New Cancer Interception Strategy Regresses Pancreatic Precancers
🆕 @ScienceMagazine An exciting new approach vs pancreatic cancer: "cancer interception" Considered ubiquitous, the pancreas in healthy adults has hundreds of PanINs of microscopic premalignant cancer that can be regressed in the experimental model https://t.co/erVtthSMjS https://t.co/2xHIYdIPrx
Microbes in Tumors: Unraveling a Controversial Role
What is the significance of microbes in tumors, a field mired in controversy? https://t.co/D5sHkLLsrT https://t.co/ntGLlke4iC
RFK Jr Promotes Unproven Peptides, BPC‑157 Lacks Solid Data
RFK Jr is trying to get 14 peptides, without data on safety or efficacy, licensed and approved by FDA. His favorite is BPC-157. "Only three small human studies of BPC-157 exist, for instance, the largest of which is a telephone...
GenAI Health Tools Multiply: ChatGPT, Claude, CoPilot
In January there was ChatGPT Health, Claude Health. Today there's Microsoft CoPilot Health. And more to come in the genAI -> health landscape https://t.co/TInH9YTvwA
LLMs Are Homogenizing Human Thought, Researchers Warn
In their paper today, the authors assert that LLMs are "homogenizing" human thought and expression https://t.co/HEaJyizbBL https://t.co/436zQieCKy
Gut Microbes Modulate Age‑related Memory and Cognition
Gut microbes signal the brain influencing age-associated memory and cognitive function in the experimental model @arcinstitute @Nature https://t.co/elSw3RXbI9 https://t.co/6fRfCk4Z9n
GLP‑1 Drug Linked to Longer Survival in Brain Metastases
Another potential GLP-1 drug benefit seen in people with diabetes and brain metastases for improved survival; a retrospective study that needs further assessment but intriguing https://t.co/nZm3xEYQMH https://t.co/V76S7o1MJb
Alzheimer’s Blood Markers Also Flag Certain Amyloidosis Types
The blood neuromarkers p-tau181 and p-tau217 that can predict and diagnose Alzheimer's disease are also abnormal in certain types of amyloidosis, indicating both some non-specificity and potential help in diagnosis of these conditions https://t.co/jodvMY6TNK
Severe COVID/Flu May Boost Lung Cancer Risk
A causal link between severe Covid or flu and lung cancer risk by impairing immunity and promoting inflammation, as shown in multiple murine models https://t.co/NvE6uIYFZh
AI Augments, Not Replaces, Human Insight in Complex Biology
"AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition." A perspective on future applications for cancer neuroscience https://t.co/TnDFZ7NRFN @scisignal https://t.co/ijbhfbjXcs
Doctors Still Beat AI on Practicality and Cost
Comparison of AI and primary care physicians for 100 patients in a prospective real-world assessment —The physicians outperformed AI [AIME] for practicality and cost-effectiveness —AI was comparable for diagnosis, management plan, appropriateness and safety @AdamRodmanMD @alan_karthi @PeterBrodeurMD @googledeepmind https://t.co/FNWYoHVkkw
Blood Test Predicts Alzheimer's up to 25 Years Early
Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70 https://t.co/aOActAUN27 https://t.co/Bxl2YZxnlf
AI Proven to Boost Breast Cancer Screening Accuracy
3 new reports and an editorial @NatureCancer reinforce the benefit of AI for breast cancer screening https://t.co/MlFns7M0yB https://t.co/MF3fj0CuIE https://t.co/a436srKDaD https://t.co/1XTMIsAPfg
Plastic Chemical DEHP Linked to Higher Breast Cancer Risk
The link between exposure to DEHP and its metabolite MEHP, found in plastics, and risk of breast cancer in a 20-year prospective study https://t.co/wKEVlMxWHT https://t.co/j5NL5QfTBu
Psoriasis' Immune Activation Reduces Skin Cancer Risk
Chronic inflammation generally poses a higher risk of cancer, so why does psoriasis-like disease have a lower risk of skin cancer. Why? Sustained immune cell activation https://t.co/kcxUHC8Ahk https://t.co/igqNDv5mdj
Societal Issues Stall US Life Expectancy Growth
Why hasn't life expectancy been increasing in the United States? It's complicated. "The fact that the United States is far from a leader in longevity and that it continues to fall further behind nearly all other high-income countries indicates that there are...
Obesity Raises Risk for Multiple Cancer Types
Obesity and overweight are risk factors for several types of cancer. Why? A @JAMA_current review https://t.co/fn5tfxNnsM https://t.co/caCsAt2vuB
Inactivity Kills 5 Million Annually; Policies Remain Unimplemented
5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them. No improvement in >20 years! 3 new papers @NatureMedicine @NatureHealthJnl https://t.co/Nvl1AhTz2h https://t.co/hGneBJTJBO https://t.co/g94vzx3Ydu
Multivitamin Modestly Slows Epigenetic Aging; Cocoa Doesn’t
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Utah's AI Prescription Plan Faces Conflict‑of‑interest Critique
Appropriate critique of Utah going with AI for prescriptions based on a @Doctronic preprint written by the company, by @JosephSakran gift link https://t.co/HcFqBy86wb https://t.co/QpVA7HGjRT
FMT Triples the Boost to Cancer Immunotherapy
Not just replication, but triplication of the benefit of revving up cancer immunotherapy with FMT (Yes💩) https://t.co/rXyQdO74FJ
Add AI Breast Artery Calcification Scan to Mammograms
Mammography should include AI assessment of breast artery calcification, since it provides very useful information about cardiovascular risk https://t.co/yfTbTRrOuY https://t.co/h1C8ZnHepJ
83% Unaware of DORAs: Sleep Knowledge Gap
There's a lot you can learn about sleep. Like 83% hadn't heard of DORAs. https://t.co/2lV3Fw6cwg https://t.co/IWRTdPTMOL
Cures for some Autoimmune Diseases Now a Reality
One of the most impressive advances we've ever seen for some autoimmune diseases: cures https://t.co/OZDuq4Iooy
PEP Slows Aging by Blocking Inflammation Pathway
PEP protects against age-related inflammation, puts the brake on the aging process in mice, high levels in humans correlate with low inflammation So what is PEP, you ask? phosphoenolpyruvate, from glucose metabolism, a, master regulator, blocks cGAS-STING https://t.co/glMvaHSjOq https://t.co/MSVMBJbHm4
Caloric Restriction Extends Lifespan in Animals, Human Applicability Unclear
Dietary (caloric) restriction has so many salutary effects for slowing the aging process in animal models, but whether that can be simulated in some way in people remains unclear. This new comprehensive review @NatureAging is outstanding https://t.co/xw5bmK3NaW https://t.co/t8bBmS8HGB
New Sleep Regularity Index Reveals Hidden Rest Patterns
Interested in the latest sleep science and getting better quality sleep? New Ground Truths with Prof Yo-El Ju, @WashUNeurology https://t.co/2lV3Fw6cwg SRI-sleep regularity index https://t.co/zRWbVNmeap
Self‑amplifying RNA Could Protect Future Heart‑attack Patients
Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation https://t.co/FcJme1ElyU https://t.co/lABFRkR3qg
Engineered Astrocytes Use CAR‑A to Remove Amyloid Plaques
New @ScienceMagazine Engineering the brain's astrocytes to clear amyloid plaque! "CAR-A," in mouse model https://t.co/u9zJGnCLUj https://t.co/eIrrFx7iTg https://t.co/x56FDtuVW2
Aging Cells Harbor Protective Mutations That Inspire New Drugs
We're chock full of somatic mutations in our cells and tissue as we age. Some even protect us from disease! And we can learn from them to discover new medications. @CellCellPress https://t.co/mnUsarpYoR https://t.co/4c5XOD7NuC
AI Generalist Excels Across Diverse Medical Imaging Modalities
Can an AI model be a generalist to work and perform well for all types of medical images? Just published, our MedVersa paper @NEJM_AI Led by @pranavrajpurkar Free access https://t.co/5llNf94hAF https://t.co/Bf01zUZ1sk
Yamanaka Stem Cells Earn Conditional Approval for Heart and Parkinson's
20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan https://t.co/8oxKxXYafu by Shinya Yamanaka @CellStemCell https://t.co/U878IxSfSi @ScienceMagazine https://t.co/HCCPaTEP7e
GLP‑1 Drugs Cut Substance‑abuse Risk in Veterans
Best evidence yet that GLP-1 drugs reduce the risk of substance abuse, from >600,00 US Veterans across alcohol, nicotine, opioid, cocaine, cannabis @bmj_latest @zalaly @Miao_Cai_SLU https://t.co/rcqUt0kY77
Cell‑free DNA Test Predicts Liver Disease and Mortality
We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions @ScienceTM https://t.co/IJxPMq7hGU
AI Predicts 5‑year Health Risks From Routine CT Scans
When your "normal" abdominal CT tells you about the 5-year future risks that can't be seen by radiologists, but can by AI (Merlin) https://t.co/DemC983uKz https://t.co/9jqZyVTD3p
Evo 2 Open‑Source Tool Predicts Non‑Coding Pathogenicity
It got me at "across all domains of life" Predicting pathogenicity of non-coding regions, produces sequences at genome scale, and much more Evo 2, open-source, @Nature today @arcinstitute @pdhsu @BrianHie https://t.co/9CZWmPFhjd
Future Cancer Blood Tests May Accurately Screen High‑Risk Groups
Cancer blood tests for screening? Not the way they've been studied to date (age 50+) A new feature @Nature “I’m confident we’re going to see more accurate tests going forward. In high-risk groups, such as those with a genetic predisposition,...
Gut Health and Toxins Drive Parkinson’s Disease Surge
The gut and environmental toxins are key underpinnings of the Parkinson's disease pandemic @jclinicalinvest https://t.co/e8o4UuIafG https://t.co/7634Yg2Qo5
LLM Medical Research Overwhelmingly Lacks Real Clinical Data
A new systematic review of LLMs in medicine @NatureMedicine @ekoermann https://t.co/npvDeqUvel “Despite thousands [4,609] of publications since late 2022, only a small fraction use real clinical data and just 19 randomized trials exist.”
P‑tau 217 Blood Test Outperforms Total P‑tau 217 For
The breakthrough blood test p-tau 217 for risk and diagnosis of Alzheimer's disease is more accurate than total p-tau 217, in a head-to-head comparison using PET imaging https://t.co/faILpVr9Ua https://t.co/lzUgFnFUP5
GLP‑1 Weight‑Loss Drugs Work Better for Women
A systematic RCT analysis of GLP-1 drugs show they are more effective in women than men for weight loss https://t.co/cycwi4nnN5 https://t.co/KOl0FgKaZD
AI Pathology for Cancer Markers Hindered by Shortcut Learning
AI of whole slide images for cancer molecular markers is not ready for clinical use due to confounding and biases ("shortcut learning"), supported by multiple examples @natBME https://t.co/zG8uVIxrJf https://t.co/hQ0tjiapIJ
Exercise‑derived Muscle Vesicles Boost Brain Microglia, Improve Cognition
A new mechanism for improved cognitive function from exercise in the Alzheimer's disease model Skeletal muscle EC vesicles interact with the brain and rev up microglia function https://t.co/eZu14YVasY
Antibody Plus Ozempic Drives Significant Weight Loss
New @NatureMedicine A randomized trial of antibody vs activin type II receptors with or without semaglutide (Ozempic). The antibody, bimagrumab, promotes muscle growth. Marked weight loss with the combination https://t.co/XUK93GTAmA
Future: Real-Time Immune Monitoring Like Glucose Tracking
Someday we'll be able to track our immune system like we do glucose Today @NatBME https://t.co/HFcFiUeyFg Previously @ScienceMagazine https://t.co/EcgBdwGxcd https://t.co/SpoZ5bLtjx
Accelerating CAR Engineering Shows Promising Cancer Immunotherapy
Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell https://t.co/1Qz2rCs8I5 https://t.co/sJ6BwaXyjk
Smartphone AI Beats Endocrinologists in Acromegaly Diagnosis
AI is helping to make the diagnosis of rare diseases. A new multicenter study in Japan showed smartphone AI diagnosis of acromegaly via hands was better than experienced endocrinologists https://t.co/qBiazetToV https://t.co/dSZpJ2us84
Obesity Accelerates Neurodegeneration, New NatMetabolism Study Shows
How does obesity catalyze neurodegeneration? Our paper just out @NatMetabolism https://t.co/kx25urgpJx free access https://t.co/aL1FBN9MyI Phenomenal work by @chen_bandy pulling this together
Gut Bacteria Interactions Dictate Health and Disease Risk
🆕 @ScienceMagazine How gut bacteria interactions [cooperation vs competition, positive vs negative] shape risk for health and disease https://t.co/q8TvbaHDQI https://t.co/kS0S3uUIli
Immune Cells Drive Transition From Healthy Aging to Alzheimer’s
What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time? The critical role of the immune system, particularly T cells and microglia. A new, excellent review @ImmunityCP https://t.co/XqEBcptTuG https://t.co/Xt24BvkDWe