Scientists Caution: Only Nerve Cells, Not Whole Mice, Age-Reversed
This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone supposed to know what’s real? https://t.co/mbog1IL1TN
Age Is Dynamic, Not Fixed—A Century‑Defining Insight
Age is not fixed. It’s dynamic. This is one of the most remarkable discoveries of the century
Reprogramming Caps at ~75% Epigenetic Age Reversal
🤣 That’s why we make sure the reprogramming technologies we develop can’t take cells back in epigenetic age more than ~75%
Calorie Restriction Slows Human Biological Aging 2‑3% in Two Years
In humans, calorie restriction slows biological aging pace by ~2–3% over 2 years (CALERIE trial) https://t.co/Eg8wBzhDpQ
Bridging the Gap: Evidence-Based Health for All
Exactly why I started https://t.co/eHRde0kDRf - so everyone, including uncles & grandparents, can get evidence-based knowledge Too many people are not getting the latest health information or completely wrong information from social and legacy media
Breakthroughs Require Aligned People, Tech, and Mission
Most breakthroughs like age reversal don’t happen in isolation. They happen when the right people, technology & mission align. That’s why I’m building Lifespan Follow the science. Join the community. Shape the future
I Still Take Low-Dose Aspirin Despite Guidelines
Another reason I take a coated baby 81 mg aspirin a day, even though it’s no longer generally recommended
13-Year Study Becomes One of Cell’s Longest Papers
This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself https://t.co/Ra0CX1i5zt https://t.co/LbGXx2u4cq
Changing Biological Age Unlocks Future Lifespan Gains
A new paper says lifespan gains will be small due to our biology That’s true - if we don’t change. But if we can change our biological age, the equation changes In 1700, we couldn’t imagine moving faster than a horse. Biology...
BCG Veteran Michael Ringel Becomes Life Biosciences COO
Michael Ringel spent 25+ years as a senior partner at Boston Consulting Group, helping build some of the world’s most successful countries and organizations. Now he’s COO @lifebiosciences How cool is that? https://t.co/idQMHyhSde
Undergrads: Summer Positions Available with Credit or Funding
Undergrads: If you would like to join us over the summer and can get course credits or funding (a requirement of dept) read this👇 https://t.co/wu3fyW7CUd
Aging Meets Disease Criteria: Measurable, Pathological, Treatable
Apparently aging isn’t a disease because it’s “natural,” therefore it should be managed, not treated I disagree. Aging has causes, biomarkers, clear pathology, and is modifiable If something can be measured & treated, it should be considered a disease https://t.co/a2a2cNdobC
P7C3 Boosts NAD Enzyme, Improves Mouse Alzheimer Model
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏
Missing Violet Light Accelerates Age‑Related Vision Loss
Eye fact 👀: ~80% of people over 45 have reduced focusing ability & according to Japan’s Dr. K. Tsubota, the lack of violet light hitting our retinas, in part due to doctor’s recommendations to avoid sunlight, is a major cause...
Scientists' Risk Fuels Life‑Saving Medicines, Not COI Fear
Scientists who stick their necks out and make medicines are my heroes There’s too much concern about COI for seasoned scientists with exemplary records Without commercial activity, we’d have zero medicines and ER-100 would still be in mice, not FDA cleared for...
Aging Is Information Loss in Self‑Organizing Biology
Strong work👏 This is less Watson and Crick, and more Turing and Wiener, where biological form and function emerge from information processing #Burr If biology is information processing, then aging can be understood as information loss #shannon
Sleep's Nightly Brain‑drain Discovered in 2013
Not a new fact. Since 2013, we've known about our nightly brain-drain during sleep, thanks largely to the pioneering work of Dr. Dr. Nedergaard and team https://t.co/VeG4PnMVzG
Believing in Yourself Beats 25 Years of Doubt
For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy Looking back, it was 100% worth it Here’s why you should believe in yourself… 🧵
SIRT1: Longevity Gene Proven to Suppress Cancer
Fun fact: in 2008, when we published that NAD-dependent SIRT1 suppresses cancer, almost no one believed us. How could a longevity gene suppress cancer? they asked https://t.co/aPAG3zf470
End Meetings Early for Stretch, Walk, Bathroom Breaks
Calendar apps should - by default - end meetings five minutes before the entered time to give us all a chance to stretch, walk around, and use the bathroom
Single‑cell Atlas Maps Brain Aging Epigenome Across 36 Cell Types
Exciting new work in @CellCellPress: a detailed single-cell multiomics atlas of 36 cell types during brain aging in mice. This level of resolution is what we need to track how and why the epigenome changes with age 🧵 https://t.co/w5eSYG8aIf
Aging Driven by DNA Instability and Mitochondrial Decline
So great to see the OG work that helped spark the longevity revolution taken to the next level: New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell Is this relevant to...
Nicotinamide Study on Amyloid Beta Retracted Over Editing Concerns
FYI - Retracted paper in the NAD field: Nicotinamide Ameliorates Amyloid Beta-Induced Neurodegeneration in Adult Mouse Brain. The editors lost confidence in the findings after "indications" of inappropriate editing & partial duplication https://t.co/WVJBCeKjQ4 https://t.co/lmUObhFxcK
Exercise Boosts BDNF, Enhancing Brain Plasticity
Exercise increases brain-derived neurotrophic factor, supporting brain plasticity. Trends in Neurosciences, 2002. Cotman and Berchtold https://t.co/jux3TwN0fS
Aging Mouse Brains Show Gradual Cellular Identity Drift
New study of mouse brain aging identifies a progressive drift in cellular identity, consistent with information theory (ITOA) https://t.co/OaB2p9GUgT
NAD⁺ Controls Aging Hallmarks, Offering Therapeutic Paths
NAD⁺ as a central hub regulating the hallmarks of aging: Mechanisms and therapeutic implications https://t.co/Mw45GF0QhL https://t.co/pvAGRxXQZv
Stevia Boosts Muscle Metabolism and Prevents Loss
If avoiding sugar, consider stevia. A stevia plant extract (from Pharmingen, Korea) improved muscle metabolism, mitochondrial function, and attenuated muscle loss in obese mice while activating SIRT1. Non-ultraprocessed stevia resembles matcha powder 🍵 https://t.co/tWvBmZzk2g
Geroscience Hypothesis Now as Outdated as Flat Earth
The once bold idea that treating aging will treat chronic diseases (which some refer to as the Geroscience Hypothesis) is about as innovative today as the round Earth hypothesis
Syringic Acid Shields Rodents From Neurotoxicity and Inflammation
Syringic acid is a naturally occurring molecule in grapes, olives, pumpkins & herbs with antiinflammatory, anti-microbial & anticancer properties. New study finds it prevents rodent neurotoxicity & inflammation. Not yet sold widely but will be I expect https://t.co/3XtSesFb9I https://t.co/C3RqjvK6NY
Epigenetic Therapy Marks New Era in Glaucoma Treatment
Great to see ophthlamologists adopting epigenetic modifications and resets to treat eye diseases like glaucoma. A paradigm shift in medicine https://t.co/g2gr3WVpkf https://t.co/6gbBVHJuXI
New Team Targets Longevity Gap Amid Funding Shortfall
Longevity research is being starved of funds just when the US needs to be more competitive. Have assembled a team working on it. Launch date: April 2026 https://t.co/DOgprwaSzv
Biology's Slow Validation: AI May Accelerate Breakthroughs
In my experience, ideas that take seconds to conceive take years to confirm in the lab and 1–2 years to get published in a top journal. This is biology’s Achilles heel Let’s see if AI can fix that https://t.co/3On4DrTcU6
OSK Gene Combo Reverses Joint Damage via Epigenetics
Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵 https://t.co/AlOIwcEXEQ
Whale Protein Boosts DNA Repair, Slowing Aging
DNA breaks are a potent accelerator of epigenetic drift, which some researchers think drives aging. Great work by the Gorbunova lab 👏
UT San Antonio Awarded $38B ARPA-H Grant for Drug Trials
UT San Antonio has been given a $38biin ARPA-H grant to study the health benefit effects of three drugs in humans, namely, rapamycin, dapagliflozin and semaglutide …🧵 https://t.co/fAX14ngoyD
Resveratrol Eases Neuropathic Pain via Mitochondrial Restoration
Neuropathic pain affects 7-10% of all people globally. New 🐁 study finds resveratrol alleviates neuropathic pain associated with restoration of mitochondrial dynamics 👏 https://t.co/zJ8LvwZ9UP https://t.co/hdCK7UgqBj