DIY Gut Microbiome Tests Are Unreliable and Flawed
Direct-to-consumer gut microbiome assessments are unreliable, problematic: a review of 7 companies with significant methodologic issues https://t.co/atwmZUNjVE https://t.co/SqlMljuW0y
Orforglipron Outperforms Other Oral GLP‑1s in T2D Trial
Head-to-head trial of the oral GLP-1 drugs in people with T2D. Orforglipron was superior https://t.co/9B7RXIgdJY
Progress Toward Off‑the‑Shelf Vaccines for Hereditary Cancer
We're making headway for off the shelf preventive cancer vaccines in people with hereditary forms of cancer, e.g. Lynch syndrome https://t.co/F3LqKS46BQ
GLP‑1 Drugs Plus Healthy Habits Cut Heart Events
The combination of GLP-1 drugs (such as Ozempic) and healthy lifestyle factors was associated with less major adverse cardiovascular events in ~100,000 people with T2D @TheLancetEndo https://t.co/phNzEBy7zY https://t.co/DDVi8uedRP
Stem Cell Therapy Boosts Frailty Walk Test Performance
A randomized trial of a stem cell therapy vs placebo for aging frailty showed durable and dose-dependent improvement in the 6-minute walk test @CellStemCell https://t.co/2jOYuIgUrY https://t.co/04mEV7OdLo
Super Agers Generate More Neurons Than Much Younger Adults
New @Nature The brains of Super Agers produce more neurons than people some 40 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills https://t.co/tNB0dTea2F
Combining EMR and Multi‑omics Sharpens Biological Age Predictions
Assessment of biological age integrating electronic medical records and multi-omics increases accuracy for predicting outcomes @NatureAging https://t.co/7y60SSPTQf https://t.co/u02OlWMdQz
Circulating piRNAs May Predict Elderly Survival and Longevity
Strong claim that needs independent replication: "Our findings provide compelling evidence that circulating smRNAs—especially piRNAs—are powerful predictors of survival in older adults and potential biomarkers of longevity" https://t.co/oi4220zxGY https://t.co/yk3MX4VdQj
CRISPR Unlocks Causal Insights Into Immune Complexity
The complexity of our immune system is daunting. But there's a path to deconvolute it and understand causal relationships. It's CRISPR. open-access @JExpMed https://t.co/QF6Cvkbfz2 https://t.co/OTL2z1fow0
Combined DNA and Methylation Analysis Reveals Colon Cancer Risks
By systematically assessing both DNA sequence variants and methylation, we're learning a lot more about risk of (and protection from) colon cancer @ScienceAdvances https://t.co/eA0Y0lrntr https://t.co/5iL4sg0rRC
Monocyte IL‑10 Explains Sex Differences in Pain Duration
Sex differences in pain duration Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people) @SciImmunology https://t.co/fOsciwav7Y
Nasal Mucosa Targeted for Universal Respiratory Vaccine
How to get a universal vaccine vs respiratory threats? Block via the nasal mucosa @ScienceMagazine https://t.co/IjCkbF05LB @NatRevImmunol https://t.co/2W7SZ1fHSR https://t.co/XcEzcMeXrB
Cyborg Islet-Cell Implant Boosts Precision Diabetes Therapy
A cyborg pancreatic islet-cell implant takes the stem cell strategy to a new level of precision and potential future therapy for T1 diabetes @ScienceMagazine https://t.co/gkmsrzU1e4 https://t.co/qgegRPlEIl
Screening Cuts Advanced Colon Cancer, Boosts Early Detection
Screening works for colon cancer. Largest trial ever done. Today @NatureMedicine A randomized trial of colon cancer screening by colonoscopy or occult blood (FIT) vs control in nearly 280,000 participants showed signficantly more early diagnosis (stage I-II) and less stage...
EBV DNA Linked to Multiple Autoimmune Diseases in 800k Genomes
🆕@Nature Genome sequencing of >800,000 people finds Epstein-Barr virus reads and their association with other autoimmune diseases besides multiple sclerosis, including type 1 diabetes, inflammatory bowel disease, and hypothyroidism https://t.co/FKCV4OInT5
Adding Fragmentomics Boosts GRAIL’s Multicancer Detection Accuracy
The most used multicancer early detection (MCED) blood test (liquid biopsy) uses methylation (GRAIL). But combining that with DNA fragmentomics, as reported today @NatureCancer, improves early detection https://t.co/VkNDR4XuW3
Blood P‑tau217 Test Predicts Alzheimer’s Symptoms 20 Years Ahead
Predicting when symptoms of Alzheimer's disease will occur with elevated p-tau217 blood test and a person's age, even 20+ years in advance @NatureMedicine https://t.co/EYaGglBh1H
AI Automates Cytology, Streamlining Cell Pre‑Screening
AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses today @Nature https://t.co/ZI3F2pkMxE https://t.co/WsUcRjkHFN https://t.co/mdz1DM6xs7
Brain’s Venous Sinuses Patrol Immune Cells and Drain Fluid
What's ruffling? Large veins interfacing the skull (venous sinuses) that patrol immune cells and help drain the brain https://t.co/WsML3Jd1yA
MRNA Vaccines Advance Triple‑negative Breast Cancer Therapy
The unfounded move by @HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today @Nature Adds to successful pancreatic, renal cell, melanoma reports...
Listen to Biology’s Early Whispers to Prevent Disease
We could prevent diseases so much better but we haven't learned to listen to when biology whispers long (10 + years) in advance. A key theme in Super Agers, too. https://t.co/0pSap3f32N @NathanPriceSci @ @nrappapo @BuckInstitute example below for Type 2...
Agentic AI Enables Accurate Rare Disease Diagnosis via DeepRare
Another good use case for agentic AI in medicine: diagnosis of rare diseases. Exemplified by DeepRare https://t.co/XBd68V3iDl https://t.co/rBl5yn95sI
GLP‑1 Safety: New Data Highlights Retinal Risks
A short thread on GLP-1s based on new publications. 1. The safety story Table of potential side effects and very good description of mechanisms, especially w/r to retina https://t.co/L5GNZyArrn https://t.co/MyXVOF3SYv
Free, Ad‑free Biomed Insights Reaching 200k Globally
Ground Truths are free essays and podcasts on the hot topics in biomedicine and health. Mostly things the media doesn't cover or adequately highlight. No ads or sponsors. Join ~200,000 subscribers from 212 countries https://t.co/ZgnO2Y0P4L
B‑Cell Depletion: Rebooting Immunity to Cure Autoimmunity
"Immune Reset" Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases https://t.co/253NtyFmCN
Women Show Higher P‑tau217 Levels and Tau Deposition
p-tau217 is a breakthrough blood test for risk of developing Alzheimer's disease. Important to know there are sex differences for this biomarker, with women having higher values at baseline and more tau deposition. @JAMANeuro https://t.co/Xrr8SjsiVY https://t.co/eyDt6mgSqR
Psychedelic Shows Rapid Depression Relief in Small Trial
A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine https://t.co/vvug72VGBi https://t.co/Tn58rP0ufS
LLM-Edited Radiology Reports Boost Patient Understanding, Preserve Accuracy
When the LLM rewrites the radiology report, patient understanding is increased and clinical accuracy is maintained. @LancetDigitalH @curtlanglotz @smrabd https://t.co/q2UHebBQG7 https://t.co/IwZAx59brY
15‑PDGH Inhibition and Ozempic May Restore Cartilage
Two things that may help restore cartilage —15-PDGH inhibition https://t.co/chCj9Lj5qk —Semaglutide (Ozempic), independent of weight loss https://t.co/fqbrQQYfRt https://t.co/6CRdY1QtC1
Immune System Drives the Biological Process of Aging
Our immune system is the driver of the biologic process of aging. A new and comprehensive review @NatRevImmunol https://t.co/0Fm9w7U341 https://t.co/alPoABMozO
Healthy Diet Adds 2‑3 Years Lifespan, Especially Early
A healthy diet, accounting for longevity-related genes, associated with 2-3 more years of life expectancy from >100,000 people followed 10.6 years, max benefit for starting at youngest age (Figure) @uk_biobank @ScienceAdvances https://t.co/Ji7Wlhj9ZA https://t.co/B6UxuE97xG
Genetic Evidence Shows BMI Directly Shapes Gut Microbiome
A successful hunt of human genome variants identifying some (with MR) that provide causal evidence that BMI affects microbe composition @NatureGenet https://t.co/1uxvnFNrbK https://t.co/SuItRHAnFe
Semaglutide Linked to Higher NAION Risk in Veterans
Among US veterans (mean age 60) with T2 diabetes who received semaglutide (Ozempic) there was a risk of 0.3% in the first 2 years of NAION, a serious vision loss event, that exceeded SGLT-2 inhibitor drugs (graph) @JAMAOphth https://t.co/c3zDHa7OQB https://t.co/hYTxAs6ThH
Exercise Rewires Brain, Boosting Endurance in Mice
How exercise rewires the brain to promote endurance https://t.co/h7fiahzoAn as demonstrated in the mouse model https://t.co/DfUWadNKgt https://t.co/vhrsv1pkUs
Molecular Mimicry Links J&J Vaccine to Rare Clotting
Cracking the case: how did adenoviral vector vaccine such as the J&J's Covid induce very rare and potentially fatal clotting, bleeding? An elegant proof of molecular mimicry—genetic background + rogue antibodies https://t.co/yp6TNE8ZQC https://t.co/NhhYDvntmT @rkhamsi @TheAtlantic https://t.co/xY7f6MVkx9 @kakape @GretchenVogel1 @ScienceMagazine
90% Want Free AI Mammograms, Yet None Receive It
Over 90% of responders believe it's time for mammography to incorporate AI for every readout, whereas close to 0% who get screened are getting that interpretation now, and at no out-of-pocket charge https://t.co/hITOBNd7pg https://t.co/x1I6Ffxfio
US Stalls Flu Vaccine, Lags China on Nasal COVID
Not only has the US blocked a significant advance for a flu vaccine, but it has done nothing, unlike China, to advance a nasal Covid vaccine that achieves mucosal immunity to block infections https://t.co/FXnaWjxkWV https://t.co/WABn5324U8
Tylenol Use in Pregnancy Shows No Increased Neurodevelopmental Risks
Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out https://t.co/Kjwp1h3PBP
Super Agers Show APOE‑ε4 Reduction, Like Healthy Controls
Super Agers with intact cognitive function and the frequency of the APOE-ε4 and APOE-ε2 alleles compared with controls and people with Alzheimer’s disease https://t.co/vMYcSTVCDS
Intentional GenAI Use Can Reduce Global Health Inequities
GenAI has the potential to worsen health inequities. In a new review @NatureHealthJnl we show that with intent, confronting the challenges, it could be just the opposite, globally @nliulab https://t.co/jwmslSVIV1 https://t.co/5q3gq9mnez
Lynch Syndrome Vaccine Shows Strong Immune Response, Safety
A vaccine to prevent colon cancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for Lynch syndrome https://t.co/EfXDlTJlIz https://t.co/RtxfB4oGZ1
Obesity Rewires Macrophages, Triggers NLRP3 Inflammation
How does obesity lead to immune system dysregulation and chronic inflammation? Macrophage metabolism is rewired, with activation of the NLRP3 inflammasome @ScienceMagazine https://t.co/bkAUgOE1c2 https://t.co/It6YaXT1b5
Multimodal AI Promises Patient‑centric Mental Health, Needs Validation
New @ScienceMagazine A thoughtful and comprehensive review on how multimodal AI can transform mental health, with emphasis on a patient-centric approach "The successful translation of AI into clinical practice will require robust validation" https://t.co/xSACrFI0tW https://t.co/8jiV6P1vdj
He Jiankui Returns, Society Still Unready for Embryo Editing
The reckless human embryo genome editor, He Jiankui, known as China's Dr. Frankenstein, is back at it. "People were not yet ready to accept what I was doing." We're still not. https://t.co/UYIwWj0qf1
Long COVID Linked to Elevated P‑tau181, Alzheimer Risk
Not good to see the rise in p-tau181, a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease, in a prospective cohort (mean age 56 years) with #LongCovid and neurological symptoms https://t.co/XTd5qeN24e @eBioMedicine https://t.co/B1fkhoydFI
GLP‑1 Therapies
A 5★ new review of the GLP-1 drugs, what they have achieved, and where the field is headed with so many new molecules and combinations @TheLancet https://t.co/E1Xa15fk1q https://t.co/Jjmw01L5KM
Improved Survival and Return-to-Play Guidelines for Athletes
An excellent @NEJM review of sudden cardiac death in athletes with what constitutes the appropriate workup, potential for returning to sports, and very good trend for survival over the years https://t.co/PgoBaEcbZI
AI Boosts Individual Impact, Shrinks Collective Research Breadth
How has AI impacted science? Analysis of >41m papers. A paradox: Expansion of individual's impact but contraction in breadth of topics researched collectively https://t.co/npovh0eSL8 https://t.co/iMY3cEd9LE https://t.co/iErtpnuJQR
Invisible Immune Deficits Make Low‑risk Infections Deadly
Why do so many apparently healthy people die or get severely ill from infections that would be considered low risk? For one, we don't have any way of assessing a person's immune system function in the clinic https://t.co/CshtAxDep9 https://t.co/uk5nDnyjnr
CGM‑based AI Outperforms HbA1c in Predicting Diabetes, Heart
Continuous glucose monitoring sensor data, with a foundation model, predicts risk of Type 2 diabetes and cardiovascular outcomes better than HbA1c New @Nature @segal_eran @WeizmannScience @GLutsker "66% of incident diabetes cases and 69% of cardiovascular deaths occurred in the top risk...