As a Doctor, I Tell Patients to Get Rid of These 5 Medications

The Washington Post
The Washington PostMar 27, 2026

Why It Matters

Removing ineffective, high‑risk OTC drugs prevents avoidable side effects and healthcare costs, prompting patients to adopt safer, evidence‑based alternatives.

Key Takeaways

  • Phenylphrine nasal decongestants are ineffective; use pseudoephedrine instead
  • Diphenhydramine (Benadryl) raises fall risk in seniors; choose safer antihistamines
  • Daily aspirin benefits only for specific heart patients; reassess with doctor
  • Docusate sodium isn’t effective alone; replace with fiber supplements like psyllium
  • Codeine cough syrup offers no advantage over placebo; dispose safely

Summary

The video’s core message is a doctor‑led call to purge five widely used over‑the‑counter medicines that offer little benefit and pose unnecessary risks. He highlights oral phenylphrine, the common nasal decongestant found in Dayquil and similar products, which the FDA determined in 2023 to be ineffective, recommending pseudoephedrine as the only proven alternative. He then outlines the hazards of diphenhydramine (Benadryl), especially for patients over 65, linking it to confusion, falls, and urinary retention, and suggests newer antihistamines such as loratadine or fexofenadine. Daily low‑dose aspirin, once a blanket preventive, now follows 2022 guidelines limiting use to those with prior heart attacks or strokes, prompting a doctor‑patient risk‑benefit discussion. Docusate sodium, the active ingredient in many stool softeners, fails to work as a standalone laxative per randomized trials, making fiber supplements—particularly psyllium husk—more effective. Finally, codeine cough syrup shows no benefit over placebo in controlled studies, rendering it an unnecessary opioid exposure. The doctor cites specific regulatory findings: the FDA’s 2023 phenylphrine review, the 2022 aspirin guideline revisions, and multiple RCTs debunking docusate and codeine efficacy. He underscores safer alternatives—pseudoephedrine behind the counter, modern antihistamines, targeted aspirin therapy, fiber‑based laxatives, and non‑opioid cough remedies—while urging proper drug disposal via pharmacy take‑back kiosks. For consumers, the advice translates into immediate medication audits, physician consultations, and a shift toward evidence‑based OTC options. Eliminating these low‑value drugs can reduce adverse events, lower healthcare costs, and improve overall patient safety, especially among older adults.

Original Description

It’s time to do some spring cleaning — of your medicine cabinet.
Some of those medications have been sitting there for years, and the science around them may have quietly changed. Here are five that deserve a second look, says Dr. Trisha Pasricha, a physician at Beth Israel Deaconess Medical Center, an assistant professor of medicine at Harvard Medical School and The Washington Post’s Ask a Doctor columnist.
But before you stop taking them, you should have a discussion with your doctor, just to be sure.
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