GLP‑1 Drugs Now Help Psoriatic Arthritis Beyond Weight Loss
The list of conditions for which GLP-1 drugs provide benefit independent of weight loss keeps growing. Add psoriatic arthritis #AAD26 @AADskin https://t.co/kJej6osXTS
Writing Genomes Opens Post‑Darwinian Era of ABI
Artificial Biological Intelligence (ABI) In a post-Darwinian era of being able to write genomes, the implications—both for good and harm—are profound. In conversation with @AdrianWoolfson on his new book On the Future of Species https://t.co/2OahzzxAAa
PCSK9 Inhibitor Cuts Cardiovascular Events in Diabetics
In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current https://t.co/mzuI79c4IN https://t.co/16Cpxf7IBx
Intensive LDL < 55 Mg/dL Cuts Cardiovascular Events
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) @NEJM #ACC26 https://t.co/oLnkqhawOd
Biological Age Outperforms Chronological Age in Outcome Prediction
In the era of molecular and organ clocks and marked inter- and infra-individual variability of the aging process, we need to move beyond chronological age. "biologic measures predict outcomes more robustly than chronologic age" @NEJM https://t.co/DKmIfdJJUF https://t.co/d5Gc6xGKqn
UCLA Health Omits Patient Polygenic Risk Scores From Study
Kudos to @UCLAHealth for assessing genomics of their patient population, published @CellCellPress today. But why weren't the results of increased polygenic risk scores (PGS) provided to the patient participants? https://t.co/F15isJfDQy https://t.co/3AW7peHa1C
Lancet Calls for Wider Access to GLP‑1 Drugs
This week's @TheLancet cover and editorial about getting GLP-1 drugs available for the people who need them the most https://t.co/BU9NZdmdGo https://t.co/TWOIKvfuth
Cells Store Inflammation Memory via Epigenetic Chromatin Domains
🆕 @ScienceMagazine How do our cells have long term memory of inflammation that can later lead to persistent, chronic inflammation and disease? Through specific epigenetic chromatin changes, aka "memory domains" @ScienceVisuals https://t.co/mt70OwH144 https://t.co/DMk7SaIuBc https://t.co/FaPpN0331q
New Study Exposes AI Sycophancy in Scientific Research
The problem of AI sycophancy addressed in the new issue: @ScienceMagazine cover and original research by @chengmyra1 and colleagues https://t.co/P8112DRIIH https://t.co/7natpzaVpG
Obesity Prevention Offers Far Greater Cancer Protection Than Expected
"A much stronger cancer-preventive potential of obesity prevention and control than previously established" https://t.co/QatHKVMbfz @JAMAOnc https://t.co/OQ62MunGTu
APOE4 Linked to Meningeal Lymphatic Dysfunction, In
1 of 4 people have an APOE4 allele, a risk factor for Alzheimer's disease. New evidence this is linked to abnormal meningeal lymphatic function, brain inflammation, and important sex-differences @NeuroCellPress https://t.co/mUUqLedS9V https://t.co/FADCoemvum
Six Corporate Chemicals Linked to 31% Global Deaths
Corporations as vectors of chronic disease, @NEJM Calling out 6 commercial products that contribute to 31% of all deaths globally. Chemicals include pesticides, PFAS, manufactured. And counterstrategies to address https://t.co/b6iDYcEyct https://t.co/JYJId8uNyV
Health Experts Warn EPA Rollback Threatens Public Health
"We health professionals must call urgent attention to this silent but deadly assault [EPA dismantling ] on American's health...." @NEJM https://t.co/FJYbZh5O1m https://t.co/hajEmMWHTs
New Review Links Β‑cell Stress to Type 1 Diabetes
Rethinking why the pancreas β-cells become vulnerable to autoimmune attack, leading to Type 1 diabetes. An illuminating review with ideas to counter β-cell stress @ScienceTM https://t.co/zn6a6wEg7u https://t.co/BV0LYnWRNL
AI Matches Dermatologists in Melanoma Diagnosis, Study Shows
How good is AI for diagnosing melanoma? A systematic review of 11 studies, 2500 patients, finds accuracy and performance comparable to 50 dermatologists, with promise for broad use requiring further validation @JAMADerm This is important with the big shortage of dermatologists...
Engineered Immune Cells Target Refractory Myeloma, Broader Cancer Potential
Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers https://t.co/K3IksrCFlg https://t.co/1AQ5rLuH1g
Exercise Protects Blood‑Brain Barrier, Slowing Alzheimer’s
New on exercise —the best medicine vs age-related chronic diseases, a review @Cell_Metabolism https://t.co/z9RpD0SlYW —salutary effect on the blood brain barrier (BBB) vs Alzheimer's and brain aging gift link https://t.co/jmhJwXGWms by @GretchenReynold —original research on BBB integrity via liver produced exercise factor @CellCellPress https://t.co/3tSN8knpYF
Radiologists and AI Struggle to Spot Deepfake Scans
The majority of radiologists and 4 LLMs were unable to differentiate synthetic, deepfake scans from real ones https://t.co/aAJhP0cpfG @RSNA https://t.co/q0wdIKicK6
Minor Lifestyle Tweaks Cut Major Heart Risks
Even small differences in sleep, physical activity and nutrition (SPAN) can have significant favorable impact vs major adverse cardiovascular events @uk_biobank, >53,000 participants, median age 63 yrs https://t.co/iZJjENsOiM https://t.co/WNiGfGGDYL
Thymus Gland Emerges as Key to Healthy Aging
Don't take the time to read about the new landmark studies that put our thymus gland at center stage for healthy aging https://t.co/ENhIn2A2l3 https://t.co/oY2PLSenmf
Higher Thymic Health Scores Predict Longer Healthspan
Your Thymus and Your Healthspan https://t.co/ENhIn2A2l3 High vs Low Thymic Health Scores and Outcomes https://t.co/oOz9sOK8RV
Agentic AI Could Spark Billion-Mind Intelligence Explosion
"The recent explosion of agentic AI suggests the possibility of something similar at the scale of billions of interacting minds, human and non-human alike." An essay on the Intelligence Explosion @ScienceMagazine by @profjamesevans @bratton @blaiseaguera https://t.co/Fl0DP86XWd
Companies Hide Device Risks, Harm Thousands
This is a recurrent fiasco. Health care companies that now the serious risk of their device or drug but keep selling it and do not acknowledge the hazard. Until so many people are harmed. Today's front page @nytimes by @katie_thomas @bostonsci...
Higher Fitness Linked to Lower Dementia, Depression, Psychosis Risk
The relationship between increased cardiorespiratory fitness (METS) and reduced risk of all-cause dementia, depression, and psychotic disorders. From over 4 million individuals in 27 studies @NatMentHealth [association, not cause and effect evidence] https://t.co/iQdGRc0Nrz
Tumor Whole-Genome Sequencing Influences Care in 40%+ Patients
Why should tumor whole genome sequencing (WGS) be done for cancer? In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40% @NatureMedicine https://t.co/kFho0yuLS7
AI Deciphers Life’s Language in New Nature Biotech Review
AI to understand the language of life. Our review @NatureBiotech just published https://t.co/i0WMaXBCHl Free access https://t.co/3LPulNxlD0 @VishRao5 @serena2z @BrianPlosky @pdhsu @BoWang87 @james_y_zou @marinkazitnik @pranavrajpurkar
Hydration Doesn't Reduce Kidney Stone Recurrence, Study Finds
If you've had a kidney stone, you've been advised that the most important thing to prevent another bout is to increase hydration. Now a randomized trial of hydration in over 1600 participants showed no benefit, despite evidence of increase...
Stress Triggers Skin Inflammation via Newly Identified Neural Circuit
New @ScienceMagazine Discovery of a circuit that connects stress and skin inflammation https://t.co/Dkmmcs96JT https://t.co/chrXyKrG2N https://t.co/7nOPn9fCoU
Four Biomarkers Can Meaningfully Assess Coronary Artery Disease Risk
The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank https://t.co/CPfBPVRENq https://t.co/xTlj2ykr45
Oral Ozempic Trials Fail to Show Alzheimer's Benefit
The negative oral Ozempic randomized trials (EVOKE, EVOKE+) for Alzheimer's disease have now been published @TheLancet https://t.co/Xx0YknTSC2
GLP‑1 Drugs May Protect Heart, Vessels, Kidneys in Type 1 Diabetes
GLP-1 drugs have established benefit for Type 2 diabetes. New data suggests that extends to Type 1 diabetes, with heart, vascular, and kidney protection https://t.co/nZDKHoFIRm https://t.co/lTHIgoj4ir
Implant vs Meds: Randomized Trial Questions LAA Closure Benefit
Questioning the benefit of an implant to close the left atrial appendage vs medical therapy in a randomized trial @NEJM https://t.co/N0hpdIfmLe https://t.co/8bkk8FzLuY
Stopping GLP‑1 Therapy Quickly Erodes Cardiovascular Protection
A new finding after stopping GLP-1 drugs in a large cohort with Type 2 diabetes: rapid erosion of CV benefit/protection New @bmj_latest by @zalaly @Biostayan https://t.co/JG6yB8wTJJ See thread: https://t.co/6JvfIIjVBw https://t.co/wUgWhvs9Yy
In‑body Genome Editing Promises Cheaper, Practical CAR‑T Therapies
What if we could engineer T cells in the body, making CAR T vs cancer, autoimmune diseases, and other applications far more practical, much less expensive? A step forward today via genome editing T cells https://t.co/FjgQA8NUlu https://t.co/XXk43WL1ac https://t.co/rpC7eCAlJH
Mitochondrial Transfer Shows Promise Against Parkinson’s in Animals
Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress https://t.co/c0oqfagddX https://t.co/KyBc1zQttc
World's Largest In‑Vivo CRISPR Data Engine Unveiled
From Prof Jin and my colleagues @scrippsresearch the largest in vivo CRISPR data engine, nearly 8 million cells, in collaboration with @nvidia and featured at GTC
GLP‑1 Weight Loss Shows No Extra Muscle Loss
A study asserts lack of disproportionate loss of muscle mass or strength cf weight loss from GLP-1 drug treatment, in mice and a small short term (12 weeks) trial in men The issue remains unsettled and counters the efforts by companies...
Single-Cell Analysis Advances Neurodegenerative Disease Understanding
Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand https://t.co/Pkz4qW0ELM @jclinicalinvest https://t.co/LiJ4FojRYZ
Women Comprise Two‑thirds of Alzheimer’s; Midlife Origins Examined
Why do women account for nearly 2/3rd of all cases of Alzheimer's disease? A new, thorough review @jclinicalinvest, open-access, on its origins in midlife. https://t.co/obITwhEiYG https://t.co/RXBffM9jKV
GenAI Predicts Insulin Resistance Using Wearables and Routine Labs
Innovation with genAI, predicting insulin resistance from wearable device data (for steps, heart rate, sleep) integrated with demographics and routine blood parameters. Without CGM. @aametwally1 @GoogleResearch @NatureMedicine https://t.co/PRZPLGjuxZ https://t.co/ShbFyO55qP
Multi-Ancestry Polygenic Score Predicts T2D, Obesity, GLP‑1 Need
A polygenic risk score that predicts Type 2 diabetes, obesity, and likelihood for requiring a GLP-1 drug. Across 6 ancestries. https://t.co/5hTVv8kqlK https://t.co/IgXhx8vFA6
AI-Driven Digital Biology Delivers Custom Cancer Vaccine for Dog
The era of digital biology, exemplified by making a bespoke and effective vaccine for cancer in a dog, is taking off. Access to the AI-Coscientist. A new feature @NatureMedicine https://t.co/AR9lqne7E1
Aged Blood Stem Cell Mutations Drive Aortic Aneurysm Growth
Just weeks ago we didn't know that mutant clones of our aged blood stem cells could be linked to expansion of an aortic aneurysm. No less how. And so much more https://t.co/YuEmJPkdg2 https://t.co/qQq2dgAfWf
GLP‑1 Drugs: Promising yet Unproven Healthspan Extension
GLP-1 drugs for extending healthspan? Intriguing but we're a long way off from evidence Discussed at length in Super Agers as a candidate drug beyond lifestyle + factors @TheEconomist gift link https://t.co/A2dpfcnApF https://t.co/3gY8iACeGs
Dynamic Evaluation Framework for LLMs in Patient Care
Our new @NatureMedicine paper proposing a path for better, dynamic evaluation of large language models for patient care https://t.co/VHvyxDFKuc CES-clinical environment simulator @pranavrajpurkar https://t.co/Q9tyeupEk3
Cancer Vaccines Show Promise for Hard-to-Treat Tumors
Cancer vaccines are showing marked efficacy vs refractory cancers and are going to be part of the future Rx armamentarium. Beyond that, ultimately, for prevention in high-risk individuals. A new stellar review @NatureMedicine https://t.co/PhtdZDtSBl https://t.co/okmwCD8AyB
Amyloid Antibody Therapy Triggers 100 Microhemorrhages in APOE4 Patient
100 brain microhemorrhages in a patient with cerebral amyloid angiopathy and 2 copies of APOE4 after amyloid antibody therapy https://t.co/ASpVuijFNW https://t.co/hdtwtv1usq
HSV-1 Reactivation Linked to Faster Aging, Dementia
The reactivation of herpes simplex virus (HSV-1, not only herpes zoster) may be tied to accelerated aging and dementia, and account in part for the mechanism of Shingrix vaccine''s protection @WIRED https://t.co/iKF1JcYSu0
Gut Microbiome Proteins Influence Aging Speed, Metabolic Disease
Links between gut microbiome proteins and pace of aging, metabolic diseases, and medications @Cell_Metabolism https://t.co/Vg6vMPjnXm https://t.co/3SKNH6IEhJ
High‑fat Diet Pushes Gut Bacteria to Brain via Vagus
How to get bacteria to move from the gut into the brain? —eat a high-fat diet —vagus nerve is the conduit —in the mouse model https://t.co/BI6HIbVgPl