Chat's Download Fails After First Statistical Analysis Use
Is anyone using Chat to perform statistical analysis, and after asking for a downloadable file, which works the first time, it doesn't work for subsequent analyses? What LLMs are people using for statistical analysis?
Higher Albumin Levels Linked to Longer Lifespan
High albumin is associated with longevity Association between age and malnutrition in oldest-old and centenarian populations https://t.co/0denO96lEh
Healthy Diet Cuts Mortality Risk Among Chinese Elderly
Association between Dietary Patterns and All-Cause Mortality in the Chinese Old: Analysis of the Chinese Longitudinal Healthy Longevity Survey Cohort https://t.co/4FoNf4WnRt #mdpinutrients
Garlic Intake Linked to Lower Mortality in Chinese Elders
Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study https://t.co/Oda8CifdOX #mdpinutrients
Soluble Fiber Modestly Lowers Weight and Improves Glucose
Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials https://t.co/I18LeZHCIC
Higher Manganese Levels Linked to Poorer Sleep in US Adults
Manganese and Sleep Outcomes in United States Adults: Results from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) https://t.co/TTxn5pAXCe
Consistent Workouts May Preserve Fitness Better Than Constant Switching
In terms of slowing the age-related loss of fitness, I'd bet the same is true for those who standardize their workouts, when compared with those who "switch it up"
Risk-Weighted ApoB Outperforms LDL in CVD Prediction
LDL is only part of the equation. What's your Lp(a), VLDL, ApoB? Risk-weighted ApoB, which incorporates all of the above, is a better measure than LDL for predicting CVD risk: https://t.co/y5Hc9ZXIWG
Solitude Sparks Originality and Invention
The mind is sharper and acute in isolation and uninterrupted solitude. You don't need a big lab to think about. Originality thrives in isolation, free from external influences that beat us to paralyze the creative mind. To be alone, that's...
Rhizopus Microsporus Linked to COVID-19 Mucormycosis Case
Anyone have access to this paper? Rhizopus microsporus as Causative Agent of Mucormycosis in COVID-19 Patient https://t.co/Ao0uPXhzPY
Nanosecond Electric Pulses Rejuvenate Aging Endothelial Cells
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication https://t.co/DT8GXNLlxO
Bioelectric Reprogramming Repairs Birth Defects, Sparks Rejuvenation Hope
Fixing Birth Defects With Bioelectrical Reprogramming (Featuring Michael Levin, PhD) Aging and rejuvenation next? https://t.co/CHaRqozCph
Light Therapy Eases Fatigue in Hashimoto’s Patients
The effect of photobiomodulation therapy on fatigue and behavioural status in patients with Hashimoto’s thyroiditis https://t.co/AJx5dvqHyw
Spermidine Linked to Heritable Red Blood Cell Longevity Trait
The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity https://t.co/rHT8XoWHFz
Low Visceral Fat May Slow the Aging Process
Keeping Visceral Fat Low Is A Top-Tier Intervention For Potentially Slowing The Aging Rate Visceral adiposity, metabolic health and aging https://t.co/wyZSa83k4q
GDF15: AI‑derived Senescence Marker Predicts Mortality
Hopefully blood testing companies can measure GDF15 sooner than later... A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes https://t.co/lqM7w3aPfJ
Metabolomic Markers Reveal Secrets of Extreme Longevity
I spy a familiar name in the author list... Metabolomic signatures of extreme old age: findings from the New England Centenarian Study https://t.co/0p8oALZ4Kf
Microtubule Nexus Unites Amyloid and Tau in Alzheimer’s
The microtubule nexus linking amyloid beta and tau: A simple and unifying theory for the underlying cause of Alzheimer's disease https://t.co/dRJUJku6yu
LLMs Outperform Search, Yet Demand Critical Verification
Working with LLMs to figure out solutions to hard problems is an upgrade over traditional search engines, but man, (currently) time consuming, as they need to be continuously challenged to make sure it's not a hallucination I worry about people who...
Low‑caffeine Green Tea Boosts Seniors' Sleep by Reducing Stress
Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress https://t.co/kkkrKHlwv2
New Evidence Strengthens Ergothioneine’s Health Narrative
This adds to the building story for ergothioneine, which we covered in a deep dive (2h): https://t.co/VvaoPbC3eB
Top Epigenetic Clocks Predict All-Cause Mortality Risk
I'd still rather measure the actual biomarkers, but the best epigenetic clocks (PhenoAge, GrimAge, DunedinPACE) are consistently associated with all-cause mortality risk Another study was just published showing this: https://t.co/RZntDTn02c
DIY Agentic AI: Juggling LLMs for Biomarker Analysis
I'm not yet using Agentic AIs to assist with biomarker data interpretation, but juggling info from standard LLMs (Chat, Grok, Gemini, Perplexity, Claude), I become the Agentic AI Anyone else using a similar approach, and is there a better way? I'm open...
Daytime Napping Not Causally Linked to Brain Health
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank https://t.co/AQI9U7Mpri
Fermented Cordyceps Broth Improves Primary Insomnia in Trial
Effectiveness of fermentation broth of Cordyceps sinensis for primary insomnia: a randomized clinical trial with digital health tool https://t.co/g5iOuzkctO
SCFA Blood Levels Reveal Gut‑Brain Dysfunction in Depression
Circulating Short-Chain Fatty Acid (SCFA) Profiles as a Biomarker of Gut-Brain Axis Dysfunction: A Meta-Analysis for the SCFA Signature in Major Depression https://t.co/qwMAwaKR6d
Fecal pH May Predict Neurodegenerative Disease Risk
I've been saying this for the longest time, and including fecal pH in my grant applications, too I predict that we'll see a significant correlation for fecal pH with neurodegenerative diseases in future papers...
Multiple Drugs Fail to Extend UM-HET3 Mouse Lifespan
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice https://t.co/k0vERH4LSg
Senolytics May Harm Brain Myelin, Use Supplements Cautiously
It's studies like this why I treat supplements are a secondary, and last resort, not a primary approach Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum https://t.co/t3jMFTcKcL
Kynurenine Blocks Autophagy, Drives Stem Cell Aging via AhR
One reason why I'm tracking and attempting to optimize kynurenine levels Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway https://t.co/w1abVwROig
Track 2‑Hour Post‑Meal Glucose with Simple Finger‑Pricks
Even though the spike from oat milk could be true, see for yourself, test your own 2h glucose Not specifically for oat milk (which I don't drink), but I'm currently doing this after all meals CGM not needed, finger-prick is how I'm...
Senescent Cells Drive Inter‑organ Aging Signals
Communication breakdown: senescent cells in interorgan communication of aging: Trends in Endocrinology & Metabolism By the great @MattYousefzadeh https://t.co/PcavJgfq5z
Complement Proteins Predict Dementia Risk over a Decade
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY
Aged Amygdala Reacts to Refined Diets, Not Fat or Sugar
The aged amygdala’s unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis https://t.co/0eVLV5Kual
Coffee and Tea Linked to Reduced Neurodegenerative Disease Risk
Consumption of coffee and tea and the risk of developing neurodegenerative diseases: a cohort study in the UK biobank https://t.co/bv0q79xKni
Aging Linked to Naive CD8 T‑cell Shortage
Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging https://t.co/NSDiR30N6W
Herbal Terpenoids Boost Autophagy, Guard Against Aging
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging https://t.co/gtpKOmoxDS
B‑vitamins Lower Homocysteine, Slow Brain Atrophy in MCI
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial https://t.co/Xt9HqmmyGi
HGH May Harm Tendon‑Bone Healing Recovery
Human Growth Hormone May Be Detrimental When Used to Accelerate Recovery from Acute Tendon-Bone Interface Injuries https://t.co/L4EOFMKjys
Avoid AGEs: Steam Veg, Use Olive Oil for Longevity
AGE products shorten lifespan on a CR diet Ha, I wonder if @bryan_johnson watched my video on it 5y ago: https://t.co/h5FppnQpk9
Higher Dietary Fiber Linked to Stronger Bones
Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies https://t.co/Q3yGX1Xd8j
Sleep Quality Tied to Eating Timing and Duration
Indices of Sleep Health Are Associated With Timing and Duration of Eating in Young Adults - Journal of the Academy of Nutrition and Dietetics https://t.co/RztLzXUScr
Wrist Temperature Validated as Sleep Marker in Actigraphy
Wrist temperature as a sleep marker in actigraphy: Chronobiology International: Vol 43, No 2 https://t.co/HElT9CO7XS
Plasma Lactate: A Key Indicator of Metabolic Health
Plasma Lactate as a Marker for Metabolic Health : Exercise and Sport Sciences Reviews https://t.co/6IeA9Y9FGQ
Low Insulin Can Be Healthy—Check HbA1c and Liver
Insulin has an inverse U-shape during aging, so by itself low values may be optimal, but also indicative of B-cell failure Adding HbA1c provides more context. If it's low with low insulin this is potentially good news Also check liver enzymes, to...