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Iñigo San‑Millán, PhD

Iñigo San‑Millán, PhD

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Metabolic health, mitochondrial function and athletic performance scientist; fueling strategies underpinning Zone 2, lactate metabolism.

Lactate: Key Regulator Shaping Health and Disease
Social•Apr 4, 2026

Lactate: Key Regulator Shaping Health and Disease

After 30 years studying lactate, I have learned this: Lactate is not just a metabolite. It is a major regulator in the human body body. It can support metabolic health or contribute to disease. Same molecule. Different context. Lactate has been the most misunderstood molecule in biology. If you want to learn more about lactate and its multiple roles, link to my Substack article here 👇 https://t.co/WWDf5nntRm

By Iñigo San‑Millán, PhD
Detect Polyps Early, Prevent Cancer Decades Later
Social•Mar 31, 2026

Detect Polyps Early, Prevent Cancer Decades Later

March has been colorectal cancer awareness month. A reminder of the work of Bert Vogelstein, one of the most cited cancer researchers in history. He showed that colorectal cancer is a slow, stepwise process (often over 20–25 years): normal tissue ➡️...

By Iñigo San‑Millán, PhD
Lactate: Misunderstood Molecule, Actually Helps, Not Harms
Social•Mar 28, 2026

Lactate: Misunderstood Molecule, Actually Helps, Not Harms

"Lactate was at the scene of the crime but was not the criminal. It was actually trying to help" Lactate: The Most Misunderstood Molecule in Biology👇 https://t.co/3skDRDEuqw

By Iñigo San‑Millán, PhD
Zone 2: Optimal Metabolic Equilibrium for Most
Social•Mar 27, 2026

Zone 2: Optimal Metabolic Equilibrium for Most

A mechanistic articulation on why zone 2 is the maximum metabolic equilibrium state for most people. 👇 https://t.co/W8MxJC40Yi

By Iñigo San‑Millán, PhD
Lactate: The Most Misunderstood Molecule in Physiology
Social•Mar 24, 2026

Lactate: The Most Misunderstood Molecule in Physiology

The lactate story. The Most Misunderstood Molecule in Human Physiology. Coming up tomorrow on Substack https://t.co/cyvmQexhzr

By Iñigo San‑Millán, PhD
Beyond VO₂max: Rethinking Performance and Longevity
Social•Mar 17, 2026

Beyond VO₂max: Rethinking Performance and Longevity

Working on a new article for my Substack. Those of us working with elite athletes have relied on our good old friend VO₂max for decades. It’s essential, but it’s not the full picture. Now that VO₂max has re-emerged in the world of longevity,...

By Iñigo San‑Millán, PhD
Guard Your Thoughts Like Health, Shape Your Character
Social•Mar 16, 2026

Guard Your Thoughts Like Health, Shape Your Character

Great message from Marcus Aurelius reminding us to guard our thoughts. If our thoughts are filled with resentment, fear, envy or bitterness, those impressions slowly shape our character. They become our emotional baseline. Over time they define how we see the...

By Iñigo San‑Millán, PhD
Both Zone 2 and HIIT Essential for Peak Power
Social•Mar 15, 2026

Both Zone 2 and HIIT Essential for Peak Power

Many years of TrainingPeaks data from top cyclists I have worked with show a consistent pattern: ~40–60% of the best 5, 10 and 20 min power outputs were achieved during training in individually prescribed HIIT sessions ~40–60% occur during races. In simple...

By Iñigo San‑Millán, PhD