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Steve Horvath, PhD

Steve Horvath, PhD

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Developer of epigenetic clocks; posts about biological aging and clocks applications.

Vitamin C Blocks Ferro‑aging, Boosting Longevity in Primates
Social•Mar 16, 2026

Vitamin C Blocks Ferro‑aging, Boosting Longevity in Primates

Simple nutrients, serious science. March 2026 is turning into a good month for longevity research on everyday supplements. First, a Nature Medicine paper (COSMOS trial) showing daily multivitamins modestly slowed epigenetic aging clocks (GrimAge and PhenoAge) in older adults: around 4 months over 2 years. Now, Liu et al. identify vitamin C as a direct inhibitor of ACSL4, a key driver of age-related iron-dependent lipid peroxidation (ferro-aging). Long-term supplementation in aged monkeys reduced tissue damage and improved metabolic/neurological function. Lixiao Liu, Jing Qu, Guang-Hui Liu (2026) Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. https://t.co/ir71Mj2bSW

By Steve Horvath, PhD
Cell Painting Images Predict Cellular Age Without Methylation
Social•Mar 16, 2026

Cell Painting Images Predict Cellular Age Without Methylation

A model that predicts cellular age from Cell Painting microscopy images alone. No DNA methylation needed. The model captures morphological aging hallmarks across nuclear and cytoplasmic compartments, correlates with chronological age AND epigenetic clocks. The promise: screen for rejuvenation compounds...

By Steve Horvath, PhD
Single‑cell Methylation Reveals Age
Social•Mar 16, 2026

Single‑cell Methylation Reveals Age

Epigenetic aging happens at different rates in individual cells within the same tissue. Using single-cell DNA methylation analysis, Hagit Masika, Tommy Kaplan, Howard Cedar, and colleagues show polycomb CpG island methylation creates 'young' vs 'old' cell subpopulations even at fixed...

By Steve Horvath, PhD
Adenine Methylation Forms New Linear Brain Aging Clock
Social•Mar 13, 2026

Adenine Methylation Forms New Linear Brain Aging Clock

A completely novel axis of epigenetic aging. N6-methyldeoxyadenosine (N6medA), i.e. NOT the usual 5 methyl cytosine, increases linearly with age in human prefrontal cortex (r=0.95). Genome-wide profiling reveals age-associated ADENINE methylation changes reminiscent of classic CpG based epigenetic clocks. Abdur...

By Steve Horvath, PhD