UAE's $8 Trillion Healthy‑Ageing Market Opens Investment Opportunities
Dubai Longevity Authority: Investment opportunities in UAE’s $8 trillion healthy ageing market 💫"We firmly believe that every scientific breakthrough should deliver tangible benefits to people's lives, and that serving humanity will always remain the ultimate purpose of every investment in science, knowledge and innovation." — Sheikh Mohammed bin Rashid Al Maktoum https://t.co/UzgWOxfTfv
AI Uncovers Peptide Structures for Healthy Aging
Dietary geroprotective peptides: structural determinants, AI-driven discovery, and synthetic biology production for healthy ageing https://t.co/ihAsC3PVJM https://t.co/3aogpRk97I
Low Vitamin D Fuels Inflammation, Heightens Motoric Cognitive Risk
Vitamin D, systemic inflammation, and motoric cognitive risk: exploring the risk factors and mediation pathways https://t.co/0SjbPdiwwR
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Cognitive Decline in Atherosclerotic Diseases: Mechanisms and Potential Solutions Dissecting out the unexpected effects of SGLT2 inhibitors on human aging Get https://t.co/k1mppbz6Ta
Exercise's Antidepressant Power Explained by New Framework
From movement to motivation: a proposed framework to understand the antidepressant effect of exercise https://t.co/fUsPto3XIM https://t.co/QnQhhN1bpM
Risk‑Based Framework Redefines Breast Cancer Screening Frequency
Beyond the mammogram: a framework for smarter breast cancer screening A risk-based framework for deciding when, how often, and which way to screen https://t.co/HjbhIcFDJm https://t.co/FYOkjspWK2
Mitochondrial Transfer Advances Stem Cell Therapies
The progress of mitochondrial function and transfer in stem cell regulation and therapy https://t.co/rltLeBPkHU https://t.co/WreIarDoAo
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Tiny Tweaks in Sleep, Activity, Diet Extend Lifespan
Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study https://t.co/5q1WnJhN78
Harvard Unveils First Evidence‑Based Longevity Report
Pathways to Longevity Harvard Medical School's first Special Report dedicated to longevity science.👨⚕️ 250+ comments and 100+ reposts from across the field since launch. Evidence-based longevity reaching a mainstream audience, on medicine's terms. 🔗https://t.co/LkYEpplFjK
From Self-Optimization to Collective Joyful Longevity Raves
From self-optimization to collective joy at scale By @TinaWoods 🏆 Note for readers: Dr. Woods is not only a global thought leader on healthspan, the exposome, & joyspan, she is also a talented DJ. Her “Longevity Rave” events come highly recommended 🪩 https://t.co/D0vRHnvjc4...
Multivitamins, Veggies, and Omega‑3 Slow Biological Aging
How to Slow Biologic Aging with a Multivitamin, Vegetables, and Omega-3 I set a high bar for longevity science content I suggest to patients and clients. Dr. Rhonda Patrick, PhD clears it again with this @prof_horvath PhD interview 👨🏻⚕️ https://t.co/GOm9c0hNEh https://t.co/Q4TErVrdoo
Lake Sturgeons May Live Up to 400 Years
Lake sturgeon (Acipenser fulvescens) growth and longevity estimated from adult capture–mark–recapture data 🤯"Age estimated for a 160 cm FL male lake sturgeon across the five populations ranged from 90 to 279 years. Age for a 180 cm FL female across populations ranged from 99...
X Chromosome Plays Bigger Role in Health than Thought
The misunderstood sex chromosome: how X affects your health Researchers are gaining a new appreciation for the genes on the X and Y chromosomes and how they shape sex differences in health and disease susceptibility. By @ClaireAinsworth https://t.co/XxvoI4WD9d https://t.co/emMa0k4vNr
Alzheimer’s Drug Review Sparks Expert Dispute over Benefits
Analysis of Alzheimer’s Drugs Stirs Debate About Their Effectiveness By @PamBelluck "The review said a certain class of drugs had little clinical benefit, but many Alzheimer’s experts criticized the analysis, saying it unfairly lumped failed drugs with two recently approved treatments..." https://t.co/xjPGVCwtja
First Human Trial of Cellular-Reprogramming Eye Therapy
World-first: therapy to make cells young again trialled in a person A participant in a landmark clinical trial has been given a cellular-reprogramming treatment that aims to rejuvenate damaged cells in the eye. By Heidi Ledford | @heidiledford @Nature https://t.co/OlrhvNuXVC https://t.co/MfHAQdX3fm
First Reverse‑aging Drug Administered to Human
The first-ever reverse-aging drug was just injected into a human Featuring @lifebiosciences @M_S_Ringel and @davidasinclair, with interviews by Daniel Oliver @rejuvenatebio, @mkaeberlein, @BKennedy_aging, and many more.👨⚕️ By @Hilarx @BusinessInsider🗞️ https://t.co/vdxr1geDzM https://t.co/sL2Ts1IjPA
Calorie Restriction Lowers C3a, Curbing Inflammaging
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging "complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging" https://t.co/UaBPbf7wAe
Long‑term Multimorbidity Profiles Boost Precise Glycemic Care
Longitudinal multimorbidity trajectories shape personalized glycaemic patterns "...suggests that integrating longitudinal multimorbidity profiling with circulating proteomics may enhance precision glycaemic management, offering actionable insights for dietary interventions in the older population." https://t.co/hvpr59aT9e
Plant‑based Diets Extend Life for Cardiometabolic Patients Worldwide
Associations of plant-based diets with all-cause and cause-specific mortality and life expectancy among participants with cardiometabolic disorders from UK, USA, and China https://t.co/IAF3t9rEuh https://t.co/Jk4giqyov4
Losartan Partially Reverses Age‑related Metabolic Changes in Mice and Humans
Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan 👉 "our results suggest that losartan can partially reverse age-related metabolomic changes in both male mice and humans, with distinct species-specific responses." https://t.co/MUeKMyOWmD
Marrying Into Long-Lived Families Boosts Spouse Health Beyond Genetics
Familial healthy aging and longevity: the role of spouses "Spouses marrying into longevity-enriched families exhibit a substantial and broad health advantage that is not attributable to shared genetic predisposition to longevity or socioeconomic differences." https://t.co/UzWkyMq7Kq
Metformin Shows No Impact on Epigenetic Aging in HIV Patients
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial "...no significant difference was noted in the primary outcome between groups..." https://t.co/gfrIJIq1f8
Exercise Redirects Energy to Repair, Slowing Aging
Physical activity and metabolic rates in humans "we also review the evidence, mostly from humans, that increased levels of physical activity slow aging and reduce vulnerability to disease by diverting energy away from processes that improve reproductive success at the expense...
Golden Spiny Mice Defy Aging with Superior Tissue Repair
Immunometabolic resistors of aging in long-lived golden spiny mice 🗣️High tissue repair capacity, reduced frailty with lower inflammaging, fibrosis, cellular senescence, and youthful transcriptome even beyond 4 years https://t.co/An1O5LQxBh https://t.co/AfD8NDAChU
Nanoplatform Revives Aged Stem Cells for Bone Healing
A sustained NAD+ supplementation-biosynthesis nanoplatform for metabolic restoration in aged bone regeneration "...These findings demonstrate that this nanoplatform can effectively restore the functions of senescent BMSCs, providing a promising therapeutic strategy for aging-related bone regeneration." https://t.co/V6anCVfDPU
Risk Factors Impact Early‑onset Dementia More than Late‑onset
Risk factors for early-onset and late-onset dementia: a prospective cohort study "...Several exposures were more strongly associated with early-onset dementia than with late-onset dementia. The protective association between female versus male sex and dementia was more pronounced for early-onset dementia than...
NAD+ Connects Nutrition, Metabolism, and Healthy Aging
Mechanisms of NAD+ Homeostasis in Aging and Disease "...Together, these perspectives position NAD+ as a unifying framework linking nutrition, metabolic resilience, and the mechanisms of healthy aging and disease..." https://t.co/aOb7X48jBq
Resistance Training Boosts Strength and Body Composition at Any Age
It's never too late: The impact of resistance training on strength and body composition in females across the lifespan – A systematic review and meta-analysis https://t.co/kZMU3fsQFL https://t.co/WX5rrbenCQ
Dormant Longevity Pathways Reactivated by Clusterin Protein
Long-Living Wild Mouse May Hold Secret to Healthy Aging “And it seems other mice—and humans—may have these pathways too, they’ve just gone dormant for some reason or another. But they can be reactivated by proteins like clusterin.” https://t.co/5FGKxXMTXf https://t.co/YeAUMSZqOW
SGLT2 Inhibitors Linked
Association of SGLT2 Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study https://t.co/AcdrF0K9sd https://t.co/Un3NeLFsGD
Most Cardiovascular Events Follow Poorly Managed Risk Factors
Very High Prevalence of Nonoptimally Controlled Traditional Risk Factors at the Onset of Cardiovascular Disease ⚡️"These results not only challenge claims that CHD events frequently occur without antecedent major risk factors but also demonstrate that other CVD events, including HF or...
Cross-Species Cell Atlas Reveals Organelle Resilience for Longevity
Organelle resilience as a comparative blueprint for longevity 🗣️I introduce the Comparative Metabolic Longevity Cell Atlas (CMLCA), a cross-mammalian platform integrating standardized cellular systems, organelle-resolved multi-omics, and computational analysis to identify conserved features of resilience and inform next-generation strategies to improve...
Many STEMI Patients Lack Traditional Risk Factors, Outcomes Similar
ST‐Segment–Elevation Myocardial Infarction (STEMI) Patients Without Standard Modifiable Cardiovascular Risk Factors—How Common Are They, and What Are Their Outcomes? https://t.co/ntbIex0nOp
AI‑generated Fake Citations Threaten Scientific Literature Integrity
Hallucinated citations are polluting the scientific literature. What can be done? Tens of thousands of publications from 2025 might include invalid references generated by AI, a Nature analysis suggests. https://t.co/rfmBGeu2po By @MiryamNaddaf & @ElizQuill https://t.co/lgS1w7MwCw
Longevity Medicine: Upstream Prevention Over Hype
My friend & colleague @Primas wrote a thoughtful reflection on longevity medicine “I didn’t leave Internal Medicine. I followed it upstream.” It separates serious longevity medicine from hype: prevention, judgment, function, & evidence applied early.👨⚕️ https://t.co/6Jndf6ycKl https://t.co/j28DnIwPPs
Air Pollution Accelerates Brain Aging, Boosts Dementia Risk
Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study "Our findings support the association between air pollution and dementia, as well as a reduction in global and several regional brain volumes. Notably, biological...
Cognitive Resilience Lets some Avoid Dementia Despite Alzheimer’s
Not all Alzheimer’s leads to dementia "Why do some people experience memory loss and cognitive decline as Alzheimer’s builds up in their brain, while others stay mentally sharp? This question lies at the heart of new research into “cognitive resilience”, a...
SMuRF‑less ACS Patients Face Higher Mortality, Receive Fewer Therapies
Higher mortality in acute coronary syndrome patients without standard modifiable risk factors: Results from a global meta-analysis of 1,285,722 patients "Despite lower body mass index and fewer comorbidities, SMuRF-less patients had increased in-hospital mortality and cardiogenic shock. However, despite worse outcomes,...
Athlete Sudden Death Shows Flawed Screening, Mixed Guidance
Sudden Cardiac Death in Famous Athletes, Lessons Learned, Heterogeneity in Expert Recommendations and Pitfalls of Contemporary Screening Strategies "In this review, we highlight a few cases that generated intense scrutiny by the public, media and medical professionals..." https://t.co/Ab8gWwGZ1t
Sex and Age Shape Immune Response, Undermining Uniform Treatments
The problem with one-size-fits-all medicine: Biological sex and the aging immune system @BBParis1984 https://t.co/kd5H69wTCZ https://t.co/E3AjzFl0xC
Higher Teen IQ Predicts Lower Dementia Risk Later
Adolescent IQ and risk of dementia: a 67-year prospective study 🥳Adolescent IQ is an early life factor associated with a lower risk of dementia in older adulthood. This research highlights the importance of a life-course perspective on brain health.🧠 https://t.co/6AaXKrXEND
Time‑restricted Feeding Restores Metabolic Health in Aging Mice
Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice "These results underscore the potential of TRF as a dietary intervention to mitigate adipose dysfunction and promote metabolic health in the aging population." https://t.co/JgTEjivlCM
Exercise Revives Aging Muscles Through Mitochondrial Remodeling
Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans "We report that exercise-induced improvements in functional capacity, including reduced frailty in old mice, are dependent on mitochondrial adaptations in skeletal muscle at structural, enzymatic,...
Adipocyte SLC25A51 Controls Mitochondrial Function and Aging Metabolism
The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging https://t.co/4SuyuA0UsH https://t.co/h1nYczP9Jl
Short-Term Diet Shifts Affect Markers, Not Age Reversal
Short-Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing 🔎"[Though] caution is warranted in interpreting such changes as evidence of biological age reversal as observed shifts may reflect acute physiological responsiveness to dietary inputs rather than altered ageing trajectories." https://t.co/kQflQ3i3Kw
Higher DI‑GM Scores Cut Mortality via Slower Aging
Association of dietary index for gut microbiota with premature and all-cause mortality: A mediation analysis of biological age 👉"Elevated DI-GM scores were associated with a lower premature death and all-cause mortality, with biological aging serving as a significant mediator in this...
Mito‑Nuclear Communication Breakdown Drives Alzheimer’s Pathology
Mitochondrial-nuclear crosstalk: A central axis in Alzheimer’s disease 👉Mito–nuclear crosstalk is disrupted in Alzheimer’s disease. https://t.co/grY0fnE0RV https://t.co/ZxSWTOPwg4
Vigorous Exercise Reduces Pressure‑Independent Arterial Stiffness
Intensity Matters: Vigorous Activity is Associated with Lower Pressure-Independent Arterial Stiffness in the UK Biobank 😅"Vigorous activity was consistently associated with lower ASI-PI, suggesting beneficial vascular adaptations to exercise beyond its effects on hemodynamic load." https://t.co/12Dv4bmWOD
Low CAD Genetic Risk Drives Multigenerational Longevity
Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging https://t.co/mwkzNuRK2D https://t.co/xr1dKT8kjB