Daytime Napping Not Causally Linked to Brain Health
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank https://t.co/AQI9U7Mpri
Fermented Cordyceps Broth Improves Primary Insomnia in Trial
Effectiveness of fermentation broth of Cordyceps sinensis for primary insomnia: a randomized clinical trial with digital health tool https://t.co/g5iOuzkctO
SCFA Blood Levels Reveal Gut‑Brain Dysfunction in Depression
Circulating Short-Chain Fatty Acid (SCFA) Profiles as a Biomarker of Gut-Brain Axis Dysfunction: A Meta-Analysis for the SCFA Signature in Major Depression https://t.co/qwMAwaKR6d
Fecal pH May Predict Neurodegenerative Disease Risk
I've been saying this for the longest time, and including fecal pH in my grant applications, too I predict that we'll see a significant correlation for fecal pH with neurodegenerative diseases in future papers...
Multiple Drugs Fail to Extend UM-HET3 Mouse Lifespan
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice https://t.co/k0vERH4LSg
Senolytics May Harm Brain Myelin, Use Supplements Cautiously
It's studies like this why I treat supplements are a secondary, and last resort, not a primary approach Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum https://t.co/t3jMFTcKcL
Kynurenine Blocks Autophagy, Drives Stem Cell Aging via AhR
One reason why I'm tracking and attempting to optimize kynurenine levels Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway https://t.co/w1abVwROig
Track 2‑Hour Post‑Meal Glucose with Simple Finger‑Pricks
Even though the spike from oat milk could be true, see for yourself, test your own 2h glucose Not specifically for oat milk (which I don't drink), but I'm currently doing this after all meals CGM not needed, finger-prick is how I'm...
Senescent Cells Drive Inter‑organ Aging Signals
Communication breakdown: senescent cells in interorgan communication of aging: Trends in Endocrinology & Metabolism By the great @MattYousefzadeh https://t.co/PcavJgfq5z
Complement Proteins Predict Dementia Risk over a Decade
Adding complement proteins to the blood testing schedule is in the arena Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years https://t.co/qDwmnbxHHY
Aged Amygdala Reacts to Refined Diets, Not Fat or Sugar
The aged amygdala’s unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis https://t.co/0eVLV5Kual
Coffee and Tea Linked to Reduced Neurodegenerative Disease Risk
Consumption of coffee and tea and the risk of developing neurodegenerative diseases: a cohort study in the UK biobank https://t.co/bv0q79xKni
Aging Linked to Naive CD8 T‑cell Shortage
Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging https://t.co/NSDiR30N6W
Herbal Terpenoids Boost Autophagy, Guard Against Aging
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging https://t.co/gtpKOmoxDS
B‑vitamins Lower Homocysteine, Slow Brain Atrophy in MCI
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial https://t.co/Xt9HqmmyGi
HGH May Harm Tendon‑Bone Healing Recovery
Human Growth Hormone May Be Detrimental When Used to Accelerate Recovery from Acute Tendon-Bone Interface Injuries https://t.co/L4EOFMKjys
Avoid AGEs: Steam Veg, Use Olive Oil for Longevity
AGE products shorten lifespan on a CR diet Ha, I wonder if @bryan_johnson watched my video on it 5y ago: https://t.co/h5FppnQpk9
Higher Dietary Fiber Linked to Stronger Bones
Association between dietary fiber intake and bone mineral density: a systematic review and meta-analysis of observational studies https://t.co/Q3yGX1Xd8j
Sleep Quality Tied to Eating Timing and Duration
Indices of Sleep Health Are Associated With Timing and Duration of Eating in Young Adults - Journal of the Academy of Nutrition and Dietetics https://t.co/RztLzXUScr
Wrist Temperature Validated as Sleep Marker in Actigraphy
Wrist temperature as a sleep marker in actigraphy: Chronobiology International: Vol 43, No 2 https://t.co/HElT9CO7XS
Plasma Lactate: A Key Indicator of Metabolic Health
Plasma Lactate as a Marker for Metabolic Health : Exercise and Sport Sciences Reviews https://t.co/6IeA9Y9FGQ
Low Insulin Can Be Healthy—Check HbA1c and Liver
Insulin has an inverse U-shape during aging, so by itself low values may be optimal, but also indicative of B-cell failure Adding HbA1c provides more context. If it's low with low insulin this is potentially good news Also check liver enzymes, to...