Triple Therapy Could Block Newborn Meningitis without Antibiotics
Researchers at ETH Zurich and the University of Basel have devised a triple‑pronged therapy that prevents transmission of the K1 strain of E. coli from pregnant mothers to newborns. The regimen pairs an oral vaccine that weakens the pathogen, bacteriophages that force it to discard its protective outer layer, and a probiotic that outcompetes the weakened bacteria. In mouse models, the treatment reduced neonatal transmission from 83 % to 23 %. The team envisions an antibiotic‑free, single‑capsule product for human use.
How Cells Clear Immune Signals Could Reshape Drug Design and Cancer Spread Research
Researchers at the Institute of Cell Biology and Immunology Thurgau decoded the signaling pathway of the atypical chemokine receptor ACKR4, revealing its continuous trafficking between the cell surface and internal organelles to internalize and degrade excess chemokines. The study identified...
The Link Between HIV and Chronic Pain
Over half of people living with HIV suffer chronic pain, a condition that remains hard to treat. A new study in the Journal of Neuroscience shows that the HIV envelope protein gp120, when injected into the mouse spinal cord, boosts...
Blood Samples Uncover Concussion in Older Adults, Offering More Objective Diagnosis
Researchers at Monash University and The Alfred have validated a blood test that detects the glial fibrillary acidic protein (GFAP) to diagnose concussion in adults over 60. In a study of 89 patients, GFAP levels were markedly higher in those...
First Comprehensive Look at Breast Cancer in Native American Women Reveals Key Genetic Differences
Researchers at the University of Notre Dame published the first detailed genetic analysis of breast cancer in Native American women, comparing 17 tumor samples with nearly 700 white‑patient cases from The Cancer Genome Atlas. The study, appearing in npj Precision...
Dual PET Imaging Detects Tumor Progression and Heart Inflammation During Cancer Treatment
Researchers unveiled a dual PET imaging method that simultaneously visualizes tumor growth and cardiac inflammation using a CCR2‑targeted radiotracer, 64Cu‑DOTA‑ECL1i. In mouse models, checkpoint inhibitor therapy slowed tumors but heightened cardiac CCR2 signals, while adding the JAK1 inhibitor itacitinib improved...
Early Interventions Can Help Women Achieve Optimal Weight Gain During Pregnancy, Review Suggests
A systematic review in BMJ Global Health finds that early nutrition, education and physical‑activity interventions in low‑ and middle‑income countries help pregnant women achieve optimal gestational weight gain, reducing both under‑ and over‑gain. Physical activity programs were most effective at...
Long-Term Leukemia Trial Reveals MRD-Triggered Treatment May Slow or Prevent Relapse
The RELAZA2 trial has released its long‑term data, confirming that azacitidine administered at the first sign of measurable residual disease (MRD) can significantly delay relapse in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). As the world’s first prospective MRD‑triggered...
How a Remarkable Trial on Bedrest During the Korean War Led to Evidence‑based Medicine
In 1955, Dr. Thomas Chalmers conducted a randomized trial at a U.S. army hospital in Kyoto that showed hepatitis patients recovered just as quickly with unrestricted activity as with strict bed rest. The findings, published in a 73‑page report, disproved the...
New AI Approach Aims to Predict Radiation Dose Before Therapy in Advanced Prostate Cancer
Researchers presented a machine‑learning model that predicts absorbed radiation dose for ⁷⁷Lu‑PSMA therapy using pre‑therapy ¹⁸F‑PSMA PET/CT scans in metastatic castration‑resistant prostate cancer. The proof‑of‑concept study involved nine patients, analyzing 57 tumors, 36 salivary glands and 18 kidneys, and demonstrated...
New Analysis Finds Geographical Differences in Access to Donor Lungs, Transplants
A new study by Cleveland Clinic and Case Western Reserve University, published in *CHEST*, shows that geographic location still heavily influences access to donor lungs in the United States despite recent reforms to the lung Composite Allocation Score (CAS). Analyzing...
AI Repurposes Routine Chest X-Rays to Catch Silent Bone Loss Before Fracture
Researchers at St. Paul’s Hospital and National Taiwan University have shown that artificial intelligence can analyze routine chest X‑rays to identify silent osteoporosis, a condition often missed by standard screening. The study, published in npj Digital Medicine, found that more than...
Q&A: Researcher Discusses Early-Onset Breast Cancer in East Africa
Doctoral researcher Tove Ekdahl Hjelm defended her thesis on early‑onset breast cancer in Uganda and Ethiopia, revealing stark gaps in diagnosis, surgery, and comprehensive treatment. The study found that only one in five patients with potentially curable disease completed the...
Tezepelumab Helps Severe Asthma Patients Reduce Oral Steroids over 28 Weeks
A Phase III SUNRISE trial published in The Lancet Respiratory Medicine shows tezepelumab enables severe asthma patients to sharply cut their reliance on oral corticosteroids. Over 28 weeks, 69% of participants on the drug achieved at least a 50% dose reduction...
An Overlooked Protein May Decide How Fast Male Fertility Starts to Unravel with Age
Researchers at the Universitat Autònoma de Barcelona and collaborators identified the SIRT7 protein as a critical regulator of genome stability in male germ cells. In mouse models, SIRT7 limits the epigenetic marker H3K36ac, preserving spermatogonia and preventing DNA fragmentation as...