44‑Metabolite Signature Improves Prediction of Diabetes Progression
There are about 100m Americans with pre-diabetes. But who will progress? Enhanced risk prediction of Type 2 diabetes from a 44 -metabolite signature @NatureMedicine https://t.co/UxmQaD88s4 https://t.co/jhmP3enyTa
Combined Exercise, Sleep, and Diet Boost Healthspan and Lifespan
Concurrent improvements in physical activity (MVPA), sleep, and diet are associated with meaningful improvements in healthspan (DFLE) and lifespan LD-low quality diet, MD-moderate, HD-high New @eClinicalMed, @uk_biobank 59,000 participants w/ 8 year follow-up https://t.co/gl36VSQVFh
Glucose Metabolism Fluctuations Drive Cognitive Aging Changes
The brain's glucose metabolism, cognition, and aging: "Variability in the moment-to-moment metabolism of glucose is biologically and functionally important to cognition and in explaining metabolic and brain network changes in aging." https://t.co/0cFbXJFQD5 https://t.co/sCO98PHBL0
Fasting‑mimicking Diet Eases Symptoms, Reduces Inflammation in Crohn’s
A fasting-mimicking diet improved the clinical course and suppressed inflammation in people with mild or moderate Crohn's disease in a randomized trial https://t.co/pVVJ4HD4gD https://t.co/2PyJObeAqQ
Epiploic Fat Fuels Inflammation in Severe Obesity
Fat surrounding the large intestine (epiploic) is rich in immune cells and can drive inflammation. Study in people with severe obesity. @Cell_Metabolism https://t.co/kN1B77XrCm https://t.co/YlNrpCGZjI
New Cell Studies Link EBV to Multiple Sclerosis Mechanisms
3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement https://t.co/JXThwhZugq https://t.co/fO1aDsZmmB https://t.co/fO1aDsZmmB https://t.co/eUNrrRGw0s
Total‑body MRIs Yield High False‑positive and False‑negative Rates
Total body MRI scans generate lots of false positive results. Then there's the false negatives, too. https://t.co/7NITyu2sqM @PeterWhoriskey https://t.co/PW1Q2XjOn4
New Delivery Breakthroughs Expand Genome Editing Beyond Blood, Liver, Eye
Genome editing for treatment of diseases has been constrained to blood, liver and eye targets due to delivery obstacles. But that's about to change. a @NatureBiotech review https://t.co/NJHiMlHMVY https://t.co/pFDftgEWRX
Spaceflight Deforms Brains, Accelerates Disease in Humans
Humans are not well suited for prolonged spaceflight —Brain deformation patterns https://t.co/7CGvKyHUzG —Alteration of molecular networks and accelerated disease https://t.co/S1SyjNGZ61 https://t.co/3RYuwH8PYa
Longevity Clinics Cashing in on Pseudoscience Boom
The big business of longevity pseudoscience and marketing https://t.co/2Os0Q2frQl by @TrishaThadani "The boom in consumer demand has inspired as many as 800 longevity clinics to spring up around the country,... These clinics often charge as much as tens of thousands of...
Mitochondrial Transfer Fuels Cancer Spread, Impairs Immunity
The double whammy of mitochondrial transfer from immune cells to cancer cells, reducing immune cel function and powering tumor spread through lymph nodes @Cell_Metabolism https://t.co/q3ZcRObLAc https://t.co/eUAPrxSxlh
AI Giants Race Into Healthcare Sector
A few days ago it was @OpenAI, now @Anthropic. The others soon. The push into healthcare https://t.co/5jVJVJ39MH
Heart Scarring, Not Training, Drives Arrhythmias in Veteran Athletes
Occurrence of ventricular arrhythmias in endurance male athletes age 50+ correlated with prior heart scarring (myocardial fibrosis), not exercise patterns https://t.co/CTWLLEZVSI https://t.co/fqVhTkV7BN
CHIP Clones Raise Cardiovascular Risk in Cancer Survivors
More evidence that blood stem cell clones (CHIP), common with increasing age, increase the risk of cardiovascular events, from people treated with cancer https://t.co/56YDjxshjg https://t.co/kdUksoCFmI
Red Blood Cells Drive Vascular Damage in Long‑Term Type 2 Diabetes
Implicating red cells as an underpinning of the vascular damage seen with long duration Type 2 diabetes https://t.co/FzvmreCtn7 https://t.co/MdgpHmpRvo
APOE Ε3/Ε4 Alleles Drive Majority of Alzheimer’s Cases
A new report claims that the APOE gene alleles accounts for the vast majority of Alzheimer's cases: "Without strong underlying risks from APOE ε3 and ε4, almost all AD and half of all dementia would not occur." https://t.co/KgRFx36WOn
Multi-Omic Atlas Shows Women’s Stronger Immunity, Age‑Related Decline
We're learning more about our immune system from a new, comprehensive, multi-omic atlas in @ScienceMagazine today, such as the stronger immune system in women and the age-related features of immunosenescence https://t.co/4B85BwohBb https://t.co/DHNIUKcQmE
AlphaFold Sparks Surge in Genome-Wide Drug Discovery
In the post-AlphaFold era, drug discovery is on a tear —Genome-wide virtual screening @ScienceMagazine https://t.co/GPyjSK6PcM —Transforming the industry in many ways @TheEconomist https://t.co/ppAMkbFqMp
AI-Driven Tracking of Tumor Evolution Reshapes Cancer Therapy
The plan to revolutionize cancer treatment by tracking and responding to evolution of tumor, emergence of resistance, and multimodal AI https://t.co/9PhOrtkiBM @Cancer_Cell @ARPA_H
Cellular Reprogramming Paves Path to Anti‑Aging Organs
Anti-aging and organ rejuvenation strategies, a review https://t.co/ZycCqjZwKk @CellStemCell Figure summary of cellular reprogramming efforts https://t.co/YKgGKukuYb
Treg Breakthroughs: Nobel‑winning Science Moves Toward Clinics
The science of regulatory T cells (Tregs) got the @NobelPrize last year. Now a first-rate review of where they are headed in the clinical arena https://t.co/4xjNAeG3MV https://t.co/MZCDyBc4jq
Low‑dose IL‑2 Curbs Artery Inflammation, Boosts Tregs
Blocking artery inflammation and increasing Treg cells in a small randomized trial with low-dose interleukin-2 https://t.co/ecEEnwUuhr
2026 Marks First AI Prescription Renewals and ChatGPT Health
2026 is off with two new precedents in health and medical AI —@doctronic given green light in Utah for AI prescription renewals, pilot study 250 patients https://t.co/EQ3fmqWwyz —ChatGPT Health initiated https://t.co/VOvd3wVkeR @fidjissimo Both need prospective study, rigorous independent assessment, and report of results
AI Predicts Hundreds of Diseases Years Ahead From Health Data
Large health models and predicting diseases —In September, >1,200 diseases predicted and when, by EHR and lifestyle factors, for 20-years forward https://t.co/31prJJL1v6 —Yesterday, >130 diseases were predicted from 1 night of sleep data and EHR (Figure) https://t.co/ebHlmaWjfK
Two Novel Strategies Supercharge Cancer Immunity
2 new ways to get the immune system revved up vs cancer —intratumor vaccination https://t.co/PUWOHy8Dkw —bacterial outer membrane vesicles https://t.co/2xC5PAC8OG
High Lp(a) Raises Long‑Term Risk; Therapies Coming
The risk of high lipoprotein A [Lp(a)] in nearly 28,000 healthy women followed for 30 years. Fortunately, after waiting for decades, we will have drugs vs Lp(a) soon to reduce this risk https://t.co/SfXTtpaV0i https://t.co/PdykVP6nKB
Mitochondria Transfer From Glia Offers Neuropathy Therapy
Discovery of a new potential approach for treating peripheral neuropathy: mitochondria transfer from satellite glial cells to neurons @Nature https://t.co/EZxAkbi6kk https://t.co/I4td8aScPP
Atrial Fibrillation Drives Cognitive Decline, Not Prevented by Blood Thinners
Atrial fibrillation and cognitive decline. Blood thinners don't help. Possible explanations not mentioned here include less brain clearance of metabolic waste products with this heart rhythm, recently documented https://t.co/IWzR05JaBN https://t.co/5UA4vcW3GO