Blood P‑tau217 Test Predicts Alzheimer’s Symptoms 20 Years Ahead
Predicting when symptoms of Alzheimer's disease will occur with elevated p-tau217 blood test and a person's age, even 20+ years in advance @NatureMedicine https://t.co/EYaGglBh1H
AI Automates Cytology, Streamlining Cell Pre‑Screening
AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses today @Nature https://t.co/ZI3F2pkMxE https://t.co/WsUcRjkHFN https://t.co/mdz1DM6xs7
Brain’s Venous Sinuses Patrol Immune Cells and Drain Fluid
What's ruffling? Large veins interfacing the skull (venous sinuses) that patrol immune cells and help drain the brain https://t.co/WsML3Jd1yA
MRNA Vaccines Advance Triple‑negative Breast Cancer Therapy
The unfounded move by @HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today @Nature Adds to successful pancreatic, renal cell, melanoma reports...
Listen to Biology’s Early Whispers to Prevent Disease
We could prevent diseases so much better but we haven't learned to listen to when biology whispers long (10 + years) in advance. A key theme in Super Agers, too. https://t.co/0pSap3f32N @NathanPriceSci @ @nrappapo @BuckInstitute example below for Type 2...
Agentic AI Enables Accurate Rare Disease Diagnosis via DeepRare
Another good use case for agentic AI in medicine: diagnosis of rare diseases. Exemplified by DeepRare https://t.co/XBd68V3iDl https://t.co/rBl5yn95sI
GLP‑1 Safety: New Data Highlights Retinal Risks
A short thread on GLP-1s based on new publications. 1. The safety story Table of potential side effects and very good description of mechanisms, especially w/r to retina https://t.co/L5GNZyArrn https://t.co/MyXVOF3SYv
Free, Ad‑free Biomed Insights Reaching 200k Globally
Ground Truths are free essays and podcasts on the hot topics in biomedicine and health. Mostly things the media doesn't cover or adequately highlight. No ads or sponsors. Join ~200,000 subscribers from 212 countries https://t.co/ZgnO2Y0P4L
B‑Cell Depletion: Rebooting Immunity to Cure Autoimmunity
"Immune Reset" Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases https://t.co/253NtyFmCN
Women Show Higher P‑tau217 Levels and Tau Deposition
p-tau217 is a breakthrough blood test for risk of developing Alzheimer's disease. Important to know there are sex differences for this biomarker, with women having higher values at baseline and more tau deposition. @JAMANeuro https://t.co/Xrr8SjsiVY https://t.co/eyDt6mgSqR
Psychedelic Shows Rapid Depression Relief in Small Trial
A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine https://t.co/vvug72VGBi https://t.co/Tn58rP0ufS
LLM-Edited Radiology Reports Boost Patient Understanding, Preserve Accuracy
When the LLM rewrites the radiology report, patient understanding is increased and clinical accuracy is maintained. @LancetDigitalH @curtlanglotz @smrabd https://t.co/q2UHebBQG7 https://t.co/IwZAx59brY
15‑PDGH Inhibition and Ozempic May Restore Cartilage
Two things that may help restore cartilage —15-PDGH inhibition https://t.co/chCj9Lj5qk —Semaglutide (Ozempic), independent of weight loss https://t.co/fqbrQQYfRt https://t.co/6CRdY1QtC1
Immune System Drives the Biological Process of Aging
Our immune system is the driver of the biologic process of aging. A new and comprehensive review @NatRevImmunol https://t.co/0Fm9w7U341 https://t.co/alPoABMozO
Healthy Diet Adds 2‑3 Years Lifespan, Especially Early
A healthy diet, accounting for longevity-related genes, associated with 2-3 more years of life expectancy from >100,000 people followed 10.6 years, max benefit for starting at youngest age (Figure) @uk_biobank @ScienceAdvances https://t.co/Ji7Wlhj9ZA https://t.co/B6UxuE97xG
Genetic Evidence Shows BMI Directly Shapes Gut Microbiome
A successful hunt of human genome variants identifying some (with MR) that provide causal evidence that BMI affects microbe composition @NatureGenet https://t.co/1uxvnFNrbK https://t.co/SuItRHAnFe
Semaglutide Linked to Higher NAION Risk in Veterans
Among US veterans (mean age 60) with T2 diabetes who received semaglutide (Ozempic) there was a risk of 0.3% in the first 2 years of NAION, a serious vision loss event, that exceeded SGLT-2 inhibitor drugs (graph) @JAMAOphth https://t.co/c3zDHa7OQB https://t.co/hYTxAs6ThH
Exercise Rewires Brain, Boosting Endurance in Mice
How exercise rewires the brain to promote endurance https://t.co/h7fiahzoAn as demonstrated in the mouse model https://t.co/DfUWadNKgt https://t.co/vhrsv1pkUs
Molecular Mimicry Links J&J Vaccine to Rare Clotting
Cracking the case: how did adenoviral vector vaccine such as the J&J's Covid induce very rare and potentially fatal clotting, bleeding? An elegant proof of molecular mimicry—genetic background + rogue antibodies https://t.co/yp6TNE8ZQC https://t.co/NhhYDvntmT @rkhamsi @TheAtlantic https://t.co/xY7f6MVkx9 @kakape @GretchenVogel1 @ScienceMagazine
90% Want Free AI Mammograms, Yet None Receive It
Over 90% of responders believe it's time for mammography to incorporate AI for every readout, whereas close to 0% who get screened are getting that interpretation now, and at no out-of-pocket charge https://t.co/hITOBNd7pg https://t.co/x1I6Ffxfio
US Stalls Flu Vaccine, Lags China on Nasal COVID
Not only has the US blocked a significant advance for a flu vaccine, but it has done nothing, unlike China, to advance a nasal Covid vaccine that achieves mucosal immunity to block infections https://t.co/FXnaWjxkWV https://t.co/WABn5324U8
Tylenol Use in Pregnancy Shows No Increased Neurodevelopmental Risks
Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out https://t.co/Kjwp1h3PBP
Super Agers Show APOE‑ε4 Reduction, Like Healthy Controls
Super Agers with intact cognitive function and the frequency of the APOE-ε4 and APOE-ε2 alleles compared with controls and people with Alzheimer’s disease https://t.co/vMYcSTVCDS
Intentional GenAI Use Can Reduce Global Health Inequities
GenAI has the potential to worsen health inequities. In a new review @NatureHealthJnl we show that with intent, confronting the challenges, it could be just the opposite, globally @nliulab https://t.co/jwmslSVIV1 https://t.co/5q3gq9mnez
Lynch Syndrome Vaccine Shows Strong Immune Response, Safety
A vaccine to prevent colon cancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for Lynch syndrome https://t.co/EfXDlTJlIz https://t.co/RtxfB4oGZ1
Obesity Rewires Macrophages, Triggers NLRP3 Inflammation
How does obesity lead to immune system dysregulation and chronic inflammation? Macrophage metabolism is rewired, with activation of the NLRP3 inflammasome @ScienceMagazine https://t.co/bkAUgOE1c2 https://t.co/It6YaXT1b5
Multimodal AI Promises Patient‑centric Mental Health, Needs Validation
New @ScienceMagazine A thoughtful and comprehensive review on how multimodal AI can transform mental health, with emphasis on a patient-centric approach "The successful translation of AI into clinical practice will require robust validation" https://t.co/xSACrFI0tW https://t.co/8jiV6P1vdj
He Jiankui Returns, Society Still Unready for Embryo Editing
The reckless human embryo genome editor, He Jiankui, known as China's Dr. Frankenstein, is back at it. "People were not yet ready to accept what I was doing." We're still not. https://t.co/UYIwWj0qf1
Long COVID Linked to Elevated P‑tau181, Alzheimer Risk
Not good to see the rise in p-tau181, a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease, in a prospective cohort (mean age 56 years) with #LongCovid and neurological symptoms https://t.co/XTd5qeN24e @eBioMedicine https://t.co/B1fkhoydFI
GLP‑1 Therapies
A 5★ new review of the GLP-1 drugs, what they have achieved, and where the field is headed with so many new molecules and combinations @TheLancet https://t.co/E1Xa15fk1q https://t.co/Jjmw01L5KM
Improved Survival and Return-to-Play Guidelines for Athletes
An excellent @NEJM review of sudden cardiac death in athletes with what constitutes the appropriate workup, potential for returning to sports, and very good trend for survival over the years https://t.co/PgoBaEcbZI
AI Boosts Individual Impact, Shrinks Collective Research Breadth
How has AI impacted science? Analysis of >41m papers. A paradox: Expansion of individual's impact but contraction in breadth of topics researched collectively https://t.co/npovh0eSL8 https://t.co/iMY3cEd9LE https://t.co/iErtpnuJQR
Invisible Immune Deficits Make Low‑risk Infections Deadly
Why do so many apparently healthy people die or get severely ill from infections that would be considered low risk? For one, we don't have any way of assessing a person's immune system function in the clinic https://t.co/CshtAxDep9 https://t.co/uk5nDnyjnr
CGM‑based AI Outperforms HbA1c in Predicting Diabetes, Heart
Continuous glucose monitoring sensor data, with a foundation model, predicts risk of Type 2 diabetes and cardiovascular outcomes better than HbA1c New @Nature @segal_eran @WeizmannScience @GLutsker "66% of incident diabetes cases and 69% of cardiovascular deaths occurred in the top risk...
44‑Metabolite Signature Improves Prediction of Diabetes Progression
There are about 100m Americans with pre-diabetes. But who will progress? Enhanced risk prediction of Type 2 diabetes from a 44 -metabolite signature @NatureMedicine https://t.co/UxmQaD88s4 https://t.co/jhmP3enyTa
Combined Exercise, Sleep, and Diet Boost Healthspan and Lifespan
Concurrent improvements in physical activity (MVPA), sleep, and diet are associated with meaningful improvements in healthspan (DFLE) and lifespan LD-low quality diet, MD-moderate, HD-high New @eClinicalMed, @uk_biobank 59,000 participants w/ 8 year follow-up https://t.co/gl36VSQVFh
Glucose Metabolism Fluctuations Drive Cognitive Aging Changes
The brain's glucose metabolism, cognition, and aging: "Variability in the moment-to-moment metabolism of glucose is biologically and functionally important to cognition and in explaining metabolic and brain network changes in aging." https://t.co/0cFbXJFQD5 https://t.co/sCO98PHBL0
Fasting‑mimicking Diet Eases Symptoms, Reduces Inflammation in Crohn’s
A fasting-mimicking diet improved the clinical course and suppressed inflammation in people with mild or moderate Crohn's disease in a randomized trial https://t.co/pVVJ4HD4gD https://t.co/2PyJObeAqQ
Epiploic Fat Fuels Inflammation in Severe Obesity
Fat surrounding the large intestine (epiploic) is rich in immune cells and can drive inflammation. Study in people with severe obesity. @Cell_Metabolism https://t.co/kN1B77XrCm https://t.co/YlNrpCGZjI
New Cell Studies Link EBV to Multiple Sclerosis Mechanisms
3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement https://t.co/JXThwhZugq https://t.co/fO1aDsZmmB https://t.co/fO1aDsZmmB https://t.co/eUNrrRGw0s
Total‑body MRIs Yield High False‑positive and False‑negative Rates
Total body MRI scans generate lots of false positive results. Then there's the false negatives, too. https://t.co/7NITyu2sqM @PeterWhoriskey https://t.co/PW1Q2XjOn4
New Delivery Breakthroughs Expand Genome Editing Beyond Blood, Liver, Eye
Genome editing for treatment of diseases has been constrained to blood, liver and eye targets due to delivery obstacles. But that's about to change. a @NatureBiotech review https://t.co/NJHiMlHMVY https://t.co/pFDftgEWRX
Spaceflight Deforms Brains, Accelerates Disease in Humans
Humans are not well suited for prolonged spaceflight —Brain deformation patterns https://t.co/7CGvKyHUzG —Alteration of molecular networks and accelerated disease https://t.co/S1SyjNGZ61 https://t.co/3RYuwH8PYa
Longevity Clinics Cashing in on Pseudoscience Boom
The big business of longevity pseudoscience and marketing https://t.co/2Os0Q2frQl by @TrishaThadani "The boom in consumer demand has inspired as many as 800 longevity clinics to spring up around the country,... These clinics often charge as much as tens of thousands of...
Mitochondrial Transfer Fuels Cancer Spread, Impairs Immunity
The double whammy of mitochondrial transfer from immune cells to cancer cells, reducing immune cel function and powering tumor spread through lymph nodes @Cell_Metabolism https://t.co/q3ZcRObLAc https://t.co/eUAPrxSxlh
AI Giants Race Into Healthcare Sector
A few days ago it was @OpenAI, now @Anthropic. The others soon. The push into healthcare https://t.co/5jVJVJ39MH
Heart Scarring, Not Training, Drives Arrhythmias in Veteran Athletes
Occurrence of ventricular arrhythmias in endurance male athletes age 50+ correlated with prior heart scarring (myocardial fibrosis), not exercise patterns https://t.co/CTWLLEZVSI https://t.co/fqVhTkV7BN
CHIP Clones Raise Cardiovascular Risk in Cancer Survivors
More evidence that blood stem cell clones (CHIP), common with increasing age, increase the risk of cardiovascular events, from people treated with cancer https://t.co/56YDjxshjg https://t.co/kdUksoCFmI
Red Blood Cells Drive Vascular Damage in Long‑Term Type 2 Diabetes
Implicating red cells as an underpinning of the vascular damage seen with long duration Type 2 diabetes https://t.co/FzvmreCtn7 https://t.co/MdgpHmpRvo
APOE Ε3/Ε4 Alleles Drive Majority of Alzheimer’s Cases
A new report claims that the APOE gene alleles accounts for the vast majority of Alzheimer's cases: "Without strong underlying risks from APOE ε3 and ε4, almost all AD and half of all dementia would not occur." https://t.co/KgRFx36WOn
