Aging Biology Targets Key to Better Stroke Outcomes
Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration 🔎Addressing age-specific pathophysiology will be critical for improving outcomes in cerebrovascular diseases in the aging population... https://t.co/DuScTnSIh5 https://t.co/Irok29jqMx
SIRT6 Gene Therapy Remains Safe, Effective in Aged Beagles
Genflow sees sustained safety and efficacy in SIRT6 beagle trial 🐶 “Genflow Biosciences reported that three-month follow-up data from its SLAB trial in aged beagles show sustained safety and efficacy of its SIRT6 centenarian gene therapy, with no adverse events and...
Single Gene Therapy Dose Eradicates Brain Tumors in Mice
GENE THERAPY SAFELY ERADICATES BRAIN TUMOURS IN MICE A single dose of an innovative gene therapy could eliminate hard-to-treat brain tumours and prevent them from coming back, according to a pre-clinical trial in mice, reported in Nature. “More than 80 per cent...
2024 NIA‑AA Definition Connects Biomarkers Directly to Care
The 2024 NIA-AA biological definition of Alzheimer’s disease: linking biomarkers to clinical practice https://t.co/00cP1mXXHR https://t.co/VQ59YeIUR1
RFK Jr. Pushes to Overturn Peptide Ban, Officials Dispute Claims
RFK Jr. May Reverse a Peptide Ban He Calls “Illegal.” Former FDA Officials Say He Mischaracterized Their Work. https://t.co/glqreTHvKA https://t.co/Vi4OTryX3p
NRH Prevents Age‑related Hearing Loss via Sirt3‑mediated Ferroptosis Suppression
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation https://t.co/MOqQblWYNM https://t.co/uhSMXRIxDK
Lithium Reverses ApoE4 Cellular Deficits, Merits AD Trials
https://t.co/r6JzHA1RxM with ApoE4/E4 from a sporadic Alzheimer's disease patient "Given the drug's demonstrated efficacy in reversing ApoE4-driven cellular vulnerabilities, lithium salt warrants further investigation for the treatment of AD." https://t.co/r6JzHA1RxM https://t.co/v2lE0XhN7n
Molecular Evolution Explains Animal Aging Diversity
Molecular evolution of animal aging 🗣️"...As a step toward this goal, this field perspective outlines general biological mechanisms that help explain the variability in aging patterns and longevity across the animal kingdom..." https://t.co/mHVAlyQbfM https://t.co/NoronuZDaL
Targeting Liver ApoE Boosts Bone Healing in the Elderly
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing "Our work here identifies novel liver-to-bone cross-talk and a noninvasive, translatable therapeutic intervention for aged bone regeneration" https://t.co/KSzvkKOzZt https://t.co/1p0cXQlalT
Conjugated PUFAs Target Senescent Cells
Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells “ Conjugated PUFAs α-ESA and its methyl ester selectively eliminate diverse senescent cells… These lipid senolytics reduce tissue senescence and extend health span in aged mice” 👉 Lipid peroxidation underlies selective vulnerability...
Hair‑Loss Pill Redefines Masculinity and Aging
The Hair-Loss Drug Rewriting the Rules of Masculinity A pill to cure baldness is changing the way men age — and how they see themselves. https://t.co/4OiLpmOwGR https://t.co/YQLBx61gVT
First Human Trial Tests Cellular Age Reversal Therapy
This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs. 💡"Technologies to refresh ageing tissue...
AI Chatbots Warned of Nonexistent Disease From Fake Papers
Scientists invented a fake disease. AI told people it was real Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness? | @stokel https://t.co/qXWOPAhRaK https://t.co/8QoMiAfzBW
Top Experts Discuss Cutting‑Edge Longevity Strategies Live
Fund Longevity Live Stream Wednesday, April 8 11:00 AM - 12:00 PM EDT 🔗 https://t.co/gNCkMYxhfI @aubreydegrey — Combination therapy @LidskyPeter — New theory of aging Alexander Panchin — Gene therapy & science communication @longevion — Crypto & funding @cordeiro — Global longevity movement @ILAISRLA ...
Accelerating Early-Onset Cancer Cause Research for Prevention
Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers 🌟This roadmap aims to stimulate advances to accelerate cancer etiology research and prevention in the era of rising early-onset cancers. https://t.co/d0z6EHDpTh https://t.co/H6I76e4tFB
Oxytocin Reverses Isolation‑induced Neuropsychiatric Deficits via Brain, Immune, Microbiome
Oxytocin attenuates isolation-evoked emotional and social behavioral dysregulation through neural, immune, and microbiota mechanisms "Our study confirms the therapeutic effects of OXT in reversing isolation-induced neuropsychiatric disorders and elucidates its potential regulatory mechanisms, offering important implications for clinical interventions." https://t.co/hXkWRD1gMV
Exercise Cuts Visceral Fat, Boosts Insulin Sensitivity in NIDDM
Mobilization of Visceral Adipose Tissue Related to the Improvement in Insulin Sensitivity in Response to Physical Training in NIDDM: Effects of branched-chain amino acid supplements 🔘"Patients who exercised increased their VO2 peak by 41% and their insulin sensitivity by 46%... 🔘with a...
Four‑Month MDF Cuts NAFLD Liver Fat by 24%
"The 4-month intervention with this MDF was effective in reducing IHTC in patients with NAFLD by an absolute reduction of −5.89% and a relative reduction of −24.30% after adjusting for weight loss. Such effect was partly mediated by altered composition...
Ultra-Endurance Running May Speed Up Aging, RBC Damage
Ultra-Endurance Running May Accelerate Aging and Breakdown of Red Blood Cells | @ASH_hematology https://t.co/aYbsblfTwZ https://t.co/NYSKw0843c
Second Pregnancy Uniquely Reshapes Women's Brain Structure and Function
The effects of a second pregnancy on women’s brain structure and function "These findings show that a second pregnancy uniquely changes a woman’s brain, entailing both convergent and distinct neural transformations." https://t.co/E1QBL4g1t3 https://t.co/Bs4aveEsUE
Lower Cholesterol Linked to Reduced Dementia Risk
Does lowering cholesterol harm the brain? A large genetic study suggests lifelong reductions in atherogenic lipoproteins are associated with lower—not higher—dementia risk. https://t.co/QutNZzb4PH https://t.co/T84ZLIKq4A
Personality Can Be Modified at Any Age, Study Shows
People can change their personality at any stage of life https://t.co/0hNq74DUVo More: Personality intervention affects emotional stability and extraversion similarly in older and younger adults https://t.co/vt9JUlCwWk https://t.co/OtRqeIqfvr
State Policies Split American Longevity Across Geography
Policy polarization is rewriting the American geography of longevity "...because where you live is increasingly tied to how you live, as state policy contexts within the country pull father apart, so too do the patterns of American longevity..." https://t.co/vofUi8dN3S https://t.co/c68k3lJ7gb
Food Ingredients Combine to Supercharge Anti-Inflammatory Effects
Powerful Synergies Between Plant Compounds Can Dramatically Reduce Inflammation Researchers discover that familiar food ingredients can work together inside immune cells to drastically boost each other's anti-inflammatory effects. https://t.co/CfZ8b8fjw1 https://t.co/S3ZJeOWy7z
One Psychedelic Dose Quickly Eases Depression, Trial Shows
Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests https://t.co/c72qpfwQPm https://t.co/xR7hbj4v8e
Diabetes Drug Replicates Exercise Effects in Prostate Cancer Patients
How a Diabetes Drug May Echo the Benefits of Exercise in Prostate Cancer Care “From a clinical standpoint, seeing a metabolic signal that mirrors what we associate with intense exercise was striking… For patients whose treatments or symptoms limit physical activity,...
Indoor Eye Use May Drive Myopia, New Study Finds
New Research Suggests Myopia Could Be Caused By How We Use Our Eyes Indoors https://t.co/UTBhiAeP8v https://t.co/U0wlBGLvUz
Vivid Dreams Fool Brain Into Feeling Rested
Vivid dreams trick your brain into thinking you slept well Even though our brains are more active, those hyper detailed dreams may make us feel more rested. https://t.co/FwT2a7GLfG https://t.co/DVwhCS5kMh
Exercise Your Way to a Sharper Memory
Want to improve your memory? The right type of exercise can give it a boost https://t.co/yCSAqABtQE https://t.co/5gNXaBtkRy
Higher BMI Predicts Late-Life Mobility and IADL Disability
Late-life disability following the action for health in diabetes (Look AHEAD) trial 😷Regardless of age, those with higher BMI had increased late-life mobility and IADL disability. https://t.co/QeU9TJhf9y https://t.co/zeCNrGcO7x
Breakfast, Sleep, Exercise Boost Psychological Flexibility
Want to handle stress better? Start with breakfast, sleep, and exercise New study shows healthy habits build ‘psychological flexibility’ https://t.co/WGaecPUetj https://t.co/k4rgATDX4Q
Processed Foods Impair Aged Brain’s Emotional Memory via Low Fiber
Emotional memory region of aged brain is sensitive to processed foods "Lack of fiber is linked to cognitive problems, animal study suggests..." https://t.co/q6EbUnLkWc
Daily Multivitamins May Slow Aging, Especially in Older Bodies
Daily multivitamin may slow biological aging Greatest gains for participants who were biologically older, researchers say https://t.co/GhRJHwgr9B https://t.co/OxfNd0ZmEE
Psilocybin Single Dose Beats Nicotine Patches for Quitting
A single dose of psilocybin is more effective than nicotine patches for quitting smoking, study suggests https://t.co/APDQt1WYxp https://t.co/zDnXcUjFyG
Exercise‑linked Protein Target Could Rejuvenate Aging Blood‑brain Barrier
Scientists Find a Mechanism for How Exercise Protects the Brain 🗣️Finding drugs to trim proteins like TNAP could be a new way to rejuvenate the blood-brain barrier, even after it’s been degraded by age. “We’re uncovering biology that Alzheimer’s research has largely...
SIRT1 Activation Shows Promise for Age‑related Brain Disorders
SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential "...SIRT1 could be a promising pharmacological target for age-associated brain disorders, warranting more robust translational studies to validate these findings in humans..." https://t.co/hGVxZ4RErM
Better Cardio Fitness Reduces Anger, Anxiety, Boosts Resilience
Cardiorespiratory fitness is associated with lower anger and anxiety and higher emotional resilience https://t.co/PPVmVFPPS1 https://t.co/sDI77TfjiO
Veteran Male Athletes Face Heightened Ventricular Tachycardia Risk
Protecting older male athletes’ heart health “Veteran male athletes who have spent years training at high intensity may be at greater risk of serious heart problems while exercising, new University of Leeds research shows… Over the two years of the study, around...
Polyphenols and Exercise Shield Fruit Flies From Alzheimer’s
Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease https://t.co/oNhsshekPa https://t.co/o0Yltk6fMc
Obesity and Age Drive Peripheral Inflammation in Cognitive Impairment
Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact "Peripheral low-grade inflammation was common, particularly in individuals with cognitive impairment; and obesity and age were the main drivers..." https://t.co/KvjFleW6t4
Aging and Parkinson’s: Collaborative Roadmap for Better Models
Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models https://t.co/6W6iYEx0br https://t.co/eFhYxVvAuk
Statins Now Recommended for Patients as Young as 30
Updated cardiovascular guidelines—statin use in patients as young as 30 Recommendations still may not be aggressive enough, but the needle is moving https://t.co/HS9PtEdrsU https://t.co/d9YcDAFH2N
Levetiracetam Blocks Amyloid Beta via SV2a‑dependent APP Modulation
Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer’s disease models "...supporting the hypothesis that protein accumulation is a relevant pathogenic event in amyloid pathology..." https://t.co/bRqoZP1Qyf @ScienceTM
Best Diet Scores Add up to Three Extra Years
Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study "Compared with the bottom quintile, achieving the top quintile of dietary scores was associated with 1.9 to 3.0 years of life gained at 45 years in men and 1.5...
Targeted Antivirals and Vaccines Needed for CMV-Linked Cognitive Decline
Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies 🔎"We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration." https://t.co/b7Qx9aj0K3 https://t.co/KMB9ITLEzW
Machine Learning Links Spironolactone to Reduced Fibrosis Risk
Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics https://t.co/Ho2RL0RhO4 https://t.co/cHkogagDTt
Greens Boost Gut Microbiome and Epigenetics in Obese Seniors
Epigenetic and microbiome responses to greens supplementation in obese older adults: results from a randomized crossover-controlled trial https://t.co/Sz8ZmAUnxh https://t.co/zgpLh0dYG6
Exercise Mitigates Motor Unit Decline During Bedrest in Seniors
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans https://t.co/LOCU5ppBxh @ExpPhysiol https://t.co/0sdUCLOqP7
Intranasal EV Vaccine Shields Mice From H5N1, H7N9
A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9 https://t.co/WroXpi6YP3 https://t.co/umAPlnRjbF
Precision Analytics Cut Inflammation, Boost Function in Seniors
Leveraging Precision Medicine Analytics to Optimize Inflammation Reduction and Enhance Physical Function in Older Adults https://t.co/BSSN0SwK8a https://t.co/yRxbhtHG5r