AI Scans Enable Decade‑long Primary Disease Prevention for High‑risk Patients
Using AI of a medical scan to achieve primary prevention of disease over the next decade in people at high-risk @ScienceTM https://t.co/inpvk55qBA https://t.co/3awSGlBjuK
AI 3D Model Maps Whole-Body Cellular Perturbations
An AI foundation whole-body 3D model that assesses perturbations (such as obesity) across multiple systems (such as immune, neural) at the cell level. This is MouseMapper. Imagine HumanMapper someday @Nature @erturklab https://t.co/jsg3VMzOqg https://t.co/tktuINis2W
AI Retinal Scans Enable Rapid Multi-Disease Screening in Clinics
“The [AI] tool presented here will enable rapid screening for multiple systemic diseases using retinal photographs, and it is a step forward in the evolution of oculomics from experimental research to real-world clinical practice.” —Editorial Team, @NatureMedicine https://t.co/8T3Kq2o8jP
Multi‑Agent AI Boosts Biomedical Discovery Across Diseases
A big day for multi-agent AI to accelerate biomedical discovery, hypothesis generation, designing experiments with proof points of new candidate drugs (cancer, fibrosis, macular degeneration, antimicrobial resistance, and more) 2 @Nature reports @GoogleDeepMind @FutureHouseSF https://t.co/u1EYvJ05VJ https://t.co/8DpAolom0F
Urgent Need for Ebola Bundibugyo Vaccine Development
This is the kind of work, published today, that should be fully supported and prioritized at the highest level. Currently, there is no vaccine vs the Ebola Bundibugyo virus, the source of a major outbreak https://t.co/qM6bWLtmcb https://t.co/IJ7lVXKQNX
AI Uses One MRI and Demographics to Forecast Alzheimer’s Cognition
A single MRI + demographics + AI predicts current and future cognitive scores and outcomes for Alzheimer’s disease https://t.co/9Mm3kOCI8L
Once‑night Pill Proves Effective for Severe Sleep Apnea
A once a night pill for severe obstructive sleep apnea effective in a Phase 3 randomized trial https://t.co/zq2Ew65WHK https://t.co/ovQEh7taeN https://t.co/N8vXzYincy
CRISPR Shifts to DNA‑guided RNA Targeting
Expanding the CRISPR genome editing toolkit: A flip from RNA-guided DNA targeting to DNA-guided RNA targeting @NatureBiotech https://t.co/GxKVthgbxh https://t.co/UIifna0nsF https://t.co/2ZB1eJzpCe
Antibody‑Drug Conjugates Surge in Cancer Clinical Research
The progress and intensity of clinical research efforts with antibody-drug conjugates vs cancer is remarkable A new @CellCellPress review https://t.co/bkaJ2OOt63
LLMs in EHRs Enable Earlier Cancer Risk Detection
We could pick up risk of cancer and detect it much earlier if we applied LLMs to electronic health records, as shown in this @AllofUsResearch study https://t.co/VBFxeOWZAz
Thymus Role in Health Across Lifespan Redefined
Challenging medical dogma, our understanding of the thymus and its impact on our health throughout lifespan has been completely revamped w/ @HugoAerts @TheLancet https://t.co/Wx4n7zeJwp https://t.co/wq2sgYd5X6
Retina Scans Reveal Osteoporosis Risk Across the Body
Our retina image is so rich with information, a gateway to the whole body, well beyond the eye. Today add osteoporosis to the list. https://t.co/wUUsOziecv This adds to what I recently wrote about at Ground Truths https://t.co/fOsjLgAyvU
Multimodal AI Beats Physicians on 29 of 32 Metrics
A multimodal AI (AIME) had superior performance compared with 18 physicians for almost every metric (29 of 32 axes). Randomized, but simulated, not real-world clinical practice. @GoogleDeepMind @alan_karthi @RyutaroTanno https://t.co/PIs9VZmlMi https://t.co/nDC8p2jmus
GLP‑1/GIP/Glucagon Drugs Target New
Just a few conditions being pursued for secondary prevention or treatment by GLP-1/GIP/Glucagon drugs in a new and comprehensive review @NatRevDrugDisc https://t.co/pjfc2jkAGU
Optimizing Sleep May Extend Longevity and Reduce Disease
“the potential of sleep optimization to promote healthy ageing, lower disease risk and extend longevity.” @Nature Linking biological clocks and sleep data https://t.co/ptcaxy2hCh
New mRNA‑nanoparticle Vaccine Boosts Cancer Potency, Durability
An innovation taking mRNA-nanoparticle cancer vaccines to the next level for potency and durability @NatureBiotech https://t.co/6wBToMGgEA
Oral Pill
Two new randomized studies just published @NatureMedicine for weaning from injectable GLP-1 drugs to maintain weight loss —Pill, orforglipron https://t.co/r9Nx9J9vJg —Bacterial supplement for gut microbiome https://t.co/km2V3NkIOX
Personalized Neoantigen Vaccine Shows Promise Against Glioblastoma
Personalized neoantigen vaccines vs cancer: we've seen benefits for pancreatic, renal and melanoma. Today initial, encouraging results vs glioblastoma in 9 patients with this deadly brain cancer @NatureCancer https://t.co/ACdCjiXnjJ
GLP‑1 Drugs Boost Survival, Cut Recurrence in Obese Breast Cancer Patients
In women with breast cancer and obesity or T2 diabetes, a large propensity matching retrospective analysis reports association of GLP-1 drug therapy with improved survival and reduced risk of recurrence https://t.co/GjimCr97S0
Longevity Hype Ignores Limited Healthspan Evidence
Why is there such obsession with extending lifespan when the bigger issue is that average healthspan is 65 years and there are no data (except in super-centenarians) that longer lifespan = longer healthspan (known as compression of morbidity)? https://t.co/w33aRn71cn
LLMs Fail to Admit Uncertainty in Medical Contexts
Expressing uncertainty is a major weak spot of LLMs in medicine @NEJM "Can AI Say I Don't Know?" Good lines: "Contemporary LLMs have passed many Turing tests, but will they pass this modern test of not knowing? We don’t know." https://t.co/EsJR8gIDHs https://t.co/CXL0fpzP6v
MRNA Nanoparticles Reprogram T Cells In Vivo, Show Promise
Impressive. In vivo reprogramming of killer T cells with mRNA-nanoparticle packaging in non-human primates. Multiple use cases in the clinic vs pathogens and cancer, no less an alternative version vs autoimmune diseases https://t.co/ddhebnxvkE @SciImmunology
AI-Generated Hospitalization Summaries Cut Clerk Workload, Boost Physician Well‑being
Agentic AI summaries of hospitalizations were safe and reduced data clerk burden, burnout, and improved sense of well-being for physicians in a prospective study https://t.co/0nXZ0wjugg
U.S. Death Rates Remain Higher Than Peers Despite Equal Tech
"Despite similar access to advanced medical technology, the US has experienced persistently higher death rates than other high income countries" https://t.co/iIe8UJbUCs
Organ‑Specific Aging Clocks Reveal Multi‑Omics Lifespan Patterns
The big advance in the science of human aging is the ability to quantify it and relate the metrics to health and disease. A new paper today @CellCellPress takes this to the next level with organ clocks and multiple biologic...
Metformin's Primary Action Is Gut, Not Liver
Metformin, one of the most commonly prescribed drugs, was thought to work via the liver. Check that. It's primarily through the gut. @NatMetabolism https://t.co/i2CpZip61B https://t.co/bhsI7p7SYx
STING Pathway Emerges as New Cancer Immunotherapy Frontier
The number of new potential ways to rev up the immune response to cancer keeps expanding. Today it's STING-ing it. @ScienceMagazine https://t.co/p9g0Mmc8kG https://t.co/LbKfODQkO1
Aging Boosts Incremental Ideas, Stifles Disruptive Breakthroughs
How is innovation in science impacted by aging researchers? @ScienceMagazine "Aging enhances combinatorial innovation but limits disruptive breakthroughs" @ScienceVisuals Figure showing anchor publication of a scientist typically early in career (top) and declining innovation over length of career (bottom) https://t.co/E2Q6Zzdf4s
Macrophages Detect Threats Through Cell Volume Shifts
The mechanism by which macrophage cells sense danger to drive an immune response and inflammation has been elusive. A new report highlights change in cell volume as the signal @JCellBiol https://t.co/VQJHtWvczx https://t.co/DQaETZRD0L
AI Poised to Transform Surgery From Planning to Recovery
The impact of AI for surgery (pre-op, intraop, post-op) is going to be extensive A new review https://t.co/04oo4GpQG5 Our previous review @NatureMedicine https://t.co/zDuBUUJUUi https://t.co/V9zDcKQY2K
CRISPR Selectively Eliminates KRAS‑mutant Cancer Cells
The CRISPR Killer as in KRAS mutated cancer cells https://t.co/y1zrmYbIAQ Explainer thread @N8Krah co-author https://t.co/CIweqZMUqY
Hidden Microproteins Reshape Our View of Disease
"The human genome encodes for a new category of molecule" "The ‘dark proteome’ is upending our understanding of human disease" @Nature "Expanding the human proteome with microproteins and peptideins" https://t.co/5ncSKGKHBH https://t.co/2Rx65FJCbG @statnews @MeganMolteni https://t.co/7mATxNQ1EO @TheEconomist
Cut Ultraprocessed Foods to Lower Heart Disease Risk
A consensus statement from @escardio today to limit intake of ultraprocessed foods for reduced risk of heart disease https://t.co/5spHDVmkb3 https://t.co/GvTvcVzzjD
First‑in‑class Molecular Glue Shows Breakthrough Pancreatic Cancer Results
We're seeing major advances vs pancreatic cancer. Today @NEJM data for daraxonrasib @RevMedicines https://t.co/IinceclK6w Context for this first-in-class molecular glue https://t.co/IinceclK6w https://t.co/odhmXQqzMF
Six Players, No Controls: Limited Microbiome Insight
Six (yes, 6) college football players with non-concussive head injury (NHI) and changes in their gut microbiome. No controls. What can you conclude from this? Not this: "Our results provide strong evidence for a link between NHIs and changes in the...
AI Proven in Kenya, Yet Underused Stateside for Health Equity
A reminder that AI can be used to reduce health inequities. Technology not being used in the US except for a few health systems, but shown to work well in Kenya @JAMACardio https://t.co/tFbbOAeKTs
Radiologists Draft Consent for Unproven Whole-Body MRI Screening
At @JAMA_current today, 2 radiologists publish what should be the consent form for a total body MRI in healthy people Note: "no major medical society recommends whole-body MRI screening in the general population because it is unproven, and the harms likely...
Pill GLP‑1 Drugs Activate Amygdala Reward Circuit, Not Hypothalamus
Discovery of a new brain reward circuit in the amygdala for small molecule (pill) GLP-1 drug effect, unlike the injectables (hypothalamus), as shown in mice https://t.co/3lkfxROh5Z
Blood Test Now Gauges Tumor Microenvironment Non‑invasively
We've known how important the tumor microenvironment is for cancer progression and treatment, but we never had a non-invasive blood test to assess it. Today, as reported @nature, one has been discovered https://t.co/rDaF5YUwTq
Exercise Boosts Mood: Data From 8,000 Participants
Physical activity and affective well being (AWB): individual level data from over 8,000 participants with accelerometers and >330,000 AWB ratings. Figure shows AWB metrics before and after physical activity. @NatureHumBehav https://t.co/BNkZVZf3j4 https://t.co/eAB1UMPqNH
13‑Year Study Redefines Colonoscopy’s Population‑Level Impact
Colonoscopy, cancer prevention, and the new arithmetic of benefit - @TheLancet “The study's 13-year results compel a recalibration of what colonoscopy can—and cannot—achieve at the population level. https://t.co/vDOv0cSkjY
Single 25 Mg Psilocybin Dose Triggers Month-Long Brain Changes
A single 25 mg dose of psilocybin leads to brain structural changes that were seen at 1 month. From a cross-over study of 28 healthy volunteers, no prior psychedelic, who also were also assessed after 1 mg. Behavioral results in...
MRI Body Composition Predicts Diabetes, Heart Events, Mortality
Body composition from MRI of 66,000 people was linked to diabetes, major cardiovascular events, and all-cause mortality @radiology_rsna https://t.co/KUkMppvorA https://t.co/FdyHjpWqW1
AI in Healthcare Outpaces Supporting Evidence, Says Ground Truths
The current use of AI in healthcare by patients and clinicians is not aligned with the evidence. In the new edition of Ground Truths https://t.co/WxYbWP0SCs
Blue Zones After 25 Years: Mixed Evidence on Longevity
What is the status of the Blue Zones 25 years after they were claimed? @ShelleyWood2 and I did an extensive look into this question, one of the forces behind the current longevity movement @statnews https://t.co/avrbAbgr90
Nature Study Turns Into Immediate
I wrote about this 6 weeks ago at Ground Truths when the 2 @Nature papers by @HugoAerts and colleagues came out. Today it's a "Health Alert"! https://t.co/CgxBU7IAk1 https://t.co/24PijmLhzR
AI in Medicine: Overused Without Evidence, Under
It's striking. Both the under- and over-use of AI in medicine, by patients and doctors, for where there's evidence and where it doesn't exist https://t.co/jo7sFACPRp
AI Access Gaps Persist: Lower‑SES Americans Less Aware, Use Less
A study of >10,000 Americans documents AI inequalities, lack of awareness and usage among lower SES https://t.co/1s8EMg933Y https://t.co/6BA6p7g2zW
T‑cell Vesicles Deliver DNA, Converting Cold Tumors Hot
In cancer, activated T cells release abundant extracellular vesicles that transfer DNA to the nucleus of tumor and immune (dendritic) cells, turning tumors from cold to hot. An immunotherapy in the works. @Cancer_Cell https://t.co/mHcahijOJC https://t.co/oPT6d7lrFM https://t.co/I0egYxZold
AI Chatbots Capture Poorer Symptom Detail than Doctors
Symptoms reported to an AI chatbot were of lesser quality than reported to a physician, results of a randomized trial of 500 participants across multiple models https://t.co/WXP4R3y9HA https://t.co/l2hLT76AJB