Exploring Evidence-Based Longevity at LIC 2026
Excited to join LIC 2026 in Gstaad this September. Looking forward to thoughtful conversations on what evidence-based longevity actually looks like in practice, and where science, medicine, and capital can move the field forward. | @Longevity_Inv #LIC2026 🚀
Accept Trade‑offs, Find a Sustainable Personal Diet
Thinking in trade-offs: a necessary antidote to diet tribalism Finding a diet that sustainably works for you is enough of a win. Why pretend it has no downsides? https://t.co/HDBzBxocAo https://t.co/pLwqhVPBaf
Young Blood Rejuvenates Brain Vessels via Endothelial IGF‑1 Signaling
Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice "Our results identify IGF-1/IGF-1R signaling as a critical component of the molecular network through which young blood exerts...
Visceral Fat: Modifiable Key to Metabolic Health and Longevity
Visceral adiposity, metabolic health and aging 🗣️These insights highlight the view of VAT as a modifiable and context-sensitive contributor to metabolic disease and aging, and a promising target for promoting metabolic health and longevity. https://t.co/7pDMJ2n7gK https://t.co/m4VVzNhctw
Β‑NMN Restores SIRT1, Halting Liver Cell Aging
β-Nicotinamide mononucleotide prevents senescence and lipid accumulation in hepatic stellate cells by restoring SIRT1 function https://t.co/wyVHZ13QNK
Schwann Cell Exosomes Transfer Ribosomes, miRNAs for Nerve Repair
Glia-to-Axon Transfer of Ribosomes and miRNAs: A Novel Paradigm in Neural Repair "Schwann cell-derived exosomes thus represent both a novel mode of glia–neuron communication and a promising avenue for next-generation therapies for nerve regeneration." https://t.co/xU3zmkA5OA https://t.co/kK3FrVuN7T
Sustainable Diets Boost Longevity for Saudi Seniors
Nourishing longevity: sustainable healthy eating behaviors and successful aging in community-dwelling older adults, Abha, Saudi Arabia https://t.co/44TStFZyIv
Senescent Endothelial Cells Direct Plaque Communication Network
Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques https://t.co/yzyxR0KPAL https://t.co/RBqSrKkvks
Planetary Health Diet Boosts Sleep Quality in Older Adults
Association between the planetary health diet and sleep health in older adults: findings from a national community-based study "Beyond dietary factors, physical exercise was also recognized as a beneficial non-pharmacological intervention for improving sleep health among older adults..." https://t.co/o2GjMiYgkl
Better Sleep and Activity Boost Perceived Longevity
How We Sleep, How We Move, How Long We Expect to Live: An Integrative Review of Lifestyle Behaviors and Subjective Life Expectancy https://t.co/mAEBi1rxRI
Social Isolation Disrupts Hormones, Damages Blood Vessels
Social disconnection: from cortisol-oxytocin imbalance to endothelial dysfunction, a narrative review of mechanisms and potential interventions https://t.co/ONoBPawaNl https://t.co/0WZXKypZjo
Exposome Accelerates Brain Aging, Worsening Alzheimer’s Sleep Disturbances
Sleep disturbances and Alzheimer’s disease: a multiscale approach from exposome to neurobiology and precision medicine "a hypothetical integrative, stream-like model outlining how external and internal exposome factors accelerate brain aging, thereby exacerbating circadian dysregulation, orexin-mediated hyperexcitability, metabolic imbalance, and inflammaging." https://t.co/VJPZRqmM23
Stopping Alzheimer’s Drugs Speeds Decline, Raises Death Risk
Long-term effect of discontinuing anticholinesterase treatment on cognitive decline and mortality in Alzheimer's disease in France: a quasi-experiment and target trial emulation study https://t.co/YUcSc7w9HG
Network Pharmacology Reveals Natural Products' Neuroprotective Power
Network pharmacology approach to unravel the neuroprotective potential of natural products: a narrative review https://t.co/LGgQeHQHwF https://t.co/OiCYu2OxZq
Rapamycin Lessens Age‑related Motor Decline, Varies by Sex
Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice 👉"Our results are consistent with the idea that rapamycin’s beneficial effects are mediated, at least in part, by reducing oxidative stress and ER stress-mediated apoptosis... https://t.co/b8EZwrDTXP
Natural SIRT1 Activators May Shield Early Alzheimer’s Microglia
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis? 🗣️"We will describe how SIRT1 can represent a key molecular link and an appealing target to harness microglial neuroprotective potential as...
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative Lay Summary: "The role of interleukin-6 receptor (IL6R) blockade in reducing chronic-disease risk and improving longevity is uncertain. In a study of 38 807 postmenopausal women followed for...
SGLT2 Inhibitors Help HFrEF Mice via Off‑Target Effects
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice “The beneficial effects of SGLT2i treatment in gKO mice conclusively demonstrate that in a physiologically relevant preclinical model of HFrEF, SGLT2i can exert therapeutic benefits via off-target pharmacology.3...
Brain Health Is a Dynamic System, Not Static
“There is no such thing as proof in biology… 🤔 …at any given moment we’re just one well-designed experiment (or one we’ll-phrased question) away from having to completely reevaluate the way we see the world.” 🔬 - @DrRagnar 🧠
Boost NAD to Reduce Inflammation, Enhance Recovery, Slow Aging
#109 How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging Dr @CharlesMBrenner with Rhonda Patrick @foundmyfitness https://t.co/EvDW71Wj2O https://t.co/9HoFCm2gIT
When Health Tracking Becomes Obsessive Overreach
The Tyranny of the Oura Ring “I started by counting my steps. Soon, I was counting every other biometric. Was that a good thing?…” An @WSJ editorial https://t.co/DSWwkDPT7o https://t.co/8YcrcVsOsq
Rejuvenating Blood Stem Cells Boosts Whole‑Body Health
Hematopoietic (stem) cells—The elixir of life? "In this perspective article, we discuss the evidence that supports that rejuvenating or delaying aging of the blood system has a beneficial and systemic impact on human health..." @FEBS_Letters https://t.co/Y9sYcwXp1A @FEBSJournal
DNA Repair Drives Aging; OSK Reverses Epigenetic Decline
Loss of epigenetic information as a cause of mammalian aging “we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA...
Epigenetic Dysregulation Fuels Aging, Offers Therapeutic Target
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target 👉 “By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing,...
Microbial Phenolics Mediate Oats' Cholesterol‑lowering Power
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
Classifying Aging Doesn't Affect Need for Research Investment
Though authors acknowledge (as I have argued before), even *if* they are right, “classification of aging is not relevant to the importance of investing in aging research to alleviate its burden” [nor targeting it, I might add] 👨🏻⚕️
Alternate-Day Fasting Worsens Lung Disease in Schistosomiasis
Alternate-Day Fasting Exacerbates Lung Inflammatory Disease Compared to High-Sucrose Diet in Experimental Schistosomiasis Mansoni 🤔"These findings suggest that caloric restriction through ADF aggravates pulmonary disease in schistosomiasis, possibly by enhancing ectopic egg dissemination." https://t.co/FwPjvxC9CI
Β‑Hydroxybutyrate's Dual Impact on Colorectal Cancer
β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights https://t.co/pPCdm2AcFo https://t.co/mPtz1Xqiep
SIRT6 Loss Triggers Nucleolar Dysfunction and Proteostasis Collapse
SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling "Our data suggest that SIRT6 deficiency results in proteostasis loss through nucleolar dysfunction." https://t.co/w1SfUiUxg4 https://t.co/5bqVFfS0lg
Anthropic Tests Next‑gen AI that Outpaces Security Defenses
Exclusive: Anthropic acknowledges testing new AI model representing ‘step change’ in capabilities, after accidental data leak reveals its existence Get ready for "upcoming wave[s] of models that can exploit vulnerabilities in ways that far outpace the efforts of defender..." https://t.co/dMiDv9KoV3
NAD+ May Influence Ovarian Aging, Research Uncertain
Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research https://t.co/OWU1Hhcreu https://t.co/IH7uKdRsa9
Aging Research Gains Momentum: Collaboration Fuels Therapeutic Breakthroughs
Now at 1M+ views. What struck me most here wasn’t the views. It was the engagement. People are ready to engage seriously with aging biology. Now the opportunity is to turn that energy into stronger collaboration, better translational science, and...
Metabolic Disturbances Drive Multimorbidity, Offering Intervention Targets
Shared and specific blood biomarkers for multimorbidity "Metabolic disturbances emerged as a key driver of multimorbidity. If confirmed, these processes could represent targets for interventions to mitigate disease accumulation." https://t.co/3nuctP2eAC https://t.co/yxk5CZHiHV
Maximize Strength and Hypertrophy with Minimal Training Time
No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review 👉"This review shows how acute training variables can be manipulated, and how specific training techniques can be used to optimize the training response: time ratio in...
Alpha‑Lipoic Acid Shows Promise for Ischemic Heart Failure
Efficacy of Alpha-Lipoic Acid in Patients With Ischemic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Study | @JACCJournals https://t.co/nW9SbwEDfy https://t.co/qsemjmMb9k
GLP‑1 Therapies Show Promising Cardiovascular Benefits
GLP-1 and the cardiovascular system "This Review summarizes the effects of GLP-1 and GLP-1RAs in the CV system..." https://t.co/Sy7Jjb96WD https://t.co/v3T01fIcOs
Billionaires Fund Headless Human Clones for Organ Farms
Billionaire-backed scientists aim to grow 'headless humans' to farm their organs... and help biohackers live for longer https://t.co/uQOzEtBapf https://t.co/HYZCMCOPy3
Uric Acid Predicts Sex‑Specific Cognitive Decline in Seniors
Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study https://t.co/vl5LLY6mBc
Current Evidence on NAD⁺ Supplements Remains Inconclusive.
NAD⁺ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence https://t.co/au5YIC11Hw https://t.co/fMsAOSQF6f
Joining LifespanRI Advisory Board to Advance Longevity Research
Pleased to join the Scientific Advisory Board at @LifespanRI, an organization dedicated to accelerating research on age-related disease and extending healthy human lifespan. Looking forward to contributing to this important work. 🚀 https://t.co/HSdyrtABCK https://t.co/754TAi6znw
Parental Age Rarely Harms Offspring Fitness in Wild Reptiles
Parental age effects on offspring fitness in a wild population of a short-lived reptile G "adds to the growing literature suggesting that negative effects of parental age on offspring fitness may not be as prevalent as once thought, particularly in wild...
Lifespan Extension Doesn't Guarantee Morbidity Compression, Study Shows
“These findings challenge the assumption that lifespan extension necessarily compresses morbidity, highlighting the need to consider lifespan, healthspan, and CoM as endpoints when evaluating anti-aging interventions. We do not claim that life-extending interventions categorically fail to achieve CoM; rather, we demonstrate...
Inflammation Not Inevitable With Age, Environment Matters
Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations 🐒"These results parallel recent findings from humans in demonstrating that chronic inflammation is not a natural consequence of aging but may rather be driven by environmental contexts that are mismatched to the evolutionary...
Integrative Models Reveal Evolutionary Roots of Aging Variability
How and why does aging occur? Updating evolutionary theory to meet a new era of data "We argue that by incorporating richer biological detail to create more integrative predictive models, we can gain insight into expected future distributions of aging within...
Higher Phenotypic Age Accelerates Cancer Survivors' Mortality Risk
The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999–2018 "Our findings reveal a significant linear correlation between PhenoAgeAccel and both all-cause and cancer-specific mortality in cancer survivors." https://t.co/Rt7v8ECOB6
Intrinsic Human Lifespan Heritability Roughly 50% After Adjustments
Heritability of intrinsic human life span is about 50% when confounding factors are addressed https://t.co/C2je2Dao9T https://t.co/QoGTjAj6Ch
Choose Exercise by Goal, Not One‑Size‑Fits‑All
The relative effects of different exercise modes on physical and metabolic health in older adults: A network meta-analysis "Current evidence does not identify a single “best” exercise modality for improving VO2max/VO2peak in older adults. Modality selection may be better guided by...
Seven‑Domain Framework Elevates Person‑Centered Longevity Care
The Longevity Medicine Patient Experience Framework: A Seven-Domain Model for Optimizing Person-Centered Longevity Medicine "By operationalizing a patient-experienced, person-centered approach, this framework offers potential solutions to common challenges in longevity medicine, including care fragmentation, accessibility barriers, and poor patient engagement. It...
Inulin Cuts Knee OA Pain, Boosts Sensitivity and Strength
Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis "Inulin and PSE each produced meaningful pain reductions. Only inulin improved pain sensitivity and grip strength, the latter paralleled by increased GLP-1, and...
Timing Meals Aligns Circadian Clock, Improves Diabetes & Obesity
Time-restricted eating and circadian rhythms: A new frontier in diabetes and obesity management https://t.co/XekM37KqWt https://t.co/rsB3DZytIR