David Barzilai, MD PhD

David Barzilai, MD PhD

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Clinician focused on prevention/longevity; curates aging science and protocols.

Medical Schools Commit to Boost Nutrition Training for Doctors
SocialApr 18, 2026

Medical Schools Commit to Boost Nutrition Training for Doctors

FACT SHEET: Secretary Kennedy and Secretary McMahon Celebrate Medical School Commitments to Increase Nutrition Training for Future Doctors https://t.co/mLHvkJhPkB

By David Barzilai, MD PhD
Exploring Abundant Futures with Longevity Visionary David Wood
SocialApr 18, 2026

Exploring Abundant Futures with Longevity Visionary David Wood

A Roadmap to Abundant Futures: A Conversation with David Wood @dw2 is well worth your time. I have a lot of respect for him, having collaborated together, and his work with @LongevityEVF alongside @aubreydegrey, another great visionary, speaks for itself https://t.co/Jr4k0g9HnB https://t.co/qwgshYdPXT

By David Barzilai, MD PhD
Doctor Says 100 Daily Jumps Offer Limited Benefits
SocialApr 18, 2026

Doctor Says 100 Daily Jumps Offer Limited Benefits

Is jumping 100 times every day good for you? Doctor breaks down TikTok trend A new TikTok fitness trend involves jumping 100 times each day, and a doctor has explained whether this viral exercise routine actually delivers health benefits https://t.co/8LhdDx4ei2 https://t.co/jstsaJ3hte

By David Barzilai, MD PhD
Overweight Diabetics in Jeddah Use More Outpatient Care
SocialApr 18, 2026

Overweight Diabetics in Jeddah Use More Outpatient Care

Body Mass Index Impact on Health Care Utilization Among People with diabetes in Jeddah, Saudi Arabia "Regression models revealed that overweight [OR = 1.43] and obese patients [OR] utilized more outpatient services..." https://t.co/HfR5ltQTYS

By David Barzilai, MD PhD
Optimized Type 2 Diabetes Care Boosts Health and Savings in Spain
SocialApr 18, 2026

Optimized Type 2 Diabetes Care Boosts Health and Savings in Spain

Estimating the Clinical, Quality-of-Life and Economic Impact of Optimized Management of Type 2 Diabetes Patients in Spain https://t.co/L3QB4MJf57 https://t.co/pot0usHX7f

By David Barzilai, MD PhD
Implausible Apple Cider Vinegar Weight‑Loss Study Retracted
SocialApr 18, 2026

Implausible Apple Cider Vinegar Weight‑Loss Study Retracted

Implausible Apple Cider Vinegar Weight Loss Study Retracted When a trial has results that defy basic biology, it’s reasonable to be skeptical. @PharmacistScott https://t.co/ahEkiEmP7l https://t.co/yVyazUwXou

By David Barzilai, MD PhD
Sweetener and Plastic Microplastics Trigger Worm Obesity
SocialApr 18, 2026

Sweetener and Plastic Microplastics Trigger Worm Obesity

Sucralose and PMMA Microplastics Synergistically Induce Obesity with Altered Locomotion and Metabolism in Caenorhabditis elegans https://t.co/TExtjah4cV

By David Barzilai, MD PhD
Protein‑rich Breakfast
SocialApr 18, 2026

Protein‑rich Breakfast

Big breakfast diet composition impacts on appetite control and gut health: a randomized weight loss trial in adults with overweight or obesity "The HPWL diet was superior to the HFWL diet for suppressing subjective appetite (P=0.003). The faecal microbiota analysis showed beneficial...

By David Barzilai, MD PhD
PFAS Exposure Linked to Faster Biological Aging in Men
SocialApr 18, 2026

PFAS Exposure Linked to Faster Biological Aging in Men

Aging process could accelerate due to 'forever chemicals' exposure, study finds Higher concentrations of PFAS chemicals were associated with faster biological aging in men of certain age groups https://t.co/ZClEw0Gj1p https://t.co/tYBTJTmlt9

By David Barzilai, MD PhD
Exercise Activates Hypothalamic SF1 Neurons, Boosting Endurance
SocialApr 18, 2026

Exercise Activates Hypothalamic SF1 Neurons, Boosting Endurance

Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance 👉 “ These results demonstrate that exercise-induced hypothalamic SF1 neuron activity is essential for the coordination of physiological improvements following exercise training.” https://t.co/qLowm6sETh

By David Barzilai, MD PhD
Warmer Waters Accelerate Fish Life Histories, Shorten Lifespans
SocialApr 18, 2026

Warmer Waters Accelerate Fish Life Histories, Shorten Lifespans

Mixed Support for the Temperature-Size Rule in Wild Freshwater Fishes "...We also found evidence that faster life histories in warmer environments are associated with reduced lifespans..." https://t.co/oJtqRUD2o6

By David Barzilai, MD PhD
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
SocialApr 18, 2026

Genetic IL6R Blockade Shows No Impact on Disease or Longevity

Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative "Genetic IL6R blockade was not associated with incident chronic-disease risk, including invasive cancer and longevity, in a large, ethnically diverse cohort of postmenopausal women. No significant...

By David Barzilai, MD PhD
Nocebo's Power Equals Placebo in Health Education
SocialApr 17, 2026

Nocebo's Power Equals Placebo in Health Education

Nocebo deserves as much airtime as placebo in patient education and provider training It matters as much for diets: tell someone a food is harmful and their body will often cooperate, which "confirms" the belief and pushes them to cut foods...

By David Barzilai, MD PhD
Digital Tools Boost Seniors' Health, Independence, and Home Life
SocialApr 17, 2026

Digital Tools Boost Seniors' Health, Independence, and Home Life

The “ELDERDES” model: how older adults' adoption of digital environment solutions improves residential experiences, health outcomes, and enables independent living https://t.co/jSDPgnP5Ax https://t.co/ZZEfaWZWOF

By David Barzilai, MD PhD
Claude Self‑diagnoses Its Own Tool Error, Hinting at Autonomous AI
SocialApr 17, 2026

Claude Self‑diagnoses Its Own Tool Error, Hinting at Autonomous AI

This is quite fascinating. Claude gave me 3 options A, B, and C for a possible approach and left A completely blank. It states below the blank "The tool rendered one. Here are the two other strategic angles to choose...

By David Barzilai, MD PhD
Childhood NAD+ Deficiency Triggers Lifelong Muscle Aging
SocialApr 17, 2026

Childhood NAD+ Deficiency Triggers Lifelong Muscle Aging

Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood https://t.co/K0MAkv7hIB https://t.co/eRCOesGwL5

By David Barzilai, MD PhD
OpenAI and InSilicoMeds Partnership Promises Significant Growth
SocialApr 17, 2026

OpenAI and InSilicoMeds Partnership Promises Significant Growth

A collaboration between @OpenAI and @InSilicoMeds has great upward potential. Would you be open to exploring this @sama ?

By David Barzilai, MD PhD
Blood Test Identifies Molecules Predicting Short‑term Survival
SocialApr 17, 2026

Blood Test Identifies Molecules Predicting Short‑term Survival

New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe

By David Barzilai, MD PhD
AI Boosts PhD Work, Yet Threatens Core Skills
SocialApr 17, 2026

AI Boosts PhD Work, Yet Threatens Core Skills

AI and the PhD student: friend or foe? Graduate students increasingly use artificial-intelligence tools to draft, code and search... but many fear it could erode the very skills a doctorate is meant to build. https://t.co/b8cdoCI6Bh https://t.co/scTkfsXuCW

By David Barzilai, MD PhD
Stable Weight Maintenance Predicts Longer Lifespan in Mice
SocialApr 17, 2026

Stable Weight Maintenance Predicts Longer Lifespan in Mice

Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice "We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an...

By David Barzilai, MD PhD
Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp
SocialApr 17, 2026

Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp

‘Harvard Thinking’: How super-agers keep their brains young Experts break down ‘biological contradiction’ of a 65-year-old with the memory of a 25-year-old — and what that means for the rest of us https://t.co/29qpNudp1J https://t.co/X951FiSfiS

By David Barzilai, MD PhD
Women Experience Faster Tau Buildup and Cognitive Decline
SocialApr 17, 2026

Women Experience Faster Tau Buildup and Cognitive Decline

Women show greater tau buildup and faster cognitive decline than men in Alzheimer's https://t.co/5GKfzXZPSo https://t.co/8L9wxDsFAp

By David Barzilai, MD PhD
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
SocialApr 17, 2026

High SHBG Increases Sarcopenia Risk; Free Hormones Protect

Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...

By David Barzilai, MD PhD
Perceived Sleep Quality Beats Objective Data in Reducing Worry
SocialApr 17, 2026

Perceived Sleep Quality Beats Objective Data in Reducing Worry

Better Sleep Can Reduce Worry and Rumination in Older Adults People’s perceptions of their sleep also proves to have stronger associations with their worry and rumination than objective sleep quality monitored with a device. https://t.co/rgAxrILC6E https://t.co/JpHwzEczjH

By David Barzilai, MD PhD
7‑8 Hours Nightly Cuts Type 2 Diabetes Risk
SocialApr 17, 2026

7‑8 Hours Nightly Cuts Type 2 Diabetes Risk

This Is How Much Sleep You Need to Lower Your Type 2 Diabetes Risk https://t.co/UI9VyQiv3a https://t.co/ac9eBXPIBu

By David Barzilai, MD PhD
Review Panel Finds Anti‑amyloid Alzheimer Drugs Offer Little Benefit
SocialApr 17, 2026

Review Panel Finds Anti‑amyloid Alzheimer Drugs Offer Little Benefit

Medical Review Group Questions Usefulness of Some Alzheimer’s Drugs Group says anti-amyloid treatments don’t offer noticeable benefits https://t.co/Z9tRQquyZX

By David Barzilai, MD PhD
GLP‑1 Drugs Show Promise for Treating All Addictions
SocialApr 17, 2026

GLP‑1 Drugs Show Promise for Treating All Addictions

GLP-1 medications get at the heart of addiction: study Diabetes and obesity drugs show promise in treating and preventing all substance use disorders https://t.co/buHywnw9Wk https://t.co/0lunbQbjsb

By David Barzilai, MD PhD
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
SocialApr 16, 2026

Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets

Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS

By David Barzilai, MD PhD
Trust Outweighs Taste in Organic Food Choices
SocialApr 16, 2026

Trust Outweighs Taste in Organic Food Choices

Choosing to buy organic food depends more on trust than taste – what our new study in the UK and Japan shows https://t.co/BEYetT9k5O https://t.co/kcJEOByvR8

By David Barzilai, MD PhD
Ageing Happens Unevenly Across Organs, Not Uniformly
SocialApr 16, 2026

Ageing Happens Unevenly Across Organs, Not Uniformly

Mosaic ageing: from organ-specific decline to the cause of death “A growing body of biomedical and evolutionary studies increasingly questions the notion of uniform ageing: rather than a whole-body (single) trajectory, ageing appears to occur unevenly across organs, tissues and even...

By David Barzilai, MD PhD
Elevated Lipoprotein(a Drastically Raises 30‑Year CVD Risk
SocialApr 16, 2026

Elevated Lipoprotein(a Drastically Raises 30‑Year CVD Risk

Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a) 👉"Multivariable adjusted hazard ratios for levels above 120 mg/dL vs below 10 mg/dL or above the 99th percentile vs below the 50th percentile (11 mg/dL) were 1.54...

By David Barzilai, MD PhD
Accelerated Biological Aging Raises Dementia Risk in Women
SocialApr 16, 2026

Accelerated Biological Aging Raises Dementia Risk in Women

Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study "In this cohort study of older women, accelerated biological aging measured by AgeAccelGrim2 was associated with higher risk of incident MCI/probable...

By David Barzilai, MD PhD
Aged Polystyrene Microplastics Speed Worm Aging via Ferroptosis
SocialApr 16, 2026

Aged Polystyrene Microplastics Speed Worm Aging via Ferroptosis

Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway https://t.co/gGPlKDdgW1 https://t.co/NZ31ToOTp2

By David Barzilai, MD PhD
Americans Trust Career Scientists Over Agency Leaders
SocialApr 16, 2026

Americans Trust Career Scientists Over Agency Leaders

Stark Divide: Americans More Confident in Career Scientists at U.S. Health Agencies Than Leaders A new survey by the Annenberg Public Policy Center finds that 67% of Americans have confidence in career scientists working at U.S. federal health agencies, compared with...

By David Barzilai, MD PhD
Clonal Haematopoiesis Reveals New Insights Into Aging Biology
SocialApr 16, 2026

Clonal Haematopoiesis Reveals New Insights Into Aging Biology

Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis "...how CH enhances our understanding of the biology of ageing." https://t.co/9MKGZIakFY https://t.co/noyHAviY3E

By David Barzilai, MD PhD
Scientists Explore Possibility of Slowing Human Aging
SocialApr 15, 2026

Scientists Explore Possibility of Slowing Human Aging

Can aging be slowed? Some academic scientists think so with @NirBarzilaiMD, @mkaeberlein, and @sessi73 https://t.co/1EoZ7evdDF @AAMC https://t.co/StDgRGSRqr

By David Barzilai, MD PhD
First Five Get $99 Vitalist Bay 2026 Pass
SocialApr 15, 2026

First Five Get $99 Vitalist Bay 2026 Pass

Courtesy @adamgries... @VitalistBay 2026: 🗓 May 14-17 🔗https://t.co/5dh7N2M7bv "The first 5 can use the code LI-T-MINUS-30 for $99" 🎤 110+ speakers across 6 tracks 🛠 60+ hands-on workshops 🧘 20+ activations running all day, every day" https://t.co/JMMNaUHMIs

By David Barzilai, MD PhD
Aging Autistics: Higher Health Risks and Potential Benefits
SocialApr 15, 2026

Aging Autistics: Higher Health Risks and Potential Benefits

How do autistic people age — and what does it mean for their health? Most research on autism focuses on younger people, but some studies suggest older adults face increased risks — and perhaps benefits. https://t.co/3YAztmYqGh https://t.co/VKdej4ke2Y

By David Barzilai, MD PhD
Engineered Brain Cells Erase Alzheimer’s Proteins in Mice
SocialApr 15, 2026

Engineered Brain Cells Erase Alzheimer’s Proteins in Mice

Enhanced brain cells clear away dementia-related proteins New cellular immunotherapy approach for Alzheimer’s disease shows promise in mice https://t.co/YBoqUZLvJo https://t.co/FjG699Etga

By David Barzilai, MD PhD
Dietary Restriction Extends Lifespan via Conserved Molecular Pathways
SocialApr 15, 2026

Dietary Restriction Extends Lifespan via Conserved Molecular Pathways

Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species https://t.co/JodR3q7w2z https://t.co/46npim9J0m

By David Barzilai, MD PhD
Statins Don't Harm Muscle Health in Older Adults
SocialApr 15, 2026

Statins Don't Harm Muscle Health in Older Adults

Statin use does not impair muscle health in older adults: findings from the SCOPE study https://t.co/WKjk9Ov0rG https://t.co/xTo9mk3vbw

By David Barzilai, MD PhD
AI Tackles Tough Challenges, Shaping Science, Health, Humanity
SocialApr 15, 2026

AI Tackles Tough Challenges, Shaping Science, Health, Humanity

Solving a hard problem with AI… and next steps A high quality discussion with @demishassabis Thoughtful approaches to harnessing AI for better science, health, and personal welfare across humanity. https://t.co/Uyz6BpuWCi https://t.co/Uv2DyyPXES

By David Barzilai, MD PhD
Biology Needs Systems Thinking, Not Just Parts Cataloguing
SocialApr 15, 2026

Biology Needs Systems Thinking, Not Just Parts Cataloguing

Can a biologist fix a radio?—Or, what I learned while studying apoptosis Yuri Lazebnik’s classic 2002 paper hilariously exposes the flaws of reductionist biology. He imagines biologists studying a broken radio by removing random parts to see what breaks. If pulling...

By David Barzilai, MD PhD
Elderly Can Harbor Amyloid Yet Remain Cognitively Normal
SocialApr 15, 2026

Elderly Can Harbor Amyloid Yet Remain Cognitively Normal

“ In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significant amyloid burden can remain cognitively normal.” Small sample size, but with numerous confirmatory studies...

By David Barzilai, MD PhD
Energy Levels Reveal Early Healthspan Decline Signals
SocialApr 15, 2026

Energy Levels Reveal Early Healthspan Decline Signals

Energy isn't just a feeling. It may be one of the earliest biological windows into healthspan decline. New from @BuckInstitute's Healthspan Horizons, led by @NathanPriceSci, exploring how mitochondrial function, sleep, glucose stability, and inflammation converge as early warning signals. This matters for...

By David Barzilai, MD PhD
Molecular Signature Differentiates Aging Cognitive Resilience vs Decline
SocialApr 15, 2026

Molecular Signature Differentiates Aging Cognitive Resilience vs Decline

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease 👉"Together, our study points to a multiomic molecular signature of the hippocampus that distinguishes cognitive resilience and deterioration with ageing." https://t.co/rRkFg6HKO0

By David Barzilai, MD PhD
Brain Age Gap Predicts Lifestyle Impact on Mental Health
SocialApr 15, 2026

Brain Age Gap Predicts Lifestyle Impact on Mental Health

Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health https://t.co/kgvgyZ9v4S

By David Barzilai, MD PhD
Mouse Watching “The Matrix” Guides Massive Brain Map
SocialApr 15, 2026

Mouse Watching “The Matrix” Guides Massive Brain Map

How a mouse watching 'The Matrix' helped scientists create the largest map of a brain to date https://t.co/wXYV0tGtAD https://t.co/QaBSJ6qpnv

By David Barzilai, MD PhD
Depleting Microbiome Restores
SocialApr 15, 2026

Depleting Microbiome Restores

Microbiome depletion rejuvenates the aging brain "Our findings demonstrate that age-associated microbial inflammation contributes to brain aging and that its attenuation can restore youthful features at the molecular, cellular, and functional levels." https://t.co/GuBPBxxzeH

By David Barzilai, MD PhD