Veteran Male Athletes Face Heightened Ventricular Tachycardia Risk
Protecting older male athletes’ heart health “Veteran male athletes who have spent years training at high intensity may be at greater risk of serious heart problems while exercising, new University of Leeds research shows… Over the two years of the study, around one in four participants experienced ventricular tachycardia during or just after exercising… three in four of the athletes who had these episodes had heart scarring. There were three longer and potentially more serious episodes of sustained ventricular tachycardia. These occurred during exercise, and all were in athletes with heart scarring.” https://t.co/kCIYvO1dYr
Polyphenols and Exercise Shield Fruit Flies From Alzheimer’s
Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease https://t.co/oNhsshekPa https://t.co/o0Yltk6fMc
Obesity and Age Drive Peripheral Inflammation in Cognitive Impairment
Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact "Peripheral low-grade inflammation was common, particularly in individuals with cognitive impairment; and obesity and age were the main drivers..." https://t.co/KvjFleW6t4
Aging and Parkinson’s: Collaborative Roadmap for Better Models
Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models https://t.co/6W6iYEx0br https://t.co/eFhYxVvAuk
Statins Now Recommended for Patients as Young as 30
Updated cardiovascular guidelines—statin use in patients as young as 30 Recommendations still may not be aggressive enough, but the needle is moving https://t.co/HS9PtEdrsU https://t.co/d9YcDAFH2N
Levetiracetam Blocks Amyloid Beta via SV2a‑dependent APP Modulation
Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer’s disease models "...supporting the hypothesis that protein accumulation is a relevant pathogenic event in amyloid pathology..." https://t.co/bRqoZP1Qyf @ScienceTM
Best Diet Scores Add up to Three Extra Years
Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study "Compared with the bottom quintile, achieving the top quintile of dietary scores was associated with 1.9 to 3.0 years of life gained at 45 years in men and 1.5...
Targeted Antivirals and Vaccines Needed for CMV-Linked Cognitive Decline
Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies 🔎"We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration." https://t.co/b7Qx9aj0K3 https://t.co/KMB9ITLEzW
Machine Learning Links Spironolactone to Reduced Fibrosis Risk
Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics https://t.co/Ho2RL0RhO4 https://t.co/cHkogagDTt
Greens Boost Gut Microbiome and Epigenetics in Obese Seniors
Epigenetic and microbiome responses to greens supplementation in obese older adults: results from a randomized crossover-controlled trial https://t.co/Sz8ZmAUnxh https://t.co/zgpLh0dYG6
Exercise Mitigates Motor Unit Decline During Bedrest in Seniors
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans https://t.co/LOCU5ppBxh @ExpPhysiol https://t.co/0sdUCLOqP7
Intranasal EV Vaccine Shields Mice From H5N1, H7N9
A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9 https://t.co/WroXpi6YP3 https://t.co/umAPlnRjbF
Precision Analytics Cut Inflammation, Boost Function in Seniors
Leveraging Precision Medicine Analytics to Optimize Inflammation Reduction and Enhance Physical Function in Older Adults https://t.co/BSSN0SwK8a https://t.co/yRxbhtHG5r
Silicon Valley's Immortality Bet Reaches 91‑year‑old
Longevity treatments for a 91-year-old. That's the kind of story that captures where Silicon Valley's immortality bet is actually heading. Great piece by @AmyDMarcus, who I had the chance to meet in Boston recently. She brings serious depth to this beat,...
FGF21 Boosts Lactate Metabolism For
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice https://t.co/WInPF6Nm1C https://t.co/f9BxVAApln
Epigenetic Aging Markers Predict Dementia Risk Beyond Age
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study 🧠"These findings provide evidence linking epigenetic biomarkers of biological aging with MCI and dementia development, independent of chronological age." https://t.co/GKmn44gsqj
Exercise Boosts NAD+, Enhancing Muscle Function in Aging
Healthy aging and muscle function are positively associated with NAD+ abundance in humans “… conversely, exercise-trained older individuals had NAD+ levels that were more similar to those found in younger individuals. NAD+ abundance positively correlated with average number of steps per day...
Kids' Bedrooms Harbor Harmful Chemicals, Study Finds
Young Children’s Exposure to Chemicals of Concern in Their Sleeping Environment: An In-Home Study https://t.co/PIv6V5yVVo https://t.co/81UD6d8M1m
Lifestyle Factors Modulate Autophagy in Alzheimer’s
Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease https://t.co/aFGuo2R84Y https://t.co/vu2Jt7OvuZ
Food-Derived Bacterium Boosts Nanoplastic Excretion in Mice
Efficient biosorption of nanoplastics by food-derived lactic acid bacterium 👉 Strain CBA3656 enhanced fecal excretion of nanoplastics from the germ-free mouse intestine. 🔎 CBA3656 as a food-derived microbial biosorbent for NP mitigation https://t.co/eweZxEKYwL https://t.co/UbEYXADXwq
NMN and NR Show No Benefit for Elderly Muscle
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis “… In conclusion, current evidence does not support the use of NMN and NR as effective interventions for improving muscle function and mass...
Therapeutic SASP Targets Halt Brain Cell Senescence Spread
Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types "we identified specific SASP targets for therapeutic intervention in the context of human brain cells and thereby informed the SASP-dependent reaction of immune cells and age-related tissue dysfunction across...
NR & NMN Boost Blood NAD+ via Gut Microbiome
The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans “Collectively, the clinical data combined with the ex vivo human microbiota and human whole-blood experiments led us to propose a human model where NR and...
Chronic Cannabis Smoke Elevates Brain and Peripheral Inflammation, Age‑Dependent
Effects of Chronic Cannabis Smoke Exposure on Inflammatory Markers in Periphery and Brain in Young and Aged Mice https://t.co/QeOw5EVOnk https://t.co/PV4A1OBJzO
Oral NR/NMN Boosts Blood and Brain NAD in Two Weeks
The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation 🔎 “… oral NR or NMN in humans produces a slow but robust and sustained elevation of systemic and cerebral NAD that stabilizes after ∼2 weeks…” https://t.co/Hvp1NvRwl0
Dead Worms Boost Lifespan Through Separate Mechanisms
Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways https://t.co/B1VE91Y1lj
Gut Microbiome Depletion May Rejuvenate Aging Brain
Microbiome depletion rejuvenates the aging brain "...targeting the gut microbiome or its circulating mediators may therefore represent a non-invasive approach to promote brain health and cognitive resilience in aging..." https://t.co/GuBPBxx1p9
Personalized NAD Boosting Needed; Redox Fingerprints Reveal Disease
Dynamics of blood NAD and glutathione in health, disease, aging and under NAD-booster treatment “In healthy population (n=299;18-70 year-olds) redox metabolites follow normal distribution in blood and remain unchanged during aging. NAD-boosting increased 4-6 fold the blood NAD+ depending on individual,...
Severe Infections Independently Raise Dementia Risk, Study Shows
The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study "These results support the role of severe infections as independent risk factors for dementia..." https://t.co/7gG41XSiy7
Cocoa Activates Sirtuins to Shield Cochlea From Aging
Sirtuins mediate the reduction of age-related oxidative damage in the cochlea under a cocoa-rich diet 📢"These results indicate that cocoa protects against oxidative damage through Sirtuins." 🍫 https://t.co/MLRfhChFYy https://t.co/BPh3sETpFm
Obesity, Bad Lipids, Inflammation, and Vascular Aging Linked to Depression
Associations of adiposity, atherogenic lipid phenotypes, systemic immune-inflammatory indices, and vascular aging markers with depression in US adults: NHANES 2005–2020 "Adiposity, dyslipidemia, systemic immune-inflammatory activation, and vascular aging were independently associated with depression." https://t.co/PdlWJxoHiY
Valine Restriction Boosts Healthspan, Extends Male Lifespan
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice "Our results demonstrate for the first time that Val-R improves multiple aspects of healthspan in mice of both sexes and extends lifespan in males, and suggests that...
Exercise Restores Aging Mice Gut Microbiome, Cuts Heart Risk
Late-in-life treadmill training mitigates gut microbiome imbalances and cardiovascular disease risk in mice "Here we demonstrate that a 12-wk treadmill running program in older mice rejuvenates the gut microbiome and attenuates markers of cardiovascular disease (CVD) risk. Notably, specific microbial taxa correlate...
Young Plasma Boosts Antioxidant Defense, Preserves Aged Lungs
Young plasma transfer enhances antioxidant defense and preserves structural integrity in aged lung tissue https://t.co/v1lR1EyCKv https://t.co/ZYJu1qNsDl
High‑dose Flu Shot Cuts Alzheimer Risk in Seniors
Risk of Alzheimer Dementia After High-Dose vs Standard-Dose Influenza Vaccination🤔 🔎"High-dose influenza vaccination is associated with reduced AD risk compared with standard-dose vaccination in adults ≥65 years, with a stronger effect among women." https://t.co/fKq34aZErj https://t.co/lZ5OnaYVaM
Nasal Dantrolene Nanoparticles Curb Inflammation‑induced Depression, Anxiety
Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice [Context: Dantrolene is a skeletal muscle relaxant used for malignant hyperthermia and chronic spasticity from spinal cord injuries, MS, or stroke. It inhibitings calcium release in muscle cells. Common side...
Structured Longevity Training Boosts Physician Confidence, Needs Policy Support
Upskilling in Healthy Longevity Medicine and Its Association With Physicians’ Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study 👉 "These findings underscore the critical role of structured HLM curricula in bridging the translational gap between geroscience and everyday medical practice......
Vitamin B3 May Undermine Pancreatic Cancer Chemotherapy
Title and header via the @cwru press release: New research reveals dangers of ‘anti-aging’ supplements in cancer protection Vitamin B3 could be making chemotherapy less effective in pancreatic cancer patients https://t.co/vIfcvuiS6P Discussion + thoughtful debate welcome👇👨⚕️ https://t.co/aHewoWeIle
NAD+ Decline Drives Cardiac Aging; NR Restores Rhythm
NAD+ controls circadian rhythmicity during cardiac aging https://t.co/NNVx94IIC8 Fig. 2: Cardiac NAD+ decreases with aging, with restoration by supplementation with nicotinamide riboside. https://t.co/z4uSqKrYjR
Debunking Myths: Longevity Science Funding Is Essential
Are you (will you be) in London Wednesday April 8? 👉Arguments against funding longevity science - and why they are all wrong Hosted by London Futurist, my friend (and friend to longevity science) David Wood @dw2 https://t.co/HTj6Xoeu1J https://t.co/13pwYx0ZrU
Year-Long Aerobic Exercise Preserves White Matter, Boosts Cognition
Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial "These findings suggest that 1 year of aerobic training may reduce [Free Water Fraction] in the CC body and that higher...
Mitochondrial Dysfunction Triggers Early Cerebral Amyloidosis
Human in vitro and rodent in vivo models highlight progressive mitochondrial dysfunction as a starting point of cerebral amyloidosis https://t.co/CEfTOeosnu https://t.co/Rd12PlVTAQ
Aging Immune System Shapes Allergy and Biologic Response
Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies https://t.co/DMVxerI64T https://t.co/TUPGK6SqUK
Advocating Bills to Expand Right‑to‑Try for Severe Illnesses
Today @theA4LI is at the New Hampshire State House supporting HB 1734 and HB 1735, two bills that would license experimental treatment centers and expand Right to Try protections to patients with severe illness, not just terminal conditions. As a longevity...
Obesity‑Gut Microbiota Drive
Neuroinflammation in Alzheimer's Disease: The Role of Obesity, Gut Microbiota, and Therapeutic Potential of Omega-3 Fatty Acids and Neural Stem Cells https://t.co/IB7nxSSupQ https://t.co/YSLYmsInF2
Adiponectin: Key Protector Against Age‑Related Decline
Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons "Adiponectin has been implicated in aging and the onset of age-related disease.... Adiponectin signaling protects multiple tissues from age-associated decline... Adiponectin signaling agonists as therapeutics in metabolic and age-related disease." https://t.co/9NcjtjlbjR
Plant‑based Diets Cut Most Cancer Risks, Raise a Few
Vegetarian diets and cancer risk: pooled analysis of 1.8 million women and men in nine prospective studies on three continents "Compared to meat eaters, poultry eaters had lower risk of prostate cancer (0.93, 0.88–0.98), pescatarians had lower risks of colorectal (0.85,...
Dietary Restriction's Molecular Pathways Extend Lifespan Universally
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species https://t.co/JodR3q83S7 https://t.co/qUGeAe8A2D
Targeted Nutrition May Lower Inflammation, Preserve Cognition
The impact of dietary constituents on inflammation and cognitive function in healthy older Irish adults: A pilot study "his study highlights the importance of nutrition and lifestyle in managing inflammation and cognitive decline in ageing. Targeted dietary interventions which address nutrient...
Bifunctional Enzyme Restores Redox
A metabolic safety valve for reductive stress "...Pan et al. rewire this circuit with a bifunctional enzyme that uncouples NAD⁺ regeneration from lipogenesis, restoring redox homeostasis under respiratory stress..." https://t.co/EChxGHwyXU https://t.co/LYIZNylLrr