Why You Feel Tired All The Time After 40 | Baran Dilaver

Cynthia Thurlow
Cynthia ThurlowApr 27, 2026

Why It Matters

Restoring NAD and creatine addresses the root cause of age‑related fatigue, presenting a scientifically backed, consumer‑friendly solution that could reshape the anti‑aging supplement market.

Key Takeaways

  • NAD levels decline with age, driving fatigue and inflammation.
  • Creatine and NAD precursors synergize to boost cellular energy.
  • Bioavailable NAD precursors (NMN, NR) are essential for supplementation.
  • Innovative delivery: creatine‑infused dark chocolate improves consumer compliance.
  • Ongoing clinical trials (e.g., Yale 700‑patient NAD study) validate efficacy.

Summary

The video explores why people over 40 often feel chronically tired, focusing on the role of cellular energy molecules NAD and creatine. It explains how age‑related NAD depletion and suboptimal creatine availability impair mitochondrial ATP production, leading to fatigue, brain fog, and heightened inflammation. Key insights include the biochemical partnership of NAD and creatine in powering gut and brain cells, the importance of bioavailable NAD precursors such as NMN and NR, and the challenges of delivering these nutrients effectively. The host highlights a new consumer product—a dark chocolate bar fortified with creatine and NAD precursors—designed to make supplementation enjoyable while overcoming dosage and taste hurdles. Notable examples feature an analogy likening NAD to mountain water that irrigates the body’s “farms,” and a reference to a Yale‑led 700‑patient trial investigating NAD precursors for fertility. The founder recounts meeting Dr. Sausman, whose early work on NAD and cancer sparked the venture, and describes the five‑year R&D journey to perfect flavor, ingredient sourcing, and scaling. The discussion underscores that restoring NAD and creatine levels could mitigate age‑related energy loss, improve gut integrity, and reduce systemic inflammation, offering a tangible strategy for longevity‑focused consumers and a potential market niche for functional foods.

Original Description

To purchase my new book, The Menopause Gut please visit here: https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/
Between April 15 and April 30, listeners can receive a travel size Youngr™ NMN pouch ($22 value) with their first order using the code CYNTHIATHURLOW (US orders only)
I’m delighted to connect with Baran Dilaver. Baran is an entrepreneur, creator, and accomplished executive, and also the co-founder of Wonderfeel Biosciences, a longevity-focused bioscience company that pioneers cellular health innovations through its patented NAD products. (You will likely remember the dynamic interview I did last year with Dr. Andrew Salzman, the MD and Chief Medical Officer of Wonderfeel.)
In today’s conversation, Baran and I explore the science of cellular energy and its wide-ranging benefits. We cover the physiology of NAD and other nutraceuticals, the key markers of inflammation, and the precursors in Wonderfeel’s formulas that enhance absorption and assimilation. We discuss how NAD and creatine monohydrate each fuel cellular energy, their powerful synergistic effects, and the NAD-creatine combination as a powerful midlife stack. We also get into brain fog, mood, and stress resilience, along with the FDA’s clarification on NMN and other nutraceuticals, and why NAD injections and IV NAD may fall short compared to oral precursors like NMN and NR. I also share my experience trying Wonderfeel’s newest product, ChocoCreatin™.
You won’t miss this in-depth conversation with Baran Dilaver of Wonderfeel, as he shares his expert perspective on NAD and creatine monohydrate supplementation.
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For more information please visit me here: https://cynthiathurlow.com/
This video is for educational and informational purposes only and solely as a self-help tool for your own use. I am not providing medical, psychological, or nutrition therapy advice. You should not use this information to diagnose or treat any health problems or illnesses without consulting your own medical practitioner. Always seek the advice of your own medical practitioner and/or mental health provider about your specific health situation.

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