GLP-1 Receptor Agonists and Risk of Suicide or Suicide Attempts – A Nationwide Cohort and Self-Controlled Case Series Study
A nationwide Danish registry study examined whether glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) increase suicide or suicide attempts compared with active comparators—SGLT‑2 and DPP‑4 inhibitors. Across two new‑user cohorts totaling over 200,000 GLP‑1 RA initiators, adjusted hazard ratios showed no elevated risk (HR 0.93 vs SGLT‑2; HR 0.58 vs DPP‑4). A self‑controlled case series further revealed lower incidence rate ratios during both early and late treatment periods. The findings counter earlier safety signals and suggest GLP‑1 RAs do not raise suicidal behavior risk.
Ceruloplasmin Deficiency Drives a Fusiform-Centric Lipid–Myelin Pathology Underlying a Visual Subtype in Autism
A multimodal study of 179 children with autism identified a distinct fusiform‑centric lipid‑myelin pathology in those with atypical visual processing (ASD‑AVP). Using Dixon‑based PDFF mapping, synthetic MRI myelin quantification, and serum iron‑ceruloplasmin‑lead profiling, researchers found elevated lipid accumulation and abnormal...
Exploring the Lung-Brain Axis in Perioperative Neurocognitive Disorders: A Potential Therapeutic Target
Recent research highlights the lung‑brain axis as a promising therapeutic target for perioperative neurocognitive disorders (PNDs). Studies reveal that general anesthesia reshapes the lung microbiome, while lung‑derived immune cells and cytokine pathways can modulate amyloid‑beta and tau pathology in the...
Loss of Schizophrenia Risk Gene XPO7 Disrupts Neuronal Excitability and Network Regularity via Altered Na+ Channel Dynamics in Human Neurons
Researchers used CRISPR‑edited human iPSC‑derived neurons to delete one or both copies of the schizophrenia‑risk gene XPO7. Loss‑of‑function altered voltage‑gated Na⁺ channel conductance, shifting activation and inactivation curves and increasing channel density, especially in heterozygous cells. Electrophysiology and high‑density MEA...
Postpartum Psychosis Is Associated with Elevated Neuromelanin-MRI Signal in the Midbrain
A new study published in Molecular Psychiatry reports that women with a history of postpartum psychosis (PP) exhibit significantly higher neuromelanin‑MRI (NM‑MRI) signal in the substantia nigra, ventral tegmental area, and related midbrain nuclei compared with demographically matched controls. The...
Genome-Wide Tandem Repeat Expansions Modify Schizophrenia Risk in the Presence of a 22q11.2 Deletion
Researchers sequenced the genomes of 438 individuals with the 22q11.2 deletion and discovered that rare tandem repeat expansions (TREs) are significantly enriched in those who develop schizophrenia. The burden of genic TREs showed odds ratios of 1.75–2.14, comparable to the...
Accelerated Intermittent Theta Burst Stimulation Targeting Personalized Fronto-Parietal Control Network Improves Core Symptoms of Autism Spectrum Disorder: A Double-Blind, Randomized...
A double‑blind, randomized trial evaluated a 12‑week accelerated intermittent theta‑burst stimulation (iTBS) protocol that targeted each participant’s fronto‑parietal control network using individualized functional MRI maps. Among 57 severely affected individuals with autism spectrum disorder, 55% of the active iTBS group...
Clinical Innovations and Future Directions of Nanoparticles in the Treatment of Psychiatric and Neurological Disorders
Nanoparticles are emerging as a transformative platform for treating psychiatric and neurological disorders such as depression, schizophrenia, Alzheimer’s disease and Parkinson’s disease. Their physicochemical design enables crossing the blood‑brain barrier, targeted drug delivery, and enhanced imaging for early diagnosis. The...
Response To: “Re-Examining Interneuron-Specific Nrp2 Deletion: Overlooked Striatal and Cortical Contributions”
The authors of a 2025 Molecular Psychiatry paper on neuropilin‑2 (Nrp2) loss in inhibitory neurons issued a formal response to a comment that questioned whether their findings overlooked striatal and cortical contributions to autism‑related behaviors and seizures. They emphasize that...
Pleiotropic Modulation of the Gut-Brain-Lung Axis by Ketamine and Its Enantiomers
A new review examines how ketamine and its enantiomers reshape the gut‑brain‑lung axis by modulating microbiota, microbial metabolites, and immune‑cell trafficking. Both arketamine (R‑ketamine) and esketamine (S‑ketamine) reduce systemic inflammation, but they differ mechanistically: arketamine leverages vagus‑mediated gut‑brain signaling, while...
Pyrazole-Derived TRPC3 Antagonist Ameliorates Synaptic Dysfunctions and Memory Deficits in Alzheimer’s Disease Models
Researchers have engineered a pyrazole‑derived, metabolically stable TRPC3 antagonist that readily penetrates the CNS. In cultured neurons, amyloid‑beta oligomers up‑regulate TRPC3, leading to calcium overload and toxicity. Administration of the compound to 5xFAD and APPKI mouse models reversed synaptic deficits...
Multi-Omics and Electrophysiological Examination of GABAA Receptors in the Dorsolateral Prefrontal Cortex of Humans with Alcohol Use Disorder
Researchers recorded electrophysiological activity of reactivated GABA_A receptors from the dorsolateral prefrontal cortex of postmortem brains of individuals with alcohol use disorder (AUD). Multi‑omics analysis revealed significantly lower mRNA levels for several GABA_A subunits, yet protein abundance and synaptic function...
Adolescent Disordered Eating and Epigenetic Age Acceleration
A new longitudinal analysis of the Australian Raine Study examined whether adolescent disordered eating predicts epigenetic age acceleration (EAA). Using DNA‑methylation data from 797 participants at ages 14 and 17, the researchers found that restrictive eating behaviors at 14 were...
Analysis of Rare Coding Variants in Schizophrenia-Associated Genes and Generalised Cognition in the UK Biobank
The study examined whole‑exome data from 396,848 UK Biobank participants to test whether rare damaging coding variants in schizophrenia‑linked genes affect generalised cognitive ability (g) in individuals without psychiatric diagnoses. Rare protein‑truncating variants (PTVs) and deleterious missense mutations in loss‑of‑function...
The Cognitive Benefits of Nitrate in Patients with Alcohol Use Disorder: Unraveling the Oral Microbiome Ectopic Colonization Pathway
A 2025 clinical trial found that dietary nitrate supplementation improves cognitive performance in patients with alcohol use disorder (AUD). The benefit was traced to a reshaping of the oral microbiome, which increased nitrate‑reducing bacteria and limited ectopic colonization of oral...