Obesity Raises Risk for Multiple Cancer Types
Obesity and overweight are risk factors for several types of cancer. Why? A @JAMA_current review https://t.co/fn5tfxNnsM https://t.co/caCsAt2vuB
Inactivity Kills 5 Million Annually; Policies Remain Unimplemented
5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them. No improvement in >20 years! 3 new papers @NatureMedicine @NatureHealthJnl https://t.co/Nvl1AhTz2h https://t.co/hGneBJTJBO https://t.co/g94vzx3Ydu
Multivitamin Modestly Slows Epigenetic Aging; Cocoa Doesn’t
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Utah's AI Prescription Plan Faces Conflict‑of‑interest Critique
Appropriate critique of Utah going with AI for prescriptions based on a @Doctronic preprint written by the company, by @JosephSakran gift link https://t.co/HcFqBy86wb https://t.co/QpVA7HGjRT
FMT Triples the Boost to Cancer Immunotherapy
Not just replication, but triplication of the benefit of revving up cancer immunotherapy with FMT (Yes💩) https://t.co/rXyQdO74FJ
Add AI Breast Artery Calcification Scan to Mammograms
Mammography should include AI assessment of breast artery calcification, since it provides very useful information about cardiovascular risk https://t.co/yfTbTRrOuY https://t.co/h1C8ZnHepJ
83% Unaware of DORAs: Sleep Knowledge Gap
There's a lot you can learn about sleep. Like 83% hadn't heard of DORAs. https://t.co/2lV3Fw6cwg https://t.co/IWRTdPTMOL
Cures for some Autoimmune Diseases Now a Reality
One of the most impressive advances we've ever seen for some autoimmune diseases: cures https://t.co/OZDuq4Iooy
PEP Slows Aging by Blocking Inflammation Pathway
PEP protects against age-related inflammation, puts the brake on the aging process in mice, high levels in humans correlate with low inflammation So what is PEP, you ask? phosphoenolpyruvate, from glucose metabolism, a, master regulator, blocks cGAS-STING https://t.co/glMvaHSjOq https://t.co/MSVMBJbHm4
Caloric Restriction Extends Lifespan in Animals, Human Applicability Unclear
Dietary (caloric) restriction has so many salutary effects for slowing the aging process in animal models, but whether that can be simulated in some way in people remains unclear. This new comprehensive review @NatureAging is outstanding https://t.co/xw5bmK3NaW https://t.co/t8bBmS8HGB
New Sleep Regularity Index Reveals Hidden Rest Patterns
Interested in the latest sleep science and getting better quality sleep? New Ground Truths with Prof Yo-El Ju, @WashUNeurology https://t.co/2lV3Fw6cwg SRI-sleep regularity index https://t.co/zRWbVNmeap
Self‑amplifying RNA Could Protect Future Heart‑attack Patients
Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation https://t.co/FcJme1ElyU https://t.co/lABFRkR3qg
Engineered Astrocytes Use CAR‑A to Remove Amyloid Plaques
New @ScienceMagazine Engineering the brain's astrocytes to clear amyloid plaque! "CAR-A," in mouse model https://t.co/u9zJGnCLUj https://t.co/eIrrFx7iTg https://t.co/x56FDtuVW2
Aging Cells Harbor Protective Mutations That Inspire New Drugs
We're chock full of somatic mutations in our cells and tissue as we age. Some even protect us from disease! And we can learn from them to discover new medications. @CellCellPress https://t.co/mnUsarpYoR https://t.co/4c5XOD7NuC
AI Generalist Excels Across Diverse Medical Imaging Modalities
Can an AI model be a generalist to work and perform well for all types of medical images? Just published, our MedVersa paper @NEJM_AI Led by @pranavrajpurkar Free access https://t.co/5llNf94hAF https://t.co/Bf01zUZ1sk
Yamanaka Stem Cells Earn Conditional Approval for Heart and Parkinson's
20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan https://t.co/8oxKxXYafu by Shinya Yamanaka @CellStemCell https://t.co/U878IxSfSi @ScienceMagazine https://t.co/HCCPaTEP7e
GLP‑1 Drugs Cut Substance‑abuse Risk in Veterans
Best evidence yet that GLP-1 drugs reduce the risk of substance abuse, from >600,00 US Veterans across alcohol, nicotine, opioid, cocaine, cannabis @bmj_latest @zalaly @Miao_Cai_SLU https://t.co/rcqUt0kY77
Cell‑free DNA Test Predicts Liver Disease and Mortality
We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions @ScienceTM https://t.co/IJxPMq7hGU
AI Predicts 5‑year Health Risks From Routine CT Scans
When your "normal" abdominal CT tells you about the 5-year future risks that can't be seen by radiologists, but can by AI (Merlin) https://t.co/DemC983uKz https://t.co/9jqZyVTD3p
Evo 2 Open‑Source Tool Predicts Non‑Coding Pathogenicity
It got me at "across all domains of life" Predicting pathogenicity of non-coding regions, produces sequences at genome scale, and much more Evo 2, open-source, @Nature today @arcinstitute @pdhsu @BrianHie https://t.co/9CZWmPFhjd
Future Cancer Blood Tests May Accurately Screen High‑Risk Groups
Cancer blood tests for screening? Not the way they've been studied to date (age 50+) A new feature @Nature “I’m confident we’re going to see more accurate tests going forward. In high-risk groups, such as those with a genetic predisposition,...
Gut Health and Toxins Drive Parkinson’s Disease Surge
The gut and environmental toxins are key underpinnings of the Parkinson's disease pandemic @jclinicalinvest https://t.co/e8o4UuIafG https://t.co/7634Yg2Qo5
LLM Medical Research Overwhelmingly Lacks Real Clinical Data
A new systematic review of LLMs in medicine @NatureMedicine @ekoermann https://t.co/npvDeqUvel “Despite thousands [4,609] of publications since late 2022, only a small fraction use real clinical data and just 19 randomized trials exist.”
P‑tau 217 Blood Test Outperforms Total P‑tau 217 For
The breakthrough blood test p-tau 217 for risk and diagnosis of Alzheimer's disease is more accurate than total p-tau 217, in a head-to-head comparison using PET imaging https://t.co/faILpVr9Ua https://t.co/lzUgFnFUP5
GLP‑1 Weight‑Loss Drugs Work Better for Women
A systematic RCT analysis of GLP-1 drugs show they are more effective in women than men for weight loss https://t.co/cycwi4nnN5 https://t.co/KOl0FgKaZD
AI Pathology for Cancer Markers Hindered by Shortcut Learning
AI of whole slide images for cancer molecular markers is not ready for clinical use due to confounding and biases ("shortcut learning"), supported by multiple examples @natBME https://t.co/zG8uVIxrJf https://t.co/hQ0tjiapIJ
Exercise‑derived Muscle Vesicles Boost Brain Microglia, Improve Cognition
A new mechanism for improved cognitive function from exercise in the Alzheimer's disease model Skeletal muscle EC vesicles interact with the brain and rev up microglia function https://t.co/eZu14YVasY
Antibody Plus Ozempic Drives Significant Weight Loss
New @NatureMedicine A randomized trial of antibody vs activin type II receptors with or without semaglutide (Ozempic). The antibody, bimagrumab, promotes muscle growth. Marked weight loss with the combination https://t.co/XUK93GTAmA
Future: Real-Time Immune Monitoring Like Glucose Tracking
Someday we'll be able to track our immune system like we do glucose Today @NatBME https://t.co/HFcFiUeyFg Previously @ScienceMagazine https://t.co/EcgBdwGxcd https://t.co/SpoZ5bLtjx
Accelerating CAR Engineering Shows Promising Cancer Immunotherapy
Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell https://t.co/1Qz2rCs8I5 https://t.co/sJ6BwaXyjk
Smartphone AI Beats Endocrinologists in Acromegaly Diagnosis
AI is helping to make the diagnosis of rare diseases. A new multicenter study in Japan showed smartphone AI diagnosis of acromegaly via hands was better than experienced endocrinologists https://t.co/qBiazetToV https://t.co/dSZpJ2us84
Obesity Accelerates Neurodegeneration, New NatMetabolism Study Shows
How does obesity catalyze neurodegeneration? Our paper just out @NatMetabolism https://t.co/kx25urgpJx free access https://t.co/aL1FBN9MyI Phenomenal work by @chen_bandy pulling this together
Gut Bacteria Interactions Dictate Health and Disease Risk
🆕 @ScienceMagazine How gut bacteria interactions [cooperation vs competition, positive vs negative] shape risk for health and disease https://t.co/q8TvbaHDQI https://t.co/kS0S3uUIli
Immune Cells Drive Transition From Healthy Aging to Alzheimer’s
What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time? The critical role of the immune system, particularly T cells and microglia. A new, excellent review @ImmunityCP https://t.co/XqEBcptTuG https://t.co/Xt24BvkDWe
DIY Gut Microbiome Tests Are Unreliable and Flawed
Direct-to-consumer gut microbiome assessments are unreliable, problematic: a review of 7 companies with significant methodologic issues https://t.co/atwmZUNjVE https://t.co/SqlMljuW0y
Orforglipron Outperforms Other Oral GLP‑1s in T2D Trial
Head-to-head trial of the oral GLP-1 drugs in people with T2D. Orforglipron was superior https://t.co/9B7RXIgdJY
Progress Toward Off‑the‑Shelf Vaccines for Hereditary Cancer
We're making headway for off the shelf preventive cancer vaccines in people with hereditary forms of cancer, e.g. Lynch syndrome https://t.co/F3LqKS46BQ
GLP‑1 Drugs Plus Healthy Habits Cut Heart Events
The combination of GLP-1 drugs (such as Ozempic) and healthy lifestyle factors was associated with less major adverse cardiovascular events in ~100,000 people with T2D @TheLancetEndo https://t.co/phNzEBy7zY https://t.co/DDVi8uedRP
Stem Cell Therapy Boosts Frailty Walk Test Performance
A randomized trial of a stem cell therapy vs placebo for aging frailty showed durable and dose-dependent improvement in the 6-minute walk test @CellStemCell https://t.co/2jOYuIgUrY https://t.co/04mEV7OdLo
Super Agers Generate More Neurons Than Much Younger Adults
New @Nature The brains of Super Agers produce more neurons than people some 40 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills https://t.co/tNB0dTea2F
Combining EMR and Multi‑omics Sharpens Biological Age Predictions
Assessment of biological age integrating electronic medical records and multi-omics increases accuracy for predicting outcomes @NatureAging https://t.co/7y60SSPTQf https://t.co/u02OlWMdQz
Circulating piRNAs May Predict Elderly Survival and Longevity
Strong claim that needs independent replication: "Our findings provide compelling evidence that circulating smRNAs—especially piRNAs—are powerful predictors of survival in older adults and potential biomarkers of longevity" https://t.co/oi4220zxGY https://t.co/yk3MX4VdQj
CRISPR Unlocks Causal Insights Into Immune Complexity
The complexity of our immune system is daunting. But there's a path to deconvolute it and understand causal relationships. It's CRISPR. open-access @JExpMed https://t.co/QF6Cvkbfz2 https://t.co/OTL2z1fow0
Combined DNA and Methylation Analysis Reveals Colon Cancer Risks
By systematically assessing both DNA sequence variants and methylation, we're learning a lot more about risk of (and protection from) colon cancer @ScienceAdvances https://t.co/eA0Y0lrntr https://t.co/5iL4sg0rRC
Monocyte IL‑10 Explains Sex Differences in Pain Duration
Sex differences in pain duration Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people) @SciImmunology https://t.co/fOsciwav7Y
Nasal Mucosa Targeted for Universal Respiratory Vaccine
How to get a universal vaccine vs respiratory threats? Block via the nasal mucosa @ScienceMagazine https://t.co/IjCkbF05LB @NatRevImmunol https://t.co/2W7SZ1fHSR https://t.co/XcEzcMeXrB
Cyborg Islet-Cell Implant Boosts Precision Diabetes Therapy
A cyborg pancreatic islet-cell implant takes the stem cell strategy to a new level of precision and potential future therapy for T1 diabetes @ScienceMagazine https://t.co/gkmsrzU1e4 https://t.co/qgegRPlEIl
Screening Cuts Advanced Colon Cancer, Boosts Early Detection
Screening works for colon cancer. Largest trial ever done. Today @NatureMedicine A randomized trial of colon cancer screening by colonoscopy or occult blood (FIT) vs control in nearly 280,000 participants showed signficantly more early diagnosis (stage I-II) and less stage...
EBV DNA Linked to Multiple Autoimmune Diseases in 800k Genomes
🆕@Nature Genome sequencing of >800,000 people finds Epstein-Barr virus reads and their association with other autoimmune diseases besides multiple sclerosis, including type 1 diabetes, inflammatory bowel disease, and hypothyroidism https://t.co/FKCV4OInT5
Adding Fragmentomics Boosts GRAIL’s Multicancer Detection Accuracy
The most used multicancer early detection (MCED) blood test (liquid biopsy) uses methylation (GRAIL). But combining that with DNA fragmentomics, as reported today @NatureCancer, improves early detection https://t.co/VkNDR4XuW3
