The Reality of Human Growth Hormone.

Dave Asprey (Bulletproof Radio)
Dave Asprey (Bulletproof Radio)Mar 15, 2026

Why It Matters

The anecdote highlights MK-677 as a non-injectable option that may restore depleted growth hormone in adults, raising interest in alternative hormone-replacement strategies and biohacking approaches; it also underscores the need for medical oversight and more rigorous evidence. This could influence patient choices and demand for off-label supplements in wellness and anti-aging markets.

Summary

The speaker recounts using human growth hormone (HGH) replacement therapy for five years after having near-zero growth hormone and IGF-1 levels, then tapering off successfully after rebuilding his biology. After a later decline in GH due to travel and biotoxin exposure, he chose to use the oral secretagogue MK-677 for three months, which restored his HGH levels to normal. He contrasts MK-677 and peptide stimulants with direct HGH injections and frames these interventions as part of a broader biohacking effort to regain physiological function and agency over health. The account is anecdotal and presented as a personal experiment rather than clinical guidance.

Original Description

The reality of human growth hormone.
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