
Ep 10. Sleep: The Other Vital Sign | Medicine Made General
In this episode of Medicine Made General, Johns Hopkins neurologist Dr. Charlene Gamaldo frames sleep as the "other vital sign," arguing that without adequate rest the body’s systems operate like a car missing its steering wheel—functional but dangerously misdirected. She explains that while a tiny fraction of the population are true short sleepers, the vast majority who claim five hours are actually operating below optimal capacity, and she encourages patients to experiment with unrestricted sleep during vacations to gauge their true needs. The discussion delves into practical strategies for chronic partial sleep deprivation, emphasizing that weekend catch‑up sleep is preferable to none, though it cannot fully reverse long‑term deficits. Wearable sleep trackers have surged in popularity, raising awareness but often lacking FDA validation; their reliance on motion can misclassify deep sleepers or insomniacs, sometimes spawning the newly recognized disorder orthosomnia, where anxiety over device data worsens sleep. Memorable analogies pepper the conversation: sleep as a steering wheel, and the quantified‑self obsession turning data into a new insomnia. Dr. Gamaldo also highlights the public‑health impact of daylight‑saving time changes, citing increased traffic accidents and a mini‑jet‑lag effect that can linger up to a week, prompting sleep specialists to lobby for its abolition. For clinicians and consumers alike, the episode underscores the need to treat sleep with the same rigor as blood pressure or heart rate, to use wearables as educational tools rather than diagnostic ones, and to advocate for policies—like ending daylight‑saving shifts—that align societal schedules with our circadian biology.

Belina Yi, D.O. | Pediatric Rheumatologist
The video introduces Dr. Bellina Yi, a pediatric rheumatologist at Johns Hopkins Children’s Center, who treats children with autoimmune and autoinflammatory diseases. She emphasizes that, unlike common perception, arthritis and systemic conditions can affect patients from infancy through adolescence. Dr. Yi...

Bone Health of Women with CF Across the Age Spectrum
At the 2025 North American Cystic Fibrosis Conference, pediatric endocrinologist Melinda Woo presented findings on bone health among women with cystic fibrosis, emphasizing how contraceptive choices may influence osteoporosis risk. The study, part of the CASE for CF project, surveyed...

Recurrent Brain Tumor | Elena's Story
Elena, a patient at Johns Hopkins Kimmel Cancer Center, was diagnosed with a rare brain cancer and achieved remission after initial treatment. Years later, her tumor recurred, prompting physicians to administer a novel drug. The medication stems from a 2008...

EphB2-Ephrin-B1 Signaling in Microglia and Implications for NeuroHIV
The seminar presented Dr. Marcus Call’s recent work on EphB2‑ephrin‑B1 signaling in microglia and its relevance to neuroHIV. While antiretroviral therapy has reduced systemic viral loads, roughly half of people living with HIV still develop neurocognitive impairment, ranging from asymptomatic...

Johns Hopkins Psychiatry Grand Rounds | Preteen Suicide Assessment
Johns Hopkins psychiatrists present a five‑year NIMH‑funded study developing a reliable, developmentally appropriate assessment for suicidal thoughts and behaviors in children ages eight to twelve. The initiative grew from a 2021 NIMH call to address the emerging public‑health crisis of...

Johns Hopkins Psychiatry Grand Rounds | Mild Behavioral Impairment (MBI)
The Grand Rounds presentation introduced Mild Behavioral Impairment (MBI) as a framework for understanding neuropsychiatric symptoms that emerge before overt dementia, using a 72‑year‑old patient with late‑onset depression and subsequent Alzheimer’s pathology as a case study. The speaker highlighted that...

Two Heart Transplant | Chandra's Story
The video follows Chandra’s journey through two heart transplants, detailing how the first graft failed shortly after surgery and a second donor heart ultimately saved her life. It highlights the emotional and medical challenges she faced, from prolonged hospitalization to...

Adaptive Rock Climbing in Rehabilitation
Movement Timmonium hosted its second adaptive wall‑climbing event, showcasing how climbing can be modified for individuals recovering from traumatic injuries or living with disabilities. The organizers highlighted a range of adaptations—custom harnesses, tactile route markers, and specialized coaching techniques—that transform a...

Living Donor Evaluation Process
The video outlines Johns Hopkins Hospital’s step‑by‑step living liver donor evaluation, guiding prospective donors through registration, testing, review, and pre‑operative phases. Candidates must first register online, confirming age (18+), absence of cancer, infections, substance use, and a solid support network. An...

Dr. Yannis Paulus | Medical and Surgical Retina
Dr. Yannis Paulus, the Jonas Freedom Professor of Ophthalmology and Biomedical Engineering at Johns Hopkins, heads a multidisciplinary retina program that treats macular degeneration, diabetic retinopathy, retinal vein and artery occlusions, and other sight‑threatening conditions. He emphasizes a family‑like,...

Intestinal Bowel Ultrasound (IUS) | Q&A
The video introduces intestinal bowel ultrasound (IUS) as a bedside, non‑invasive imaging modality designed to evaluate the small and large intestines in patients with inflammatory bowel disease (IBD). Using a handheld transducer, high‑frequency sound waves generate real‑time images that can identify...

Johns Hopkins Medicine Cost Estimate Tool
Johns Hopkins Medicine launched an online cost estimate tool that lets patients preview the price of medical procedures before receiving care. The platform pulls data from the health system’s billing database and adjusts figures based on a user’s insurance information....

TIMS 2026 | Johns Hopkins Medicine
The video introduces TIMS – a Technology‑Enabled Interview Management System pioneered at Johns Hopkins Medicine by ICU chaplain Elizabeth Tracy during the COVID‑19 surge. Faced with patients isolated behind ventilators, Tracy designed a brief, four‑question interview to capture each person’s...

Millions of Oligodendrocytes Mapped in the Mouse Brain over Its Lifespan
Johns Hopkins researchers combined 3D light‑sheet microscopy, specialized optics and AI‑driven image analysis to chart more than 10 million oligodendrocytes across the mouse brain throughout its lifespan. The resulting atlas pinpoints myelin density at the level of individual circuits, revealing how...

Maie St. John, M.D., Ph.D., F.A.C.S. | Head and Neck Surgeon
Dr. Maie St. John, professor and director of otolaryngology‑head and neck surgery at Johns Hopkins, recounts how a childhood encounter with a facial tumor set her on a path to become a head‑neck cancer surgeon. She describes a recent case of...

Cognitive Speed Training and Dementia | The ACTIVE Study
The ACTIVE study examined whether a brief cognitive speed‑training regimen can lower the incidence of dementia among older adults. Using Medicare claims data, participants who completed an hour‑long exercise twice a week for six weeks showed a 25 % reduction in dementia...

Informatics Grand Rounds with Dr. Ahmed Hassoon
The talk introduced a sweeping vision for AI alignment in medicine, emphasizing that today’s health‑care ecosystem is rapidly filling with autonomous agents—clinical decision‑support bots, patient‑facing assistants, insurance claim processors, and emerging regulatory AIs. Dr. Hassoon framed this proliferation as an...

Nakul S. Talathi, M.D. | Pediatric Orthopaedic Surgeon
Dr. Nakul S. Talathi, also introduced as Nick Totti, is a pediatric orthopedic surgeon at Johns Hopkins Medicine, specializing in hip, spine, and trauma care for children, adolescents, and young adults. He stresses a listening‑first philosophy, collaborates closely with families to...

Your Reproductive Health in Your 20s & 30s: What to Know, What to Watch For
The video walks viewers through comprehensive reproductive‑health care for women in their twenties and thirties, emphasizing the annual OB‑GYN visit as a cornerstone of lifelong preventive medicine. It outlines what the exam entails—pelvic and breast exams, pap smears, HPV testing after...