Targeting Aging: New Strategies From Fedichev
How We Should Target Aging | Peter Fedichev Love what @EleanorSheekey is doing with @SheekeyScience. One of the sharpest geroscience #scicomm channels around, and @fedichev always brings the fire 🧪 https://t.co/bh6MVJJvRs https://t.co/1VTerakN9p
Potatoes Omitted From Healthy Plate Due to Sugar Risks
"The School’s Healthy Eating Plate does not include potatoes in its vegetable recommendations given their negative impact on blood sugar. Researchers at the School and elsewhere have found that diets high in potatoes and similarly rapidly digested, high-carbohydrate foods can...
Current and Future Strategies for Parkinson's Therapy
Parkinson disease therapy: current strategies and future research priorities https://t.co/5wq36T3ZQ4 Today is World Parkinson's Day 🧠https://t.co/XUVY6eSg61 Fig. 1: Pathophysiological mechanisms underlying Parkinson disease and possible disease-modifying therapies. 👇👨⚕️ https://t.co/0G7mqNA6nm
Poor Drug Selection Hampers Stroke Treatment Breakthroughs
1,026 experimental treatments in acute stroke (2006) "The results question whether the most efficacious drugs are being selected for stroke clinical trials. This may partially explain the slow progress in developing treatments..." https://t.co/WllAIz3Xul
Progerin Bridges Premature and Natural Aging, Biomarker Potential
Progerin expression in humans: implications for natural ageing "These insights may collectively position progerin as a mechanistic link between premature ageing and physiological ageing, positioning it as a potential component of biomarker strategies." https://t.co/KZuV0c7TOK
Stroke Research Stuck: Preclinical Successes Fail Clinically
Translational Block in Stroke: A Constructive and “Out-of-the-Box” Reappraisal 👉"The literature is saturated by >1000 effective preclinical studies in acute stroke research... yet almost none are successfully transferred to the acute clinical routine. This is the well-known translational failure or block...
IL6R Protects, IL6 Harms: Genetic Proof of Survival Impact
Causal effects of inflammation on long-term mortality: A mendelian randomization study 🔑"The IL6/IL6R axis has a causal impact on human survival through cardiovascular mechanisms: IL6R exerts a protective effect, whereas IL6 is detrimental." https://t.co/0TwQldDrQe
DNA's Quantum Nature Links Aging, Evolution to Cosmic Time
DNA as a quantum system in evolution ".... This framework connects cellular ageing and evolution to the flow of cosmic time and suggests experiments to probe DNA’s sensitivity to time‑dependent perturbations..." https://t.co/gKVEdE8ZBZ https://t.co/5A5qZeJ5Nq
Everyday Courage Shows Heroism Lives in Us
Acts of heroism remind us what people are capable of when it matters most. Life is full of challenges, but courage isn’t reserved for a few. 👨🏼🚀 👉 Every day, in small and quiet ways, we each get the chance to...
Redefine Longevity: Target True North Beyond Healthspan
Peakspan: The True North of Longevity and Why We Must Aim Beyond Healthspan 👉"We need a new metric. We need a concept that goes beyond simply keeping people out of the hospital..." https://t.co/a6JclqZrVC @biogerontology https://t.co/KPLdg5GveE
Extra 1,700–5,500 Steps Daily Cuts Chronic Disease Risk
Adding steps offsets risk of chronic disease: Study "Adding as little as 1,700 to 5,500 steps per day can offset the risk of a list of chronic diseases — including obesity, diabetes and sleep apnea — according to a new study...
Standardizing Rodent Exercise Protocols Boosts Metabolic Research
How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research 👉Molecular or pathway-level changes that are functionally important in a disease-relevant & physiology-relevant context. "Here, we outline key experimental considerations in rodents, including protocol design, exercise...
Sardinemaxxing: Nutrient‑Rich Canned Fish Trend Explained
What is “sardinemaxxing” and should you try it? These canned fish pack a nutritional punch, making them the latest food craze online. https://t.co/KHN7poPizf @Northeastern https://t.co/cfaYQE52ZI
Neuralink Threatens Agency, Turns Minds Into Marketable Data
Study analyses how Neuralink technology paves the way to psychopolitics 🤔I'm still excited by this technology, but I'm curious to hear what Elon Musk and others have to say. "The researchers have noted four clear risks arising from this technology. Firstly, loss of...
Artificial Sweeteners Trigger Multigenerational Gut and Gene Shifts
Artificial and natural non-nutritive sweeteners drive divergent gut and genetic responses across generations "Sucralose consumption affects glucose tolerance, the expression of liver Srebp1 and intestinal Tnf and Tlr4, fecal microbiota composition and SCFA concentrations, and these changes are transmitted across generations....
Regeneration Depends on Environment, Oxygen, and Epigenetics
Awakening latent regeneration in mammals “regeneration is not simply a fixed genetic trait but rather a state that is dependent on the extracellular environment, oxygen sensing, and epigenetics.” https://t.co/HtTXENUEur
Shingles Vaccine May Curb Inflammation, Aging, Dementia
From rash to resilience: how herpes zoster vaccination may influence inflammation, aging biology, and dementia risk https://t.co/hA0U1BlLp9
Menopause Market Booms; Doctors Warn Against Hype
Menopause products are having a hot minute. But doctors urge women to be wary of the marketing surge https://t.co/hUy7IghPF6 https://t.co/0cnzrlcdl5
Modest LLM Matches Specialized Aging Clocks Across Modalities
The End of Aging Clocks: Training Foundation Models to Reason in Aging and Longevity 🤔 “These results demonstrate that a single modestly sized LLM can match or replace purpose-built aging clocks across data modalities.” https://t.co/WkOvpxDBiU @biogerontology https://t.co/Knb0368KN4
Exercise Cuts Dementia Risk; Sitting and Irregular Sleep Raise It
The Relationships between physical activity, sedentary behaviour, sleep, and dementia: A systematic review and meta-analysis of cohort studies "Regular physical activity significantly reduced the risk of incident dementia (pooled RR = 0.75... Prolonged sedentary behaviour (8 + hours/day sitting) increased dementia risk (RR = 1.27)... both short (8 hours;...
Family's Funding Fuels Hope for New Dementia Therapies
Investing in hope A wealthy family fighting its own disease boosted research.. Can it spur new dementia treatments? 🗣️"Here was this beautiful family that really wanted to find a cure. And none of us scientists wanted to let them down." https://t.co/DBmpjpkxkl
Rising RBP4 Drives Inflammation and Age‑Related Disease
RBP4 in Ageing "During aging, an increase in the blood concentration of RBP4 is observed. This alteration has been associated with different effects in various organs, such as an increase in pro-inflammatory factors and an activation of macrophages toward the M1...
Schizophrenia Linked to Barrier Dysfunction and AhR Modulators
Schizophrenia as a Disorder of Biological Barriers: A Narrative Review and Potential Interventions https://t.co/IEkOVzShh6 @IJMS_MDPI "AhR ligands relevant to neuropathology. Microbial and synthetic phenazines, pollutants, lipid peroxidation derivatives, and nutrients are AhR modulators..."👇
Aging Biology Targets Key to Better Stroke Outcomes
Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration 🔎Addressing age-specific pathophysiology will be critical for improving outcomes in cerebrovascular diseases in the aging population... https://t.co/DuScTnSIh5 https://t.co/Irok29jqMx
SIRT6 Gene Therapy Remains Safe, Effective in Aged Beagles
Genflow sees sustained safety and efficacy in SIRT6 beagle trial 🐶 “Genflow Biosciences reported that three-month follow-up data from its SLAB trial in aged beagles show sustained safety and efficacy of its SIRT6 centenarian gene therapy, with no adverse events and...
Single Gene Therapy Dose Eradicates Brain Tumors in Mice
GENE THERAPY SAFELY ERADICATES BRAIN TUMOURS IN MICE A single dose of an innovative gene therapy could eliminate hard-to-treat brain tumours and prevent them from coming back, according to a pre-clinical trial in mice, reported in Nature. “More than 80 per cent...
2024 NIA‑AA Definition Connects Biomarkers Directly to Care
The 2024 NIA-AA biological definition of Alzheimer’s disease: linking biomarkers to clinical practice https://t.co/00cP1mXXHR https://t.co/VQ59YeIUR1
RFK Jr. Pushes to Overturn Peptide Ban, Officials Dispute Claims
RFK Jr. May Reverse a Peptide Ban He Calls “Illegal.” Former FDA Officials Say He Mischaracterized Their Work. https://t.co/glqreTHvKA https://t.co/Vi4OTryX3p
NRH Prevents Age‑related Hearing Loss via Sirt3‑mediated Ferroptosis Suppression
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation https://t.co/MOqQblWYNM https://t.co/uhSMXRIxDK
Lithium Reverses ApoE4 Cellular Deficits, Merits AD Trials
https://t.co/r6JzHA1RxM with ApoE4/E4 from a sporadic Alzheimer's disease patient "Given the drug's demonstrated efficacy in reversing ApoE4-driven cellular vulnerabilities, lithium salt warrants further investigation for the treatment of AD." https://t.co/r6JzHA1RxM https://t.co/v2lE0XhN7n
Molecular Evolution Explains Animal Aging Diversity
Molecular evolution of animal aging 🗣️"...As a step toward this goal, this field perspective outlines general biological mechanisms that help explain the variability in aging patterns and longevity across the animal kingdom..." https://t.co/mHVAlyQbfM https://t.co/NoronuZDaL
Targeting Liver ApoE Boosts Bone Healing in the Elderly
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing "Our work here identifies novel liver-to-bone cross-talk and a noninvasive, translatable therapeutic intervention for aged bone regeneration" https://t.co/KSzvkKOzZt https://t.co/1p0cXQlalT
Conjugated PUFAs Target Senescent Cells
Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells “ Conjugated PUFAs α-ESA and its methyl ester selectively eliminate diverse senescent cells… These lipid senolytics reduce tissue senescence and extend health span in aged mice” 👉 Lipid peroxidation underlies selective vulnerability...
Hair‑Loss Pill Redefines Masculinity and Aging
The Hair-Loss Drug Rewriting the Rules of Masculinity A pill to cure baldness is changing the way men age — and how they see themselves. https://t.co/4OiLpmOwGR https://t.co/YQLBx61gVT
First Human Trial Tests Cellular Age Reversal Therapy
This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs. 💡"Technologies to refresh ageing tissue...
AI Chatbots Warned of Nonexistent Disease From Fake Papers
Scientists invented a fake disease. AI told people it was real Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness? | @stokel https://t.co/qXWOPAhRaK https://t.co/8QoMiAfzBW
Top Experts Discuss Cutting‑Edge Longevity Strategies Live
Fund Longevity Live Stream Wednesday, April 8 11:00 AM - 12:00 PM EDT 🔗 https://t.co/gNCkMYxhfI @aubreydegrey — Combination therapy @LidskyPeter — New theory of aging Alexander Panchin — Gene therapy & science communication @longevion — Crypto & funding @cordeiro — Global longevity movement @ILAISRLA ...
Accelerating Early-Onset Cancer Cause Research for Prevention
Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers 🌟This roadmap aims to stimulate advances to accelerate cancer etiology research and prevention in the era of rising early-onset cancers. https://t.co/d0z6EHDpTh https://t.co/H6I76e4tFB
Oxytocin Reverses Isolation‑induced Neuropsychiatric Deficits via Brain, Immune, Microbiome
Oxytocin attenuates isolation-evoked emotional and social behavioral dysregulation through neural, immune, and microbiota mechanisms "Our study confirms the therapeutic effects of OXT in reversing isolation-induced neuropsychiatric disorders and elucidates its potential regulatory mechanisms, offering important implications for clinical interventions." https://t.co/hXkWRD1gMV
Exercise Cuts Visceral Fat, Boosts Insulin Sensitivity in NIDDM
Mobilization of Visceral Adipose Tissue Related to the Improvement in Insulin Sensitivity in Response to Physical Training in NIDDM: Effects of branched-chain amino acid supplements 🔘"Patients who exercised increased their VO2 peak by 41% and their insulin sensitivity by 46%... 🔘with a...
Four‑Month MDF Cuts NAFLD Liver Fat by 24%
"The 4-month intervention with this MDF was effective in reducing IHTC in patients with NAFLD by an absolute reduction of −5.89% and a relative reduction of −24.30% after adjusting for weight loss. Such effect was partly mediated by altered composition...
Ultra-Endurance Running May Speed Up Aging, RBC Damage
Ultra-Endurance Running May Accelerate Aging and Breakdown of Red Blood Cells | @ASH_hematology https://t.co/aYbsblfTwZ https://t.co/NYSKw0843c
Second Pregnancy Uniquely Reshapes Women's Brain Structure and Function
The effects of a second pregnancy on women’s brain structure and function "These findings show that a second pregnancy uniquely changes a woman’s brain, entailing both convergent and distinct neural transformations." https://t.co/E1QBL4g1t3 https://t.co/Bs4aveEsUE
Lower Cholesterol Linked to Reduced Dementia Risk
Does lowering cholesterol harm the brain? A large genetic study suggests lifelong reductions in atherogenic lipoproteins are associated with lower—not higher—dementia risk. https://t.co/QutNZzb4PH https://t.co/T84ZLIKq4A
Personality Can Be Modified at Any Age, Study Shows
People can change their personality at any stage of life https://t.co/0hNq74DUVo More: Personality intervention affects emotional stability and extraversion similarly in older and younger adults https://t.co/vt9JUlCwWk https://t.co/OtRqeIqfvr
State Policies Split American Longevity Across Geography
Policy polarization is rewriting the American geography of longevity "...because where you live is increasingly tied to how you live, as state policy contexts within the country pull father apart, so too do the patterns of American longevity..." https://t.co/vofUi8dN3S https://t.co/c68k3lJ7gb
Food Ingredients Combine to Supercharge Anti-Inflammatory Effects
Powerful Synergies Between Plant Compounds Can Dramatically Reduce Inflammation Researchers discover that familiar food ingredients can work together inside immune cells to drastically boost each other's anti-inflammatory effects. https://t.co/CfZ8b8fjw1 https://t.co/S3ZJeOWy7z
One Psychedelic Dose Quickly Eases Depression, Trial Shows
Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests https://t.co/c72qpfwQPm https://t.co/xR7hbj4v8e
Diabetes Drug Replicates Exercise Effects in Prostate Cancer Patients
How a Diabetes Drug May Echo the Benefits of Exercise in Prostate Cancer Care “From a clinical standpoint, seeing a metabolic signal that mirrors what we associate with intense exercise was striking… For patients whose treatments or symptoms limit physical activity,...
Indoor Eye Use May Drive Myopia, New Study Finds
New Research Suggests Myopia Could Be Caused By How We Use Our Eyes Indoors https://t.co/UTBhiAeP8v https://t.co/U0wlBGLvUz