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Artificial Sweeteners Trigger Multigenerational Gut and Gene Shifts

David Barzilai, MD PhD
David Barzilai, MD PhDApr 10, 2026

Artificial and natural non-nutritive sweeteners drive divergent gut and genetic responses across generations "Sucralose consumption affects glucose tolerance, the expression of liver Srebp1 and intestinal Tnf and Tlr4, fecal microbiota composition and SCFA concentrations, and these changes are transmitted across generations. The effects of stevia are mainly observed in the F1 generation." https://t.co/Bssy97z9uc

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