the 2000s, our lab invented new terms, just so we could converse about the Information Theory of Aging: Epigenetic noise Epigenetic drift Exdifferentiation Redifferentiation The Observer… No one understood us. We couldn’t publish Crazy to see them being used widely now https://t.co/7bkYUrudfp
Epigenetic Clock Detects Aging and Cancer via Blood Test
This is the future: An epigenetic clock for the simultaneous assessment of biological aging and cancer from a simple, cheap blood test 👏 https://t.co/uzGoZWos9C
Aging Isn't Destiny—It's a Modifiable Biological Process
Most people treat aging as fate. Biology treats it as a process that can be changed
3D-Printed Scaffold + Vesicles Boost Bone Regeneration
Reprogramming of cells via a 3D printed scaffold and extracellular vesicles substantially enhances bone regeneration https://t.co/w6AyvguUjS https://t.co/R32ULM1Rzt
Fatty Acids Target and Eliminate Aging “Zombie” Cells
NEW STUDY finds certain fatty acids selectively kill senescent "zombie" cells. The molecules exploit a fundamental biophysical weakness in senescent cells, a totally new approach. Could we simply consume these moleculs to treat aging? ...🧵 https://t.co/EceCAfdlvz
Aging Intervention Possible—Now Prioritize Safety and Frequency
The question is no longer if we can intervene in aging. It’s how safely and how many times
Immune Training Against Senescent Cells Reduces Tumor Growth
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Resveratrol Alters Sperm Epigenetics, Boosts Offspring Metabolism
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications"...
Promoting OSKM Therapy with MYC Is Borderline Criminal
The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal
AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation
New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd
Genomic Instability and Epigenetic Reprogramming Drive Vascular Aging
DNA repair-driven epigenetic changes as a cause of disease is going mainstream. A general medical review on CVD says: Genomic instability & epigenetic reprogramming are the deep mechanisms of vascular aging. Intervention strategies are the most promising & complex interventions https://t.co/xbEytAnIUH
Preserving Human Knowledge and Biology for Future Longevity
At Lifespan, we care about you, your loved ones, and humanity. A special project is to record and safeguard human knowledge and biological information, so civilization and our biology can be restored if lost. @joinlifespan, and let's achieve longevity for...
Cures Emerge From Incremental Advances, Not Single Breakthroughs
The media makes it seem like cures are one breakthrough away. In reality, cures come from smaller breakthroughs and improvements made by the work of thousands of scientists, drug developers and doctors. We’re witnessing this evolution in real time with...
Seeing Biological Age Data Drives Real Health Improvements
Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...
Scientists Caution: Only Nerve Cells, Not Whole Mice, Age-Reversed
This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone...
Age Is Dynamic, Not Fixed—A Century‑Defining Insight
Age is not fixed. It’s dynamic. This is one of the most remarkable discoveries of the century
Reprogramming Caps at ~75% Epigenetic Age Reversal
🤣 That’s why we make sure the reprogramming technologies we develop can’t take cells back in epigenetic age more than ~75%
Calorie Restriction Slows Human Biological Aging 2‑3% in Two Years
In humans, calorie restriction slows biological aging pace by ~2–3% over 2 years (CALERIE trial) https://t.co/Eg8wBzhDpQ
Bridging the Gap: Evidence-Based Health for All
Exactly why I started https://t.co/eHRde0kDRf - so everyone, including uncles & grandparents, can get evidence-based knowledge Too many people are not getting the latest health information or completely wrong information from social and legacy media
Breakthroughs Require Aligned People, Tech, and Mission
Most breakthroughs like age reversal don’t happen in isolation. They happen when the right people, technology & mission align. That’s why I’m building Lifespan Follow the science. Join the community. Shape the future
I Still Take Low-Dose Aspirin Despite Guidelines
Another reason I take a coated baby 81 mg aspirin a day, even though it’s no longer generally recommended
13-Year Study Becomes One of Cell’s Longest Papers
This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself https://t.co/Ra0CX1i5zt https://t.co/LbGXx2u4cq
Changing Biological Age Unlocks Future Lifespan Gains
A new paper says lifespan gains will be small due to our biology That’s true - if we don’t change. But if we can change our biological age, the equation changes In 1700, we couldn’t imagine moving faster than a horse. Biology...
BCG Veteran Michael Ringel Becomes Life Biosciences COO
Michael Ringel spent 25+ years as a senior partner at Boston Consulting Group, helping build some of the world’s most successful countries and organizations. Now he’s COO @lifebiosciences How cool is that? https://t.co/idQMHyhSde
Undergrads: Summer Positions Available with Credit or Funding
Undergrads: If you would like to join us over the summer and can get course credits or funding (a requirement of dept) read this👇 https://t.co/wu3fyW7CUd
Aging Meets Disease Criteria: Measurable, Pathological, Treatable
Apparently aging isn’t a disease because it’s “natural,” therefore it should be managed, not treated I disagree. Aging has causes, biomarkers, clear pathology, and is modifiable If something can be measured & treated, it should be considered a disease https://t.co/a2a2cNdobC
P7C3 Boosts NAD Enzyme, Improves Mouse Alzheimer Model
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏
Missing Violet Light Accelerates Age‑Related Vision Loss
Eye fact 👀: ~80% of people over 45 have reduced focusing ability & according to Japan’s Dr. K. Tsubota, the lack of violet light hitting our retinas, in part due to doctor’s recommendations to avoid sunlight, is a major cause...
Scientists' Risk Fuels Life‑Saving Medicines, Not COI Fear
Scientists who stick their necks out and make medicines are my heroes There’s too much concern about COI for seasoned scientists with exemplary records Without commercial activity, we’d have zero medicines and ER-100 would still be in mice, not FDA cleared for...
Aging Is Information Loss in Self‑Organizing Biology
Strong work👏 This is less Watson and Crick, and more Turing and Wiener, where biological form and function emerge from information processing #Burr If biology is information processing, then aging can be understood as information loss #shannon
Sleep's Nightly Brain‑drain Discovered in 2013
Not a new fact. Since 2013, we've known about our nightly brain-drain during sleep, thanks largely to the pioneering work of Dr. Dr. Nedergaard and team https://t.co/VeG4PnMVzG
Believing in Yourself Beats 25 Years of Doubt
For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy Looking back, it was 100% worth it Here’s why you should believe in yourself… 🧵
SIRT1: Longevity Gene Proven to Suppress Cancer
Fun fact: in 2008, when we published that NAD-dependent SIRT1 suppresses cancer, almost no one believed us. How could a longevity gene suppress cancer? they asked https://t.co/aPAG3zf470
End Meetings Early for Stretch, Walk, Bathroom Breaks
Calendar apps should - by default - end meetings five minutes before the entered time to give us all a chance to stretch, walk around, and use the bathroom
Single‑cell Atlas Maps Brain Aging Epigenome Across 36 Cell Types
Exciting new work in @CellCellPress: a detailed single-cell multiomics atlas of 36 cell types during brain aging in mice. This level of resolution is what we need to track how and why the epigenome changes with age 🧵 https://t.co/w5eSYG8aIf
Aging Driven by DNA Instability and Mitochondrial Decline
So great to see the OG work that helped spark the longevity revolution taken to the next level: New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell Is this relevant to...
Nicotinamide Study on Amyloid Beta Retracted Over Editing Concerns
FYI - Retracted paper in the NAD field: Nicotinamide Ameliorates Amyloid Beta-Induced Neurodegeneration in Adult Mouse Brain. The editors lost confidence in the findings after "indications" of inappropriate editing & partial duplication https://t.co/WVJBCeKjQ4 https://t.co/lmUObhFxcK
Exercise Boosts BDNF, Enhancing Brain Plasticity
Exercise increases brain-derived neurotrophic factor, supporting brain plasticity. Trends in Neurosciences, 2002. Cotman and Berchtold https://t.co/jux3TwN0fS
Aging Mouse Brains Show Gradual Cellular Identity Drift
New study of mouse brain aging identifies a progressive drift in cellular identity, consistent with information theory (ITOA) https://t.co/OaB2p9GUgT
NAD⁺ Controls Aging Hallmarks, Offering Therapeutic Paths
NAD⁺ as a central hub regulating the hallmarks of aging: Mechanisms and therapeutic implications https://t.co/Mw45GF0QhL https://t.co/pvAGRxXQZv
Stevia Boosts Muscle Metabolism and Prevents Loss
If avoiding sugar, consider stevia. A stevia plant extract (from Pharmingen, Korea) improved muscle metabolism, mitochondrial function, and attenuated muscle loss in obese mice while activating SIRT1. Non-ultraprocessed stevia resembles matcha powder 🍵 https://t.co/tWvBmZzk2g
Geroscience Hypothesis Now as Outdated as Flat Earth
The once bold idea that treating aging will treat chronic diseases (which some refer to as the Geroscience Hypothesis) is about as innovative today as the round Earth hypothesis
Syringic Acid Shields Rodents From Neurotoxicity and Inflammation
Syringic acid is a naturally occurring molecule in grapes, olives, pumpkins & herbs with antiinflammatory, anti-microbial & anticancer properties. New study finds it prevents rodent neurotoxicity & inflammation. Not yet sold widely but will be I expect https://t.co/3XtSesFb9I https://t.co/C3RqjvK6NY