Fight Aging!

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Personal longevity science blog tracking advances in anti-aging biotechnology, rejuvenation research, and advocacy for life-extension therapies

Partial Reprogramming of Neurons Encoding Memory Improves Cognitive Function in Aged Mice

Researchers applied cyclic OSK (Oct4‑Sox2‑Klf4) gene therapy to memory‑encoding neurons in aged mice, achieving partial cellular reprogramming without full pluripotency. The intervention reversed senescence‑related gene expression, restored youthful epigenetic patterns, and normalized synaptic plasticity in both hippocampal and prefrontal engrams. In Alzheimer’s‑model mice, the treatment also reduced neuronal hyperexcitability. Across brain regions and behavioral tests, reprogrammed mice performed on par with young, healthy controls, indicating robust cognitive rejuvenation.

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Fight Aging!

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Partial Reprogramming of Neurons Encoding Memory Improves Cognitive Function in Aged Mice

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Technology Pulse

Fight Aging!

Recent Posts

Partial Reprogramming of Neurons Encoding Memory Improves Cognitive Function in Aged Mice

Reduced APOE Expression Improves Bone Regeneration in Aged Mice

IRF7 Expression Drives Instability in Atherosclerotic Plaques

The Aging of Retinal Vasculature Reflects the Aging of the Brain

People Are Still Working on the Senolytic Peptide FOXO4-DRI

Increased O-GlcNAc Transferase Expression as an Approach to Improving Function in the Aging Brain

Inflammatory Glycogen Produced by Gut Microbes Contributes to Neurodegeneration

The ARMOR Study of Fecal Microbiota Transplantation to Treat Aging

The Ethical Case for the Development of Means to Treat Aging as a Medical Condition

Interactions Between Neurons and Glial Cells in the Aging Brain

Position Effect Variegation as a Way to Visualize Age-Related Structural Change of Nuclear DNA

MTOR Inhibitors Reduce DNA Damage and Consequent Cellular Senescence in Immune Cells

Endoplasmic Reticulum Autophagy Is Important in Aging

More Evidence for a Prevalent Accumulation of Aggregated Proteins in the Aging Brain

A Reinvigorated Alcor and Growth in Cryonics

BDNF Gene Therapy Improves Cognitive Function in Alzheimer's Model Mice

A Technique for Generating Artificial Lymph Nodes

Arguing for a Higher Heritability of Human Longevity

CUL5 as a Potential Target to Reduce Tau Levels in the Aging Brain

Better Understanding How Misfolded Α-Synuclein Moves From Gut to Brain

Perspectives on Aging Research and the Near Future of the Field

Sex Differences in Atherosclerotic Cardiovascular Disease

Α-Ketoglutarate Interacts with TET to Regulate Cellular Senescence

Functional Amyloids Are Involved in Long Term Memory

The First Clinical Trial of Partial Reprogramming Will Start Soon

Ferroptosis in Alzheimer's Disease Is Reduced by Exercise

Considering Autophagy as a Means to Modestly Slow Aging