ARCH Funds Flourish to Expand Low‑Power Distributed Cognition
ARCH is excited to back Flourish in its initial financing. Low power, distributed cognition is how humans invented these words and LLM’s. Exploring how it can be harnessed and expanded further will be fun and maybe world-changing.
ARCH Backs Mental‑health IPO, Celebrating Early Investment Success
Congrats to Daphne Zohar and team, and Steve Paul for an amazing IPO to fuel new drugs for mental health and brain disorders. ARCH invested early here because of the team, platform, and clinical need.
Congress Must Reform Broken IND Process for FIH Trials
Great to see FDA & the administration prioritizing FIH (First in Human) reform. The current IND process is broken & has shifted FIH trials overseas. Countries like Australia have relied on a more flexible, notification-based pathway for years. Now Congress...
Decade-Long Quest to Break Blood-Brain Barrier Highlights Biotech Challenges
When we seeded Denali the idea was to break the curse of the blood/brain barrier. It took a decade and tons of faith and money. Biotech is hard. Curing diseases is hard. This is a good summary. ...
Sauna Benefits Need BDNF Study; Cold Post‑Sauna Weak
Sauna data interesting. Need a study that actually measures BDNF etc and clinical outcomes to really prove. But I am doing it. Low risk. The evidence for cold afterwards is weak
Stable FDA Rules Essential for Patient Safety and Investment
To invest the billions it costs to make new medicines, companies need to be able to trust the word and actions of the FDA. To capaciously change the rules at the end of the game ultimately hurts patients.