Over 3,000 Brain Genes Show Sex‑Specific Expression
Sex-specific gene expression of the human brain, for >3,000 genes (of our ~20,000 total) @ScienceMagazine https://t.co/jQUFgARmuA https://t.co/0qNr9XPnP4
Drug Discovery Expands Beyond AI to New Frontiers
The marked expansion of paths and methods for new drug development including and beyond AI @Joseph_C_Wu @james_y_zou @WuXuekun @ScienceMagazine https://t.co/hTJ4Rt181n https://t.co/H3U5BNR1ER
Prediction Markets Threaten Public Health, Says Science Magazine
Prediction markets like @Polymarket are a threat for public health, asserted in a @ScienceMagazine essay https://t.co/Kk2OOVrxHy https://t.co/1pGA9aiBAh
Super‑resolution Microscopy Visualizes Live‑cell Endoplasmic Reticulum
What does the endoplasmic reticulum look like in a live cell, thanks to super-resolution microscopy? @naturemethods https://t.co/HZ0Vf9ZpZa https://t.co/fT95huDwNP
Third‑generation T‑cell Engagers Advance Cancer Immunotherapy
Cancer immunotherapy keeps revving up. Now onto a 3rd generation of T cell engagers https://t.co/h05f8h3i8L https://t.co/PP5XE8WWDr
Anti‑amyloid Drugs Show Trivial, Non‑meaningful Cognitive Benefit
The effect of current anti-amyloid drugs vs Alzheimer's disease is "trivial" for cognitive function or dementia severity, not clinically meaningful, from a systematic @cochranecollab review of 17 trials, >20,000 patients https://t.co/9A6PeZOyAt https://t.co/c1PCOYZxws
New NEJM Review Links Hormone Therapy to Cardiovascular Risk
Sex hormones, clotting disorders, and cardiovascular risk An important new @NEJM review for MHT and testosterone latest data https://t.co/UNqXAwjsKM https://t.co/4ckJsc4YyE
Immune Activation Drives Neurodegenerative Disease Progression
On the path to neurodegenerative diseases, the pivotal role of immune system activation. A new and excellent review @jclinicalinvest https://t.co/4j2OwwHcJQ https://t.co/qCMJT8miXQ
Promolytics: Targeting Cancer‑Promoting Clones to Halt Progression
A new review on tumor promotion and the evolution of cancer with the concept of "promolytics" —drugs that could prevent potentially dangerous clones and/or their progression https://t.co/IFah5gi8ZK @Nature
Training LLMs on AI‑generated Text Creates Hidden Bias
What can happen when LLM models are trained on AI outputs? A potential hidden, bad influence https://t.co/UDGSalz98r https://t.co/RxGtmml55O
Inflammation: The Overlooked Key to Preventing CAD
That's right. Inflammation is the big miss for getting ahead of coronary artery disease https://t.co/KIs1AFxflE My review of this big shift https://t.co/foSaaTYUD4 https://t.co/cCRqSd8axt
Medical AI Flaws Exposed: Bad Chatbot Answers, Unreliable Data
Issues recognized with medical AI models —Problematic responses to 5 chatbots https://t.co/V6IZHOhAm4 —Prediction based on unreliable, open-access datasets https://t.co/PnJ0TrtXK2 https://t.co/Bp8ztckFgV
High Blood Glucose Linked to Cognitive Decline via Lactate Pathway
How do high glucose levels in the blood impair cognition and predict mild cognitive impairment in people with diabetes? @scisignal Elevated plasma lactate and related pathway, with a peptide intervention to potentially address it https://t.co/ai1369HWVU https://t.co/JcszZT2Tt2
Somatic Immune Cell Mutations Linked to Autoimmunity
New evidence that somatic mutations in immune cells can be the basis for autoimmune disease @Nature https://t.co/GvzxLYgvfw
RUNX1 Identified as Key to Rejuvenate Aging T Cells
Discovery of a factor (RUNX1) that pinpoints T cell senescence and restoring its functionality achieves T cell rejuvenation. Significant implications in older adults with loss of immune system protection. https://t.co/X58DvzIUXY @ImmunityCP https://t.co/hzL3zFiPMm
GLP‑1 Receptors Protect Liver in Mouse MASH Model
Adding to the GLP-1 drug weight-loss independent effect benefit : impact on liver sinusoidal endothelial cell GLP-1 receptors for liver protection in mouse MASH model @Cell_Metabolism @DanielJDrucker @ChusaGzlzRellan https://t.co/0A13QYgm05
Low P‑tau217 Indicates Minimal Alzheimer’s Risk in Seniors
Another study indicative of predictive power of p-tau217 for Alzheimer's disease in cognitively unimpaired older adults (mean age 71 at baseline) A very low p-tau217 denoted minimal risk https://t.co/6RPJcCloWI https://t.co/XikzsvJjhM
AI Company Becomes First Autonomous Drug Prescriber in Utah
An editorial @JAMA_current on @doctronic (the AI company now prescribing renewal medications without physician involvement in Utah) entitled "The First AI Drug Prescriber" https://t.co/Wo1rVhnr4s https://t.co/hAcYbYLmIv
Current LLMs Lack Safe Clinical Reasoning Capability
Assessment of 21 LLMs for generating a differential diagnosis "Off-the-shelf LLMs have not yet achieved the intelligence required for safe deployment and remain limited in demonstrating advanced clinical reasoning." https://t.co/9Nvo0kPrZA https://t.co/Odja5lkq8F
Rare Diseases Need Molecular Surgery, Not Drug Barriers
The turning point for rare diseases, which affect >300 million people around the world. A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments gift link: https://t.co/DQ0OZ9tXXc https://t.co/RELCwTr88i
Spatial Biology, Single‑cell Profiling, and AI Map T‑cell Immunity
Towards Spatial Medicine for individualized cancer immunotherapy @SciImmunology "The convergence of spatial biology platforms, single-cell immune profiling, and machine learning is positioning the community to decode how T cell immunity is spatially organized in human tissues and to exploit that organization...
Common Bowel Issues: Causes and Simple Solutions
These bowel function issues are remarkably common. Why? How can they be resolved? https://t.co/4t91w8Mnhm https://t.co/Z3pShlF0kA
Kara Swisher Launches CNN Series on Longevity
With @karaswisher as her @CNN 6-part series on longevity and healthspan starts this weekend https://t.co/OvZxD33eJl https://t.co/Kn0Aux5G9n
Artificial Sweeteners Linked to Multi‑Generational Harm in Mice
The potential for artificial sweeteners to have adverse effects across generations, from a study in mice. open-access https://t.co/RDJsaQL14N
Sex Drives Distinct Immune Aging Patterns and Disease Risks
The way our immune cells age differs substantially by sex, from single-cell analysis of ~1,000 people. Implications for propensity for autoimmune diseases (women), vulnerability to cancer (men), immunosenescence and inflammaging @NatureAging https://t.co/GjcuZ8luNM
AI Predicts Heart Failure Five Years Early via CT
AI to detect risk of heart failure 5 years ahead of symptoms via CT scan epicardial fat tissue https://t.co/RuZu8pSIAy @JACCJournals https://t.co/Gz052Ajj4X
Three AI Tools Should Power Every Mammogram—Free, Proven, Ignored
Every mammogram should be supported by 3 different AIs for improved detection of cancer, prevention, and risk of heart disease. At no cost to patients. My new @TheLancet essay reviews the evidence and the lack of implementation https://t.co/AslAZroL73 https://t.co/znfjtV04HB
Cell Clusters Drive Cancer Spread; Strategies to Disrupt Them
A new feature @ScienceMagazine on the clusters of cells that enhance the spread of cancer, and what can be done to break them up @ScienceVisuals https://t.co/xNAOF834mU https://t.co/YrH1aZ47Xl
B‑cell Reboot Shows Promise Across Multiple Autoimmune Diseases
More success for rebooting B cells towards cure of different autoimmune diseases beyond lupus, MS and others https://t.co/sFGMiFeiEF https://t.co/Dbvca9eox8
Dietary Amino Acid Restriction Shows Promise Against Pediatric Brain Cancer
Can rebooting the diet, eliminating 2 essential amino acids, help treat an aggressive brain cancer in children? mechanism and potential established from experimental model https://t.co/wmAFM2ErRB https://t.co/PAOr5SL30y
Greater Optimism Linked to Reduced Dementia Risk
No cause and effect established, but the more optimism the less dementia in >9,000 individuals with up to 14 year follow-up https://t.co/8pTnuJ9XSF https://t.co/Lcg4uExYrO
Adaptive Coherence Framework Guides Smarter Microbiome Health
We can be smarter about our microbiome health by cueing into host interactions, an "adaptive coherence framework" @cellhostmicrobe https://t.co/mprFgV7Gjq https://t.co/rQiPeK2aJP
Genomics Predicts Individual Weight Loss From GLP‑1 Drugs
Genomics of GLP-1 drug response and side effects With genomic and demographic data it's possible to predict magnitude of weight loss response @23andMe https://t.co/iAS2Fjjxig https://t.co/AXsWnZw2Ub
Never-Married Individuals Face 70% Higher Cancer Risk
Does never-married raise the risk of developing cancer? That what a new report says with a incidence rate ratio (IRR) of ~1.70 in both men and women. https://t.co/lz3wgagNRA https://t.co/ymwPqXT19x
Shift Focus: Prioritize Cancer Prevention Over Detection
We should be prioritizing prevention of cancer instead of the major focus on detection and treatment. A new @CellCellPress perspective https://t.co/Gkso3gGPOI
Peptide Vials Contaminated, Underdosed, and Unsafe
Besides the lack of data for safety or efficacy on peptides, or any assurance of sterility, here's what an independent lab found of samples: —The vial of BPC-157 contained lead —The vial of TB-500 contained endotoxins —The vial of CJC-1295 contained <42% of...
How U.S. Healthcare Costs Soar Without Better Outcomes
The multitude of ways that jack up American healthcare costs (without improving outcomes) @armollica @WSJGraphics @annawmathews gift link https://t.co/FjseZsYQiT https://t.co/QcAmpv2L5r
Meta-Analyses Reveal Psychedelics Boost Brain Circuits
Two systematic, meta-analyses on psychedelic drugs today Brain Circuit Function @NatureMedicine https://t.co/nBmjreYEXU Depression @NatMentHealth https://t.co/zJR06AsC0Z https://t.co/qpWdjzBR4D
Cell Senescence Drives Cancer Risk, Yet Can Be Modulated
Cell senescence and how it predisposes to cancer, no less how we may be able to modulate it. An outstanding @CellCellPress review https://t.co/bmAXOS1Ybz
AI’s 15‑Year Evolution Explored in New Book
Just finished this riveting, fact-based, storytelling book on how AI rose in the past 15+ years to where it is today, by @scmallaby, featuring @demishassabis and @GoogleDeepMind. Join Sebastian and me for a Ground Truths live podcast tomorrow 12N PT https://t.co/YllXW9J82k...
Five Tech Giants Roll Out AI Health Chatbots, Journalist Tests
This year 5 tech companies have introduced AI chatbots to consumers for health support @AnthropicAI @perplexity_ai @OpenAI @Microsoft @amazon @nicnguyen, a @WSJ journalist, tried some out. gift link https://t.co/vwO261Q6qB https://t.co/VFPyvc1P9O
Living Environment Impacts Brain Aging as Much as Disease
"Where and how people live may be as important for brain aging as the specific disease they develop." Physical and social exposome factors associated with accelerated brain aging across 34 countries Physical factors primarily linked with structural MRI brain aging; social with...
NEJM Review Overlooks Inflammation in GLP‑1 Drugs
A new review of the GLP-1 receptor drugs @NEJM https://t.co/PK03jApZWB surprisingly, the word inflammation only appears once, in this diagram https://t.co/1PeBakBAQb
Genome Editing Shows Promise for Sickle Cell, Β‑Thalassemia
3 new trial results for genome editing of sickle cell disease and β-thalassemia @NEJM https://t.co/qGGdjgKqP5 (with summary Table below) https://t.co/RdiM3urCKJ https://t.co/W15cPAfMoS https://t.co/F3PHKuktPx https://t.co/t6Z35S8L7h
High‑dose Flu Shots Cut Alzheimer Risk, Especially in Women
We've seen the Shingles vaccine is linked with reduced risk of Alzheimer's and dementias in 4 large natural experiments. Today, the potential of high-dose flu vaccines vs standard dose for the same in a large retrospective age 65+ cohort [N>160,000)....
New Scalable Method Improves LLM Evaluation Beyond Benchmarks
The current science of evaluating AI models, such as primarily relying on benchmarks, is far from optimal. @Nature today a new scalable way used to assess 15 LLMs with absolute demand scales, enhancing predictor power and expandability https://t.co/fH2k1WrsHX https://t.co/k2L5QdyMeh
FDA Threatens Unprecedented Ban Lift on Untested Injectables
If FDA does this, which is highly likely succumbing to pressure from RFK Jr, it crosses a new red line and, as far as I know, is unprecedented. Lifting a ban on drugs that are injected into the bloodstream without...
Exercise Counters Mitochondrial Decline, Preserving Aging Muscle Function
Mitochondria dysfunction underlies age-related decline of skeletal muscle function, with exercise mitigating this effect. Studies in both mice and humans. @PNASnews https://t.co/QjSR8GMRsR
Vigorous Exercise Cuts Risk of Eight Diseases, Mortality
Intensity of exercise vs volume of physical activity made a difference for lower risks of 8 diseases and all-cause mortality among 96,000 @uk_biobank participants, especially noted for immune-mediated (IMID). VPA-vigorous physical activity https://t.co/MiiJHRDwxK https://t.co/818AH12Tj4
Atrial Fibrillation Impairs Brain Waste Clearance, Predicts Worse Outcomes
Heart-Brain Axis Atrial fibrillation leads to reduced brain glymphatic flow, decreased washout of waste metabolites. https://t.co/2PNjoDl4Om Today #ACC26 @JAMACardio Serum Neurofilament (sNfl), a marker for brain cell injury, is associated with adverse CV events and mortality in patients with atrial fibrillation https://t.co/fWNg8zks0C