GLP‑1 Drugs Show Promise for Treating All Addictions
GLP-1 medications get at the heart of addiction: study Diabetes and obesity drugs show promise in treating and preventing all substance use disorders https://t.co/buHywnw9Wk https://t.co/0lunbQbjsb
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Trust Outweighs Taste in Organic Food Choices
Choosing to buy organic food depends more on trust than taste – what our new study in the UK and Japan shows https://t.co/BEYetT9k5O https://t.co/kcJEOByvR8
Ageing Happens Unevenly Across Organs, Not Uniformly
Mosaic ageing: from organ-specific decline to the cause of death “A growing body of biomedical and evolutionary studies increasingly questions the notion of uniform ageing: rather than a whole-body (single) trajectory, ageing appears to occur unevenly across organs, tissues and even...
Elevated Lipoprotein(a Drastically Raises 30‑Year CVD Risk
Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a) 👉"Multivariable adjusted hazard ratios for levels above 120 mg/dL vs below 10 mg/dL or above the 99th percentile vs below the 50th percentile (11 mg/dL) were 1.54...
Accelerated Biological Aging Raises Dementia Risk in Women
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study "In this cohort study of older women, accelerated biological aging measured by AgeAccelGrim2 was associated with higher risk of incident MCI/probable...
Aged Polystyrene Microplastics Speed Worm Aging via Ferroptosis
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway https://t.co/gGPlKDdgW1 https://t.co/NZ31ToOTp2
Americans Trust Career Scientists Over Agency Leaders
Stark Divide: Americans More Confident in Career Scientists at U.S. Health Agencies Than Leaders A new survey by the Annenberg Public Policy Center finds that 67% of Americans have confidence in career scientists working at U.S. federal health agencies, compared with...
Clonal Haematopoiesis Reveals New Insights Into Aging Biology
Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis "...how CH enhances our understanding of the biology of ageing." https://t.co/9MKGZIakFY https://t.co/noyHAviY3E
Scientists Explore Possibility of Slowing Human Aging
Can aging be slowed? Some academic scientists think so with @NirBarzilaiMD, @mkaeberlein, and @sessi73 https://t.co/1EoZ7evdDF @AAMC https://t.co/StDgRGSRqr
First Five Get $99 Vitalist Bay 2026 Pass
Courtesy @adamgries... @VitalistBay 2026: 🗓 May 14-17 🔗https://t.co/5dh7N2M7bv "The first 5 can use the code LI-T-MINUS-30 for $99" 🎤 110+ speakers across 6 tracks 🛠 60+ hands-on workshops 🧘 20+ activations running all day, every day" https://t.co/JMMNaUHMIs
Aging Autistics: Higher Health Risks and Potential Benefits
How do autistic people age — and what does it mean for their health? Most research on autism focuses on younger people, but some studies suggest older adults face increased risks — and perhaps benefits. https://t.co/3YAztmYqGh https://t.co/VKdej4ke2Y
Engineered Brain Cells Erase Alzheimer’s Proteins in Mice
Enhanced brain cells clear away dementia-related proteins New cellular immunotherapy approach for Alzheimer’s disease shows promise in mice https://t.co/YBoqUZLvJo https://t.co/FjG699Etga
Dietary Restriction Extends Lifespan via Conserved Molecular Pathways
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species https://t.co/JodR3q7w2z https://t.co/46npim9J0m
Statins Don't Harm Muscle Health in Older Adults
Statin use does not impair muscle health in older adults: findings from the SCOPE study https://t.co/WKjk9Ov0rG https://t.co/xTo9mk3vbw
AI Tackles Tough Challenges, Shaping Science, Health, Humanity
Solving a hard problem with AI… and next steps A high quality discussion with @demishassabis Thoughtful approaches to harnessing AI for better science, health, and personal welfare across humanity. https://t.co/Uyz6BpuWCi https://t.co/Uv2DyyPXES
Biology Needs Systems Thinking, Not Just Parts Cataloguing
Can a biologist fix a radio?—Or, what I learned while studying apoptosis Yuri Lazebnik’s classic 2002 paper hilariously exposes the flaws of reductionist biology. He imagines biologists studying a broken radio by removing random parts to see what breaks. If pulling...
Elderly Can Harbor Amyloid Yet Remain Cognitively Normal
“ In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significant amyloid burden can remain cognitively normal.” Small sample size, but with numerous confirmatory studies...
Energy Levels Reveal Early Healthspan Decline Signals
Energy isn't just a feeling. It may be one of the earliest biological windows into healthspan decline. New from @BuckInstitute's Healthspan Horizons, led by @NathanPriceSci, exploring how mitochondrial function, sleep, glucose stability, and inflammation converge as early warning signals. This matters for...
Molecular Signature Differentiates Aging Cognitive Resilience vs Decline
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease 👉"Together, our study points to a multiomic molecular signature of the hippocampus that distinguishes cognitive resilience and deterioration with ageing." https://t.co/rRkFg6HKO0
Brain Age Gap Predicts Lifestyle Impact on Mental Health
Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health https://t.co/kgvgyZ9v4S
Mouse Watching “The Matrix” Guides Massive Brain Map
How a mouse watching 'The Matrix' helped scientists create the largest map of a brain to date https://t.co/wXYV0tGtAD https://t.co/QaBSJ6qpnv
Depleting Microbiome Restores
Microbiome depletion rejuvenates the aging brain "Our findings demonstrate that age-associated microbial inflammation contributes to brain aging and that its attenuation can restore youthful features at the molecular, cellular, and functional levels." https://t.co/GuBPBxxzeH
Young Microbiota Restores Cognition and Sperm Health via Bifidobacterium
Young Human-Derived Microbiota Ameliorates Cognitive Decline and Reproductive Senescence in Aged Mice This approach "increased intestinal Bifidobacterium levels and effectively restored hippocampal metabolomic profiles and cognitive behavior." Additionally, yFMT-based treatments "mitigated structural damage to the seminiferous tubules [and] improved sperm quality. 👉These findings...
Fructose Metabolism Fuels Brain Tumor Growth, Study Shows
Trump, Coca-Cola and the fructose frenzy that influences brain and neuronal tumor development "Dietary fructose, upon ingestion, is metabolised by gut microbiota into acetate or directly taken up by tumor cells from the bloodstream..." https://t.co/rZ2DMmuNsj https://t.co/tnJa3ldYrN
Peak Span May Outweigh Health Span for Longevity
Experts say your ‘peak span’ could be more important than your ‘health span’ – here’s why, and what it really means for health https://t.co/YVulQ49Zvh @StylistMagazine Featuring work by @biogerontology, @KejunYing, and @DomiWilczok 🔬💻⚕️ https://t.co/basWzeHBi6
Moderate Coffee Intake Cuts Stress and Anxiety Risk
Scientists Identify Coffee 'Sweet Spot'–Here's How Much to Drink Each Day for Lower Risk of Stress and Anxiety https://t.co/DohCegVD51 https://t.co/N6P8qAxfr2
Identifying Gaps in Longevity Philanthropy Landscape
What philanthropies are missing from longevity science and medicine? Is the ecosystem of foundations and nonprofits actually complete, or are there glaring gaps no one’s filling? Drop your essay (or a one-liner) below. ✍️ Or repost. 👨🏻⚕️⚕️ https://t.co/46hZGxnIQx
Ultraprocessed Diet Turns Thighs Into Marbled Steak
Ultraprocessed foods are turning human thighs into well-marbled steaks 👨🏻⚕️Figure: Diet of woman on the left was 29.5% ultraprocessed while the diet of a woman on the right was 87.1% ultraprocessed. Radiological Society of North America https://t.co/ORFHtNnSVH https://t.co/92nR6T77Oy
SGLT2 Inhibitors Protect Kidneys, Yet Raise Non‑Renal Risks
Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury Risk: A Systematic Review and Meta-Analysis of Randomized Trials "SGLT2is conferred substantial renoprotective benefits but increases the risk of certain nonrenal AEs." https://t.co/n0yhZgcShy
Serum Proteomics Distinguishes Endurance versus Strength Adaptations
Adaptations to endurance vs strength training in elite athletes revealed by serum proteomics https://t.co/ii3xAiNEcT https://t.co/hBfQ0E0v9W
Time‑restricted Eating Cuts Glucose, Insulin Resistance, HbA1c
Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis "Compared with a CON, TRE resulted in a larger reduction in fasting glucose... insulin resistance... HbA1c..." https://t.co/Jq9EpoAy3u
Peptides Are Potent Therapeutics, yet only a Few Qualify.
“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia 👨🏻⚕️
Purpose Grows by Caring for Others and Investing Time
Purpose tends to grow from caring about something beyond yourself, especially your connections with other people. The more time you’re given, the more chance you have to deepen and multiply them, if you stay open to it. 👥 https://t.co/v7JqNAtDKT
Vitamin D Overdose Cases Surge, Kids at Risk
Taking Too Much Vitamin D Can Backfire, Scientists Warn “From 2000 to 2014, there were more than 25,000 cases of vitamin D toxicity reported in the US. From 2005 to 2011, these cases increased by 1600 percent, and many involved children...
Repairing Aging Blood‑Brain Barrier to Halt CNS Disease
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders "We discuss interventions focused on barrier repair and immune recalibration, including the reinforcement of tight junctions, restoration of pericyte homeostasis, and modulation of...
Pets May Shield Against Cognitive Decline, Review Finds
The protective role of companion animal ownership in cognitive aging: current status of the literature https://t.co/TKXjlA0FTR https://t.co/kmWE6BHeQm
Appendix Presence Linked to Longer Lifespans Across Mammals
The cecal appendix is correlated with greater maximal longevity in mammals “We found, through analyses of data on 258 mammalian species, that cecal appendix presence is correlated with increased maximal observed longevity… . In addition, we show that the cecal appendix...
Singaporeans Increasingly Aware of Healthspan and Longevity Medicine
Knowledge of lifespan and healthspan and interest in Healthy Longevity Medicine among the general population in Singapore: the Singapore HEalthy LOngevity (HELO) survey https://t.co/urqgBWfzIW https://t.co/y6skIWdASG
Daily Evoked Gamma Therapy Shows Safety and Cognitive Benefit
Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease 👉 “Our results demonstrate that 1-h daily treatment with [CogTx-001] was safe and well-tolerated and demonstrated potential clinical benefits in mild to moderate AD.” 🔘 Participants underwent...
Dementia Poised as 3rd Leading Death Cause by 204
ADI leads new research forecasting dementia to become the 3rd leading cause of death by 2040 Additionally, the number of people living with dementia "is set to almost triple in number by 2050, to 139 million." https://t.co/WSm2Rhp3ju
Rebalancing Autonomic Nervous System May Slow Aging
“We propose that, at the core of aging, there is an imbalance between the SNS and PNS, which provides opportunities for therapeutic intervention.” How? Read more below👇 👨🏻⚕️ 🔎 “Hand-held, non-invasive wellness devices are being deployed in the U.S. military to enhance...
Aging Shares Disease Hallmarks, May Be Treatable
Is aging a disease? These authors reflect: “Disease is commonly defined as an abnormality of bodily structure or function, distinct from direct physical injury (Bulterijs et al., 2015). Whether ageing itself constitutes a disease has long been debated in the fields of...
Late-Night Meals May Boost Early Cancer Risk via Gut Microbes
Dark side of nocturnal eating: Unraveling the emerging axis between meal timing, gut microbiota, and early-onset cancer risk https://t.co/TLujxFSshs
One in Nine Over‑45 Americans Report Cognitive Decline
1 in 9 US adults above age 45 report cognitive decline https://t.co/LGVGmeYRUN & https://t.co/JIh6SYKrJK https://t.co/i2cQjfwUdv
Therapeutic Phlebotomy Restores Bone Marrow, Reverses Aging
Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function “our work provides preliminary evidence suggesting that periodic therapeutic phlebotomy exerts anti-aging effects by restoring bone marrow function and mitigating aging phenotypes, subsequently driving peripheral blood functional restoration.” 👉 “...
Youth Suicide Surge Linked to Social Media, Politics, Economy
Generation Z and Deaths of Despair SPA professor reviews alarming national suicide trends, including an unprecedented rise among young people, and looks at possible drivers. https://t.co/EdSgzGbDh0 👇👨⚕️ “One potential explanation getting a lot of attention is access to social media and the internet,”...
Choose Smart Wellness Travel: Biohacking vs Longevity
Biohacking Or Longevity—Which Wellness Travel Trend Is Right For You? A primer on deciphering the beneficial from the bogus. https://t.co/dCJk7gpWYB https://t.co/2e7Tmp74fB
Our Brains Filter 74GB Daily in Media Overload
Too Much Information, Too Little Time: How the Brain Separates Important from Unimportant Things in Our Fast-Paced Media World "An average person living today processes as much as 74 GB in information a day... Every year it is about 5% more...
High‑carb, Low‑fat Diets Boost Triglycerides and Fatty‑acid Synthesis
Effect of high-carbohydrate feeding on triglyceride and saturated fatty acid synthesis "The results of a series of studies in lean and obese weight-stable volunteers showed that very-low-fat (10%), high-carbohydrate diets enriched in simple sugars increased the fraction of newly synthesized fatty...