New Insights Reveal Cellular Senescence’s Role in Aging
We're learning a lot about cellular senescence, how to track it, and its role in aging and disease. Cover and commentary @CellCellPress https://t.co/bFma1UocnS https://t.co/7ZRfmmFL5Z
AI Should Empower, Not Replace, Healthcare Clinicians
Workforce survival in healthcare "The coming decade demands that we stop asking whether AI can replace clinicians and start asking how it can help us keep them." https://t.co/EkYGoRfxXj https://t.co/8Zs0G1Ssl7
Rare IL‑10 Autoantibody Subset May Respond to CAR‑T
Not every day you see an odds ratio of 50 (for interleukin-10 autoantibodies and a common HLA allele). ~80% of patients with inflammatory bowel disease (IBD) have this HLA allele These individuals (~3.5% of IBD) may benefit from B cell depletion...
Cerebellum Linked to Cognitive Resilience and Alzheimer’s
The cerebellum has long been considered spared from being tied to cognitive resilience and Alzheimer's disease. That turned out to be wrong @NatureNeuro https://t.co/ASXhQlJoaH
Sleep and Exercise Suppress Age‑Related CHIP Mutations
Blood stem cell mutation clones (CHIP) occur frequently with advanced age and portend risk of cardiovascular disease and cancer. A new report @Nature today tells us about suppression of CHIP by sleep health and exercise in the experimental model and...
AI Cuts Brain Tumor Diagnosis From Days to Minutes
Reducing brain tumor diagnosis from 12 days to 12 minutes with AI. Predicting methylation pattern from path slides. Outperformed 5 neuropathologists @NatureCancer @MoritzGerstung https://t.co/9hetQkGhLq https://t.co/hpigiOT0QG
Epigenetic Regulator of Microglial Mitochondria Emerges as Alzheimer’s Target
The pro-inflammatory role of microglia is considered a key driver of Alzheimer's disease. Today @NeuroCellPress discovery of an epigenetic regulator of microglial mitochondria in the experimental model that may be amenable as a target for therapy or prevention https://t.co/NXkEi59H8N
AI Flags Breast Cancer Risk up to Ten Years Early
AI of radiologist read as normal mammograms shown to detect high-risk of breast cancer out several years "Artificial intelligence scores from sequential mammograms in individuals diagnosed with breast cancer showed elevated scores up to 10 years before diagnosis" a retrospective study, but supported...
First Glaucoma Patient Treated with Partial Cellular Reprogramming
The first participant to receive partial cellular reprogramming for eye disease (advanced glaucoma) in a pilot study of 12 patients was treated. Using 3 of the 4 Yamanaka stem cell factors to potentially achieve cellular rejuvenation @Nature https://t.co/R4oJlrPhnS
Cardiometabolic Disease: A Lifelong Journey From Womb to Tomb
In today's @TheLancet there are 3 papers on cardiometabolic disease: biology, epidemiology, prevention/treatment. The sobering and all to common story from womb to tomb conveyed in this graphic https://t.co/rVs2Yz97NC https://t.co/OpuJTia0bC https://t.co/i714onXoCG https://t.co/q1o0tjj6d4
SGLT2 Inhibitor Cuts Heart‑failure Hospitalizations >80% in Variant Carriers
A sodium-glucose cotransporter 2 drug (SGLT2) was linked to >80% reduction of hospitalization for heart failure in people who carried a disease-causing (pathogenic or likely pathogenic) genomic variant. Compared with placebo in a randomized trial with subsequent exome sequencing...
Myostatin Inhibitor Preserves 55% Lean Mass with Tirzepatide
Preserving lean mass during tirzepatide (Zepbound) treatment. A randomized trial of a myostatin inhibitor for muscle mass building shows proof-of-concept. A 55% retention of lean mass compared with placebo https://t.co/urw9Gvy11L just published @NatureMedicine https://t.co/ukUhLbAXFL
Survodutide Delivers ~16% Weight Loss in Trials
The tide is coming in. High tide of the X-tides, that is in the new GLP-1 family of peptide drugs. Today @NEJM survodutide, a GLP-1 and glucagon dual receptor agonist (no GIP, like tirzepatide) drug that achieved ~16% body weight...
GLP‑1 Therapy Cuts Mortality and Complications in Obese Autoimmune Patients
GLP-1 drugs for people with both obesity and autoimmune diseases. The drugs were linked to reduced mortality, stroke, pulmonary embolism, and emergency room visits. From a new propensity matched analysis of 13,204 GLP-1 drug users and 13,204 controls https://t.co/2ik57mwRW0...
Future Heart Disease Prevention Targets Inflammation, Not Lipids
The next frontier for prevention of heart and vascular disease isn't targeting lipids. It's about blocking inflammation. These are some of the ongoing clinical trials @NatureMedicine https://t.co/DSLMoPFqs7 https://t.co/RDoVUXKjBl
Human‑augmented AI Screening Saves $1.3M, Adds 14.7 QALYs
A cost-effectiveness assessment of using AI in disease screening (modeling) "Implementing an annual ‘copilot’ strategy in all ages would save US$1.32 million while gaining 14.73 quality-adjusted life years over a lifetime [per 100,000 people]" "Our findings demonstrate the indispensable role of human...
CRISPR Embryos and Self‑learning AI Now Real, Risks Looming
Two of the most powerful technologies we've ever known—CRISPR human embryo editing and self-improving A.I.—are getting actualized, and carry known and unforeseen risks https://t.co/yQY4KqCIhy https://t.co/08ZSvxZ07k @AnthropicAI https://t.co/RLM7Pj93Y7
Microglia Shift Determines Alzheimer’s Progression in Elderly
Identifying an inflection point for Alzheimer's disease from the brains of 80 and 100 year old individuals. Microglia transition is key; initially it is protective vs inflammatory changes triggered by amyloid. But microglia can turn destructive linked to tau. Resilience in...
Bad Memories Can Disrupt Sleep, Not Just Vice Versa
Bad sleep leads to poor memory. But what about the reciprocal of bad memories leading to poor sleep? @ScienceMagazine https://t.co/bxlTe2bIDp https://t.co/CG7L1cXGxm https://t.co/0PqJcJZKBM
Blood Test Predicts Lung Cancer Risk Years Early
A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β Validated...
Partial Reprogramming Firms Secure Funding, Launch Clinical Trials
The longevity (aka rejuvenation) companies focused on partial cellular reprogramming are getting more investments and starting clinical trials (eye and liver) @newlimit gets a new jolt, to add to billions invested in @altos_labs, @RetroBio_ , @lifebiosciences, @turn_bio, @ShiftBioscience, @rejuvenatebio, https://t.co/gSsHpQAU1k
90-120 Min/Week of Strength Training Is Optimal
What's the right amount of time for resistance training? A new study supports 90-120 minutes/week across multiple outcomes, which plateaus beyond that for lack of additional benefit From 30-year follow-up of ~150,000 participants https://t.co/mUy9o4HkbH https://t.co/T31YKoyMmX
Mitochondrial Transfer Fuels Cancer Cell Death and Inflammation
Cancer and the mitochondria @Cell_Metabolism Effects of mitochondrial transfer between cells (pathological spelled wrong in figure) and these organelles as a driver of cell death, inflammation https://t.co/vs6b11wwEf https://t.co/4GFjBSLBYf https://t.co/GXl9RxaETU
Unprecedented Trial Results Show Major Cancer Survival Gains
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO https://t.co/8a642gUMF4
Smartphone Facial Video AI Accurately Measures Heart Rate Universally
Using smartphone facial video clips with AI to passively and accurately get heart rate, across all skin pigmentation groups @nature "This is the first demonstration that smartphones can be used to monitor both HR and daily RHR passively during normal personal phone...
No Universal Safe Alcohol Level; Risks Outweigh Benefits
Finings of an exhaustive review of alcohol effects on 20 health outcomes from 843 studies https://t.co/Xnzg1LGpGp —"Current evidence does not support a universally applicable threshold for alcohol consumption that maximizes health for all." Associations: —Increased risk of 10 cancers, pancreatitis, cirrhosis, tuberculosis, atrial fibrillation,...
Sequencing Needed: Polygenic Scores Miss Most High-Risk Carriers
To identify high-risk patients for breast cancer screening, polygenic risk scores are not enough. Sequencing to identify key mutations (PV, pathogenic variants) is necessary. The majority of PV carriers were not picked up as high-risk in this study. https://t.co/8bVdByhKC5 @JAMAOnc @ASCO
Bispecific T‑cell Engager Shows Promising Responses in Refractory
Just published @NatureMedicine and presented @ASCO Advanced, refractory solid cancers treated with a bispecific T cell engager (BiTE, Figure), Phase 1 trial, with or without Keytruda, in 61 patients. Some very favorable responses with "manageable safety profile" https://t.co/MkzQXY1psA
Retatrutide Delivers 28% Weight Loss, but Carries Risks
Retatrutide, the triple receptor (GLP-1, GIP, glucagon) most potent weight loss drug yet seen (w/ 28% body weight reduction), pushes the limits, introduces some risks, by @PostRowland gift link https://t.co/v9XrXc7vBJ https://t.co/hfg7zw3JRz
Brain Waste Drains Regionally, Bypasses Cervical Nodes, Disrupted by Disease
How the brain gets rid of its waste products, assessed by new tracer methodology, reveals regional drainage sites, little directed through cervical lymph nodes, and disruption by disease @CellCellPress https://t.co/hHBPJRfPGD
P‑tau217 Blood Test Validated for Early Alzheimer Prediction
The p-tau217 breakthrough blood test replicated again, predicting Alzheimer's disease in a large cohort mean age 61. The cover of the new issue is telling @TheLancet https://t.co/Qre6mCkpMV https://t.co/ke8SULhdvI
Reversing Mesenchymal Drift Could Extend Healthspan
With aging, cells lose their identity and undergo a mesenchymal drift. Reversing this drift may be a way to mitigate aging and promote healthspan. A new @CellCellPress review https://t.co/fr4N6b75Im https://t.co/VLtiBVN1NM
Stem‑cell Heart Patches Improve Outcomes in 12 of 20 Patients
Cardiac "remuscularization" for treating severe heart failure with patched heart muscle derived from stem cells (a biological ventricular assist device) successful in 12 of 20 patients @NEJM https://t.co/mAwgj2rAwE https://t.co/3ogxaJFDE0 https://t.co/J1ozMsS4Oh
New Stem Cell Subtype Remembers Inflammation, Impacts Prognosis
New @nature. Discovery of a new subtype of blood stem cells—HSC-iM—which have memory to previous inflammation, such as with Covid or aging, and prognostic significance https://t.co/hRfp5xnJGj
Cross-Species Transcriptomic Clocks Enhance Disease Risk Prediction
Just published @Nature Very impressive study of gene expression and hallmarks of aging across 4 mammalian species (including humans), by @gladyshev_lab. Transcriptomic clocks add to epigenetic, organ and cellular clocks for predicting health outcomes. Example of a few proteins found with...
Gut Microbiome Remains Altered Years After Polyp Removal
The gut microbiome and colon cancer. Sustained changes (+metabolites) many years after an adenomatous polyp is removed. https://t.co/Q1hR6us7vS https://t.co/GhMlrOohVE
Paricalcitol Shows Promise in Metastatic Pancreatic Cancer
A small randomized trial in patients with metastatic pancreatic cancer found benefit for paricalcitol, a Vitamin D analog https://t.co/CDnIwm0xeo Good @salkinstitute explainer https://t.co/QgEKHiquIa https://t.co/m32CFTInJA
AI Risks Undermining Skills of New Physicians
We've written about AI-induced physician deskilling that has already surfaced https://t.co/iMy6zyWnhZ @tberzin AI-induced never-skilling among newly trained doctors, while not yet proven, is a serious concern that needs to be addressed @NatureMedicine @nliulab https://t.co/yov3YvsGti
Clinician‑Machine Trust Trumps Pure Algorithm Accuracy
New @AnnalsofIM "The Human Factor in Clinical AI: Why Technology Alone is Not Enough" Gets into the trust issue and concludes: 'The most important question in medical AI may not be “how accurate is the algorithm?” but rather “how do...
Vaccines Deliver Remissions in Hardest Cancer Types
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile) https://t.co/8PE5nOMfj1
Cancer Immunotherapy Surge: Emerging Treatments and Future Outlook
I wrote about the remarkable proliferation of cancer immunotherapies, and what's in store https://t.co/od4MeFMGik https://t.co/5jI10LLbLq
New US Dietary Guidelines Flawed, Protein Section Unsubstantiated
On the things wrong in them new US dietary guidelines (DGAs) in today's @NEJM, the "most significant reset of federal nutrition policy". Section on protein below, elsewhere gets ino beef tallow and other changes w/o evidence https://t.co/uepeVk2a38 https://t.co/q6QV9r27rP
GLP‑1 Cancer Link Unclear, Dedicated Trials Needed
Whether there is a real impact of GLP-1 drugs on cancer is unresolved. If confirmed, it could simply reflect weight loss or, as seen for other conditions (e.g. heart, kidney), weight loss independent effects. We need dedicated trials to resolve...
Sleep's Complex Physiology Links Directly to Dementia Risk
Sleep physiology and dementia, a new 5★ review @ScienceMagazine, gets into glymphatics, blood volume, heart rate variability, vasoactive amines, and neuromodulators. by @MaiNedergaard https://t.co/zBMc1XQZcX https://t.co/eORVYPWmNM
Daedalus Issue Highlights AI's Transformative Role in Medicine
The new issue of Daedalus, the open-access Journal of the American Academy of Arts and Sciences, is chock full of good material on AI. w/@demishassabis @ylecun @alondra @pushmeet and so many others I wrote about the future of AI-facilitated medicine https://t.co/UMPKLcpuq5 https://t.co/wvTR1GUIvg
Retatrutide Delivers Record 28% Weight Loss, Raises Safety Concerns
Retatrutide, a triple receptor drug for GLP-1, GIP, and glucagon, is the most powerful weight loss drug yet. A significant issue is too much weight loss among the trial participants. New randomized trial results announced today with 28% body weight...
Muscle Hormone Irisin Shields Brain Cells in MS Model
An exercise hormone derived from muscle—irisin— is neuroprotective, preventing brain cell loss, as seen in the experimental model of multiple sclerosis @NatMetabolism https://t.co/CC4KDOJTn1 https://t.co/9bbcLpW4g6 https://t.co/6NP0sKx3Yr
Preservatives Linked to Hypertension and Cardiovascular Risk
The link between chronic exposure to several preservative food additives and hypertension, along with risk of cardiovascular disease https://t.co/FIm02gPv3f
Vitamin D and Calcium Don’t Prevent Fractures or Falls
Supplementation with Vitamin D or calcium, or both does not help prevent fractures or falls. From a new systematic review of 69 randomized trials and >150,000 participants https://t.co/nsMUzmBreq
IL-6 Blocker Shows Promise for Treating Depression
Would depression respond to an anti-inflammation drug (interleukin-6 blocker)? A small pilot, placebo-controlled randomized trial suggests this might be possible https://t.co/zKO76yvRAo https://t.co/e8K9YLEAQj