Ozempic Cuts Drinking in Obese AUD Patients
First randomized trial to show Ozempic reduces alcohol consumption in people seeking treatment for alcohol use disorder. Placebo-controlled, double-blind. Participants with BMI >30 kg/m2. https://t.co/M9Pk2gzKHD @TheLancet https://t.co/OT660QIn6N
AI Designs Life Using only 19 Amino Acids
Not something you'd see everyday—changing the alphabet of life. All of life organisms are are built from 20 amino acids. Now genAI is enabling life to be built with 19 amino acids, making isoleucine dispensable. @ScienceMagazine https://t.co/7CBn0Xhuxs https://t.co/tkxtCrFx9Y
AI's Role in Misinformation and Deep‑Fake Threats
Twin pieces by @kakape in the new issue @ScienceMagazine on AI, used as a purveyor of misinformation and deep fakes, open-access https://t.co/lw22frYbKY https://t.co/HWm659MERp https://t.co/akkXh59eYB
P‑tau217 Blood Test Predicts Alzheimer’s Risk Early
Good summary of p-tau217, the breakthrough blood test to predict risk of Alzheimer's in people well before onset of symptoms @ScienceMagazine https://t.co/qVJtYR4bnz https://t.co/OhjLExTroG
O‑1 Model Beats GPT‑4 and Doctors in Triage
New @ScienceMagazine The o-1 reasoning model (text only, from @OpenAI, releasedSept 2024) exceeded performance cf GPT-4 and physicians for clinical vignette management reasoning and in a real-world emergency department assessment for initial triage @AdamRodmanMD @PeterBrodeurMD @arjunmanrai @jonc101x https://t.co/tPZqZAE8cd
Better Prediction of Type 1 Diabetes Boosts Prevention Prospects
A jump in our ability to predict Type 1 autoimmune diabetes should help future preventive strategies @NatureGenet https://t.co/ako2Ic46QW https://t.co/XbW26qu5LE
Exercise Proven to Reduce Biological (Epigenetic) Age
What is the most established intervention linked to lower biological (epigenetic) age? Exercise A new systematic review @LancetLongevity of 44 studies, >145,000 participants https://t.co/agmAazwDxs
Organs Age at Different Rates; Reproductive Organs Confirmed
Our organs age at a different pace intra-individual, as tracked through plasma proteins. Now confirmed for female reproductive organs @NatureAging https://t.co/v20xGZglMU https://t.co/3oiQ14yesf
Unearthing Hidden Insights: Medicine’s Buried Knowledge
The burial and the excavation @JAMA_current commentary today https://t.co/PlzeKcj8Mq (what I wrote about in Deep Medicine, 2019) https://t.co/IehnDYXjzn
Polygenic Scores Predict Cardiovascular Risk, but Remain Unused Clinically
Polygenic risk scores for 8 cardiovascular traits in both @MassGenBrigham and @AllofUsResearch—superimposable— strongly indicate risk. Yet still not implemented in clinical practice https://t.co/DwWpwXknbJ
Quintuple Receptor Agonist Outperforms Tirzepatide in Trials
New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as...
Skin Nerve Fibers Slow Melanoma Growth, Challenging Cancer Neuroscience
A twist in cancer neuroscience with many studies showing hijacking of neurons to promote cancer—melanoma growth slowed by nerve fibers in skin https://t.co/9OWEAhJPOb https://t.co/XGSdYYPqk8
AI Detects Hidden Pancreatic Cancer at 73% Accuracy
An AI that detects occult pancreatic cancer better than radiologists (73 vs 39%) via CT with external validation https://t.co/NIiIFjlyxp https://t.co/8aVAmy0eFl
AI‑assisted Psychiatrists Match Attending Quality, Boost Accuracy
Some AI progress for mental health support seen in a real-world prospective study (<-there are few of these) "In a real-world, two-arm prospective study, resident psychiatrists assisted by PsychFound demonstrated higher consultation quality, higher diagnostic accuracy, more appropriate medication selection...
AI Reads Retinal Images to Screen Multiple Diseases
What superhuman vision can detect from the retinal photo, which human eyes cannot, is stunning. A new foundation AI model screening for diabetes hypertension, hyperlipidemia, gout, osteoporosis, and thyroid disease @NatureMedicine https://t.co/GhKvUqz4Vy https://t.co/iKcXCbLceu
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Obesity Epigenetically Reprograms CD4+ T Cells, Fueling Inflammation
The impact oif obesity on the immune system. Through methylation, obesity imprints memory to CD4+ (helper) T cells, which can last for many years, and promotes immune system dysregulation and inflammation. @emboreports https://t.co/mqGVy6mLd3
Digital Twins Will Accelerate Drug Development via Virtual Trials
How digital twins and in silico clinical trials can change the future of drug development https://t.co/lEhJNwrSlH
AI's Role in Extending Human Healthspan
My interview on healthspan and AI with @mmlederman1 and @LCalabreseDO @paijournal transcript video https://t.co/cRGtTIN1EN https://t.co/soUWAuPU02
AI in Healthcare Needs Proof, Not More FDA Oversight
An editorial by @HashemZikry @latimes @counselheatlh calling for more regulation of AI for patient use. Yes, there is "the staggering weight of unmet medical need," 1/3 Americans are using it to "diagnose symptoms and direct care," and states are moving...
GLP‑1 Drugs May Trigger New Restrictive Eating Disorders
"There is also compelling preliminary evidence suggesting that the use of these drugs [GLP-1] could exacerbate and lead to new diagnoses of restrictive eating disorders, including anorexia nervosa." @NEJM today https://t.co/PeTLgyRXiL
Proven Imaging AI Ignored, Unproven LLMs Adopted
Superhuman interpretation AI for medical images, such as mammography and endoscopy, has been proven to improve diagnostic accuracy in multiple randomized trials but mostly not implemented. But LLMs for clinical decision support have little real world medicine proof, but are...
GPX4 Inhibitors Eradicate Senescent Tumor Cells, Boost Chemo Efficacy
GPX4 inhibitors discovered that kill "zombie" senescent cells from tumors (increased w/ chemoRx) and effective in multiple preclinical models vs cancer, a new potential strategy to pursue in clinical trials https://t.co/lYX7xkI9xF @NatureCellBio https://t.co/mxbjzRQPck
Meta-Analysis Flawed by Mixing Disparate Anti‑amyloid Agents
A harsh critique of the recent @cochranecollab meta-analysis of the anti-amyloid drugs for Alzheimer's disease https://t.co/EU4JMOVWkV 'These results and their overarching conclusion that “successful removal of amyloid from the brain does not seem to be associated with clinically meaningful effects in...
Continuous Glucose Monitoring Outperforms Self‑Monitoring in Type 2 Diabetes
A randomized trial of continuous glucose monitoring (CGM) vs self-monitoring for Type 2 diabetes on basal insulin and drug therapies shows superiority of CGM for gluocse regulation https://t.co/XUymGiov1c @TheLancetEndo https://t.co/lcjFDnEG6x
Obese HFpEF Patients Show Sarcom
In people with HFpEF (heart failure with preserved ejection fraction) and severe obesity, there is a heart muscle cell defect with sarcomere hyper-phosphorylation. Besides weight loss, sarcomere enhancers (not yet studied) may help. @ScienceMagazine https://t.co/or9VaPjD8J https://t.co/FG98KIzIfN
Paxlovid Showed No Hospitalization Benefit in Vaccinated Seniors
In 2 randomized, open-label trials of Paxlovid there was lack of evidence of reduced hospitalizations among the participants, who were age 50+ with coexisting conditions, and who were vaccinated. The endpoint was very low (<1.2%) in the treatment and control...
Personalized CRISPR Poised to Become Standard Care
How individualized CRISPR genome editing can go from rare, expensive use to broader accessibility and a standard of care by @UrnovFyodor and Sadik Kassim @Nature https://t.co/ddc5ASPPAK https://t.co/GOFneIyuai
Sex Chromosomes Drive Cancer, Autoimmunity, and Brain Disease
Our X and Y chromosomes play a bigger part in health than acknowledged, including cancer, autoimmunity, and neurologic conditions. A new @nature feature https://t.co/IjVNbXzBPB
New Receptor Enables Bat Alphacoronavirus Entry Into Humans
Discovery of a new receptor by which alphacoronavirus from bats can get into human cells and the potential for transmission https://t.co/LE5sTVyfkS @Nature https://t.co/aszqnDMQqE @NatureNV https://t.co/ejnvrvr6BO
Medical AI Lacks Proof of Patient Care Benefits
On the lack of compelling evidence that medical AI is improving patient care, and what to do about it, a @NatureMedicine editorial https://t.co/kQiN6L2ai7 https://t.co/zhae0bFZ8R
AI Integrates Omics and Lifestyle to Forecast Health Outcomes
A multimodal AI agentic model that integrates electronic medical records, lifestyle, layers of biologic omics data to predict health outcomes and, with perturbations, "what if" scenarios a person improved lifestyle or took a medication @Cell_Metabolism https://t.co/qgVomjkipS https://t.co/JDaeYv0JGu
Two New Methods Advance RNA 3D Structure Prediction
Predicting RNA 3D structure is a grand challenge of biology. 2 new approaches published today to get at it https://t.co/KQ2oCGlUrN @MolecularCell https://t.co/ofupia6du2 @NatMachIntell https://t.co/EwL0iymmt2
Cancer-Like Microglial Mutations May Fuel Alzheimer's Inflammation
Somatic mutations in microglia brain cells (the same mutations as seen in cancer) are enriched in and may drive the neuroinflammation of Alzheimer's disease @CellCellPress https://t.co/PS7pIBFW4H
Pesticide Exposure Correlates with Early‑Onset Colorectal Cancer
Why are we seeing so much early-onset colorectal cancer? The correlation with pesticide exposure and its epigenetic signature, adjusted for all known risk factors. (doesn't establish cause and effect) https://t.co/1UiBiHkgo5
Replacing Personal Care Products Cuts Plastic Chemical Excretion
A randomized trial to reduce plastic exposure in food and daily life shows marked impact for reducing plastic-associated chemical (PAC) excretion. Personal care product replacement lowered an important one, MBzP https://t.co/qGGTVqf952 https://t.co/yVR4YYLKkt
GLP‑1s Preserve Muscle Better Than Diet‑Only Weight Loss
Summary for patients on GLP-1 drugs and non-drug weight loss re: muscle mass impact @AnnalsofIM https://t.co/pSDhbKkXwb https://t.co/qM7OgVJwQg
Deadliest Cancers Receive the Least Federal Funding
The worst cancers with respect to lethality get the least federal funding support https://t.co/uCJXYgpB3c https://t.co/woqbMo1oYp
First Gut Microbiome Signature Predicts Parkinson’s Risk in Healthy Carriers
We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition @NatureMedicine https://t.co/oDTItnis5L
Molecular Glue Daraxonrasib Shows Promise Against Pancreatic Cancer
Good summary of the marked benefit of the molecular glue drug (daraxonrasib) vs pancreatic cancer, from Revolution Medicines, and other progress (adds to the neoantigen vaccine with 6-year survival) gift link https://t.co/qk7Ar9dCAQ https://t.co/SMiA51fiwX
Microplastics Ubiquitous in Brains, Concentrate Near Tumors
Microplastics and nanoplastics were found in 100% of healthy brains, 99.4% of diseased brains, with much higher concentrations adjacent to brain tumors https://t.co/8BDxeOtXJr https://t.co/rB0at3ADl2
AI's 15‑Year Journey and Future Unveiled
If you're interested in how AI grew up over the past 15 years, and where it's headed, this new book tells the story in a riveting, page-turner way. In the new Ground Truths with @scmallaby https://t.co/B7ElqyDBPM
CHIP Clones Accelerate Aneurysm Growth, Offering Preventive Target
We don't measure blood stem cell clones (CHIP) in the clinic. But some are linked with fast, expanding abdominal aortic aneurysms, identification of an underlying mechanism, and a potential preventive treatment @jclinicalinvest https://t.co/4rWlLuivBJ https://t.co/vasG9hc9DK
Autonomous AI Prescriptions Raise FDA Safety Concerns
What about "Autonomous AI Managing Patient Care," as seen with the ongoing Utah @Doctronic program for prescription renewals? https://t.co/KSeSD7dn7z @NEJM "The FDA may decide to look the other way and allow this experiment to continue, leaving clinicians and patients without safety...
AI and Cheap Sequencing Will Unlock Health Risk Genomics
Our use of genomic data is woefully minimal for establishing health risks but the low cost of sequencing along with improved AI analytics can get this moving forward. Nice example here
B Cells Critical for Exercise Performance, Study Shows
Did you know immune systemB cells are essential for exercise performance? Learning from B cell deficiency in the mouse model https://t.co/BWGC0GKVIq https://t.co/OhQWwNmXLU
AP-1 Activation Emerges as New Cancer Resistance Target
The knowledge of the many mechanisms by which cancer proves resistant to treatments keeps expanding. This week @Nature highlights activation of the AP-1 transcription factors, representing a new target https://t.co/UWSYDFM0IK https://t.co/6l4TISQonQ
Anemia May Heighten Alzheimer’s Risk Alongside P‑tau217
In evaluating p-tau217 and other biomarkers for risk of Alzheimer's disease, keep an eye on anemia, which may add to the risk, as seen in this new report https://t.co/ezbcLr4HIf https://t.co/TOKLRVBM4f
Gut Microbiome Predicts Melanoma Recurrence Post-Immunotherapy
Gut microbiome markers predict recurrence of cancer after immunotherapy for metastatic melanoma @CellCellPress https://t.co/k5YuNnqfvt https://t.co/9UbuNAcYJh
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy