Unnatural Products

About Unnatural Products

Unnatural Products is a California-based biotech company focused on discovering and developing macrocyclic peptide therapeutics. Their approach centers on engineering synthetic macrocycles to target complex disease proteins that are difficult for traditional small molecules or biologics to address, leveraging an AI-enhanced (computational design) discovery workflow to design, synthesize, and screen cyclic peptide libraries. The company emphasizes nature-inspired macrocycles to bridge cell permeability and target engagement, aiming at hard-to-drug targets across human health. Located in Santa Cruz, they collaborate with researchers and drug developers to push frontier medicine.